Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies by Mehrnoosh Khodaeian, Samaneh Enayati, Ozra Tabatabaei-Malazy, Mahsa M. Amoli

“…The search terms were “gene,” “polymorphism,” “diabetes,” and “diabetic complications”; nephropathy, retinopathy, neuropathy, foot ulcer, and CAD (coronary artery diseases); and Persian equivalents. Animal studies, letters to editor, and in vitro studies were excluded. …”
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The Effects of Pregnancy Status on Lacrimal Caruncle Temperature, Intraocular Pressure and Rectal Temperature in Cats: A Preliminary Study by Candemir Ozcan, Tarik Safak, Ayse Basak Dellalbasi, Elif Dogan

“…ABSTRACT Objective The objectives of this study were to compare the body temperatures between pregnant and nonpregnant cats from two sites, lacrimal caruncle temperature (LCT) and rectal temperature (RT), and to compare intraocular pressure (IOP) between pregnant and nonpregnant cats. Animal studied This study was performed on 13 pregnant and 16 anoestrous cats. …”
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The Effects of Nigella Sativa (Black Seed) in Rhinosinusitis Subjects: A Systematic Review by Muhamad Najmi Muhamad Najemudin, Nurul Asyiqin Yusof

“…The assessment of potential bias in the studies incorporated the Joanna Briggs Institute (JBI) checklist for critical appraisal of human studies and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool for assessing bias in animal studies. Results: Twelve studies were included in this study. …”
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Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…Using machine learning, the prospects for using the main compounds of bacopa to create drugs were calculated taking into account the ATC classification, their biological effects and alternative plant sources were given. Experimental animal studies of whole aqueous or ethanolic extracts of B. monnieri have been found to support a cognitive enhancement effect. …”
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Occurrence of severe cognitive impairment in elderly individuals with poor glycemic control Vs elderly individuals with good glycemic control or no DM: a case control study” by Basma Salman, Fatima Jehangir, Aroosa Jahan, Saira Aslam, Nadra Ansari

“… ABSTRACT: Background: There is substantiatial corroboration that diabetes (both T1DM and T2DM) plays an essential role in predisposition to cognitive decline thus leading to dementia in both human and animal studies. (1,2,3). Hypoglycemia has been associated with the increased risk of developing cognitive impairment. (4). …”
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Prevalence of Trypanosoma congolense and Trypanosoma vivax in Lira District, Uganda by Aziz, Katabazi, Adamu, Almustapha Aliero, Sarah, Gift Witto, Martin, Odoki, Simon Peter, Musinguzi

“…The prevalence of trypanosomiasis infection in the animal studied is 11/254 (4.3%). Trypanosoma congolense was the most dominant trypanosome species with a proportion of 9/11 (81.8%), followed by T. vivax 1/11 (9.1%) and mixed infection of T. congolense/T. vivax1/11 (9.1%). …”
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Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults by Fengxia Yu, Dong Liu, Xia Ma, Yawen Liu, Linkun Cai, Erwei Zhao, Zixu Huang, Zhe Zhang, Tingting Zhang, PengGang Qiao, Wei Zheng, Chunyan Guo, Linxue Qian, Pengling Ren, Zhenchang Wang

“…However, the effects of dobutamine on CBF and internal carotid artery (ICA) blood flow remain unclear, with contradictory reported in both clinical and animal studies. It is necessary to investigate the effects of dobutamine on cervical and cerebral hemodynamics. …”
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Intermittent hypoxia training improves cerebral blood flow without cognitive impairment by Qihan Zhang, Qing Wang, Feiyang Jin, Dan Huang, Xunming Ji, Yuan Wang

“…Abstract Objective Brief exposure to intermittent hypoxia has been shown to potentially induce protective effects in the body. Animal studies suggest that intermittent hypoxia could increase cerebral blood flow and confer resistance to subsequent hypoxic–ischemic injury, yet clinical investigations are limited. …”
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Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…Methods We plan a systematic review and meta-analysis of in vivo animal studies comparing muscarinic receptor agonists or positive allosteric modulators with control conditions and existing D2R-blocking antipsychotics in animals subjected to any method that induces behavioural changes of relevance for psychosis. …”
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Concentrations, composition profiles, and in vitro–in silico-based mixture risk assessment of bisphenol A and its analogs in plant-based foods by Chun-Hui Chiu, Shih-Han Sun, Yun-Jia Yao, Yi Chuang, Yu-Tsung Lee, Yi-Jun Lin

