Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation: A Register-Based Nationwide Cohort Study by Jon Trærup Andersen, Morten Petersen, Espen Jimenez-Solem, Jeppe Nørgaard Rasmussen, Nadia Lyhne Andersen, Shoaib Afzal, Kasper Broedbaek, Brian Rafn Hjelvang, Lars Køber, Christian Torp-Pedersen, Henrik Enghusen Poulsen

“…The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations. …”
Get full text

Developing a framework for tracking antimicrobial resistance gene movement in a persistent environmental reservoir by Amy J. Mathers, Thomas J. X. Li, Qijun He, Sharvari Narendra, Nicole Stoesser, David W. Eyre, A. Sarah Walker, Katie E. Barry, Salvador Castañeda-Barba, Fenix W. Huang, Hardik Parikh, Shireen Kotay, Derrick W. Crook, Christian Reidys

“…Abstract Mobile genetic elements are key to the global emergence of antibiotic resistance. We successfully reconstructed the complete bacterial genome and plasmid assemblies of isolates sharing the same bla KPC carbapenemase gene to understand evolution over time in six confined hospital drains over five years. …”
Get full text

Understanding biofilm--phage interactions in cystic fibrosis patients using mathematical frameworks by Emerenini Blessing O., Hartung Doris, Reyes Grimaldo Ricardo N. G., Canner Claire, Williams Maya, Agyingi Ephraim, Osgood Robert

“…Biofilm formation in a host can be extremely problematic if left untreated, especially since antibiotics can be ineffective in treating the bacteria. …”
Get full text

Evaluating the risk of acute kidney injury and mortality associated with concomitant use of vancomycin with piperacillin/tazobactam or meropenem in critically ill and non-criticall... by Abdulmajeed M. Alshehri, Majed S. Al Yami, Atheer Aldairem, Lama Alfehaid, Abdulaali R. Almutairi, Omar A. Almohammed, Amal Mohammad Badawoud

“…Conclusion The findings suggest that the use of VPT is associated with a higher risk of AKI compared to VM and highlight the need for cautious antibiotic selection and monitoring of renal function in patients receiving these combinations.…”
Get full text

Handshake antimicrobial stewardship for adult surgical patients by Abby Kosharek, Elizabeth Neuner, Emily Welch, Spenser January, Alice Bewley, Kevin Hsueh, Sena Sayood

“…An interrupted time series found that there was an immediate (P < 0.001) and sustained (P < 0.001) decrease in antibiotic spectrum index during the post-implementation period. …”
Get full text

Accelerated treatment concept in postpneumonectomy empyema with bronchopleural fistula by Gian-Marco Monsch, Harry Etienne, Sven Hillinger, Claudio Caviezel, Olivia Lauk, Isabelle Opitz, Didier Schneiter

“…Therapy consisted of repeated surgical debridement of the pleural cavity, evaluation for loco-regional flap, negative pressure wound therapy and definitive closure after installation an antibiotic solution in the cavity. Primary endpoint was perioperative mortality, focusing on comparison between patients with (= group A) and without bronchopleural fistula (= group B). …”
Get full text

High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens by Nireshni Mitchev, Ravesh Singh, Veron Ramsuran, Arshad Ismail, Mushal Allam, Stanford Kwenda, Florah Mnyameni, Nigel Garrett, Khine Swe Swe-Han, Abraham J. Niehaus, Koleka P. Mlisana

“…N. gonorrhoeae isolates, from female and male patients presenting for care at a sexually transmitted infections clinic in Durban, South Africa, were analysed using phenotypic and genotypic methods for identification and antibiotic susceptibility testing (AST). Real-time PCR and high-resolution melting analysis were used to detect porA pseudogene (species-specific marker) and resistance-associated targets. …”
Get full text

Grimontia hollisae Sepsis in a 9‐Month‐Old Female Infant: A Case Report by Abdulsalam Olawale Yusuf, Osei Isaac, Wutor Baleng Mahama, Williams Oluwatosin Adefila, Keita Modou Lamin, Ilias Hossain, Minteh Molfa, Ousman Barjo, Mayowa Banke Omotosho, Rasheed Salaudeen, Grant Mackenzie

“…It also emphasizes the need for blood culture investigation and administering the appropriate antibiotics in the diagnosis of children presenting with suspected sepsis.…”
Get full text

Acceptability and feasibility of pre-exposure prophylaxis for bacterial STIs: a systematic review. by Julie-Anne Carroll, Amy B Mullens, Sarah Warzywoda, Philip R A Baker, Meika Stafford, Faye McMillan, Jacintha Manton, Daniel Demant

“…Treatment in the form of antibiotic pre-exposure prophylaxis (STI PrEP) is a potential solution. …”
Get full text

Characterization of YdgH: a mediator of beta-lactam susceptibility in Enterobacterales by Jacob E. Lazarus, Matthew K. Waldor, David C. Hooper

“…ABSTRACT Beta-lactam antibiotics are often the treatment of choice for serious bacterial infections. …”
Get full text

Kounis Syndrome as First Manifestation of Allergic Sensitization by D. Forlani, G. Scarano, A. D’Alleva, M. Di Marco, L. Paloscia, A. Gatta, L. Della Valle, A. Farinelli, A. Lumaca, C. Petrarca, R. Paganelli, L. Di Giampaolo, M. Di Gioacchino

