Binding of HCN channels to GABAB receptors in dopamine neurons of the VTA limits synaptic inhibition and prevents the development of anxiety by Enrique Pérez-Garci, Kateryna Pysanenko, Giorgio Rizzi, Florian Studer, Daniel Ulrich, Thorsten Fritzius, Simon Früh, Alessandra Porcu, Valérie Besseyrias, Adolf Melichar, Martin Gassmann, Tania Rinaldi Barkat, Rostislav Tureček, Kelly R. Tan, Bernhard Bettler

“…We now show that KCTD16, an auxiliary GBR subunit, anchors hyperpolarization-activated cyclic nucleotide-gated (HCN) channels containing HCN2/HCN3 subunits to GBRs. …”
Get full text

G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis by Morgan G. Stykel, Shehani V. Siripala, Eric Soubeyrand, Carla L. Coackley, Ping Lu, Suelen Camargo, Sharanya Thevasenan, Gerardo Balderas Figueroa, Raphaella W.L. So, Erica Stuart, Rachi Panchal, Elissavet-Kalliopi Akrioti, Jeffery T. Joseph, Omid Haji-Ghassemi, Era Taoufik, Tariq A. Akhtar, Joel C. Watts, Scott D. Ryan

“…This leads to decreased nicotinamide adenine dinucleotide phosphate (NADP/H) and glutathione (GSH) levels, resulting in DA oxidation and decreased total DA levels. We find that α-syn anchors the PPP enzyme G6PD to synaptic vesicles via the α-syn C terminus and that this interaction is lost in PD. …”
Get full text

Cytoskeletal Interactions at the Nuclear Envelope Mediated by Nesprins by Surayya Taranum, Ilknur Sur, Rolf Müller, Wenshu Lu, R. N. Rashmi, Martina Munck, Sascha Neumann, Iakowos Karakesisoglou, Angelika A. Noegel

“…Nesprin-1 is a giant tail-anchored nuclear envelope protein composed of an N-terminal F-actin binding domain, a long linker region formed by multiple spectrin repeats and a C-terminal transmembrane domain. …”
Get full text

Construction of cross-linked PEO grafting copolymer for high-performance gel electrolyte by Shuangshuang Wang, Huizi Zhang, Jilu Ma, Dejia Liu, Tonghui Zhang, Yuchao Li, Guang Li

“…Firstly, PGMA with controlled chain length can be highly efficient covalent anchored on PEO main chain with the assistance of N-hydroxyphthalimide (NHPI) catalysis combined with activators regenerated by electron transfer ATRP (ARGET-ATRP). …”
Get full text

Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer by Yanbo Pan, Olena Berkovska, Soumitra Marathe, Georgios Mermelekas, Greta Gudoityte, Amare D. Wolide, Taner Arslan, Brinton Seashore-Ludlow, Janne Lehtiö, Lukas M. Orre

“…Summary: Farnesylation is a lipid post-translational modification of proteins crucial for protein membrane anchoring and cellular signaling. Farnesyltransferase inhibitors (FTIs), such as tipifarnib, are being tested in cancer therapy. …”
Get full text

Chromosome-level genome assembly of a destructive leaf-mining moth Eriocrania semipurpurella alpina by Gui-fang Wang, Jin-wu He, Cheng Sun, Xue-yan Li, Pei-feng Qi, Dan-dan Feng, Cai-qing Yang, Ai-bing Zhang

“…The genome was 523.71 Mb in length, with a scaffold N50 of 17.55 Mb, and 95.56% of the assembly anchored onto 32 pseudochromosomes. BUSCO completeness values of 97.6%. 49.02% of the genome sequences were recognized as repetitive sequences, and a total of 22,581 protein-coding genes were annotated. …”
Get full text

Left Ventricle Outflow Obstruction by Reverse-Oriented Tricuspid Semilunar Valve-Like Endocardial Duplicatures by Kristína Mikuš-Kuracinová, Pavel Babál, Eliška Kubíková

“…These structures were hanging on the regular muscular ventricular wall, without any visible fibrous anchoring structure and without formation of commissures, and were composed of fine collagen and elastic fibers. …”
Get full text

A combined method for the evaluation of contributing factors to maritime dangerous goods transport accidents by Özge Eski, Leyla Tavacioglu

“…Specifically, maritime DG transport accidents are most likely to be caused by collisions during sailing, passage, maneuvering, and bunkering operations, as well as occupational accidents during cargo loading, anchoring, berthing, and mooring operations. The results of this paper can support stakeholders in developing the needed policies to guarantee the safety of maritime DG transport.…”
Get full text

PREVALENCE AND CONSEQUENCES OF KIDNAPPING IN SOUTHERN TARABA STATE, NIGERIA by YIKWABS PETER YIKWAB, WAJIM JOHN, ALEGBEJO NOAH KOLAWOLE, AROKOYO JACOB

