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81
Rodent Models for Investigating the Dysregulation of Immune Responses in Type 1 Diabetes
Published 2013-01-01“…Previous reports based on epidemiological and animal studies have demonstrated that both genetic factors and environmental parameters can either promote or attenuate the progression of autoimmunity. …”
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82
Leptospirosis in Vellore: A Clinical and Serological Study
Published 2014-01-01“…Blood samples were collected from 129 patients. Animal studies were conducted from 24 rodents captured form the market place of the Vellore municipality. …”
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83
Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease
Published 2015-01-01“…Subsequently, the effect of xanthophylls in the prevention and treatment of various eye diseases has been examined through epidemiological studies, animal studies, and clinical trials. This paper attempts to review the epidemiological studies and clinical trials investigating the effects of xanthophylls on the incidence and progression of various eye diseases. …”
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84
Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction
Published 2012-01-01“…Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. …”
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85
Effect of Ginseng Supplementation on Exercise Endurance as a Support for Cardiovascular Disease Management: A Systematic Review and Meta-Analysis
Published 2024-12-01“…The results suggest that ginseng supplementation may have a positive effect on CK levels in animal studies. Similar observations were stated in relation to serum lactate and BUN. …”
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86
Early Polytherapy for Probably Benzodiazepine Refractory Naïve Status Epilepticus (Stage 1 Plus)
Published 2025-01-01“…The objective of this review is to provide pathophysiological and pre-clinical evidence, mostly from animal studies, for the different approach of combined polytherapy from the start for those cases of SE falling in the definition of Stage 1 Plus.…”
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87
Liberal Preoperative Fasting in Adults Undergoing Elective Surgery: A Scoping Review Protocol
Published 2024-01-01“…This scoping review only examines literature in the database, without reference to human or animal studies, and therefore does not require ethical approval. …”
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88
Green Dentistry: State of the Art and Possible Development Proposals
Published 2025-01-01“…Non-full-text papers, animal studies, studies in languages other than English, and studies not related to the topic under consideration were excluded. …”
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89
The Anti-Inflammatory Role of Vitamin E in Prevention of Osteoporosis
Published 2012-01-01“…Anticytokine therapy using cytokine antagonists such as IL-receptor antagonist and TNF-binding protein was able to suppress the activity of the respective cytokines and prevent bone loss. Several animal studies have shown that vitamin E in the forms of palm-derived tocotrienol and α-tocopherol may prevent osteoporosis in rat models by suppressing IL-1 and IL-6. …”
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90
The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus
Published 2017-01-01“…There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. …”
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91
Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy
Published 2010-01-01“…Reported research in animal studies indicated that vaccine immunity could be a promising alternative therapy for cancer patients. …”
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92
Animal-based evidence supports protective activity of bioengineered silver and gold nanomaterials on hepatic and renal function profile parameters
Published 2025-01-01“…This review highlights the emerging role of eco-friendly, bioengineered silver (AgNPs) and gold nanoparticles (AuNPs) as protective agents for liver and kidney health, based on evidence from animal studies. The discussion emphasizes green synthesis approaches, which offer sustainable and biocompatible routes for nanoparticle production. …”
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93
Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy
Published 2016-01-01“…This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. …”
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94
Inflammatory Bowel Disease: Progress Towards a Gene
Published 2000-01-01“…Replicated class II HLA associations include HLA DRB1*0103 and DR2 (DRB1*1502), involved in UC susceptibility, and HLA DRB1*03 and DR4 as resistance alleles for CD and UC respectively. Animal studies have provided insights from targeted mutations and quantitative trait locus analysis. …”
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95
Targeting gut microbiota in osteoporosis: impact of the microbial-based functional food ingredients
Published 2024-01-01“…Moreover, additional animal studies and clinical trials are needed to understand the interactions between gut microbiota and bone metabolism before further applications.…”
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96
Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work?
Published 2018-01-01“…While many promising chemical agents have been trialed for the prevention of IRI in small animal studies, all have failed in human trials. The aim of this review is to highlight the techniques and drugs that target HIF-1α and ameliorate IRI associated with renal ischemia. …”
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97
Exercise-Induced Neuroplasticity in Parkinson’s Disease: A Metasynthesis of the Literature
Published 2020-01-01“…During the last decade, there has been an increased interest in investigating physical exercise as a neuroprotective mechanism in PD. Animal studies have suggested that exercise may in fact induce neuroplastic changes, but evidence in humans is still scarce. …”
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98
Ethnomedicinal, Pharmacological, and Phytochemical Overview of Diplazium esculentum
Published 2025-01-01“…Evaluation of the safety profile through animal studies and clinical trials underscores its potential as a safe therapeutic agent albeit with considerations for dosage and administration. …”
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99
Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome Associated with Deletion of Chromosome 20q
Published 2018-01-01“…Elliptocytosis in the setting of MDS has rarely been reported, and association with 20q deletion is even rarer. Animal studies have shown that haploinsufficiency of L3MBTL1 contributes to some (20q−) myeloproliferative neoplasms and myelodysplastic syndromes by affecting erythroid differentiation. …”
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100
Fetal Safety in MRI During Pregnancy: A Comprehensive Review
Published 2025-01-01“…Regarding gadolinium-based contrast agents, the evidence is conflicting: while some studies suggest risks such as stillbirth and rheumatological conditions, animal studies show minimal fetal retention and no significant toxicity, and later clinical research has not substantiated these risks. …”
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