“…In Cases 1 and 2, the association of intense chest pain with acute urticaria after an allergenic contact (wasp sting and betalactam antibiotic administration, respectively) was suspected to be an attack of angina related to an allergic reaction. …”
Get full text

Characterization and Biofilm Inhibition of Multidrug-Resistant Acinetobacter baumannii Isolates by Poonam Yadav, Sreska Shrestha, Deepak Basyal, Ananda Tiwari, Ranjit Sah, Anil Kumar Sah, Bishal Yadav, Mark Willcox, Shyam Kumar Mishra

“…Identification and antibiotic sensitivity testing of A. baumannii isolates from clinical specimens were conducted according to the guidelines of the American Society for Microbiology. …”
Get full text

A Case of Skull Base Osteomyelitis with Multiple Cerebral Infarction by Haruka Miyabe, Atsuhiko Uno, Takahiro Nakajima, Natsue Morizane, Keisuke Enomoto, Masayuki Hirose, Toshinori Hazama, Yukinori Takenaka

“…Osteomyelitis was treated successfully by long-term antibiotic therapy; however, the patient experienced cefepime-induced neurotoxicity during therapy. …”
Get full text

A comparison of two systems for group housing of gestating sows - effects on productivity, removal, and treatments by Kaisa Ryytty Sylvén, Torun Wallgren, Pontus Almerheim, Lena Eliasson Selling, Magdalena Jacobson, Per Wallgren

“…Conclusions This study indicated that sows kept in larger groups provided with a larger floor space (a total area of 156 m2, corresponding to 3.9 m2 per sow) and housed on deep straw had a higher number of liveborn and weaned piglets and lower incidence of antibiotic treatments than sows with less floor space (a total area of 24.5 m2, corresponding to 2.5–3.1 m2 per sow) and less bedding/manipulable material.…”
Get full text

Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines. by Orit Gat, James E Galen, Sharon Tennant, Raphael Simon, William C Blackwelder, David J Silverman, Marcela F Pasetti, Myron M Levine

“…<h4>Background</h4>Antibiotic-resistant Salmonella enterica serovar Paratyphi A, the agent of paratyphoid A fever, poses an emerging public health dilemma in endemic areas of Asia and among travelers, as there is no licensed vaccine. …”
Get full text

Prevalence and Antimicrobial Resistance of Escherichia coli in Chicken Meat and Edible Poultry Organs Collected from Retail Shops and Supermarkets of North Western Province in Sri... by R. A. S. S. Ranasinghe, D. A. Satharasinghe, P. S Anwarama, P. M. S. D. K. Parakatawella, L. J. P. A. P. Jayasooriya, R. M. S. B. K. Ranasinghe, R. P. V. J. Rajapakse, J. T. Y. Huat, Y. Rukayadi, Y. Nakaguchi, M. Nishibuchi, S. Radu, J. M. K. J. K. Premarathne

“…Molecular confirmation for the positive samples was done through polymerase chain reaction (PCR) using previously designed primers. An antibiotic susceptibility test was performed according to CLSI using nine antibiotics: ampicillin, amoxicillin, chloramphenicol, ceftazidime, ciprofloxacin, cephalexin, erythromycin, gentamicin, and tetracycline. …”
Get full text

Evaluation of the Outcomes of Coronectomy Procedure versus Surgical Extraction of Lower Third Molars Which Have a High Risk for Inferior Alveolar Nerve Injury: A Systematic Review by Nedal Abu-Mostafa, Lulwah M. AlRejaie, Fahad A. Almutairi, Ruba A. Alajaji, Maram M. Alkodair, Nourah A. Alzahem

“…This systematic review revealed that coronectomy is an efficient alternative for the management of impacted 3rd M with a high risk of IANI. Patients who got antibiotics postcoronectomy procedures had lower infection rates than those who did not receive antibiotic therapy. …”
Get full text

Management of Orbital Granulomatous Polyangiitis Presenting with Lacrimal Gland Involvement: Treatment of Subsequent Peripheral Ulcerative Keratitis, Anterior Uveitis, and Exudativ... by Murat Oklar, Elif Sarı, Hatice Selen Kanar, Hikmet Süslü, Tufan Çiftçi, Mehmet Engin Tezcan

“…The patient was referred to us when his symptoms had persisted and worsened despite topical and oral antibiotic therapy administered at another center. Based on clinical and laboratory findings from evaluation and consultations, GPA was diagnosed and confirmed by biopsy. …”
Get full text

Factors associated with hospital length of stay in patients with thoracic hydatid cyst disease undergoing surgical intervention: a retrospective study by Reza Ershadi, Mohammadreza Salehi, Ghazal Roostaei, Niloofar Khoshnam Rad, Sara Soltanmohammadi, Hesam Amini

Get full text

OMP38 of Carbapenem‐Resistant Acinetobacter Baumannii‐Mediated mtDNA Release Activates the cGAS‐STING Signaling to Induce Inflammatory Response by Yang Yang, Yuanyuan Zeng, Jianjie Zhu, Jianjun Li, Lei Gu, Lin Wei, Zeyi Liu, Jian‐an Huang

“…Abstract Carbapenem‐resistant Acinetobacter baumannii (CRAB) has become a major threat in the treatment of bacterial infection, and immunotherapy in a non‐antibiotic‐dependent manner is an effective way to overcome CRAB infection. …”
Get full text