Adrenal Disorders and the Paediatric Brain: Pathophysiological Considerations and Clinical Implications by Vincenzo Salpietro, Agata Polizzi, Gabriella Di Rosa, Anna Claudia Romeo, Valeria Dipasquale, Paolo Morabito, Valeria Chirico, Teresa Arrigo, Martino Ruggieri

“…The development and maturation of the central nervous system (CNS) through childhood is tightly regulated by intrinsic, paracrine, endocrine, and external modulators, and perturbations in any of these factors, including those related to adrenal hormone imbalance, could result in consequences that affect the structure and function of the paediatric brain. Animal experiments and clinical studies demonstrated that the developing (i.e., paediatric) CNS seems to be particularly vulnerable to alterations induced by adrenal disorders and/or supraphysiological doses of corticosteroids. …”
Get full text

Prevalence and associated risk factors of bovine Schistosoma and Fasciola infections among cattle in South Achefer District, North West Ethiopia by Solomon Tesfaye, Mastewal Yeshambel, Amir Alelign, Tilahun Yohannes

“…Bovine schistosomiasis and fasciolosis, caused by flatworms from different species of Schistosoma and Fasciola, continue to be significant animal health concerns in cattle farming in developing countries like Ethiopia. …”
Get full text

Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia by Eric G. Lee, Lerin R. Luckett-Chastain, Kaitlin N. Calhoun, Benjamin Frempah, Anja Bastian, Randle M. Gallucci

“…Wound closure was delayed 4-5 days in hyperglycemic animals. Hyperglycemic wounds displayed greater IL-6 and IL-6Rα protein expression at 1, 7, and 10 days of postwounding compared to euglycemic control. …”
Get full text

A video intervention to improve patient understanding of tumor genomic testing in patients with cancer by Deloris J. Veney, Lai Y. Wei, Amanda E. Toland, Carolyn J. Presley, Heather L. Hampel, Tasleem J. Padamsee, Clara N. Lee, William J. Irvin Jr, Michael J. Bishop, James J. Kim, Shelly R. Hovick, Leigha A. Senter, Daniel G. Stover

“…Methods Based on a quality improvement cycle, an animated video was created to be applicable to any cancer type, incorporating culturally diverse images, available in English and Spanish. …”
Get full text

A Genome-Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients by Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen

“…Among the 9 confirmed lncRNAs, lncRNA MSTRG.128697 and lncRNA MSTRG.128958 were novel and human-specific; however, further validation is required. lncRNA MSTRG.63013 has orthologous sequences in the mouse genome and was identified as a key node for etiology and pathophysiology in animal studies, which will help understand the epigenetic mechanisms of T1D complications.…”
Get full text

Deixadas para morrer: sobre búfalas, desinformação e especismo estrutural by Fabio Alves Gomes de Oliveira, Érica Quadros do Amaral

“…Como metodologia, adotamos a revisão bibliográfica, correlacionando o arcabouço teórico dos saberes da Ciência da Informação, Estudos Críticos Animalistas, Ecofeminismos e análise do mencionado caso paradigmático por meio de relatos divulgados pela mídia para apuração da complexa trama que chamamos de “paradoxo da opressão”, envolvendo o movimento de ativismo em defesa da causa animal, a mídia e o agronegócio. Nossas considerações finais nos direcionam ao entendimento do especismo estrutural como um problema de ordem informacional por ser produto de estratégias de desinformação e desempenhar o papel de provimento do senso comum, produção de ignorância e manutenção de estruturas de poder que asseguram sua própria existência como um modo de opressão que impacta animais não humanos e humanos…”
Get full text

The Bile Acid Metabolism of Intestinal Microorganisms Mediates the Effect of Different Protein Sources on Muscle Protein Deposition in <i>Procambarus clarkii</i> by Xiaodi Xu, Xiaochuan Zheng, Qunlan Zhou, Cunxin Sun, Aimin Wang, Aimin Zhu, Yuanyuan Zhang, Bo Liu

“…This study established an all-animal protein source (AP) and an all-plant protein source group (PP), with a feeding period of 8 weeks (four replicates per group, 45 individuals per replicate). …”
Get full text

The impact of Sudafed on spleen of albino mice by L. Alsaadi Yasmin, K. Abdul Ameer Bassam, Jasim Mohamad Ban, Kathum Omra Faiza

“…The acute group was further divided into five subcategories with 3 mice in each, and the animals received a single intraperitoneal injection of 0.3 ml of each of the following concentrations of drug for 24 hours: 500 mg/kg, 250 mg/kg, 125 mg/kg, 62.52 mg/kg, and 31.24 mg/kg. …”
Get full text

Dynamic Variation in Hippocampal Metabolism after Acute Stress Exposure: An In Vivo Proton Magnetic Resonance Spectroscopy Study at 9.4 T by Yoon Ho Hwang, Min-Hee Lee, Chang-Soo Yun, Yong-Tae Kim, Hyeon-Man Baek, Bong Soo Han, Dong Youn Kim

“…All mice in the acute stress group were physically restrained for two hours in a 50 mL conical tube. A 9.4 T animal MRI and MRS scanner was used with point-resolved spectroscopy technique for data acquisition, which was repeated four times without interscan interval. …”
Get full text

Periodontal diseases in Down syndrome during childhood: a scoping review by Valentin Vergier, Anne-Margaux Collignon, Marjolaine Gosset, Anne-Laure Bonnet

“…The excluded articles were reviews, in vitro or animal studies, studies on teenagers or adults, and studies involving patients with disabilities other than DS. …”
Get full text

‘Tobolyak’: an oat cultivar for universal use by M. N. Fomina, Yu. S. Ivanova, O. A. Pay, N. A. Bragin

