Do NSAIDs Prevent Colorectal Cancer? by Nadir Arber

“…This observation is supported by animal studies that show fewer tumours per animal and fewer animals with tumours after administration of several different NSAIDs. …”
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Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease by Nicole K. Scripsema, Dan-Ning Hu, Richard B. Rosen

“…Subsequently, the effect of xanthophylls in the prevention and treatment of various eye diseases has been examined through epidemiological studies, animal studies, and clinical trials. This paper attempts to review the epidemiological studies and clinical trials investigating the effects of xanthophylls on the incidence and progression of various eye diseases. …”
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Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters by Hamed Barabadi, Hesam Noqani, Maha Soltani, Ayeh Sabbagh Kashani

“…This review highlights the emerging role of eco-friendly, bioengineered silver (AgNPs) and gold nanoparticles (AuNPs) as protective agents for liver and kidney health, based on evidence from animal studies. The discussion emphasizes green synthesis approaches, which offer sustainable and biocompatible routes for nanoparticle production. …”
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The Role of Mitochondria from Mature Oocyte to Viable Blastocyst by Scott Chappel

“…Mitochondrial augmentation of oocytes is now reconsidered in light of our current understanding of mitochondrial function and the publication of a number of animal studies. With a better understanding of the role of this organelle in oocytes immediately after fertilization, blastocyst and offspring, mitochondrial augmentation may be reconsidered as a method to improve oocyte quality.…”
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Gut Microbiome in Obsessive Compulsive Disorder: Potential of Probiotics as an Adjuvant Therapy by Grace Yong-En Kong, Vengadesh Letchumanan, Loh Teng-Hern Tan, Jodi Woan-Fei Law

“…As an approach to restoring the balance of the gut microbiome, probiotics serve as an effective solution. In vivo animal studies showed that probiotics can potentially improve OCD symptoms. …”
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Clinical Effect of Photobiomodulation on Wound Healing of Diabetic Foot Ulcers: Does Skin Color Needs to Be Considered? by Thabo Dhlamini, Nicolette Nadene Houreld

“…A literature search was conducted and resulted in articles on cell studies, animal studies, and clinical trials. Only 13 clinical trials and 2 clinical case studies were adopted and used in this review. …”
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The Heart-Placenta Axis in the First Month of Pregnancy: Induction and Prevention of Cardiovascular Birth Defects by Kersti K. Linask

“…Extrapolating from animal studies to human pregnancy, our studies showed that folate (FA) deficiency as well as one-time exposure to environmental factors in the first two to three weeks of human gestation can result in severe congenital heart defects (CHDs). …”
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Nanomodified Peek Dental Implants: Bioactive Composites and Surface Modification—A Review by Shariq Najeeb, Zohaib Khurshid, Jukka Pekka Matinlinna, Fahad Siddiqui, Mohammad Zakaria Nassani, Kusai Baroudi

“…Melt-blending with bioactive nanoparticles can be used to produce bioactive nanocomposites, while spin-coating, gas plasma etching, electron beam, and plasma-ion immersion implantation can be used to modify the surface of PEEK implants in order to make them more bioactive. However, more animal studies are needed before these implants can be deemed suitable to be used as dental implants.…”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

“…Although underscored by animal studies, the endotypes of human RDEB are poorly understood. …”
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Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients by Pauline Duffuler, Khushwant S. Bhullar, Jianping Wu

“…Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.…”
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MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy by Lihua Chen, Jiaying Yang, Lingyu Jia, Xiaolu Wei, Huijun Wang, Zhuo Liu, Shan Jiang, Pengyue Li, Yanyan Zhou, Hongjie Wang, Nan Si, Baolin Bian, Qinghe Zhao, Haiyu Zhao

“…Additionally, it significantly promoted cell apoptosis by upregulating pro-apoptotic proteins such as Bax, Bax/Bcl-2, cytochrome C. Animal studies have shown that the tumor inhibition efficiency of ZIAMH nanomedicines was three fold higher than that of free drugs. …”
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Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss by Lijuan Shi, Ying Chang, Xiaowei Li, Steve Aiken, Lijie Liu, Jian Wang

“…Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.…”
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Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols by Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li

“…By analyzing recent publications, we have covered across chemistry models, cell lines and animal studies. Tea polyphenols, particularly catechins, showed outstanding antiglycation effect by trapping α-dicarbonyl compounds and impeding AGEs formation. …”
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The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis by A. S. Nazrun, M. Norazlina, M. Norliza, S. Ima Nirwana

“…Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. …”
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Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure by Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-Fan Hu, Tao Li

“…However, the efficacy of this cell therapy in animal studies needs to be significantly improved before it can be translated into clinics. …”
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A Look into Stem Cell Therapy: Exploring the Options for Treatment of Ischemic Stroke by Cesar Reis, Michael Wilkinson, Haley Reis, Onat Akyol, Vadim Gospodarev, Camila Araujo, Sheng Chen, John H. Zhang

“…Understanding the role of endogenous neural stem and progenitor cells under normal physiological conditions aids in analyzing their effects after ischemic injury, including their impact on functional recovery and neurogenesis at the site of injury. Recent animal studies have utilized unique subsets of exogenous and endogenous stem cells as well as preconditioning with pharmacologic agents to better understand the best situation for stem cell proliferation, migration, and differentiation. …”
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Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond by Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos

“…High-throughput technologies in human and animal studies have revealed novel molecular and cellular pathways involved in tissue inflammation of rheumatoid arthritis (RA). …”
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Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy by Ting Gong, Boon Chin Heng, Edward Chin Man Lo, Chengfei Zhang

“…This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. …”
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Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention by Rajani Katta, Danielle Nicole Brown

“…These results have been substantiated by animal studies. In human studies, researchers have evaluated both oral AO supplements and dietary intake of AOs via whole foods. …”
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Hopeful News for Physicians Who Involved in the Treatment of Critical Aluminum Phosphide (Rice Pill) Poisoning Patients by Fatemeh Vafapour, Moslem Sedaghattalab

“…Aluminum phosphide is a lethal poison without antidote and causes cardiocirculatory collapse and has negative inotropic cardiac effect. Human and animal studies showed that high dose insulin had positive cardiac inotropic effects. …”
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