Synthesis, Molecular Docking, MEP and SAR Analysis, ADME-Tox Predictions, and Antimicrobial Evaluation of Novel Mono- and Tetra-Alkylated Pyrazole and Triazole Ligands by Y. Kaddouri, B. Bouchal, F. Abrigach, M. El Kodadi, M. Bellaoui, R. Touzani

“…ADME-Tox studies suggested that compounds 12 and 13 exhibit better toxicity profiles than the commercial antibiotic streptomycin. MEP studies suggested that compounds 12 and 13 have the same charge locations but differ in their values which are due to the condensed geometry of compound 13 that make it more polarizable than compound 12. …”
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Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents by Jie Dai, Qianyue Li, Ziyi Li, Zhonglin Zang, Yan Luo, Chenghe Zhou

“…The overprescription of antibiotics in medicine and agriculture has accelerated the development and spread of antibiotic resistance in bacteria, which severely limits the arsenal available to clinicians for treating bacterial infections. …”
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Improving Geldanamycin Production in <i>Streptomyces geldanamycininus</i> Through UV Mutagenesis of Protoplast by Yuan Yuan, Lu Yang, Zhikai Fang, Haimin Chen, Fei Sun, Hong Jiang, Jian Zhou

“…Geldanamycin, a benzoquinone ansa antibiotic, has been extensively applied in medical, agricultural, and health research areas due to its antitumor, antifungal, herbicidal, and antiradiation effects. …”
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The Result of Timely Therapy for Whipple's Disease: a Clinical Case by S. N. Mekhtiev, O. A. Mekhtieva, E. Yu. Kalinina, V. E. Karev, A. V. Vanyan, O. M. Berko

“…Timely diagnosis and initiation of antibiotic therapy will help to avoid late complications of the disease, including death.…”
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Adsorption characteristics of metronidazole on CoZr-LDH and its GO nanocomposite: Experimental and theoretical study by Edris Jamshidi, Fateme Fathabadi, Faranak Manteghi, Rahime Eshaghimalekshah

“…CoZr-LDH and its Graphene Oxide (GO) nanocomposite were synthesized by mechanochemical and hydrothermal methods, respectively, and were applied to absorb metronidazole as a pollutant antibiotic from an aqueous solution. In this study, Tetravalent and divalent metal cations were employed. …”
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Effects of butyric acid and Protoxin probiotic in the feeding of Siberian sturgeon (Acipenser baerii) by Rasool Zare, Abdolmohammad Abedian Kenari

“…Introduction: Using antibiotics to combat microbes and as a growth-enhancing tool in aquaculture is a common trend. …”
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Epidemiology of Respiratory Pathogens in Children with Severe Acute Respiratory Infection and Impact of the Multiplex PCR Film Array Respiratory Panel: A 2-Year Study by Asmae Lamrani Hanchi, Morad Guennouni, Meriem Rachidi, Toufik Benhoumich, Hind Bennani, Mounir Bourrous, Fadl Mrabih Rabou Maoulainine, Said Younous, Mohamed Bouskraoui, Nabila Soraa

“…It also highlighted the importance of multiplex PCR in confirming viral origin, thus avoiding irrational prescription of antibiotics in paediatric settings.…”
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Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or Streptococcus by Anders Brüggemann, Nils P. Hailer

“…Infection-free survival was defined as the absence of (1) further surgery to the index joint due to PJI, (2) suppressive antibiotic therapy, and (3) death due to PJI and was assessed using the Kaplan–Meier method. …”
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Real-time monitoring by interferometric light microscopy of phage suspensions for personalised phage therapy by Benjamine Lapras, Camille Merienne, Emma Eynaud, Léa Usseglio, Chloé Marchand, Mathieu Médina, Camille Kolenda, Thomas Briot, Frédéric Laurent, Fabrice Pirot, PHAGEinLYON

“…Abstract Phage therapy uses viruses (phages) against antibiotic resistance. Tailoring treatments to specific patient strains requires stocks of various highly concentrated purified phages. …”
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Risk of Multidrug Resistant Bacteria Acquisition in Patients with Declared β-Lactam Allergy during Hospitalization in Intensive Care Unit: A Retrospective Cohort Study (2007-2018) by Alessio Strazzulla, Maria Concetta Postorino, Nabil Belfeki, Laura Iordache, Astrid de Pontfarcy, Aurelia Pitsch, Pierre Leroy, Sebastien Jochmans, Mehran Monchi, Sylvain Diamantis

“…The study included all patients admitted in ICU and receiving antibiotic treatment from January 2007 to December 2018. …”
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Effects of the stress hormone norepinephrine on the probiotic properties of Levilactobacillus: antibacterial colonization, anti-inflammation, and antioxidation by Lingdi Niu, Mingchun Gao, Yifan Li, Chaonan Wang, Chaonan Wang, Chuankun Zhang, Haoyuan Duan, Hai Li, Fang Wang, Junwei Ge

