Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum by Abhishek Singh

“…Evaluation of the safety profile through animal studies and clinical trials underscores its potential as a safe therapeutic agent albeit with considerations for dosage and administration. …”
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Fetal Safety in MRI During Pregnancy: A Comprehensive Review by Gal Puris, Angela Chetrit, Eldad Katorza

“…Regarding gadolinium-based contrast agents, the evidence is conflicting: while some studies suggest risks such as stillbirth and rheumatological conditions, animal studies show minimal fetal retention and no significant toxicity, and later clinical research has not substantiated these risks. …”
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Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats by Fouziyeh Siahpour, Hosein Sadeghi, Esmaeel Panahi kokhdan, Mohammad Khoshnoud

“…Male Wistar rats were used in animal studies. Paraquat was administered orally (R1-1) at a single dose of 40 mg/kg to induce lung fibrosis. …”
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Contribution of Experimental Animal Research Studies to the Emergency Medicine Literature by Umut Ocak, John H. Zhang

“…In conclusion, experimental animal studies are essential in the progress of contemporary scientific knowledge. …”
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Protective effect of exercise on animals with sepsis: a systematic review of the existing literature by Na Yang, Nan Jiang, Chunming Shen, Ming Gao, Qian Tong, Jian Sun

“…The quality of each study was assessed using the Center for Systematic Evaluation of Experimental Animal Studies (SYCLE) Animal Research Bias Risk Tool. …”
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Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway. by Yushuang Xing, Di Jia, Xinping Zhu, Jialu Yang, Zhipeng Gao, Nana Meng, Haohao Xu, Mengxiao Wang, Shijun Chang, Mingqian Zhao, Shanbo Zhang, Zichen Mu, Qiang Tang, Weiming Zhao

“…In addition, inotodiol showed to induce apoptosis, characterized by an increase in Bax expression, a decrease in Bcl-2, Bcl-XL and MCL1 expression, the initiation of cleaved PARP1 and cleaved caspase 3, and inhibition of the MAPK/ERK pathway. Animal studies demonstrated that inotodiol possessed the ability to suppress tumor growth in nude mice models, at the same time, there was no significant impact on the body weight and organs of the mice. …”
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Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews. by Annhild Mosdøl, Gunn Elisabeth Vist, Camilla Svendsen, Hubert Dirven, Inger Therese Laugsand Lillegaard, Gro Haarklou Mathisen, Trine Husøy

“…Systematic reviews of animal studies are lacking in this topic area. The systematic evidence only partly explore forwarded hypotheses found in the literature. …”
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Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda by Aziz, Katabazi, Adamu, Almustapha Aliero, Simon Peter, Musinguzi

“…The prevalence of trypanosomiasis infection in the animal studied is 11/254 (4.3%). Trypanosoma congolense was the most dominant trypanosome species with a proportion of 9/11 (81.8%), followed by T. vivax 1/11 (9.1%) and mixed infection of T. congolense/T. vivax1/11 (9.1%). …”
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Enhancing Infection Control in ICUS Through AI: A Literature Review by Aditya Amit Godbole, Paras, Maanya Mehra, Sumitaksha Banerjee, Poulami Roy, Novonil Deb, Sarang Jagtap

“…Methodology A comprehensive search of PubMed and Scopus was conducted for relevant articles up to January 2024, including case series, reports, and cohort studies. Animal studies and irrelevant articles were excluded, with a focus on those considered to have significant clinical relevance. …”
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The effect of light-emitting diode-mediated photobiomodulation therapy on orthodontic tooth movement: A literature review by Rashin Bahrami, Nariman Nikparto, Fateme Gharibpour, Maryam Pourhajibagher, Abbas Bahador

“…Five studies were included in the review, comprising two animal studies (ages 10 and 12 weeks) and three human studies (ages ranging from 15 to 17 years). …”
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Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial by Morgane Linard, Isabelle Garrigue, Bruno Vellas, Nicola Coley, Henrik Zetterberg, Kaj Blennow, Nicholas James Ashton, Pierre Payoux, Anne-Sophie Salabert, Jean-François Dartigues, Joachim Mazere, Sandrine Andrieu, Catherine Helmer

