The Class III PI3K/Beclin-1 Autophagic Pathway Participates in the mmLDL-Induced Upregulation of ETA Receptor in Mouse Mesenteric Arteries by Xi Xie, Chen Chen, Cang-Bao Xu, Jie Lin, Lei Cao, Gen Chen, Jie Li

“…The current study explored the effect of mmLDL on the endothelin type A (ETA) receptor in mouse mesenteric arteries in vivo, as well as the role of autophagy in this process. mmLDL was injected via the caudal vein, and the Class III PI3K autophagic pathway inhibitor 3-methyladenine (3-MA) was injected intraperitoneally. The animals were divided into physiological saline (NS), mmLDL, and mmLDL + 3-MA groups. …”
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Insulin-Sensitizing Properties of Decoctions from Leaves, Stems, and Roots of <i>Cucumis prophetarum</i> L. by Zewdie Mekonnen, Giuseppe Petito, Getasew Shitaye, Gianluca D’Abrosca, Belete Adefris Legesse, Sisay Addisu, Maurizio Ragni, Antonia Lanni, Roberto Fattorusso, Carla Isernia, Lara Comune, Simona Piccolella, Severina Pacifico, Rosalba Senese, Gaetano Malgieri, Solomon Tebeje Gizaw

“…Overall, the acquired data demonstrate the effect of reducing insulin resistance induced by the investigated decoctions, opening new scenarios for the evaluation of these effects aimed at counteracting diabetes and related diseases in animal models.…”
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Importance of benzoyltransferase GcnE and lysine benzoylation of alcohol dehydrogenase AdhB in pathogenesis and aflatoxin production in Aspergillus flavus by Xuan Chen, Lihan Wu, Yuqi Zhang, Sen Wang, Shihua Wang

“…Meanwhile, it points out the important role of Kbz in the pathogenicity of pathogenic fungi.IMPORTANCEAspergillus flavus is a ubiquitous opportunistic pathogen of plants and animals, which produces carcinogenic and toxic secondary metabolite aflatoxin. …”
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The influence of farm connectedness on foot‐and‐mouth disease outbreaks in livestock by Jean B. Contina, Rachel L. Seibel, Bhim Chaulagain, Karasi B. Mills, Michael J. Tildesley, Christopher C. Mundt

“…Abstract We applied a previously published livestock foot‐and‐mouth disease (FMD) model to estimate host connectivity using a transmission kernel based on contact tracing and measured subsequent to an animal movement ban in the 2001 United Kingdom epidemic. …”
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Recognizing and addressing burnout among healthcare workers in rural Nepal: a proof-of-concept study using Kern’s six-step theoretical framework by Raj Kumar Dangal, Eva Studer, Tula Krishna Gupta, Kristin Nguyen, Amit Suneja, Karuna Khadka, Shailina Bata Shrestha, Bibhav Acharya

“…We then developed learning objectives for knowledge, attitude, and skills domains based on the World Health Organization (WHO) definition of burnout. Then, we created animated educational videos designed to meet the learning objectives. …”
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Multi-omics analysis reveals the interplay between intratumoral bacteria and glioma by Ting Li, Zhanyi Zhao, Meichang Peng, Lu Zhang, Cheng Wang, Feiyang Luo, Meiqin Zeng, Kaijian Sun, Zhencheng Fang, Yunhao Luo, Yugu Xie, Cui Lv, Jiaxuan Wang, Jian-Dong Huang, Hongwei Zhou, Haitao Sun

“…We employed immunohistochemistry, multicolor immunofluorescence, and fluorescence in situ hybridization (FISH) staining to observe the presence and location of bacteria. Furthermore, an animal model was employed to validate the impact of key bacteria on glioma development. …”
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Rapeseed Supports Hairy Vetch in Intercropping, Enhancing Root and Stem Morphology, Nitrogen Metabolism, Photosynthesis, and Forage Yield by Jianli Ji, Zongkai Wang, Pan Gao, Xiaoqiang Tan, Xianling Wang, Jie Kuai, Jing Wang, Zhenghua Xu, Bo Wang, Guangsheng Zhou, Jie Zhao