“…High-throughput toxicokinetic modeling was used to convert in vitro ToxCast estrogen receptor (ER) bioactive concentrations into human-equivalent points of departure (PODs), which were compared to PODs derived from animal studies and applied to assess mixture risks through the margin of exposure based on the common ER pathway. …”
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L-Citrulline in Neonates: From Bench to Bed Side by Dwayne Mascarenhas, Atefeh Mohammadi, Randa Higazy, Julijana Ivanovska, Estelle Gauda, Bonny Jasani

“…Detoxification of endogenously produced superoxide radicals is inadequate in preterm infants due to immature antioxidants that leads to the production of peroxynitrite, a reactive oxygen-free radical that is cytotoxic and causes damage to organelles and cellular membranes, further disrupting the coupling of endothelial NO synthase enzyme and the generation of high levels of reactive nitrogen and oxygen species. Animal studies in lipopolysaccharide-induced models of chorioamnionitis and hyperoxia- and inflammation-induced BPD-PH in rodent lung models revealed that L-CIT supplementation significantly mitigated structural changes in the pulmonary vasculature, preserved alveolar growth, and increased vascular endothelial growth factor gene expression, highlighting the anti-inflammatory and antioxidant effects of L-CIT supplementation. …”
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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…A promising treatment is the neuropeptide oxytocin (OT), which has been shown to play a role in endogenous analgesia with human and animal studies demonstrating anti-nociceptive effects. …”
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Association of leukocyte elastase in semen and seminal plasma with sperm parameters and pregnancy outcomes in male fertility by Mausumi Das, Maha Gumssani, Julia Mullaney, Ralf Henkel, Suks Minhas, Marie Claire Aquilina, Channa N Jayasena

“…We included 28 studies reporting sperm parameters linked to LE and excluded non-English articles, reviews and animal studies. Data collected included study details, methods, population, LE levels, sperm characteristics and pregnancy outcomes. …”
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The association between recent stressful life events and brain structure: a UK Biobank longitudinal MRI study by Cheryl R.Z. See, Annabel X. Tan, Lucia R. Valmaggia, Matthew J. Kempton

“…Abstract Background Recent stressful life events (SLEs) are an established risk factor for a range of psychiatric disorders. Animal studies have shown evidence of gray matter (GM) reductions associated with stress, and previous work has found similar associations in humans. …”
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Bacillus Calmette-Guerin (BCG) infections following intravesical BCG immunotherapy: a systematic review protocol by Roberta Monardo, Sana Arif, Aparna Rege, Erin Simon, Leila Ledbetter, Arthur W. Baker, Jason Stout, Manuela Carugati

“…No temporal, geographic, or demographic limitations will be applied. Animal studies will be excluded. Gray literature, editorials, and comments will be excluded. …”
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Evaluation of Sleep Disorders in the Elderly with Vestibular Vertigo by Zahra Hosseini Dastgerdi, Nasrin Gohari, Mobina Mehrabifard, Hasti Seifi, Bahare Khavarghazalani

“…Evidence from human and animal studies suggests a link between sleep disorders and vertigo. …”
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A Genome-Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients by Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen

“…Among the 9 confirmed lncRNAs, lncRNA MSTRG.128697 and lncRNA MSTRG.128958 were novel and human-specific; however, further validation is required. lncRNA MSTRG.63013 has orthologous sequences in the mouse genome and was identified as a key node for etiology and pathophysiology in animal studies, which will help understand the epigenetic mechanisms of T1D complications.…”
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Periodontal diseases in Down syndrome during childhood: a scoping review by Valentin Vergier, Anne-Margaux Collignon, Marjolaine Gosset, Anne-Laure Bonnet

“…The excluded articles were reviews, in vitro or animal studies, studies on teenagers or adults, and studies involving patients with disabilities other than DS. …”
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Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease by Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh

“…The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. Recent animal studies have demonstrated that physical exercise improves behavioral and neuropathological deficits in PD. …”
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Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR4... by Zifan Wang, Cai Wang, Boyu Yuan, Li Liu, Haoming Zhang, Mingqiang Zhu, Hongxia Chai, Jie Peng, Yanhua Huang, Shuo Zhou, Juxiong Liu, Liyong Wu, Wei Wang

“…In recent years, multiple clinical and animal studies have shown that mitochondrial dysfunction may be involved in the pathogenesis of AD. …”
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