Effects of Sildenafil and Vitamin E on Paraquat-Induced Pulmonary Fibrosis in Rats by Fouziyeh Siahpour, Hosein Sadeghi, Esmaeel Panahi kokhdan, Mohammad Khoshnoud

“…Male Wistar rats were used in animal studies. Paraquat was administered orally (R1-1) at a single dose of 40 mg/kg to induce lung fibrosis. …”
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Contribution of Experimental Animal Research Studies to the Emergency Medicine Literature by Umut Ocak, John H. Zhang

“…In conclusion, experimental animal studies are essential in the progress of contemporary scientific knowledge. …”
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Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI by Jinhuan Zhang, Chunjian Lu, Xiaoxiong Wu, Dehui Nie, Haibo Yu

“…After searching PubMed, Web of Science, and Embase databases, 24 human and five animal studies were identified. This review focuses on the evidence on the possible mechanisms underlying mechanisms of acupuncture therapy in treating stroke by regulating brain plasticity. …”
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Neuroprotection as a Therapeutic Target for Diabetic Retinopathy by Cristina Hernández, Massimo Dal Monte, Rafael Simó, Giovanni Casini

“…Many substances have been tested in animal studies for their neuroprotective properties and for possible use in humans. …”
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Protective effect of exercise on animals with sepsis: a systematic review of the existing literature by Na Yang, Nan Jiang, Chunming Shen, Ming Gao, Qian Tong, Jian Sun

“…The quality of each study was assessed using the Center for Systematic Evaluation of Experimental Animal Studies (SYCLE) Animal Research Bias Risk Tool. …”
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Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography by Michael Ghijsen, Yuting Lin, Mitchell Hsing, Orhan Nalcioglu, Gultekin Gulsen

“…In this study, we investigated and compared different reconstruction methods and analysis approaches for regular endogenous DOT and DCE-DOT with and without MR anatomical a priori information for arbitrarily-shaped objects. Our phantom and animal studies have shown that superior image quality and higher accuracy can be achieved using DCE-DOT together with MR structural a priori information. …”
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The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan by Ning-Chia Chang, Hua-Ling Yang, Chia-Yen Dai, Wen-Yi Lin, Meng-Hsuen Hsieh, Chen-Yu Chien, Kuen-Yao Ho

“…Heat shock proteins (HSPs) were found to be associated with ARHI in animal studies. The aim of this study was to analyze the associations of single nucleotide polymorphisms (SNPs) of HSP genes with ARHI in an elderly population in Taiwan. …”
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Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss by Lijuan Shi, Ying Chang, Xiaowei Li, Steve Aiken, Lijie Liu, Jian Wang

“…Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.…”
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Best practices for the experimental design of one health studies on companion animal and owner microbiomes – From data collection to analysis by Suzanne B. Clougher, Dagmara Niedziela, Piera Versura, Grace Mulcahy

“…Finally, we propose a framework with key considerations to bear in mind when designing and carrying out owner-companion animal studies, as well as best practices to implement them.Although these studies come with additional difficulties compared to species-specific microbiome studies, they offer the opportunity to identify biomarkers, environmental triggers, and impacts of pet-owner interactions across species.…”
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Unveiling the Emerging Role of Xanthine Oxidase in Acute Pancreatitis: Beyond Reactive Oxygen Species by Chenxia Han, Yaling Wu, Juan Rong, Qing Xia, Dan Du

“…However, the optimal timing and doses for therapeutic interventions targeting XO in animal studies and the clinic, as well as the additional molecular mechanisms through which XO contributes to disease onset and progression, including metabolic regulation, remain to be elucidated. …”
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Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols by Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li

“…By analyzing recent publications, we have covered across chemistry models, cell lines and animal studies. Tea polyphenols, particularly catechins, showed outstanding antiglycation effect by trapping α-dicarbonyl compounds and impeding AGEs formation. …”
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A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer by Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He