“…An urgent problem is the development and introduction of cultivars for universal use that can meet the demand of animal husbandry for various types of feed and that of food industry for raw materials. …”
Get full text

Recovery from Liver Failure and Fibrosis in a Rat Portacaval Anastomosis Model after Neurointermediate Pituitary Lobectomy by Martín Muñoz-Ortega, Noé Macías-Segura, Javier Ventura-Juárez, Manuel Enrique Ávila-Blanco, Leonardo D. Ponce-Damian, Daniel González-Blas, Esperanza Sánchez-Alemán, Andrés Quintanar-Stephano

“…In comparison with those in the IC and PCA groups, bilirubin, protein serum, and liver glycogen levels were restored in the PCA+NIL group. NIL in the PCA animals also decreased the gene expression levels of IL-1 and COLL-I, while increasing those of IL-10, TGF-β, and MMP-13. …”
Get full text

Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice by Jin Zhang, Jin Zheng, Haitao Chen, Xinrong Li, Chenxiao Ye, Fan Zhang, Zewei Zhang, Qinghua Yao, Yong Guo

“…After tumor formation, the animals were divided into groups and given curcumin or saline interventions. …”
Get full text

Retrospective evaluation of risk factors for worsening renal function after angiotensin‐converting enzyme inhibitor treatment in dogs by Yelim Lee, Minju Baek, Dongseop Lee, Jinyeong Park, Yeon Chae, Byeong‐Teck Kang, Taesik Yun, Hakhyun Kim

“…Objectives To identify risk factors for WRF in dogs receiving ACEi for cardiac diseases, proteinuria, or systemic hypertension. Animals A total of 156 client‐owned dogs that received ACEi were included. …”
Get full text

High-resolution awake mouse fMRI at 14 tesla by David Hike, Xiaochen Liu, Zeping Xie, Bei Zhang, Sangcheon Choi, Xiaoqing Alice Zhou, Andy Liu, Alyssa Murstein, Yuanyuan Jiang, Anna Devor, Xin Yu

“…Furthermore, this study provides a thorough acclimation method used to accustom animals to the MRI environment minimizing motion-induced artifacts. …”
Get full text

Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy by Rebecca F. Slykerman, Naomi Davies, Klara Vlckova, Kenneth J. O'Riordan, Shalome A. Bassett, James Dekker, Harriët Schellekens, Niall P. Hyland, Gerard Clarke, Elaine Patterson

“…Expediting the transition from positive preclinical data to proven benefits in humans includes interpreting the promises and pitfalls of animal behavioural assays, as well as navigating mechanism‐informed decision making to select the right microbe(s) for the job. …”
Get full text

The effects of substrate and C:N ratio on water quality in denitrification systems for brackish water aquaculture by Andrew J. Ray, Leo J. Fleckenstein, Mark E. Johannemann, Jill C. Fisk

“…Recirculating aquaculture systems (RAS) accumulate dissolved nitrate in the water, which can harm animals. Denitrification can be used to remove nitrate, although some strategies can be expensive and difficult to operate. …”
Get full text

Diverse biological roles of PhoP/PhoQ in Pseudomonas plecoglossicida: Impact on stress responses and virulence by Meiqin Mao, Li He, Xiangyang Lin, Jianshao Wu, Pan Wang, Chuanzhong Zhu, Qingpi Yan

“…Pseudomonas plecoglossicida is a pathogenic bacterium affecting aquatic animals, responsible for causing a highly fatal disease known as “Visceral White Spot Disease” in various economically important fish species, leading to significant economic losses. …”
Get full text

Anti-invasion activities of heat-killed lactic acid bacteria isolates against Salmonella enterica serovar Typhimurium by Anis Syahirah Saifor Adzuan, Sharifah Aminah Syed Mohamad, Rashidah Iberahim, Noor Nadia Syahira Mohd Kamal, Nurliana Abd Mutalib, Nur Intan Hasbullah, Muneer Alsaydi, Nor'aishah Hasan, Low Kheng Oon, Olaide Olawunmi Ajibola, Rozila Alias, Maimunah Mustakim, Azlin Sham Rambely, Emida Mohamed, Mohammad Reza Pourmand

“…Lactic acid bacteria (LAB) were recognized as a prominent probiotic gastrointestinal microbiota of humans and animals that confer health-promoting and protective effects. …”
Get full text

A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis by Xirong Tian, Xirong Tian, Xirong Tian, Xirong Tian, Yamin Gao, Yamin Gao, Yamin Gao, Yamin Gao, Chunyu Li, Chunyu Li, Chunyu Li, Chunyu Li, Wanli Ma, Wanli Ma, Wanli Ma, Wanli Ma, Jingran Zhang, Jingran Zhang, Jingran Zhang, Jingran Zhang, Yanan Ju, Yanan Ju, Yanan Ju, Yanan Ju, Jie Ding, Jie Ding, Jie Ding, Jie Ding, Sanshan Zeng, Sanshan Zeng, Sanshan Zeng, Sanshan Zeng, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, Htin Lin Aung, Htin Lin Aung, Htin Lin Aung, Nanshan Zhong, Gregory M. Cook, Gregory M. Cook, Gregory M. Cook, Gregory M. Cook, Jinxing Hu, Jinxing Hu, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang

“…This novel approach offers several advantages: (1) it eliminates the need for anesthesia in mice during administration and simplifies the instrument manipulation; (2) it is cost-effective by utilizing mice instead of larger animals; (3) it shortens the time from several months to 16 or 17 days for obtaining result; (4) it is non-invasive by directly measuring the live RLUs of mice as a surrogate marker for colony-forming units for in vivo drug activity testing; (5) up to six mice can be administrated daily and simultaneously, even 2–3 times/day; (6) results are relatively objective and reproducible results minimizing human factors. …”
Get full text