Cosmic jurisdictions: quod lege naturae, moribus et consuetudine inductum est by M. I. Myklush, V. K. Marinich

“…At the same time, it is proposed to apply the principle of “Res Communis Humanitatus” to the “domestic room”, and the new principle of “Res Nullius Civitatis et Res Communis Animal Rationale” to the “alien room”. Additionally, the authors emphasize the fact that the above factors have already formed the structure of the “domestic room” regardless of the existing intentions and suggestions, leaving the world to recognize and accept it. …”
Get full text

Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model by Fatemeh Kheradmand, Seyedeh Fatemeh Yasaman Rahimzadeh, Seyed-Alireza Esmaeili, Sajad Sahab Negah, Najmeh Kaffash Farkhad, Seyedeh Elnaz Nazari, Mehrdad Hajinejad, Mohammad Ali Khodadoust, Afsane Fadaee, Jalil Tavakol Afshari, Majid Khazaei

“…Method In this study, an animal model of a specific type of IBD in C57BL/6 mice, induced by dextran sulfate sodium (DSS), was utilized. …”
Get full text

A hypomorphic mutation in the mouse Csn1s1 gene generated by CRISPR/Cas9 pronuclear microinjection by A. V. Smirnov, T. A. Shnaider, A. N. Korablev, A. M. Yunusova, I. A. Serova, N. R. Battulin

“…Regulatory elements of the casein genes could be used to direct the expression of desired transgenes into the milk of transgenic animals. Dozens of casein alleles have been identified for goats, cows, sheep, camels and horses, and these sequence variants are associated with altered gene expression and milk protein content. …”
Get full text

Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…Animals exhibit remarkable behavioral and molecular adaptations to cope with thermal stressors, which are crucial for survival in variable environments that are exacerbated by climate change. …”
Get full text

Effects of neonatal handling on behavior and stress-response in rats selected for reaction towards humans by Yu. E. Herbeck, O. A. Amelkina, M. Yu. Konoshenko, S. G. Shikhevich, R. G. Gulevich, R. V. Kozhemyakina, I. Z. Plyusnina, I. N. Oskina

“…It was found that neonatal handling of aggressive animals caused a significant decrease in aggressiveness, although considerably smaller than in generation 44. …”
Get full text

NLRP3 is a BMI-independent mediator of stable COPD by Yonca Gungor, Selin Ercan, Saliha Selin Özuygur Ermiş, Yiğit Kozalı, Gizem Kursunluoglu, Ceyda Sahan, Aylin Ozgen Alpaydin, Hulya Ayar Kayali

“…Abstract Purpose The inflammatory response in animal models of chronic obstructive pulmonary disease (COPD) is activated by the NLR-family-pyrin-domain-containing-3 (NLRP3) inflammasome pathway, which is also known to play a role in obesity-related inflammation. …”
Get full text

Unusual congenital polydactyly in mini-pigs from the breeding group of the Institute of Cytology and Genetics (Novosibirsk, Russia) by S. V. Nikitin, S. P. Knyazev, V. A. Trifonov, A. A. Proskuryakova, Yu. D. Shmidt, K. S. Shatokhin, V. I. Zaporozhets, D. S. Bashur, E. V. Korshunova, V. I. Ermolaev

“…This anomaly was first found here in 2017 in adult animals intended for culling due to incorrect positioning of the legs caused by flexor tendon laxity and resulting in weight-bearing on the palmar surface of the proximal phalanges (“bear’s paw”). …”
Get full text

In Vitro and in Vivo Hypolipidemic Effects of Protein-Polysaccharide Complexes from Three Species of Edible Fungi by GAO Chen, LI Wen, CHEN Wanchao, WU Di, ZHANG Zhong, LIU Peng, XIA Yongjun, YANG Yan

“…In vitro cell experiments showed that all the complexes significantly inhibited the accumulation of lipid droplets in hepatocytes. Animal experiments showed that they significantly inhibited the increase in body mass, triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels, blocked the swelling of the swelling of hepatocytes, and inhibited hepatic lipid deposition in mice fed a high-fat diet. …”
Get full text

Antimicrobial Resistance Profile of E. coli Isolated from Raw Cow Milk and Fresh Fruit Juice in Mekelle, Tigray, Ethiopia by Haftay Abraha Tadesse, Netsenet Berhe Gidey, Kidane Workelule, Hagos Hailu, Seyfe Gidey, Abrha Bsrat, Habtamu Taddele

“…They cause great suffering and are transmitted directly or indirectly between animals and humans and circulate in the global environment. …”
Get full text

Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease by Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh

