Duodenal Aspirates for Small Intestine Bacterial Overgrowth: Yield, PPIs, and Outcomes after Treatment at a Tertiary Academic Medical Center by Diana L. Franco, Molly B. Disbrow, Allon Kahn, Laura M. Koepke, Lucinda A. Harris, M. Edwyn Harrison, Michael D. Crowell, Francisco C. Ramirez

“…Similar proportions of patients with SIBO improved whether or not they received antibiotic treatment, calling into question the use of this expensive therapy for this disorder.…”
Get full text

Decomposition of the pangenome matrix reveals a structure in gene distribution in the Escherichia coli species by Siddharth M. Chauhan, Omid Ardalani, Jason C. Hyun, Jonathan M. Monk, Patrick V. Phaneuf, Bernhard O. Palsson

“…This approach reveals the genetic basis for differential traits across phylogroups, offering insights into pathogenicity, antibiotic resistance, and evolutionary adaptations. …”
Get full text

Doxycycline Degradation by the Oxidative Fenton Process by Alexandre A. Borghi, Milena F. Silva, Saleh Al Arni, Attilio Converti, Mauri S. A. Palma

“…Doxycycline is a broad-spectrum tetracycline occurring in domestic, industrial, and rural effluents, whose main drawback is the increasing emergence of resistant bacteria. This antibiotic could be degraded by the so-called Fenton process, consisting in the oxidation of organic pollutants by oxygen peroxide (H2O2) in the presence of Fe2+. …”
Get full text

An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH by Claire Healy, Sabine Ehrt, Alexandre Gouzy

“…This study reveals an unexpected role of the Pi starvation response in regulating acid growth arrest and highlights the intricacy of the mechanisms regulating redox homeostasis, acid stress response, and nutrient utilization in Mtb.IMPORTANCEDespite the availability of antibiotic treatment, M. tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major infectious disease killer worldwide. …”
Get full text

PREDISPOSITION FACTORS ANALYSIS FOR FOURNIER'S GANGRENE DEFECTS CLOSURE COMPLICATION by Bayu Fasi Bermani, Sitti Rizaliyana, Ira Handriani

“…All patients received broad-spectrum antibiotic therapy, and extensive surgical excision. …”
Get full text

Prevalence, Diagnostics and Treatment of Small Intestinal Bacterial Overgrowth in the Clinical Practice in Southern Federal District of the Russian Federation by N. V. Korochanskaya, I. L. Kliaritskaya, S. N. Serikova, A. V. Tkachev, M. V. Koroleva, M. A. Basenko

“…In the group of people with a predominance of hydrogen-producing microbiota, there are fewer men than women (30.8 % vs. 69.2 %), in the group with a predominance of methane-producing microflora, the ratio of men and women was 27.4 % vs. 72.6 %, and in the group with a predominance of hydrogen- and methane-producing microbiota, this ratio was 16.6 % vs. 83.4 %, respectively.Antibacterial therapy after confirmation of the diagnosis is carried out in accordance with national clinical guidelines; probiotics, mainly Saccharomyces boulardii, are prescribed to prevent antibiotic-associated diarrhea.Conclusions. The widespread introduction of various versions of the breath test into the work of healthcare institutions will make it possible to overcome diagnostic difficulties in relation to verification of this diagnosis, substantiate and individualize the approach to prescribing antibacterial and probiotic therapy.…”
Get full text

Dermatologic Adverse Events Following Afatinib in a Woman with Non-Small-Cell Lung Cancer: A Case Report by Tsaqilah L, Putri AD, Avriyanti E

“…The administration of afatinib was continued and the patient was treated with moisturizer, sunscreen, and mild cleanser, topical antibiotic, and topical steroid along with oral doxycycline and oral cetirizine for four weeks. …”
Get full text

Novel silver nanoparticle-based biomaterials for combating Klebsiella pneumoniae biofilms by Eslam Elashkar, Rihaf Alfaraj, Ola M. El-Borady, Mahmoud M. Amer, Abdelazeem M. Algammal, Azza S. El-Demerdash

“…BackgroundKlebsiella pneumoniae is a significant nosocomial pathogen that has developed resistance to multiple antibiotics, often forming biofilms that enhance its virulence. …”
Get full text

Dietary supplementation with Jasminum sambac leaf powder: Effects on growth, hematology, and immune parameters in broiler chickens by Iram Maqsood, Samreen Sareer, Shafique Ur Rehman, Ayesha Hidayat, Madeeha Shah, Saira Awaz, Rong Ke

“…Nonetheless, problems with industrial mechanization, pollution, animal welfare, and antibiotic resistance affect the poultry industry. The objective of this study was to assess the impact of adding Jasminum sambac leaf powder (JSLP) to the feed of broiler chickens on their growth performance, coliform bacterial levels, and immunological function. …”
Get full text

Estimating the Risk of Maternal Death at Admission: A Predictive Model from a 5-Year Case Reference Study in Northern Uganda by Gasthony Alobo, Cristina Reverzani, Laura Sarno, Barbara Giordani, Luigi Greco

“…This calls for prompt and better assessment of referred mothers and specific attention to antibiotic therapy before and after caesarean section, especially among HIV-positive women.…”
Get full text

Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections by Rukavina Zora, Jøraholmen May Wenche, Božić Dunja, Frankol Ivana, Gašparović Petra Golja, Škalko-Basnet Nataša, Klarić Maja Šegvić, Vanić Željka

“…Incorporation of AZT-liposomes into CHG (liposomal CHGs) was intended to ensure proper viscosity and texture properties of the formulation, modification of antibiotic release, and enhanced antibacterial activity, aiming to upgrade the therapeutical potential of AZT-liposomes in localized treatment of MRSA-related skin infections. …”
Get full text

Streptococcal periorbital necrotizing fasciitis: Case series on a rare but potentially life-threatening entity by Isabella D. Baur, Isabel Habert, Monica Markstaller, Kathrin Hartmann, Arthur Mueller

“…We performed early and consequent debridement of necrotic tissue to control the infection alongside adequate systemic antibiotic therapy including clindamycin in all cases of suspected NSTI. …”
Get full text

Application of CuFe2O4/CuS as a new green magnetic nanocomposite in adsorption of tetracycline from aqueous solutions: mathematical models of thermodynamics, isotherms, and kinetic... by Seyedeh Masoomeh Rahimi, Bahman Ramavandi, Mohammad Hadi Moslehi, Mahdi Rahiminia, Negin Nasseh

“…Batch studies were conducted to assess the impact of parameters, including pH (3.0–9.0), adsorbent dosage (0.025–2 g/L), TC concentration (5–100 mg/L), and temperature (5–50 °C) on the TC adsorption efficiency. The antibiotic was fully removed at pH 7.0, nanocomposite dose of 1.5 g/L, time of 200 min, and TC content of 5 mg/L. …”
Get full text

Lactococcus garvieae: An Uncommon Human Pathogen Causing Infective Endocarditis in a Valve-in-Valve Transcatheter Aortic Valve Replacement by Diego H. González-Bravo, Sergio Alegre-Boschetti, Richard Silva-Cantillo, Joshua Mercado-Maldonado, Reyshley Ramos-Márquez, Gabriel Torres-Rivera, Carlos Cortés, Josue Mercado-Crespo

“…Reaching a diagnosis of L. garvieae endocarditis led us to the decision of prolonging the antibiotic course for 6 weeks with successful results. …”
Get full text

Atypical Sjögrenʼs Syndrome Initially Presenting as Lymphocytic Interstitial Pneumonitis followed by Immune Thrombocytopenia by Maham Mehmood, Abhishrut Jog, Masooma Niazi, Arlene Tieng, Giovanni Franchin

“…Laboratory studies revealed hemoglobin of 11.9 g/dL, white blood cell count of 16,000/uL, and platelet count of 250,000/uL. Empiric antibiotic therapy was begun for suspected community acquired pneumonia, and then he was discharged home. …”
Get full text

A Pseudomonas-based bio-formulation to control bacterial blight of pomegranate caused by Xanthomonas axonopodis pv. punicae by Pavan Kumar, Giandomenico Corrado, Girigowda Manjunatha, Suma Ramegowda, Pradeep Kumar, Boris Basile, Ganadalu Puttaswamy Mutthuraju, Baggana Girish Jasmitha

“…This major disease is caused by Xanthomonas axonopodis pv. punicae (Xap) and it is traditionally controlled with antibiotics. Of the 151 bacterial isolates obtained from the pomegranate rhizosphere, three (UHSPS15A, UHSPS33, and UHSPS54) demonstrated the strongest inhibitory effects against Xap in vitro, and their identification as Pseudomonas was confirmed through DNA analysis. …”
Get full text

Biomolecule screen identifies several inhibitors of Salmonella enterica surface colonization by Joseph Headrick, Amital Ohayon, Shannon Elliott, Jacob Schultz, Erez Mills, Erik Petersen

“…Salmonella enterica is a foodborne pathogen commonly found in agricultural facilities; its prevalence, as well as increasing levels of disinfectant- and antibiotic-resistance, has significant costs for agriculture as well as human health. …”
Get full text

Scoliosis Surgery in Cystic Fibrosis: Surgical Considerations and the Multidisciplinary Approach of a Rare Case by George I. Mataliotakis, Athanasios I. Tsirikos, Karen Pearson, Don S. Urquhart, Carolyn Smith, Andrew Fall

“…Postoperative intensive care included noninvasive ventilation, antibiotic cover, pain management, chest physiotherapy, pancreatic enzyme supplementation, and nutritional support. …”
Get full text

Using the Sleeping Beauty Transposon System for Doxycycline-inducible Gene Expression in RAW264.7 Macrophage Cells to Study Phagocytosis by Parsa Kamali, Gregory Fairn

“…Experimentally, the system introduces two plasmids: one carrying the Sleeping Beauty transposase and the other with an integration cassette carrying the gene of interest, a reverse-doxycycline controlled repressor gene, and an antibiotic resistance gene. The construct used in this protocol provides puromycin resistance. …”
Get full text

Prosthetic Joint Infection Trends at a Dedicated Orthopaedics Specialty Hospital by Robert P. Runner, Amanda Mener, James R. Roberson, Thomas L. Bradbury, George N. Guild, Scott D. Boden, Greg A. Erens

“…These results suggest a change in the microbiologic profile of PJI when transitioning to a dedicated orthopaedic facility and that greater Gram-negative antibiotic coverage could be considered.…”
Get full text