Assessment of dermal sensitization by nickel salts in a novel humanized TLR-4 mouse model by K. A. Roach, S. E. Anderson, C. Waggy, J. Aldinger, A. B. Stefaniak, J. R. Roberts

“…NiSO4 (10%) had a stimulation index (SI) of 3.7 (females) and 3.8 (males) in hTLR-4-positive animals, and an SI of 0.5 (females) and 0.8 (males) in hTLR-4 hTLR-4-negative mice. …”
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Heterosis and heritability of traits contributing to select high yielding drought stress tolerance sweetpotato breeding lines by Mahaman Mourtala Issa Zakari, Emeka Benjamin Utobo, Zangui Souley Moussa, Josefina Ndamononghenda Abed, Ifeanyi Maxwell Nwankwo Innocent, Happiness Ogba Oselebe

“…The study recommended that (1) hybrids 5 × 12-1, 6 × 8-5, 7 × 6-1, 8 × 6-1, and 12 × 5-1 are good for SRY under drought conditions; (2) hybrids 6 × 8-5 and 11 × 7-1 are recommended for vines production under rainfall to feed animals; and (3) hybrids 3 × 12-3 and 12 × 5-1 with high dry matter content are recommended for industrial used.…”
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress by Saakshi Saini, Viney Kumar, Swati Haldar, Samrat Chauhan, Pratibha Demiwal, Souvik Ghosh, Sumeet Gupta, Debabrata Sircar, Bidhan Mahajon, Partha Roy

“…The anxiolytic activity of SM was demonstrated by improved behavior of the animals in the elevated plus maze test and increased SOD activity in the brain. …”
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Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice by Nida Rasheed, Hafiza Khushbakht Hussain, Zohabia Rehman, Azka Sabir, Waseem Ashraf, Tanveer Ahmad, Faleh Alqahtani, Imran Imran

“…In contrast, CoQ10 and curcumin combinatorial regime markedly mitigated cognitive deficits Vs. individual high-dose in AlCl3-treated animals as demonstrated by their improved performance in neurobehavioral tests such as the Y-maze, novel object recognition, passive avoidance and Morris-water maze test. …”
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Electroacupuncture Improves Clearance of Amyloid-β through the Glymphatic System in the SAMP8 Mouse Model of Alzheimer’s Disease by Pei-zhe Liang, Li Li, Ya-nan Zhang, Yan Shen, Li-li Zhang, Jie Zhou, Zhi-jie Wang, Shu Wang, Sha Yang

“…Amyloid-β (Aβ) is the key factor that triggers the course of AD, and reducing the deposition of Aβ in the brain has been considered as a potential target for the treatment of AD. In clinical and animal studies, electroacupuncture (EA) has been shown to be an effective treatment for AD. …”
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Seroprevalence of Asymptomatic Leishmania donovani among Laborers and Associated Risk Factors in Agricultural Camps of West Armachiho District, Northwest Ethiopia: A Cross-Sectiona... by Animen Ayehu, Yibeltal Aschale, Wossenseged Lemma, Animut Alebel, Ligabaw Worku, Ayalew Jejaw, Abebe Genetu Bayih

“…Leishmania donovani infection had a statistically significant association with sleeping under Balanites trees (AOR: 4.36, 95%CI: 1.186-16.06), presence of domestic animals near sleeping place (AOR: 4.68, 95% CI: 1.25-17.56), and lack of knowledge about VL transmission (AOR: 3.79, 95% CI: 1.07-13.47). …”
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PD-L1 positive platelets mediate resistance to immune checkpoint inhibitors in patients with colorectal cancer by Jiacheng Li, Jia Liu, Shifeng Yang, Yu Xia, Qingzhe Meng, Biying Sun, Yansong Liu, Bin Zhao, Jiaqi Jin, Hui Xu, Lihong Wang, Pengxia Zhang, Zhuoxin Cheng

“…In turn, platelets can also induce PD-L1 expression on cancer cells. Animal experiments revealed that antiplatelet pharmacological agents and genetic knockout of platelets potentiated the antitumour effect of the PD-L1 mAb treatment in a CD8 + T cell dependent manner. …”
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Hantavirus Cardiopulmonary Syndrome and Diffuse Alveolar Hemorrhage in the Era of COVID-19 by Khizar Hamid, Swaminathan Perinkulam Sathyanarayanan, Touba Naim, Muhammad Hamza, Mirza Omer Mahmood Baig, Emad Abu Sitta

“…Treatment is mainly supportive; however, patients are usually treated with broad-spectrum antibiotics while workup is underway. In animal models, ribavirin and favipiravir are only effective when administered in the prodromal phase. …”
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Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats by Karoline Klumpp, Frauke Lange, Alexandra S. Muscher-Banse, Nadine Schnepel, Kathrin Hansen, Adrian L. Lifschitz, Laura Mate, Mirja R. Wilkens

“…As vitamin D metabolites are widely used as feed additives or therapeutics in livestock animals, we aimed to assess whether these differences indicate species-specific responses or occurred due to the very high dosages used in the rodent studies. …”
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The impact of multiple exposures and movement on the fear response of poultry by Alexandra Jackson, Marcela Quino, Anusha Gautam, Melissa Gilpin, Katie Still, Denise Landers, Bethany Baker-Cook

