PCL/PHBV Microparticles as Innovative Carriers for Oral Controlled Release of Manidipine Dihydrochloride by Fernanda Malaquias Barboza, Willian Moreira Machado, Luiz Renato Olchanheski Junior, Josiane Padilha de Paula, Sônia Faria Zawadzki, Daniel Fernandes, Paulo Vitor Farago

“…In vitro dissolution studies showed that all microparticles prolonged MAN release, mainly which one obtained using PCL that contained 5% of drug loaded (PCL-M5). Animal studies demonstrated that formulation PCL-M5 was able to keep the variation of mean arterial pressure after phenylephrine administration up to 24 hours. …”
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The Role of Gut Microbiota in Hypertension Management - A Review by Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej

“…The state of knowledge: Key mechanisms involved into regulation of blood pressure include the production of short- chain fatty acids (SCFAs), modulation of the renin-angiotensin system (RAS), immune system regulation, and metabolite production such as trimethylamine-N-oxide (TMAO). Animal studies using fecal microbiota transplantation (FMT) have provided strong evidence for a causal role of gut microbiota in blood pressure regulation. …”
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Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…Current preclinical models, including animal studies, fail to accurately replicate human pregnancy conditions, resulting in gaps in drug safety and pharmacokinetics predictions. …”
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Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…In contrast, the parental MDA-MB-231 cells and other HRR proficient cell lines produced smaller cell populations with short term treatment, but with much less cumulative DNA damage, and minimal cell death. In animal studies, our BRCA-engineered hypomorphs and several independent PDX models with clinically relevant BRCA mutations were acutely more vulnerable to this drug combination. …”
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A Genome-Wide Analysis of Long Noncoding RNAs in Circulating Leukocytes and Their Differential Expression in Type 1 Diabetes Patients by Yihan Liu, Xiaoming Du, Jia Cui, Changlong Li, Meng Guo, Jianyi Lv, Xin Liu, Jingtao Dou, Xiaoyan Du, Hongjuan Fang, Zhenwen Chen

“…Among the 9 confirmed lncRNAs, lncRNA MSTRG.128697 and lncRNA MSTRG.128958 were novel and human-specific; however, further validation is required. lncRNA MSTRG.63013 has orthologous sequences in the mouse genome and was identified as a key node for etiology and pathophysiology in animal studies, which will help understand the epigenetic mechanisms of T1D complications.…”
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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance by Meng-Yu Zhao, Zhao-Lei Shen, Hongzhen Dai, Wan-Yan Xu, Li-Na Wang, Yu- Gu, Jie-Hui Zhao, Tian-Hang Yu, Cun-Zhi Wang, Jia-feng Xu, Guan-Jun Chen, Dong-Hui Chen, Wen-Ming Hong, Wen-Ming Hong, Fang Zhang

“…We found that elevated NUSAP1 expression correlated with poor prognosis, prompting further investigation of its functional role through both cellular and animal studies.ConclusionsNUSAP1-based risk models hold potential as predictive and therapeutic tools for personalized glioma treatment. …”
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Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa by Nell Hirt, Enzo Manchon, Qian Chen, Clara Delaroque, Aurelien Corneau, Patrice Hemon, Safaa Saker-Delye, Pauline Bataille, Jean-David Bouaziz, Emmanuelle Bourrat, Alain Hovnanian, Helene Le Buanec, Fawzi Aoudjit, Hicham El Costa, Nabila Jabrane-Ferrat, Reem Al-Daccak

“…Although underscored by animal studies, the endotypes of human RDEB are poorly understood. …”
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Evaluation on Antidiabetic Properties of Medicinal Plants from Myanmar by Dongdong Zhang, Karuppusamy Arunachalam, Yuehu Wang, Yu Zhang, Jun Yang, Pyae Phyo Hein, Aye Mya Mon, Jianwen Li, Angkhana Inta, Xuefei Yang

“…P. zeylanica, L. cubeba, H. crenulate, M. gagei, C. teeta, and M. ferrea are worthy to advance further study according to their strong antidiabetic activities and limited research on effects in in vivo animal studies, unclear chemical constitutes, and safety.…”
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Could Infectious Agents Play a Role in the Onset of Age-related Macular Degeneration? A Scoping Review by Petra P. Larsen, MD, PhD, Virginie Dinet, PhD, Cécile Delcourt, PhD, Catherine Helmer, MD, PhD, Morgane Linard, MD, PhD

“…In total, 40 articles were included, among which 30 on human data, 9 animal studies, 6 in vitro experiments, and 1 hypothesis paper (sometimes with several data types in the same article). …”
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Long-Term Voluntary Physical Exercise Exerts Neuroprotective Effects and Motor Disturbance Alleviation in a Rat Model of Parkinson’s Disease by Wan-Ling Tsai, Hsin-Yung Chen, Ying-Zu Huang, Yuan-Hao Chen, Chi-Wei Kuo, Kai-Yun Chen, Tsung-Hsun Hsieh

