(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity by Ž. Večerić-Haler, A. Cerar, M. Perše

“…Although MSCs have potent immunosuppressive properties, animal studies also suggest that transplanted MSCs may elicit immune response. …”
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Sympathoexcitation Associated with Renin-Angiotensin System in Metabolic Syndrome by Takuya Kishi, Yoshitaka Hirooka

“…As a novel aspect connecting the importance of SNS and RAS activation, we and other investigators have recently demonstrated that angiotensin II type 1 receptor (AT1R) blockers (ARBs) improve SNS activation in patients with MetS. In the animal studies, SNS activation is regulated by the AT1R-induced oxidative stress in the brain. …”
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Examining the therapeutic potential and side effects of calcium channel blockers in mortality and morbidity of patients with stroke: A systematic review of pre-clinical and clinica... by Sevak Hatamian, Asad Abdi, Fatemeh Sadat Seyedi Asl, Armin Tafazolimoghadam, Arian Tavasol, Seyed Ali Mousavi Nejad, Reza Madadi, Zohre Tajabadi, Mina Dehghani, Najmeh Ahmadpoor, Mobina Fathi, Mohammadreza Hajiesmaeili, Navid Nooraei

“…After the title and abstract screening, 56 human and animal studies were selected to be discussed in this article. …”
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Bovine Antibody-Based Oral Immunotherapy for Reduction of Intragastric Helicobacter pylori Colonization: A Randomized Clinical Trial by CM den Hoed, AC de Vries, PBF Mensink, CM Dierikx, H Suzuki, L Capelle, H van Dekken, R Ouwendijk, EJ Kuipers

“…Effective prevention and eradication of H pylori by passive immunization with orally administered bovine antibodies has been demonstrated in animal studies, and may serve as an alternative therapy in humans.…”
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Defining Optimal Aerobic Exercise Parameters to Affect Complex Motor and Cognitive Outcomes after Stroke: A Systematic Review and Synthesis by S. M. Mahmudul Hasan, Samantha N. Rancourt, Mark W. Austin, Michelle Ploughman

“…We synthesized data from clinical and animal studies in order to determine optimal AE training parameters and recovery outcomes for future research. …”
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Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep by Yinhan Li, Xinhui Zou, Ying Ma, Jiaqi Cheng, Xiangmin Yu, Wenya Shao, Fuli Zheng, Zhenkun Guo, Guangxia Yu, Siying Wu, Huangyuan Li, Hong Hu

“…Lactic acid was relevant to depression with Mendelian randomization analysis. Moreover, animal studies demonstrated that exposure to blue light during sleep (BLS) induced depression-like behaviors in the animals. …”
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Reward Processing in the Brain: A Prerequisite for Movement Preparation? by M. Keitz, C. Martin-Soelch, K. L. Leenders

“…In the last decade, expanding animal studies on the cerebral organization of reward processing toward human in vivo situations has become possible. …”
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Impacts of Filtration on Contrast-Detail Detectability of an X-ray Imaging System

“…<p>The purpose of this study is to investigate the impacts of added filtration on the contrast-detail detectability of a digital X-ray imaging system for small animal studies. A digital X-ray imaging system specifically designed for small animal studies was used. …”
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Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction by E. W. Yates, A. Rupani, G. T. Foley, W. S. Khan, S. Cartmell, S. J. Anand

“…Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. …”
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Absence of Tuberculosis-Causing Mycobacteria from Slaughtered Livestock Tissues and Environmental Samples, Gauteng Province, South Africa by Vuyokazi Mareledwane, Abiodun A. Adesiyun, Tiny M. Hlokwe

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How Are n-3 LCPUFAs Antiarrhythmic? A Reassessment of n-3 LCPUFAs in Cardiac Disease by Andrew Ramadeen, Paul Dorian

“…Long-chain n-3-polyunsaturated fatty acids (n-3 LCPUFAs), referring particularly to marine-derived eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to be effective in treating arrhythmias in some clinical trials and animal studies. The mechanism for this effect of n-3 LCPUFAs is not well understood. …”
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Pre-clinical study of curcumin in the treatment of gastric Cancer by Minghui Hao, Chungang Zhang

“…This review aims to summarize the mechanisms through which curcumin affects gastric cancer in both laboratory and animal studies, while also discussing effective strategies for enhancing its therapeutic application.…”
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Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes by Feng-Cheng Chou, Heng-Yi Chen, Shyi-Jou Chen, Mei-Cho Fang, Huey-Kang Sytwu

“…Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progression of autoimmunity. …”
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Nitrogen-containing bisphosphonate for vascular calcification: animal experiments, systematic review and meta-analysis by Wei Xu, Guoyuan Lu, Lifeng Gong, Weigang Tang, Wei Jiang

“…Our meta-analysis of human studies revealed that N-BP was not effective in the treatment of VC, but our meta-analysis of animal studies suggested a role of N-BP in inhibiting VC.…”
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Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility by Nahoko Kuga, Takuya Sasaki

“…Accumulating evidence from both clinical and animal studies has demonstrated that such biased memory processing could be triggered by the hippocampus, a region well known to be involved in declarative memories. …”
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Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission by Sasha Mikhael, Ashlee Pascoe, Joseph Prezzato

“…The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) in reproductive-aged women poses major dilemmas concerning its associated teratogenicity as observed in many animal studies. Much controversy exists regarding continuation versus discontinuation of its use in pregnancy with some studies suggesting safety of TKIs before and during pregnancy and others reporting toxicity and adverse outcomes. …”
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New perspectives on djulis (Chenopodium formosanum Koidz.) and its potential application in functional food by Amanda Tresiliana Mulio, Chien-Shan Chiu, Yung-Jia Chan, Wen-Chien Lu, Po-Hsien Li

“…Further assessment of cell and animal studies showed that djulis leaf, whole grain, hull, and seed extracts exhibited antioxidant, anti-aging, anti-diabetic, anticancer, anti-adipogenesis, hepatoprotective, anti-inflammatory, and gastric protective properties. …”
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Suppression of Tumor Angiogenesis by Nonsteroidal Anti-Inflammatory Drugs: A New Function for Old Drugs by Curzio Raegg, Olivier Dormond

“…Importantly, NSAIDs suppress colon polyp formation and progression in patients diagnosed with familial adenomatous polyposis coli (APC)[2]. In many animal studies, NSAIDs have been shown to prevent tumor formation and slow tumor progression, thus confirming and extending the clinical observations[3,4,5]. …”
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Oral manifestations of autoimmune connective tissue diseases by Akshat Pandey, Mimansha Pandey, Ved Prakash Pandey, Vinod Ravindran

“…For the purpose of this narrative review we searched the databases such as MEDLINE the Embase and Cochrane library using search terms including “rheumatic” “autoimmune,” “connective tissue diseases,” “dental,” “oral,” and “manifestations” and the names of individual known diseases and also a manual search of bibliographies of these articles and of previously published reviews and animal studies. In this review, we describe the oral manifestation and dental considerations associated with these diseases which will allow the practitioner in holistic management of these patients.…”
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Cardiovascular Risk in Chronic Kidney Disease: Role of the Sympathetic Nervous System by Jeanie Park

“…Multiple human and animal studies have shown that central sympathetic outflow is chronically elevated in patients with both end-stage renal disease (ESRD) and chronic kidney disease (CKD). …”
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