A Novel Rat Model of Orthodontic Tooth Movement Using Temporary Skeletal Anchorage Devices: 3D Finite Element Analysis and In Vivo Validation by Neelambar Kaipatur, Yuchin Wu, Samer Adeeb, Thomas Stevenson, Paul Major, Michael Doschak

“…The aim of this animal study was to develop a model of orthodontic tooth movement using a microimplant as a TSAD in rodents. …”
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Biochemical and histopathological profiling of Wistar rat treated with Brassica napus as a supplementary feed by Kazi Md. Mahmudul Hasan, Nasrin Tamanna, Md. Anwarul Haque

“…Metabolic changes together with cardiovascular and hepatic factors are related to the development of diseases like myocardial lipidosis, heart disease, and profound toxicity. The aim of this animal study is to determine the effects of high erucic acid containing rapeseed oil (Brassica napus L.) varieties on liver, kidney and heart muscles in Wistar rats. …”
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In vivo bone regeneration performance of hydroxypropyl methylcellulose hydrogel-based composite bone cements in ovariectomized and ovary-intact rats: a preliminary investigation by Mosharraf Hossain, Tamima Sultana, Ji Eun Moon, Soobin Im, Je Hoon Jeong

“…Abstract The objective of this study is to fabricate and develop hydroxypropyl methylcellulose (HPMC) hydrogel (HG)-based composite bone cements with incorporation of hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and with/without polymethylmethacrylate (PMMA) for vertebroplasty. For animal study, twenty female Wister rats (250–300 g, 12 weeks of age) were divided into four groups including a two non-ovariectomy (NOVX) groups and two ovariectomy (OVX)-induced osteoporosis groups. …”
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Hydrolase-Treated Royal Jelly Attenuates H2O2- and Glutamate-Induced SH-SY5Y Cell Damage and Promotes Cognitive Enhancement in a Rat Model of Vascular Dementia by Nualpun Sirinupong, Worrapanitch Chansuwan, Pratchaya Kaewkaen

“…This study determined the effects of royal jelly hydrolysate (RJH) and possible mechanism of cell damage and cognitive-enhancing effect in animal study. An in vitro study assessed the effects of RJH on acetylcholinesterase inhibitor, cell viability, and cell damage in SH-SY5Y neuroblastoma cells. …”
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The Supernatant of Tonsil-Derived Mesenchymal Stem Cell Has Antiallergic Effects in Allergic Rhinitis Mouse Model by In-Su Park, Ji Hye Kim, Jun-Sang Bae, Dong-Kyu Kim, Ji-Hun Mo

“…We identified the increment of TGF-β1, PGE2, and HGF in the T-MSCs-CM. In an animal study, the T-MSCs-CM-treated group showed significantly reduced allergic symptoms and infiltration of eosinophils and neutrophils in the nasal mucosa, whereas there was no significant difference in total IgE and the OVA-specific IgE level. …”
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Sildenafil as a Salvage Treatment for Ovarian Torsion: A Rat Model by Didem Alkas Yaginc, Huriye Ayse Parlakgümüs, Selcuk Yetkinel, Pinar Caglar Aytac, Huriye Eda Ozturan Ozer, Derya Akaydin Aldemir, Esra Bulgan Kilicdag

“…STUDY DESIGN: This study is an experimental animal study conducted according to the principles of the Declaration of Helsinki. …”
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Low-Concentration Hypochlorous Acid Drinking Water Alleviates Broiler Gut Microbial Load While Preserving Overall Growth Performance by Zonggang Li, Chang Liu, Dongyan Shao, Chune Tan, Yingqi Cao, Senzhong Deng, Teng Teeh Lim, Fei Xu

“…To address this gap, an animal study was conducted using flow cytometry to quantify the age-related microbial load in broiler manure and gut contents. …”
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The reliability, sensitivity and specificity of fluorescent oxidation products for measuring global oxidative stress in vivo by Bing Liang, Juan Zhang, Xue Shen, Xiaohua Zhang, Ann M. Vuong, Linghua Yang, Xinyan Shi, Xueru Ge, Huan He, Tong Liu, Shuman Yang

“…In a human study, we examined the reliability of an improved FlOP measurement. In an animal study, we examined the sensitivity and specificity of FlOPs for measuring D-galactose induced global oxidative stress. …”
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Efficacy of Photobiomodulation Therapy Utilizing 808 nm and 660 nm Alone and in Combination for Treatment of Paresthesia in Rats by Ehsan Hajesmaelzade, Mohammad Mohammadi, Sina Kakooei, Luca Solimei, Stefano Benedicenti, Nasim Chiniforush

“…<b>Methods</b>: This animal study was conducted on 36 adult male Wistar rats. …”
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Application of stem cells alone and in combination with low-level laser therapy for sciatic nerve repair in rats by Mohsen Shalalvand, Hamidreza Mahaseni Aghdam, Ahmad Asghari, Siamak Nehzat, Fatemeh Shahsavari, Rojin Ardalani

