Best practices for the experimental design of one health studies on companion animal and owner microbiomes – From data collection to analysis by Suzanne B. Clougher, Dagmara Niedziela, Piera Versura, Grace Mulcahy

“…Finally, we propose a framework with key considerations to bear in mind when designing and carrying out owner-companion animal studies, as well as best practices to implement them.Although these studies come with additional difficulties compared to species-specific microbiome studies, they offer the opportunity to identify biomarkers, environmental triggers, and impacts of pet-owner interactions across species.…”
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Transcutaneous Intraluminal Impedance Measurement for Minimally Invasive Monitoring of Gastric Motility: Validation in Acute Canine Models by Michael D. Poscente, Gang Wang, Dobromir Filip, Polya Ninova, Gregory Muench, Orly Yadid-Pecht, Martin P. Mintchev, Christopher N. Andrews

“…There were no significant GMI PCCs in the sham capsule test. Further chronic animal studies of this novel long-term gastric motility measurement technique are needed before testing it on humans.…”
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Green Dentistry: State of the Art and Possible Development Proposals by Stefano Speroni, Elisabetta Polizzi

“…Non-full-text papers, animal studies, studies in languages other than English, and studies not related to the topic under consideration were excluded. …”
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A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…AS1411-HSA-LDP-AE exhibited a strong cell-killing activity in esophageal cancer cells, inhibited cell migration and invasion, and induced cell apoptosis. The animal studies confirmed that AS1411-HSA-LDP-AE exhibited a strong anti-tumor effect. …”
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Exercise-Induced Neuroplasticity in Parkinson’s Disease: A Metasynthesis of the Literature by Hanna Johansson, Maria Hagströmer, Wilhelmus J. A. Grooten, Erika Franzén

“…During the last decade, there has been an increased interest in investigating physical exercise as a neuroprotective mechanism in PD. Animal studies have suggested that exercise may in fact induce neuroplastic changes, but evidence in humans is still scarce. …”
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Dexmedetomidine Infusion Associated with Transient Adrenal Insufficiency in a Pediatric Patient: A Case Report by Elizabeth W. Tucker, David W. Cooke, Sapna R. Kudchadkar, Sybil Ann Klaus

“…This concern was initially supported by animal studies, but subsequent human studies demonstrated mixed results. …”
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Managing Chronic Neuropathic Pain: Recent Advances and New Challenges by Namrata Hange, Sujan Poudel, Saleha Ozair, Trissa Paul, Meghna Nambakkam, Rakchhya Shrestha, Farrah Greye, Sangam Shah, Yagya Raj Adhikari, Sangharsha Thapa, Pooja Patel

“…Articles from non-English literature, reports without human subjects, animal studies, and abstracts/posters were excluded. However, human studies and studies published in English were included. …”
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Early Polytherapy for Probably Benzodiazepine Refractory Naïve Status Epilepticus (Stage 1 Plus) by Giuseppe Magro

“…The objective of this review is to provide pathophysiological and pre-clinical evidence, mostly from animal studies, for the different approach of combined polytherapy from the start for those cases of SE falling in the definition of Stage 1 Plus.…”
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Liberal Preoperative Fasting in Adults Undergoing Elective Surgery: A Scoping Review Protocol by Haoyue Gan, Hangcheng Liu, Huaping Huang, Mei He

“…This scoping review only examines literature in the database, without reference to human or animal studies, and therefore does not require ethical approval. …”
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The Role of Gut Microbiota in Hypertension Management - A Review by Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej

“…The state of knowledge: Key mechanisms involved into regulation of blood pressure include the production of short- chain fatty acids (SCFAs), modulation of the renin-angiotensin system (RAS), immune system regulation, and metabolite production such as trimethylamine-N-oxide (TMAO). Animal studies using fecal microbiota transplantation (FMT) have provided strong evidence for a causal role of gut microbiota in blood pressure regulation. …”
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Plant Extracts in the Bone Repair Process: A Systematic Review by Lyvia Lopes Miranda, Vanessa de Paula Guimarães-Lopes, Luciana Schulthais Altoé, Mariáurea Matias Sarandy, Fabiana Cristina Silveira Alves Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves

“…Essential criteria to in vivo animal studies were frequently underreported, suggesting publication bias. …”
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Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…Current preclinical models, including animal studies, fail to accurately replicate human pregnancy conditions, resulting in gaps in drug safety and pharmacokinetics predictions. …”
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Inflammatory Bowel Disease: Progress Towards a Gene by David A van Heel, Jack Satsangi, Alisoun H Carey, Derek P Jewell

“…Replicated class II HLA associations include HLA DRB1*0103 and DR2 (DRB1*1502), involved in UC susceptibility, and HLA DRB1*03 and DR4 as resistance alleles for CD and UC respectively. Animal studies have provided insights from targeted mutations and quantitative trait locus analysis. …”
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Assessing SPECT/CT for the identification of cartilage lesions in the knee joint: A systematic review by Larissa Rix, Samuel Tushingham, Karina Wright, Martyn Snow

“…Results: PubMed, Science Direct, Web of Knowledge, and NHS databases were searched for English language articles focusing on the diagnostic value of SPECT/CT for knee chondral lesions and knee pain. Animal studies, cadaver studies, comparator radiological technique other than SPECT/CT or patients with a pathology other than knee chondral lesions were excluded. …”
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Advances, challenges and future applications of liver organoids in experimental regenerative medicine by Da Gong, Jiaye Mo, Jiaye Mo, Mei Zhai, Fulin Zhou, Guocai Wang, Shaohua Ma, Xiaoyong Dai, Xiaoyong Dai, Xuesong Deng

“…Substantial theoretical feasibility has been demonstrated at the levels of gene expression, molecular interactions, and intercellular dynamics, complemented by numerous successful animal studies. However, a robust model and carrier that closely resemble human physiology are still lacking for translating these theories into practice. …”
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Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia by David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó

“…In this review, focusing on in vivo animal studies, we will specifically discuss the utilization of SZ animal models and the various methods employed to assess animal behaviour before summarising the evidence obtained to date in the field of mGluR2/3 PAMs. …”
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Pharmacological regression of atherosclerotic plaque in patients with type 2 diabetes by Loredana Bucciarelli, Daniele Andreini, Giulio Stefanini, Roberta Maria Fiorina, Marco Francone, Federica Catapano, Maria Elena Lunati, Edoardo Conte, Davide Marchetti, Paolo Fiorina

“…Vulnerable plaques are characterized by a softer atheromatous core and a thinner fibrous cap, with inflammation and hypercholesterolemia playing a crucial role in the atherothrombotic process. Based on animal studies that extend back to the 1920s, regression of atherosclerotic plaques in humans has just started to be considered and pursued. …”
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Nonparametric analysis of inter‐individual relations using an attention‐based neural network by Takashi Morita, Aru Toyoda, Seitaro Aisu, Akihisa Kaneko, Naoko Suda‐Hashimoto, Ikuma Adachi, Ikki Matsuda, Hiroki Koda

“…Abstract Social network analysis, which has been widely adopted in animal studies over the past decade, enables the revelation of global characteristic patterns of animal social systems from pairwise inter‐individual relations. …”
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Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach by Mahsa Rezazadegan, Bita Forootani, Yeganeh Hoveyda, Niloufar Rezazadegan, Reza Amani

“…The findings of some previous studies are heterogeneous due to the inclusion of various types of study (human, and animal studies) and wide exposures (phthalate, bisphenol A, HMS, etc.), and no comprehensive systematic review has investigated the association between HMs exposure and human gut microbiota composition. …”
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Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q by Sukesh Manthri, Naresh K. Vasireddy, Sindhura Bandaru, Swati Pathak

“…Elliptocytosis in the setting of MDS has rarely been reported, and association with 20q deletion is even rarer. Animal studies have shown that haploinsufficiency of L3MBTL1 contributes to some (20q−) myeloproliferative neoplasms and myelodysplastic syndromes by affecting erythroid differentiation. …”
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