Circ_0001084/miR-181c-5p/PTPN4 Axis Mitigates Cardiomyocyte Injury by Modulating the TLR4/NF-κB Pathway: Insights into Therapeutic Potential for Myocardial Reperfusion Injury by Deng H, Fan Q, Huang L, Ouyang W, Zhu W

“…Haihong Deng,1,* Qisen Fan,2,* Lichao Huang,1 Wenbo Ouyang,1 Wendian Zhu3 1Department of Anesthesiology, The First People’s Hospital of Zhaoqing, Zhaoqing City, Guangdong Province, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou City, Guangdong Province, People’s Republic of China; 3Department of Hepatobiliary Surgery, The First People’s Hospital of Zhaoqing, Zhaoqing City, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wendian Zhu, Department of Hepatobiliary Surgery, The First People’s Hospital of Zhaoqing, NO. 9 Donggang East Road, Duanzhou District, Zhaoqing City, Guangdong Province, People’s Republic of China, Email Zq2860676@163.comBackground: Myocardial ischemia/reperfusion (I/R) injury significantly impacts the recovery of ischemic heart disease patients. …”
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The Two Sides of Placebo Analgesia: Differential Functional Connectivity Reveals Mechanisms of Placebo Analgesic Response by Bush NJ, Cushnie AK, Boissoneault J, Aghabeigi S, Alexander C, Staud R, Robinson ME

“…Nicholas J Bush,1,2 Adriana K Cushnie,2 Jeff Boissoneault,1,2 Sharmagh Aghabeigi,1 Casey Alexander,1 Roland Staud,3 Michael E Robinson1 1Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; 2Department of Anesthesiology, University of Minnesota - Twin Cities, Minneapolis, MN, USA; 3Department of Medicine, University of Florida, Gainesville, FL, USACorrespondence: Nicholas J Bush, Department of Anesthesiology, University of Minnesota, Minneapolis, MN, 55414, USA, Tel +1 612-624-7357, Email bush0456@umn.eduBackground: Previous research has demonstrated that placebo induction manipulations can reduce an individual’s pain through non-specific mechanisms, such as expectancy manipulations. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

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Can Underlying Co-Morbidities Affect Cerebral Oximetry in Cardiac Surgery Patients? by Kianoush Saberi, Shahnaz Sharifi, Amirhossein Orandi

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Integration of machine learning and experimental validation to identify the prognostic signature related to diverse programmed cell deaths in breast cancer by Longpeng Li, Longpeng Li, Jinfeng Zhao, Yaxin Wang, Zhibin Zhang, Wanquan Chen, Jirui Wang, Yue Cai

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Burden of hospitalizations in newly diagnosed heart failure patients in Poland: real world population based study in years 2013–2019 by Przemysław Leszek, Daniel Waś, Kinga Bartolik, Kladiusz Witczak, Andrzej Kleinork, Bohdan Maruszewski, Katarzyna Brukało, Paulina Rolska‐Wójcik, Małgorzata Celińska‐Spodar, Tomasz Hryniewiecki, Marta Załęska‐Kocięcka

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Cholesterol metabolism regulator SREBP2 inhibits HBV replication via suppression of HBx nuclear translocation by Fan Yang, Fan Yang, Feng Hu, Hongxiao Song, Tie Li, Fengchao Xu, Jing Xu, Le Wang, Fei Wang, Yujia Zhu, Mian Huang, Yanli Gao, Min Rao, Haichun Ma, Guangyun Tan

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Two Transcutaneous Stimulation Techniques in Shoulder Pain: Transcutaneous Pulsed Radiofrequency (TPRF) versus Transcutaneous Electrical Nerve Stimulation (TENS): A Comparative Pil... by Mu-Lien Lin, Hung-Wei Chiu, Zao-Ming Shih, Po-Ying Lee, Pei-Zhi Li, Chin-Hong Guo, Yuan-Jie Luo, Shen-Chieh Lin, Kwan-Yu Lin, Yu-Ming Hsu, Angela Pang, Weiwu Pang

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Patient-Controlled Analgesia (PCA): Intravenous Administration (IV-PCA) versus Oral Administration (Oral-PCA) by Using a Novel Device (PCoA® Acute) for Hospitalized Patients with A... by Stefan Wirz, Stefanie Seidensticker, Ronit Shtrichman

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The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission by Bahia Belatar, Abdallah Elabidi, Malika Barkiyou, Mamoun El Faroudi, Rachid Eljaoudi, Laila Lahlou, Saad Kabbaj, Wajdi Maazouzi

“…A case-control study was conducted with 64 comatose patients with severe TBI, in the Department of Anesthesiology and Reanimation, Ibn Sina University Hospital and Hospital of Specialties in Rabat, Morocco; 22 healthy volunteers were recruited in Blood Transfusion Center of Rabat. …”
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Consumer Products Nerve Injuries Among Patients Products Presenting to United States Emergency Departments Between 2012 and 2021: A Nationwide Cohort by Ganga A, Mukhdomi T, Kim EJ, Ly E, Patel Y, Dankievitch KN, Kendall MC