“…The global shortage of high-quality forage has significantly constrained the development of animal husbandry. Leveraging the complementary effects of forage rapeseed and hairy vetch intercropping can enhance forage yield and quality; however, the underlying mechanisms of overyielding in forage rapeseed–hairy vetch intercropping systems remain unclear. …”
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The extremely halotolerant black yeast Hortaea werneckii - a model for intraspecific hybridization in clonal fungi by Polona Zalar, Jerneja Zupančič, Cene Gostinčar, Janja Zajc, G. Sybren de Hoog, Filomena De Leo, Armando Azua-Bustos, Nina Gunde-Cimerman

“…This was investigated in this polyphasic taxonomic analysis based on the global diversity of H. werneckii strains collected from hypersaline environments, and from humans and animals. Analysis of D1/D2domains of 28S and internal transcribed spacer rDNA revealed 10 and 17 genotypes, respectively, that were not always compliant. …”
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How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis by Eline M. L. van der Does de Willebois, MD, Vittoria Bellato, MD, Marjolijn Duijvestein, MD, PhD, Susan van Dieren, MD, PhD, Silvio Danese, MD, PhD, Pierpaolo Sileri, MD, PhD, Christianne J. Buskens, MD, PhD, Andrea Vignali, MD, PhD, Willem A. Bemelman, MD, PhD

“…Randomized controlled trials and cohort studies describing ER < 12 months after an ICR for CD were included. Animal studies, reviews, case reports (<30 included patients), pediatric studies, and letters were excluded. …”
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Water hyacinth [Eichhornia Crassipes (Mart.)] invasion: implications for livelihoods in the central Rift Valley of Ethiopia by Assefa Gudina, Dagne Getachew Woldemedhin, Aseffa Seyoum, Feyera Senbeta, Engdawork Assefa, Afework Alemayehu

“…This invasive weed affects crop production by invading farmland adjacent to the lakes and has an impact on livestock by covering grazing land meant for animal feed. Although several studies have been conducted in Ethiopia, the livelihood impact of water hyacinth has been scarcely analyzed, quantified, and documented. …”
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Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K by Lu He, Min Zhu, Rui Yin, Liangli Dai, Juan Chen, Jie Zhou

“…<b>Methods:</b> Isoprenaline injection or transverse aortic constriction-induced animal models and isoprenaline or angiotensin 2 administration-induced cell models of heart failure were established. …”
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Prevalence, Etiology, and Risk Factors of Mastitis in Dairy Cattle in Embu and Kajiado Counties, Kenya by Christine M. Mbindyo, George C. Gitao, Charles M. Mulei

“…A semistructured questionnaire was administered to 154 smallholder dairy farmers to collect data on management practices, animal factors, and disease history. A total of 395 dairy cows were initially screened for subclinical mastitis using the California mastitis test (CMT), and milk samples were aseptically collected. …”
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Bright night sleeping environment induces diabetes and impaired glucose tolerance in non-human primates by Shuxing Wang, Zhenyi Chen, Zihao Liang, Qiang Xu, Jiankai Zhang

“…This study aims to address these questions in monkeys.MethodsIn a reduced daytime bright condition resembling human living rooms, 197 Cynomolgus (130 male, 67 female) were exposed to three distinct light intensities (13, 35, 75Lux) at night for consecutive ten months. Animals were retrospectively divided into four groups according to glucose metabolic status by the end of the experimental session, spontaneous diabetes mellitus (SDM, N=11), light-induced diabetes (LID, N=83), impaired fasting glucose tolerance (IFG, N=36), and normal glucose tolerance (NGT, N=67). …”
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Climate Change-Induced Decline in Succulent <i>Euphorbia</i> in Namibia’s Arid Regions by J. J. Marion Meyer, Marie M. Potgieter, Nicole L. Meyer, Anika C. Meyer

