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81
Statins in Asthma: Potential Beneficial Effects and Limitations
Published 2015-01-01“…However, the initial excellent results from the preclinical and animal studies have not borne the results in clinical trials that the scientific world was hoping for. …”
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82
The Successful Use of Inhaled Nitric Oxide in the Management of Severe Hepatopulmonary Syndrome after Orthotopic Liver Transplantation
Published 2014-01-01“…Although the use of inhaled nitric oxide in patients with HPS has been sporadically reported in pediatric literature and in animal studies, to our knowledge, our cases are the first recorded in adult patients.…”
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83
Avian Influenza a (H5N1) Infection with Respiratory Failure and Meningoencephalitis in a Canadian Traveller
Published 2015-01-01“…The present case demonstrated the typical manifestation of H5N1 influenza but, for the first time, also confirmed previous suggestions from human and animal studies that H5N1 is neurotropic and can manifest with neurological symptoms and meningoencephalitis.…”
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84
Cerebellar Development and Plasticity: Perspectives for Motor Coordination Strategies, for Motor Skills, and for Therapy
Published 2005-01-01“…In terms of motor function, the development of the cerebellum is of particular interest because animal studies show that the development of the cerebellar cortical circuitry closely parallels motor coordination. …”
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85
The Enteric Nervous System in Intestinal Inflammation
Published 1996-01-01“…Since about the 1950s nerves in the wall of the intestine have been postulated to play a role in the pathogenesis of inflammatory bowel disease (IBD). Human and animal studies examining the role of nerves in intestinal inflammation are the focus of this review. …”
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86
Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease
Published 2025-01-01“…To date, antisense oligonucleotide (ASO) drugs targeting the pathological genes associated with ALS and HD have shown promising results in numerous animal studies and several clinical trials. This review provides a comprehensive overview of the development, mechanisms of action, limitations, and clinical applications of ASO drugs in neurodegenerative diseases, with a specific focus on ALS and HD therapeutic strategies.…”
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87
The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus
Published 2017-01-01“…There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. …”
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88
Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy
Published 2010-01-01“…Reported research in animal studies indicated that vaccine immunity could be a promising alternative therapy for cancer patients. …”
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89
Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
Published 2018-01-01“…Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration. …”
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90
Antenatal Corticosteroids: A Risk Factor for the Development of Chronic Disease
Published 2012-01-01“…The long-term effects of ACS exposure on HPA axis activity and neurological function are well documented in animal studies, and it appears that ACS, regardless of dose exposure, is capable of affecting fetal HPA axis development causing permanent changes in the HPA axis that persists through life and is manifested by chronic illness and behavioral changes. …”
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91
The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies
Published 2009-01-01“…However, basic research and animal studies strongly support angiotensin II as a proinflammatory mediator, which directly induces atherosclerotic plaque development and heart remodeling. …”
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92
El Instituto Latinoamericano de Estudios Críticos Animales como proyecto decolonial
Published 2017-01-01“…Para ello, se desarrolla una revisión de los Estudios Críticos Animales y del Institute for Critical animal Studies -ICAS-, primer impulsor de dicho campo de estudios. …”
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93
Mesenchymal Stem Cells (MSCs): A Novel Therapy for Type 2 Diabetes
Published 2022-01-01“…In this review, we present an overview of the current status of MSC therapy in treating T2DM for both animal studies and clinical studies. Potential mechanisms of MSC-based intervention on multiple pathological processes of T2DM, such as β-cell exhaustion, hepatic dysfunction, insulin resistance, and systemic inflammation, are also delineated. …”
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94
Multifunctional health-promoting effects of oolong tea and its products
Published 2022-05-01“…These promising studies mainly gained from animal studies might broaden the consumption and usage of the phenolic-enriched oolong tea and its products in food and pharmaceutical industries. …”
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95
Bidirectional relationship between sleep and depression
Published 2025-02-01“…How antidepressants affect sleep in patients with depression might provide clues to understanding the effects of sleep, but caution is required considering that antidepressants have diverse effects other than sleep. Recent animal studies support the bidirectional relation between depression and sleep, and animal models of depression are expected to be beneficial for the identification of neuronal circuits that connect stress, sleep, and depression. …”
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96
Neuroprotection as a Therapeutic Target for Diabetic Retinopathy
Published 2016-01-01“…Many substances have been tested in animal studies for their neuroprotective properties and for possible use in humans. …”
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97
Form and Function of Sleep Spindles across the Lifespan
Published 2016-01-01“…Despite a broad general understanding of mechanisms of spindle generation gleaned from animal studies, the mechanisms underlying certain features of spindles in the human brain, such as “global” versus “local” spindles, are largely unknown. …”
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98
Mechanism of Human Tooth Eruption: Review Article Including a New Theory for Future Studies on the Eruption Process
Published 2014-01-01“…Accordingly, the mechanism of eruption depends on the correlation between space in the eruption course, created by the crown follicle, eruption pressure triggered by innervation in the apical root membrane, and the ability of the periodontal ligament to adapt to eruptive movements. Animal studies and studies on normal and pathological eruption in humans can support and explain different aspects in the new theory. …”
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99
Gene Therapy: A step toward advanced orthodontics – A narrative review
Published 2023-07-01“…After the introduction of gene therapy in dentistry, this field is also flourishing rapidly in the branch of orthodontics and dentofacial orthopedics as it can prevent many prenatal and postnatal dentofacial anomalies which have the genetical etiology. Despite various animal studies showing promising results, a lot more is left to be explored. …”
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100
Epithelial Tight Junctional Changes in Colorectal Cancer Tissues
Published 2011-01-01“…This review will present recent data from clinical and animal studies showing how altered TJ protein expression is a feature of certain CRCs. …”
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