“…The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. Recent animal studies have demonstrated that physical exercise improves behavioral and neuropathological deficits in PD. …”
Get full text

A Toxicological Evaluation of Methylliberine (Dynamine®) by Timothy S. Murbach, Róbert Glávits, John R. Endres, Amy E. Clewell, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné

“…No mortality or morbidity was observed and no toxicologically relevant clinical effects or effects on clinical pathology parameters were observed. In male animals, test item-related effects on body weight and sexual organs, which were not reversible after a 28-day recovery period without treatment, were observed in the high-dose group. …”
Get full text

Adaptability of high-protein barley genotypes under the conditions of the Volga-Vyatka region by I. Yu. Zaytseva, I. N. Shchennikova, L. V. Panikhina, E. V. Dyagileva

“…One of the urgent tasks is to develop high-yielding cultivars with good grain quality, thus reducing protein deficiency in farm animal feeds and meeting the need for fodder grain that increases every year. …”
Get full text

Effect of Platelet-activating Factor on in vitro and in vivo Interleukin-6 Production by B. Pignol, T. Maisonnet, P. Guinot, J. M. Mencia-Huertac, P. Braquet

“…The increase of IL-6 induced by 3 μg/kg PAF was not observed when the animals were treated with the PAF antagonist, BN 52021 (1 to 60 mg/kg0. …”
Get full text

Toxic Assessment of Heavily Traffic-related Fine Particulate Matter Using an in-vivo Wild-type Caenorhabditis elegans Model by Meng-Ching Chung, Kuo-Lin Huang, Japheth L. Avelino, Lemmuel L. Tayo, Chih-Chung Lin, Ming-Hsien Tsai, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Ching-Kai Su, Sen-Ting Huang

“…In the present study, the toxicity of traffic-related-air-pollutant (TRAP) PM2.5 was evaluated in the animal model Caenorhabditis elegans (C. elegans) using different toxicological endpoints such as lethality, survivability (lifespan), behavioral (head thrashing and body bending), and reproduction (brood size). …”
Get full text

Exploring the impact of robot interaction on learning engagement: a comparative study of two multi-modal robots by Ka Yan Fung, Kwong Chiu Fung, Tze Leung Rick Lui, Kuen Fung Sin, Lik Hang Lee, Huamin Qu, Shenghui Song

“…The system integrates various interactive elements, such as animations, songs, dance, gestures, and touch, to enhance students’ learning engagement, interaction, and motivation and cater to their diverse needs. …”
Get full text

Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats by Md. Yousuf Ali, Nur-E Noushin Rumpa, Sudip Paul, Md. Sakib Hossen, E. M. Tanvir, Tareq Hossan, Moumoni Saha, Nadia Alam, Nurul Karim, Md. Ibrahim Khalil, Siew Hua Gan

“…Long Evans rats were divided into four groups of eight animals each. The rats were orally treated with three doses of pomelo (250, 500, and 1000 mg/kg) once daily for 21 days. …”
Get full text

Why do acute healthcare staff engage in unprofessional behaviours towards each other and how can these behaviours be reduced? A realist review protocol by Ruth Abrams, Aled Jones, Johanna Westbrook, Jill Maben, Russell Mannion, Judy M Wright, Mark Pearson, Justin Avery Aunger

“…Dissemination will occur through presentation at conferences, innovative methods (cartoons, videos, animations and/or interactive performances) and peer-reviewed journals.PROSPERO registration number CRD42021255490.…”
Get full text

A nociceptor-specific RNAi screen in Drosophila larvae identifies RNA-binding proteins that regulate thermal nociception by Amber Dyson, Gita Gajjar, Katherine C. Hoffman, Dakota Lewis, Sara Palega, Erik Rangel Silva, James Auwn, Andrew Bellemer

“…Some of the genes identified have well-understood roles in the regulation of translation initiation and regulation of nociceptor sensitization in vertebrate and invertebrate animal models, suggesting an evolutionarily conserved role for these mechanisms in regulating nociceptor sensitivity. …”
Get full text

Dissecting the role of single nucleotide polymorphism of lymphotoxin beta gene during pig domestication using bioinformatic and experimental approaches by R. B. Aitnazarov, E. V. Ignatieva, N. E. Bazarova, V. G. Levitsky, S. P. Knyazev, Y. Gon, N. S. Yudin

“…Studies of wild and laboratory animals have revealed a trade-off between reproductive success and immunity. …”
Get full text

Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…C3 transferase, a potent inhibitor of the RhoA pathway, has shown promise in facilitating neurological recovery in animal models of SCI and is currently being evaluated in clinical trials. …”
Get full text