“…Abstract This study evaluated the efficacy of tubular constructs containing stem cells and Type I collagen, both independently and in conjunction with low-level laser therapy (LLLT), in repairing the sciatic nerve in a rat model. In this animal study, the right sciatic nerve of 30 male Wistar rats, each weighing 250–300 g, was surgically excised to a length of 8 mm. …”
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Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis by Chieko Niwata, Takayuki Nakagawa, Takako Naruse, Miyuki Sakuma, Nao Yamakado, Misaki Akagi, Shigehiro Ono, Kei Tobiume, Jing Gao, Eijiro Jimi, Kouji Ohta, Tomonao Aikawa

“…LEF dose-dependently suppressed endothelial tube formation. In the animal study, LEF significantly suppressed tumor growth in both immunodeficient and syngeneic mice. …”
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Deep-learning based electromagnetic navigation system for transthoracic percutaneous puncture of small pulmonary nodules by Muyun Peng, Xinyi Fan, Qikang Hu, Xilong Mei, Bin Wang, Zeyu Wu, Huali Hu, Lei Tang, Xinhang Hu, Yanyi Yang, Chunxia Qin, Huajie Zhang, Qun Liu, Xiaofeng Chen, Fenglei Yu

“…In the phantom study, the DL-EMNS group showed a higher technical success rate (95.6% vs. 77.8%, p = 0.027), smaller error (1.47 ± 1.62 mm vs. 3.98 ± 2.58 mm, p < 0.001), shorter procedure duration (291.56 ± 150.30 vs. 676.44 ± 246.12 s, p < 0.001), and fewer number of CT acquisitions (1.2 ± 0.66 vs. 2.93 ± 0.98, p < 0.001) compared to the traditional CT-guided group. In the animal study, DL-EMNS significantly improved technical success rate (100% vs. 84.0%, p = 0.015), reduced operation time (121.36 ± 38.87 s vs. 321.60 ± 129.12 s, p < 0.001), number of CT acquisitions (1.09 ± 0.29 vs. 2.96 ± 0.73, p < 0.001) and complication rate (0% vs. 20%, p = 0.002). …”
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Basic research for ultrasound-guided injection into skeletal muscle lesions in an experimental animal model by KiyomitsuFujimoto, TakashiKanamoto, ShunyaOtani, RyoMiyazaki, KosukeEbina, KenNakata

“…Conclusion: This experimental animal study demonstrated the potential of ultrasound to quantitatively visualize abnormalities of skeletal muscle. …”
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Effects of biophilic virtual reality on cognitive function of patients undergoing laparoscopic surgery: study protocol for a sham randomised controlled trial by Bin Gao, Yanling Zhou, Jianhua Wang, Binbin Zhu, Qiuyan Weng, Wenjun Luo, Xiuchao He, Lufei Jin, Qinwen Wang, Ahmad Khaled Ahmad Harb

“…Due to the lack of an effective postoperative follow-up system, the incidence of POCD in China is not clear, and although many drugs have been proposed to improve POCD in the animal study, their clinical applications are limited, while VR provides an innovative method to provide non-pharmacological management.Methods and design This is a single-centre, randomised, double-blind, sham-controlled clinical trial. …”
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Detection of Pathogenic Serogroups and Virulence Genes in Listeria monocytogenes Strains Isolated from Beef and Beef Products Retailed in Gauteng Province, South Africa, Using Phen... by James Gana, Nomakorinte Gcebe, Rebone Moerane, Yusuf B. Ngoshe, Khomotso Moabelo, Abiodun A. Adesiyun

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Efficacy and Safety Concerns with Sn-Mesoporphyrin as an Adjunct Therapy in Neonatal Hyperbilirubinemia: A Literature Review by Prakar Poudel, Sudhir Adhikari

“…This review evaluates in-vitro studies, animal studies, and clinical trials for the efficacy and safety of tin analogues of metalloporphyrin. …”
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Cyclosporine and Herbal Supplement Interactions by D. Colombo, L. Lunardon, G. Bellia

“…Decreased CyA blood concentration has been shown with St John’s wort in case reports and, in vivo animal studies, with ginger, liquorice, scutellariae radix, and quercetin. …”
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Nutritional Supplementation with the Mushroom Agaricus sylvaticus Reduces Oxidative Stress in Children with HIV by Marcela S Figueira, Luana A Sá, Amanda S Vasconcelos, Danilo R Moreira, Paula SOC Laurindo, Danielle RG Ribeiro, Rogério S Santos, Paulo Guzzo, Maria F Dolabela, Sandro Percario

“…BACKGROUND: The involvement of free radicals and oxidative stress in HIV infection has been extensively studied, and the benefits of antioxidant supplementation in animal studies have been demonstrated. However, few studies have demonstrated a benefit in clinical studies.…”
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The Role of Gut Microbiota Modification in Nonalcoholic Fatty Liver Disease Treatment Strategies by Hessam Yaghmaei, Amirhossein Bahanesteh, Masood Soltanipur, Sobhan Takaloo, Mahdi Rezaei, Seyed Davar Siadat

“…However, further investigations are required to generalize the outcomes of animal studies to humans.…”
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Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation by Rajabalaya Rajan, Mun Chung Yee, Chellian Jestin, Chakravarthi Srikumar, David Sheba R.

“…There were no significant interactions between TT and other excipients. Animal studies indicated that the TT patch reduced the incidence of side effects; however, studies of longer duration are required to determine the effectiveness in treating OAB.…”
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