“…Fear tests are a common research method to assess the affective state of an animal. This study aimed to assess: 1) the impact of repeated exposure to fear tests on fear response and, 2) how the addition of movement to fear stimuli during a novel object test impacts bird fear response. …”
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Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…This formula is not toxic in mice (LD₅₀ > 2000 mg/kg body weight). Moreover, animals administered the CBF at 200 mg/kg/day presented a significant decline in their body weight gain, adipose tissue weight, plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C) level, and glycaemia after 10 weeks’ treatment. …”
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Anti-Inflammatory Effect of a Peptide Derived from the Synbiotics, Fermented Cudrania tricuspidata with Lactobacillus gasseri, on Inflammatory Bowel Disease by Jimyeong Ha, Hyemin Oh, Nam Su Oh, Yeongeun Seo, Joohyun Kang, Min Hee Park, Kyung Su Kim, Shin Ho Kang, Yohan Yoon

“…To confirm IBD induction, the weights of the animals and the disease activity index (DAI) scores were evaluated once every two days. …”
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Ocular infections in international travelers by Francesca F. Norman, Julio J. González-López, Diego Gayoso-Cantero, Marta Vicente-Antolin, Maria-Dolores Corbacho-Loarte, Rogelio López-Vélez, Marta González-Sanz

“…Increasing exposure to animals, undercooked food consumption or poor hygiene during international travels might be leading to the emergence of certain parasitic eye diseases. …”
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Wildlife policy, the food system and One Health: a complex systems analysis of unintended consequences for the prevention of emerging zoonoses in China, the Democratic Republic of... by Zhuoyu Wang, Tarra L Penney, Mala Ali Mapatano, Chloe Clifford Astbury, Janielle Clarke, Kathleen Chelsea Togño, Shital Desai, Anastassia Demeshko, Russel Aguilar, Angran Li, Zhilei Shi, Cary Wu, Marc K Yambayamba, Hélène Carabin, Valentina De Leon, Eduardo Gallo-Cajiao, Kirsten Melissa Lee, Krishihan Sivapragasam, Mary Wiktorowicz

“…In each country, we highlighted context-specific impacts of the FTF on zoonotic spillover risk and key food system outcomes.Conclusion Our use of systems thinking highlights how system adaptation may undermine prevention policy aims, with a range of unintended consequences for food systems and human, animal and environmental health. A broader application of systems-informed policy design and evaluation could help identify instruments approporiate for the disruption of system traps and improve policy success. …”
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Correlation between Therapeutic Efficacy of CD34+ Cell Treatment and Directed In Vivo Angiogenesis in Patients with End-Stage Diffuse Coronary Artery Disease by Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Pei-Hsun Sung, Chi-Hsiang Chu, Mel S. Lee, Yuan-Ping Lin, Hon-Kan Yip, Fan-Yen Lee

“…., mean fluorescent units in angioreactors with EPCs/mean fluorescent units in angioreactors without EPCs) was obtained for each animal with implanted EPCs from each patient. Results and Conclusions. …”
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The effects of acute and chronic exercise on immune markers of TH1/TH2 cells in older adults: a systematic review by Thiago Henrique Teodoro, Katerine Palharini Manfrin Costa, Jonato Prestes, José Campanholi, James Navalta, Guilherme Borges Pereira

“…This review investigates the impact of acute and chronic exercise on immune markers of Th1 and Th2 cells in the older adults.MethodsThis study was conducted as a systematic review, following PRISMA guidelines, databases including PubMed, Web of Science, Embase, Science Direct, and Scopus were searched until March 2024, identifying randomized controlled trials and prospective observational studies that examined the effects of acute and chronic exercise on intracellular and surface markers, cytokines, and immunoglobulins in older adults. Studies involving animal subjects, isolated cells, diseased patients, or exposure to medications and drugs were excluded. …”
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Decomposing the Tea Bag Index and finding slower organic matter loss rates at higher elevations and deeper soil horizons in a minerogenic salt marsh by S. G. Reddy, W. R. Farrell, F. Wu, S. C. Pennings, J. Sanderman, M. Eagle, C. Craft, A. C. Spivak

“…Tea bags were buried at 10 and 50 cm depths across an elevation gradient in a subtropical <i>Spartina alterniflora</i> marsh in Georgia (USA). Plant and animal communities and soil properties were characterized once, while replicate tea bags and porewaters were collected several times over 1 year. …”
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Repurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and prog... by Michaela Prchal-Murphy, Julia Zehenter, Marlene Fischer, Anita Pirabe, Madeleine Themanns, Behnaz Afrashteh, Eva Maria Putz, Karoline Kollmann, José Basílio, José Basílio, Manuel Salzmann, Wolfgang Strohmaier, Günther Krumpl, Alex Farr, Veronika Sexl, Michael Freissmuth, Eva Zebedin-Brandl

“…Eight-week-old female and male C57BL/6J, BALB/c, or female NSG mice served as recipient models.ResultsWhen administered concomitantly, treprostinil and cinacalcet exhibited mutual antagonism: the survival of recipient animals was lower when both drugs were administered together compared to either agent alone. …”
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Predictive models for the implementation of targeted reproductive management in multiparous cows on automatic milking systems by Fergus P. Hannon, Martin J. Green, Luke O'Grady, Chris Hudson, Anneke Gouw, Laura V. Randall

“…Key to the utility of TRM is the accuracy with which an animal's reproductive performance can be predicted. …”
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A consort‐guided randomized, blinded, controlled clinical trial on the effects of 6 weeks training on heart rate variability in thoroughbred horses by Emma Santosuosso, Renaud Léguillette, Sierra Shoemaker, Ryan Baumwart, Sierra Temple, Kaneesha Hemmerling, Tessa Kell, Warwick Bayly

“…Hypothesis The linear domain HRV variables are affected by fitness. Animals Twelve healthy untrained thoroughbreds were randomly split into a training group (6 weeks of incremental racetrack training) and a control group (no training). …”
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