“…AS1411-HSA-LDP-AE exhibited a strong cell-killing activity in esophageal cancer cells, inhibited cell migration and invasion, and induced cell apoptosis. The animal studies confirmed that AS1411-HSA-LDP-AE exhibited a strong anti-tumor effect. …”
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Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway. by Yushuang Xing, Di Jia, Xinping Zhu, Jialu Yang, Zhipeng Gao, Nana Meng, Haohao Xu, Mengxiao Wang, Shijun Chang, Mingqian Zhao, Shanbo Zhang, Zichen Mu, Qiang Tang, Weiming Zhao

“…In addition, inotodiol showed to induce apoptosis, characterized by an increase in Bax expression, a decrease in Bcl-2, Bcl-XL and MCL1 expression, the initiation of cleaved PARP1 and cleaved caspase 3, and inhibition of the MAPK/ERK pathway. Animal studies demonstrated that inotodiol possessed the ability to suppress tumor growth in nude mice models, at the same time, there was no significant impact on the body weight and organs of the mice. …”
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Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews. by Annhild Mosdøl, Gunn Elisabeth Vist, Camilla Svendsen, Hubert Dirven, Inger Therese Laugsand Lillegaard, Gro Haarklou Mathisen, Trine Husøy

“…Systematic reviews of animal studies are lacking in this topic area. The systematic evidence only partly explore forwarded hypotheses found in the literature. …”
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Dexmedetomidine Infusion Associated with Transient Adrenal Insufficiency in a Pediatric Patient: A Case Report by Elizabeth W. Tucker, David W. Cooke, Sapna R. Kudchadkar, Sybil Ann Klaus

“…This concern was initially supported by animal studies, but subsequent human studies demonstrated mixed results. …”
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Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach by Mahsa Rezazadegan, Bita Forootani, Yeganeh Hoveyda, Niloufar Rezazadegan, Reza Amani

“…The findings of some previous studies are heterogeneous due to the inclusion of various types of study (human, and animal studies) and wide exposures (phthalate, bisphenol A, HMS, etc.), and no comprehensive systematic review has investigated the association between HMs exposure and human gut microbiota composition. …”
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Managing Chronic Neuropathic Pain: Recent Advances and New Challenges by Namrata Hange, Sujan Poudel, Saleha Ozair, Trissa Paul, Meghna Nambakkam, Rakchhya Shrestha, Farrah Greye, Sangam Shah, Yagya Raj Adhikari, Sangharsha Thapa, Pooja Patel

“…Articles from non-English literature, reports without human subjects, animal studies, and abstracts/posters were excluded. However, human studies and studies published in English were included. …”
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Bidirectional relationship between sleep and depression by Shinnosuke Yasugaki, Hibiki Okamura, Ami Kaneko, Yu Hayashi

“…How antidepressants affect sleep in patients with depression might provide clues to understanding the effects of sleep, but caution is required considering that antidepressants have diverse effects other than sleep. Recent animal studies support the bidirectional relation between depression and sleep, and animal models of depression are expected to be beneficial for the identification of neuronal circuits that connect stress, sleep, and depression. …”
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Nanomodified Peek Dental Implants: Bioactive Composites and Surface Modification—A Review by Shariq Najeeb, Zohaib Khurshid, Jukka Pekka Matinlinna, Fahad Siddiqui, Mohammad Zakaria Nassani, Kusai Baroudi

“…Melt-blending with bioactive nanoparticles can be used to produce bioactive nanocomposites, while spin-coating, gas plasma etching, electron beam, and plasma-ion immersion implantation can be used to modify the surface of PEEK implants in order to make them more bioactive. However, more animal studies are needed before these implants can be deemed suitable to be used as dental implants.…”
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Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity by Akadiri Yessoufou, Magloire P. Nekoua, Adam Gbankoto, Yohana Mashalla, Kabirou Moutairou

“…While controversies still exist about omega-3 PUFA effects on antioxidant status regarding the level of omega-3 PUFA in diet supplementation, their lipid-lowering effects are unanimously recognized by researchers. Animal studies have shown that omega-3 PUFA contributes to the maintenance of the immune defense system by promoting the differentiation of T helper (Th) cell to a Th2 phenotype in diabetic pregnancy and by shifting the Th1/Th2 ratio from a deleterious proinflammatory Th1 phenotype to a protective anti-inflammatory Th2 phenotype in macrosomia and in adulthood obesity that results from macrosomia at birth. …”
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