“…Arjun Ganga,1 Taif Mukhdomi,2 Eric J Kim,1 Eric Ly,3 Yash Patel,3 Korinne N Dankievitch,3 Mark C Kendall3 1Warren Alpert School of Medicine, Brown University, Providence, RI, 02903, USA; 2Department of Pain, Pain Zero, New Albany, OH, 43054, USA; 3Department of Anesthesiology, Warren Alpert School of Medicine, Brown University, Providence, RI, 02903, USACorrespondence: Mark C Kendall, Department of Anesthesiology, Warren Alpert School of Medicine, Brown University, 593 Eddy Street, Davol #129, Providence, Rhode Island, 02903, USA, Tel +414-444-5172, Email mark.kendall@lifespan.orgIntroduction: Nerve injuries and resultant pain are common causes of emergency department (ED) visits in the United States. …”
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A pre- and post-course survey of an elective Chinese medicine curriculum among junior Western medical students in Taiwan by Sunny Jui-Shan Lin, Shung-Tai Ho, Yi-Chang Su, Chien-Sung Tsai, Shu-Meng Cheng, Cheng-Yi Cheng, Tso-Chou Lin, Chien-Jung Lin

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Surgical Treatment of Primary Intracardiac Myxoma: 20-Year Experience in “Shahid Modarres Hospital”—A Tertiary University Hospital—Tehran, Iran by Zahra Ansari Aval, Hamid Ghaderi, Hassan Tatari, Mahnoosh Foroughi, Seyedeh Adeleh Mirjafari, Mohammad Forozeshfard, Kamal Fani, Isa Khaheshi

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Problem of pain in the USA: evaluating the generalisability of high-impact chronic pain models over time using National Health Interview Survey (NHIS) data by Sean Mackey, Titilola Falasinnu, Md Belal Hossain, Mohammad Ehsanul Karim, Kenneth Arnold Weber

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Comparative Efficacy of Esketamine vs Sufentanil with Propofol for Sedation in EUS: A Randomized, Controlled Study by Liu C, Wang Y, Yin Y, Wang P, Ji X, Sun J, Zhao S, Jia Y, Liu S, Zhou Z

“…Cuicui Liu,1,* Yanting Wang,1,* Yanwei Yin,2 Pei Wang,1 Xiangyu Ji,1 Jian Sun,1 Shuo Zhao,1 Yanfang Jia,1 Shanling Liu,1 Zangong Zhou1 1Daytime Anesthesiology Department, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People’s Republic of China; 2Pain Department, the Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zangong Zhou, Daytime Anesthesiology Department, the Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Shinan District, Qingdao, Shandong Province, 266000, People’s Republic of China, Tel +86 532-82912511, Email zhouzangong@qdu.edu.cnPurpose: This randomized, controlled trial aimed to assess the sedative effects of esketamine and sufentanil combined with propofol during EUS.Patients and Methods: Three hundred and forty patients undergone EUS were randomly divided into two groups to receive esketamine 0.25 mg/kg combined with propofol (esketamine group) or sufentanil 0.1 μg/kg combined with propofol (sufentanil group). …”
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ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke by Huang R, Huang X, Yang H, Wu H, Liu F, Saw PE, Cao M

“…Rong Huang,1 Xiaoyan Huang,1 Hongmei Yang,1 Haixuan Wu,1 Fan Liu,1 Phei Er Saw,2,3 Minghui Cao1,4 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Anesthesiology, Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Shanwei, 516600, People’s Republic of ChinaCorrespondence: Phei Er Saw; Minghui Cao, Email caipeie@mail.sysu.edu.cn; caomh@mail.sysu.edu.cnIntroduction: ATF3, a stress-induced transcription factor, has been implicated in the injury processes of various cell types, including neurons. …”
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Prevalence, causes and outcomes of hospital admissions in Mongolia: a national registry-based descriptive analysisResearch in context by Altanchimeg Sainbayar, Ganbold Lundeg, Naranpurev Mendsaikhan, Jens Meier, Martin W. Dünser

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Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation by Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S, Shen W, Zhu Y

“…Qiao Wang,1,* Xin Luo,1,* Yuwen Su,1 Yi Jin,1 Qiqi Kuang,1 Siying Li,1 Weiyun Shen,2 Yanshan Zhu1 1Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Anesthesiology, Second Xiangya Hospital, Anesthesiology Research Institute of Central South University, Changsha, Hunan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Luo; Yanshan Zhu, Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Clinical Medical Research Center of Major Skin Diseases and Skin Health of Hunan Province, Central South University, 139 Renmin Middle Road, Changsha, Hunan, People’s Republic of China, Email 248201037@csu.edu.cn; 218202091@csu.edu.cnBackground: Psoriasis is an immune-related inflammatory systemic condition characterized by dysregulated keratinocyte proliferation and chronic inflammation. …”
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Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus by Han-Fang Wu, Yi-Ju Chen, Su-Zhen Wu, Chi-Wei Lee, I-Tuan Chen, Yi-Chao Lee, Chi-Chen Huang, Chung-Hsi Hsing, Chih-Wei Tang, Hui-Ching Lin

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The Use of Electronic Consent (eConsent) Within the Ketamine for Long-Lasting Pain Relief After Surgery (KALPAS) Multicenter Trial by Doan LV, Burr J, Perez R, Martinez H, Cuevas R, Watt K, Wang J

“…Lisa V Doan,1,2 Jeri Burr,3 Raven Perez,1,2 Hamleini Martinez,1,2 Randy Cuevas,1,2 Kevin Watt,3 Jing Wang1,2,4 1Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University Grossman School of Medicine, New York, NY, USA; 2Interdisciplinary Pain Research Program, New York University Grossman School of Medicine, New York, NY, USA; 3Department of Pediatrics, University of Utah, Salt Lake City, UT, USA; 4Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, USACorrespondence: Lisa V Doan; Jing Wang, Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University Grossman School of Medicine, New York, NY, USA, Email Lisa.doan@nyulangone.org; jing.wang2@nyulangone.orgBackground: The informed consent process has traditionally taken place in person. …”
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