“…Probiotics as antibiotic alternatives are unstable for use under stress in clinical applications. …”
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Transition from irrigation with untreated wastewater to treated wastewater and associated benefits and risks by Benjamin J. Heyde, Melanie Braun, Leila Soufi, Kathia Lüneberg, Sara Gallego, Wulf Amelung, Katharina Axtmann, Gabriele Bierbaum, Stefanie P. Glaeser, Elisabeth Grohmann, René Arredondo-Hernández, Ines Mulder, Dipen Pulami, Kornelia Smalla, Christiane Zarfl, Christina Siebe, Jan Siemens

“…While this transition reduces many health risks, it may decrease crop yields, and soil carbon storage, cause a release of accumulated pollutants from soils, and increase the spread of antibiotic resistance in the environment. A holistic view on multiple SDGs is necessary to maximize benefits and minimize risks of wastewater treatment for irrigation.…”
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A Case Report of Bowel Perforation in a Gravid COVID-19 Patient by A. T. Guiritan, J. G. Cataluña

“…Patient was eventually intubated and was given a total of two doses of tocilizumab, adequate antibiotic treatment, remdesivir, and dexamethasone. …”
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Probiotic Potential of Lactic Acid Starter Cultures Isolated from a Traditional Fermented Sorghum-Millet Beverage by Stellah Byakika, Ivan Muzira Mukisa, Yusuf Byenkya Byaruhanga, Charles Muyanja

“…The candidate and reference microorganisms were resistant to 10 of 21 and 5 of 21 antibiotics, respectively. The isolates exhibited hydrophobic, auto-aggregation and coaggregation properties. …”
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Antimicrobial Resistance of Escherichia coli Isolated from Ground Beef in Huasca de Ocampo, Hidalgo, Mexico by A. P. Cordero-López, V. Vega-Sánchez, V. M. Martínez-Juárez, J. I. Olave-Leyva, F. R. Gómez-De Anda, N. E. Reyes-Rodríguez

“…In addition, the bacterial resistance profile showed that all the isolated strains were resistant to antibiotics of the β-lactam family, while some antibiotics, such as fluoroquinolones, are highly sensitive drugs for the treatment of possible E. coli infections in the area studied. …”
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Bovine Hydroxyapatite-Based Bone Scaffold with Gentamicin Accelerates Vascularization and Remodeling of Bone Defect by Aniek S. Budiatin, Maria A. Gani, Samirah, Chrismawan Ardianto, Aulia M. Raharjanti, Indah Septiani, Ni Putu K. P. Putri, Junaidi Khotib

“…This study aims to determine the effect of bovine hydroxyapatite-gelatin-based bone implants with gentamicin as an antibiotic (BHA-GEL-GEN implant) on the regeneration of bone defects in vivo. …”
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In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity by Gianandrea Guidetti, Alessandro Di Cerbo, Angela Giovazzino, Valentina Rubino, Anna Teresa Palatucci, Sara Centenaro, Elena Fraccaroli, Laura Cortese, Maria Grazia Bonomo, Giuseppina Ruggiero, Sergio Canello, Giuseppe Terrazzano

“…Accumulation of OTC, the elective drug for gastrointestinal and respiratory infectious disease treatment in broiler chickens, was reported in chicken edible tissues and could represent a potential risk for pets and humans that could assume this antibiotic as residue in meat or in meat-derived byproducts. …”
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Pyogenic Lumbar Facet Joint Infection with Foot Drop by Haruka Maehara, Toshihiro Sano, Yuki Yanagawa, Kyuichi Hashimoto, Nobuaki Tadokoro

“…She was admitted for examination and treatment of fever of unknown origin and low back pain. Antibiotic treatment started the day after hospitalization since the first report of the blood culture taken upon admission tested positive to gram-positive cocci. …”
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Bacterial isolates and drug susceptibility patterns in infected lesions of cutaneous leishmaniasis patients at ALERT hospital, Addis Ababa, Ethiopia by Gizealew Ayalew, Asegedech Asmamaw, Mistire Wolde, Regasa Diriba, Biruk Zerfu

“…Over 80% of the isolates demonstrated multi-drug resistance to two or more antibiotics. S. aureus showed high resistance to penicillin (86.4%), methicillin (83.9%), and tetracycline (47.5%). …”
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Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes by Islam Alfreahat MS, Hamdi Nsairat PhD, Ibrahim Deeb Aldeeb PhD, Ali Al-Samydai PhD, Walhan Alshaer PhD

“…Clarithromycin (CAM), a macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. …”
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