“…This paper therefore, examines kidnapping from its prevalence and consequences on the citizenry in Southern Taraba State Nigeria. The study was anchored on routine activity theory. Exploratory research design was adopted using qualitative method (key Informant Interview and In-depth Interview) for the collection of data. …”
Get full text

Analyse de l’effet L1 dans l’émergence de l’auxiliation en français L2 by Cyrille Granget

“…The discourse hypothesis stipulates that information structure and temporal anchoring of the discourse trigger the use of auxiliary verbs to maintain reference to number and adopt the L1 conceptualization of events. …”
Get full text

Marqueurs territoriaux ou marqueurs patrimoniaux : l’appropriation de l’espace marin coutumier au sahel tunisien face aux disruptions des récentes logiques environnementales de l’É... by Racha Sallemi

“…Building on the experience of the first MPA project in Tunisian sahel in the Kuriat islands (east-central coast), this article analyses the levels of acceptability of the MPA by gauging the level of anchoring of fishermen in the marine space, notably through their TEK. …”
Get full text

IMPLICATIONS OF XENOPHOBIA ON AFRICAN UNITY by AGIDI EJIME PALLY, PHD

“…The paper is a qualitative one that relied on secondary source of information and anchored on system theory as its theoretical framework of analysis. …”
Get full text

EFFECT OF SOCIAL MEDIA IN PROMOTING INSECURITY AND PROPAGANDA IN NIGERIA by ABDULWAHAB ABDULKABIR, NURUDEEN SOLA IBRAHIM

“…The study utilizes secondary data sourced through books, academic journals, online sources among other documents. The study is anchored on the theory of uses and gratifications theory which emphasized how people use media to fulfill their various needs. …”
Get full text

EXCHANGE RATE MISALIGNMENT AND PERFORMANCE OF THE NIGERIAN ECONOMY by Okoi Innocent Obeten, Maryjoan Ugboaku Iheanacho, Comfort Innocent Okoi

“…The aims were to assess the effect of exchange rate fluctuations on gross domestic product and how inflation, real money supply and trade openness affect gross domestic product in Nigeria. The study anchored on Purchasing Power Parity theory (PPP).  …”
Get full text

How breakthroughs happen: Unearthing the boundary conditions of eco-friendly deliberate practice and eco-innovation performance. by Yin-Shi Jin, Asia Sohail, Shahid Iqbal, Tehreem Fatima, Arslan Ayub

“…Surprisingly innovation process based on deliberate practice has rarely been unearthed that might explore the boundary conditions of the eco-friendly deliberate practice and eco-innovation performance relationship. Anchored on the organizational support theory and the social cognitive, the current study seeks to investigate the impacts of perceived organizational support (POS) and developmental leadership (DL) on eco-innovation performance (EP) through the mediating role of eco-friendly deliberate practice (EDP). …”
Get full text

Increased Matrix Metalloproteinase-2 and Matrix Metalloproteinase-3 Concentrations in Corneal Epithelium of Patients with Recurrent Corneal Erosions by Katarzyna Jadczyk-Sorek, Wojciech Garczorz, Beata Bubała-Stachowicz, Tomasz Francuz, Ewa Mrukwa-Kominek

“…The results obtained in the study can prove that matrix metalloproteinase-2 and matrix metalloproteinase-3 having the ability to dissolve anchoring fibers and the corneal epithelial basement membrane could be responsible for epithelial instability and their accumulation in the corneal epithelium may induce recurrence of erosion.…”
Get full text

(Re-)Positioning and recognising the influence of internal communication on employee engagement for maximum organisational performance by Tsietsi Mmutle

“…The study explores the strategic importance of internal communication in accordance with a management philosophy anchored on collaborative, open and transparent communication. …”
Get full text

EFFECT OF VENTURE CAPITAL FINANCING ON THE FINANCIAL PERFORMANCE OF SMEs IN CROSS RIVER STATE by EGU USANG INAH, OLOFU MATHIAS AJOR, MANNAH ELIZABETH JACOB, UWALAKA BENEDICTA CHISOBEM, IBAYE THERESA MBONG

“…Specifically, the study sought to determine the effect of venture capital financing on the Net sales, net profit and Return On Assets of SMEs in cross river state. The study anchored significantly on pecking order theory. Descriptive survey research design was used for the study. …”
Get full text

Household Waste Management Strategy in Upper Middle Housing by Susan Rendra Utama, Mei Ahyanti

“…Instruments developed by the researcher were employed for data collection. Analysis was anchored on a univariate approach and the SWOT (Strengths, Weaknesses, Opportunities, Threats) method. …”
Get full text

African Indigenous Research to Decolonisation of African Universities’ Curricula by Mogomme Masoga

“…The present research is anchored on a critical race theory (CRT) in which narrative inquiry as a methodological approach is utilised. …”
Get full text