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  1. 70561

    Effects of Climatic Conditions and Agronomic Practices on Health, Tuber Yield, and Mineral Composition of Two Contrasting Potato Varieties Developed for High and Low Input Producti... by Gultekin Hasanaliyeva, Ourania Giannakopoulou, Juan Wang, Marcin Barański, Enas Khalid Sufar, Daryl Knutt, Jenny Gilroy, Peter Shotton, Halima Leifert, Dominika Średnicka-Tober, Ismail Cakmak, Levent Ozturk, Bingqiang Zhao, Per Ole Iversen, Nikolaos Volakakis, Paul Bilsborrow, Carlo Leifert, Leonidas Rempelos

    Published 2024-12-01
    “…Results from both ANOVA and redundancy analysis (RDA) indicate that the effects of climatic (precipitation, radiation, and temperature) and agronomic (fertilization and crop protection) explanatory variables on crop health and yield differed considerably between the two varieties. …”
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  2. 70562

    Repairbads: An automatic and adaptive method to repair bad channels and segments for OPM-MEG by Fulong Wang, Yujie Ma, Tianyu Gao, Yue Tao, Ruonan Wang, Ruochen Zhao, Fuzhi Cao, Yang Gao, Xiaolin Ning

    Published 2025-02-01
    “…However, the position instability or jitter of OPM sensors can result in bad channels and segments, which significantly impede subsequent preprocessing and analysis. Most common methods directly reject or interpolate to repair these bad channels and segments. …”
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  3. 70563

    Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital by Jin Won Kim, Hee Young Na, Sejoon Lee, Ji-Won Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jaihwan Kim, Jin-Hyeok Hwang, Kihwan Hwang, Chae-Yong Kim, Yong Beom Kim, Soomin Ahn, Kyu Sang Lee, Hyojin Kim, Hye Seung Lee, So Yeon Park, Gheeyoung Choe, Jee Hyun Kim, Jin-Haeng Chung

    Published 2025-01-01
    “…A total of 990 patients were included in the analysis (median age: 62, Stage IV: 82.5%). Using the Association for Molecular Pathology genetic variant classification system, we found that 257 (26.0%) patients harbored tier I variants, and 859 (86.8%) patients carried tier II variants. …”
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  4. 70564

    Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13]) by A. DeMichele, A. C. Dueck, D. Hlauschek, M. Martin, H. Burstein, G. Pfeiler, N. Zdenkowski, A. Wolff, M. Bellet-Ezquerra, E. Winer, M. Balic, K. Miller, M. Colleoni, D. Lake, G. Rubovsky, D. Cameron, J. Balko, C. F. Singer, Z. Nowecki, H. Iwata, N. Wolmark, K. A. Parraga, H. Rugo, G. G. Steger, T. Traina, G. Werutsky, D. Czajkowska, O. Metzger, S. El-Abed, K. P. Theall, R. D. Lu, P. O’Brien, C. Fesl, E. Mayer, M. Gnant

    Published 2025-01-01
    “…Abstract Background The PALLAS trial investigated the addition of palbociclib to standard adjuvant endocrine therapy to reduce breast cancer recurrence. This pre-specified analysis was conducted to determine whether adjuvant palbociclib benefited patients diagnosed with lower risk stage IIA disease compared to those with higher stage disease. …”
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  5. 70565

    AKRASIJA IR SUBJEKTAS EGONOMIKOJE by Zenonas Norkus

    Published 2000-01-01
    “…Under certain conditions homuncular functionalist mode of analysis can have explanatory power and play heuristically indispensable role as way-station to the scientific explanation of behaviour, accomplished in the vocabularies of the construction stance and of the physical stance. …”
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  6. 70566

    Occurrence of micropollutants in surface water and removal by catalytic wet peroxide oxidation enhanced filtration using polymeric membranes loaded with carbon nanotubes by Adriano S. Silva, Paulo Zadra Filho, Ana Paula Ferreira, Fernanda F. Roman, Arthur P. Baldo, Madeleine Rauhauser, Jose L. Diaz de Tuesta, Ana I. Pereira, Adrián M.T. Silva, Juliana M.T. Pietrobelli, Marzhan S. Kalmakhanova, Daniel D. Snow, Helder T. Gomes

    Published 2025-03-01
    “…Our campaign enabled the identification and quantification of 28 contaminants and showed that 27 increased in amount after WWTP discharge entered the river. The statistical analysis revealed the correlation between the pollutants, showed the oscillation in their amounts, and enabled the identification of specific pollutant groups that deserve attention for treatment, such as antibiotics and antidepressants. …”
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  7. 70567
  8. 70568
  9. 70569

    Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older... by Joshua R Lakin, Na Wang, Howard J Cabral, Michael K Paasche-Orlow, Charlotta Lindvall, Angelo Volandes, Aretha Delight Davis, Michael R Winter, Edward T Moseley, Lori Henault, Sophia N Zupanc, Sophiya Das, Kate Sciacca, Edith A Burns, Maria T Carney, Jennifer Itty, Santiago Lopez, Kaitlin Emmert, Narda J Martin, Sherene Lambert, Jennifer Polo, Shreya Sanghani, Julianne N Dugas, Michele Gomez, Shira Gabry-Kalikow, Alexandra Dobie, Meredith Amshoff, Traci Cucinotta, Milton Joel, Lisa B Caruso, Ana Maria Ramirez, Kathleen Salerno, Qausarat Ogunneye