“…The pathologic hallmark of PD is nigrostriatal dopaminergic neuron loss, leading to several motor and nonmotor disturbances, such as akinesia, gait disturbance, depression, and anxiety. Recent animal studies have demonstrated that physical exercise improves behavioral and neuropathological deficits in PD. …”
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Advances, challenges and future applications of liver organoids in experimental regenerative medicine by Da Gong, Jiaye Mo, Jiaye Mo, Mei Zhai, Fulin Zhou, Guocai Wang, Shaohua Ma, Xiaoyong Dai, Xiaoyong Dai, Xuesong Deng

“…Substantial theoretical feasibility has been demonstrated at the levels of gene expression, molecular interactions, and intercellular dynamics, complemented by numerous successful animal studies. However, a robust model and carrier that closely resemble human physiology are still lacking for translating these theories into practice. …”
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Dose-Weighted Network Pharmacology: Evaluating Traditional Chinese Medicine Formulations for Lumbar Disc Herniation by Zhou C, Xiang T, Yu Y, Ma H, Liu C, Yang F, Yang L

“…These predictions were confirmed in animal studies, where YJD demonstrated the greatest reduction in thermal hyperalgesia and the most significant decrease in inflammatory markers, surpassing both TSD and PQT. …”
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Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver by Yuki Ito, Toshiki Nakamura, Yukie Yanagiba, Doni Hikmat Ramdhan, Nozomi Yamagishi, Hisao Naito, Michihiro Kamijima, Frank J. Gonzalez, Tamie Nakajima

“…However, species differences in the receptor functions between rodents and human make it difficult to precisely extrapolate their toxicity from animal studies to human. In this paper, we compared the species differences in the activation of mouse and human hepatic PPARα by these plasticizers using wild-type (mPPARα) and humanized PPARα (hPPARα) mice. …”
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The Usefulness of the Pressure Algometer in the Diagnosis and Treatment of Orofacial Pain Patients: A Systematic Review by Agata Kamińska, Bartosz Dalewski, Ewa Sobolewska

“…Exclusion criteria were as follows: articles published earlier than 1997, not written in English, animal studies, studies with the use of medicaments, and articles examining receptor interactions. …”
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Dynamin-1 is a potential mediator in cancer-related cognitive impairment by Ding Quan Ng, Casey Hudson, Tracy Nguyen, Sukesh Kumar Gupta, Yong Qin Koh, Munjal M. Acharya, Alexandre Chan

“…Consistently observed in both human and animal studies, the downregulation of DNM1 is linked with the onset of CRCI. …”
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Associations among circulating sphingolipids, β-cell function, and risk of developing type 2 diabetes: A population-based cohort study in China. by Huan Yun, Liang Sun, Qingqing Wu, Geng Zong, Qibin Qi, Huaixing Li, He Zheng, Rong Zeng, Liming Liang, Xu Lin

“…<h4>Background</h4>Animal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis of type 2 diabetes (T2D) via pathways involved in insulin resistance, β-cell dysfunction, and inflammation, but human studies are limited. …”
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Free Fatty Acids in CSF and Neurological Clinical Scores: Prognostic Value for Stroke Severity in ICU by Sayed Gaber, Sherine Ibrahim ElGazzar, Mahmoud Qenawi, Nora Ismail Mohamed Abbas

“…Brain ischemia initiated significant increase in FFAs in animal studies. Accumulation of FFA can lead to liberation of inflammatory byproducts that contribute to neuronal death. …”
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Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review by Boxuan Li, Shizhe Deng, Bomo Sang, Weiming Zhu, Bifang Zhuo, Menglong Zhang, Chenyang Qin, Yuanhao Lyu, Yuzheng Du, Zhihong Meng

“…After removing the literature studies, animal studies, and case reports, 16 studies were included in the final analysis. …”
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How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis by Eline M. L. van der Does de Willebois, MD, Vittoria Bellato, MD, Marjolijn Duijvestein, MD, PhD, Susan van Dieren, MD, PhD, Silvio Danese, MD, PhD, Pierpaolo Sileri, MD, PhD, Christianne J. Buskens, MD, PhD, Andrea Vignali, MD, PhD, Willem A. Bemelman, MD, PhD

“…Randomized controlled trials and cohort studies describing ER < 12 months after an ICR for CD were included. Animal studies, reviews, case reports (<30 included patients), pediatric studies, and letters were excluded. …”
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Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells by Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland

“…In conclusion, small animal studies have demonstrated the feasibility of high-throughput approaches for the discovery of pMHC epitopes recognised by directly alloreactive T cells. …”
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