“…Abstract In vitro and animal studies have suggested that inoculation with herpes simplex virus 1 (HSV-1) can lead to amyloid deposits, hyperphosphorylation of tau, and/or neuronal loss. …”
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Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells by Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland

“…In conclusion, small animal studies have demonstrated the feasibility of high-throughput approaches for the discovery of pMHC epitopes recognised by directly alloreactive T cells. …”
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Depth-electrode stimulation and concurrent functional MRI in humans: Factors influencing heating with body coil transmission by Hiroyuki Oya, Ralph Adolphs, Matthew A. Howard, J. Michael Tyszka

“…Widely used to map effective functional connectivity in animal studies, its application to the human brain has been limited due to safety concerns. …”
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Clinical outcomes and long-term efficacy of high tibial osteotomy in treating knee instability: An updated systematic review by Mustamsir Edi, Aji Aulia Pandu, Adiwangsa Ahmad Abdilla, Akmalizzan Azfar Ahnaf

“…Exclusion criteria included animal studies, non-knee joint studies, and reviews. Data on patient demographics, follow-up duration, subjective and objective outcomes, and complications were extracted. …”
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Assessing the role of selenium in Minamata disease through reanalysis of historical samples by Mineshi Sakamoto, Masumi Marumoto, Koichi Haraguchi, Takashi Toyama, Yoshiro Saito, Steven J. Balogh, Chiharu Tohyama, Masaaki Nakamura

“…Before MeHg was recognized as the cause, selenium (Se) was suspected of being the potential cause owing to elevated Se levels in patients’ organs. Subsequent animal studies indicated that Se mitigates MeHg toxicity; however, its role in Minamata disease remains unexplored. …”
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Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver by Yuki Ito, Toshiki Nakamura, Yukie Yanagiba, Doni Hikmat Ramdhan, Nozomi Yamagishi, Hisao Naito, Michihiro Kamijima, Frank J. Gonzalez, Tamie Nakajima

“…However, species differences in the receptor functions between rodents and human make it difficult to precisely extrapolate their toxicity from animal studies to human. In this paper, we compared the species differences in the activation of mouse and human hepatic PPARα by these plasticizers using wild-type (mPPARα) and humanized PPARα (hPPARα) mice. …”
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Liver Resection Promotes (Regulates) Proinflammatory Cytokines in Patients with Hepatocellular Carcinoma by Farshid Fathi, Behnam Sanei, Mazdak Ganjalikhani Hakemi, Reza F. Saidi, Abbas Rezaei

“…Background. Several animal studies have shown the roles of cytokines in regulating liver regeneration following liver resection (LR), which is a type of surgery designed to remove cancerous tumors from the liver. …”
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Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing by Wei Duan, Yue Gao, Ruru Xu, Sheng Huang, Xueqian Xia, Jingwen Zhao, Longhuan Zeng, Qiaolin Wei, Jia-Wei Shen, Jianmin Wu, Yongke Zheng

“…Furthermore, In vivo animal studies have demonstrated that Pt@PSi-based combination therapy can significantly accelerate the healing of infected burn infections by inhibiting bacterial growth, scavenging reactive oxygen species, and promoting angiogenesis with a favorable biosafety. …”
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Systemic Inflammatory Cytokines Predict the Infectious Complications but Not Prolonged Postoperative Ileus after Colorectal Surgery by G. S. A. Boersema, Z. Wu, A. G. Menon, G. J. Kleinrensink, J. Jeekel, J. F. Lange

“…Postoperative ileus (POI) is common after surgery. Animal studies indicate that the POI mechanism involves an inflammatory response, which is also activated during postoperative complications. …”
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Inhibitory properties of a latent inhibitor after its compound preexposure with several novel stimuli: evidence from human conditioning by Unai Liberal, Gabriel Rodríguez, Paula Nogueiras, James Byron Nelson, Geoffrey Hall, Geoffrey Hall

“…These results suggest that compound pre-exposure facilitates the acquisition of inhibitory properties in humans, consistent with findings from animal studies. The findings are discussed within the framework of Hall-Rodríguez model, emphasizing the role of expectancy violation during pre-exposure in strengthening inhibitory associations. …”
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