“…This is alarming, as it could threaten the survival of several animal species adapted to feed on them, especially during droughts. …”
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<i>Limosilactobacillus reuteri</i> ZY15 Alleviates Intestinal Inflammation and Barrier Dysfunction via AKT/mTOR/HIF-1α/RORγt/IL-17 Signaling and the Gut Microbiota in ETEC K88-Chal... by Xin Xu, Hongwei Zhang, Kun Meng, Hongying Cai, Weiwei Liu, Liye Song, Zihan Zhang, Qijun Zhu, Xiling Han, Yunsheng Han, Peilong Yang

“…<i>Limosilactobacillus reuteri</i>, a recognized probiotic, improves intestinal health in animals, but the mechanism remains unclear. This study investigates the mechanisms by which <i>L. reuteri</i> ZY15, isolated from healthy pig feces, mitigates intestinal barrier damage and inflammation caused by oxidative stress in Enterotoxigenic <i>Escherichia coli</i> (ETEC) K88-challenged mice. …”
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Osteoartrose lombossacra em leoa (Panthera leo) by Eduardo Augusto Terra Rossi de Barros, Paulo Fernandes Marcusso, Giovanna Valverde Magalhães Barbosa, Henrique Scomparin Guardia, Sônia Rumiko Suzuki França, Giovani Dal'Bó, Michelle Falcade Forti, Guilherme Guindolin Galassi, Fábio Henrique Viaceli Conforti, Daniela Pereira Bonini, Renato Leite Leonardo, Renata Paulino Xavier, Luciana Facco de Andrade, Everton dos Santos Cirino, Jorge Aparecido Salomão Júnior

“…Este trabalho objetivou relatar um caso de osteoartrose lombossacra em uma leoa (Panthera leo). O animal de 20 anos de idade, do Parque Ecológico de Americana – SP, apresentava sinais de apatia e hiporexia, sendo encaminhado para o Hospital Veterinário da Faculdade de Americana (FAM), onde foram realizados exames de check-up. …”
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Studying sex differences in responses to fibroblast growth factor 21 administration in obese mice consuming a sweet-fat diet by N. М. Bazhan, T. V. Jakovleva, A. Yu. Kazantseva, N. E. Kostina, P. E. Orlov, N. Yu. Balybina, K. О. Baranov, E. N. Makarova

“…In animals, obesity caused by consumption of a sweet-fat diet (SFD) is the most adequate mouse model of human diet-induced obesity. …”
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Impact of fish oil supplementation on plasma levels of highly unsaturated fatty acid-containing lipid classes and molecular species in American football athletes by Veronica Anne Mullins, Justin M. Snider, Bryce Michael, Lydia Rose Porter, Roberta Diaz Brinton, Floyd H. Chilton

“…Docosahexaenoic acid (DHA), the primary omega-3 (n-3) highly unsaturated fatty acid (HUFA) in the brain, has shown neuroprotective effects in animal models after brain injury, but clinical research has shown mixed results. …”
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Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats [version 2; peer rev... by Kulsum Kulsum, Syahrul Syahrul, Kartini Hasbalah, Ummu Balqis

“…Methods This was a laboratory experimental animal model with the post-test only control group design, namely measuring the effect of treatment by comparing the five groups of rats consisting of 30 rats. …”
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Rabies-preventive health program for mothers in maternal and child health centers: quasi experimental study by Samia Ibrahim Mabrouk Baraka, Rania Abd Elmohsen Abo El Nour, M. A. Abdelzaher, Eman Mahmoud Seif El–Nasr

“…Abstract Background Rabies spreads to people and animals via saliva, usually through bites, scratches, or direct contact with mucosa (e.g. eyes, mouth, or open wounds). …”
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