    Published 2022-07-01
    “…This paper presents the rationale, design and methods for a trial aimed at addressing barriers to goals-of-care conversations for hospitalised adults aged 65 and older and those with Alzheimer’s disease and related Dementias, regardless of age.Methods and analysis The Video Image about Decisions to Improve Ethical Outcomes with Palliative Care Educators is a pragmatic stepped wedge, cluster randomised controlled trial, which aims to improve and extend goals-of-care conversations in the hospital setting with palliative care educators trained in serious illness communication and video decision aids. …”
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  10. 70570

    Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks by Cheng-long Jin, Sheng-lin Wang, Shuang Wang, Ya-nan Zhang, Wei-guang Xia, Chang Zhang, Xue-bing Huang, Kai-chao Li, Chun-tian Zheng, Wei Chen

    Published 2025-01-01
    “…Then, according to RNA-Seq analysis, we detected those aged ducks displayed lower Ca concentration in the ovary, while Ca channel related gene expression was increased in GCs to maintain homeostasis. …”
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  11. 70571

    Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts by Linwei Fan, Yuanjun Tang, Jian Liu, Yueqi Liu, Yiwei Xu, Jiayu Liu, Han Liu, Wei Pang, Yuxuan Guo, Weijuan Yao, Tao Zhang, Qin Peng, Jing Zhou

    Published 2025-01-01
    “…This study highlights the critical role of cytosolic Phospholipase A2 (cPLA2)/ Yin Yang 1 (YY1)/ carnitine palmitoyltransferase 1b (CPT1B) signaling in coordinating VSMC mechanical activation by inhibiting fatty acid β‐oxidation. Metabolomic analysis showed that a 15%–1 Hz arterial cyclic stretch, compared to a 5%–1 Hz venous stretch, increased long‐chain fatty acids in VSMCs. cPLA2, identified as a mechanoresponsive molecule, produces excessive arachidonic acid (ArAc) under the 15%–1 Hz stretch, inhibiting CPT1B expression, a key enzyme in fatty acid β‐oxidation. …”
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  12. 70572

    A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells by Chi-Hoon Ahn, Ji Soo Myong, Kazi Rejvee Ahmed, Md Ataur Rahman, Md. Maharub Hossain Fahim, Min Choi, Muntajin Rahman, Jinwon Choi, Kiryang Kim, Seungjoon Moon, Seungjoon Moon, Mohammed Dalli, Mohammed Dalli, Rony Abdi Syahputra, Sang-Won Shin, Abdel Halim Harrath, Moon Nyeo Park, Bonglee Kim, Hwa-Seung Yoo

    Published 2025-02-01
    “…Colony formation assays revealed a significant reduction in prolif-eration, while TUNEL and annexin V-FITC/PI staining indicated enhanced apoptosis. Western blot analysis showed that ALD modulates critical survival pathways, leading to apoptotic cell death.DiscussionThese findings demonstrate that ALD exerts potent anticancer effects against metastatic prostate cancer cells through ROS-mediated apoptosis and mitochondrial dysfunction, while exhibiting minimal cytotoxicity toward normal prostate cells. …”
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  13. 70573
  14. 70574

    Uptake and hesitancy of the second booster dose of COVID-19 vaccine among the general population in China after the surge period of the COVID-19 pandemic: a large-scale national st... by Xin Liu, You Xin, Ling Zhang, Yijin Wu, Shu Jing, Zhenwei Dai, Tianrui Ren, Xiaoyang Liu, Jiaqi Fu, Xu Chen, Weijun Xiao, Hao Wang, Yiman Huang, Wenjun Wang, Xiaofen Gu, Li Ma, Shaokai Zhang, Yanqin Yu, Li Li, Tianzuo Gao, Tianyou Zhao, Yimin Qu, Xinyan Liu, Xiaoyou Su, Youlin Qiao

    Published 2025-02-01
    “…Univariate and multivariate logistic regression analysis were performed to identify factors associated with the hesitancy of the second booster dose of COVID-19 vaccine among the general population. …”
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  15. 70575

    Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study by Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong

    Published 2019-09-01
    “…The goal of this study is to inform primary care planning by: (1) identifying values and preferences shaping the practice intentions and choices of family medicine residents and early career PCPs, (2) comparing practice patterns of early-career and established PCPs to determine if changes over time reflect cohort effects (attributes unique to the most recent cohort of PCPs) or period effects (changes over time across all PCPs) and (3) integrating findings to understand the dynamics among practice intentions, practice choices and practice patterns and to identify policy implications.Methods and analysis We plan a mixed-methods study in the Canadian provinces of British Columbia, Ontario and Nova Scotia. …”
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  16. 70576
  17. 70577

    Макроморфологічні та мікроморфологічні дослідження ґрунтів Консулівського городища (І ст. до н. е. – ІІ ст. н. е.)... by Жанна Матвіїшина, Анатолій Кушнір, Надія Гаврилюк, Матера Марчин

    Published 2024-12-01
    “…Five palaeopedological sections were created in and outside the excavation, from which 158 samples were taken for further laboratory analysis. The first results were published by the authors earlier. …”
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  18. 70578
  19. 70579
  20. 70580

    Rare and common single nucleotide variants in childhood-onset systemic lupus erythematosus by Elisabet Svenungsson, Iva Gunnarsson, Lars Rönnblom, Ingrid E Lundberg, Andreas Jönsen, Niklas Hagberg, Leonid Padyukov, Marie Wahren-Herlenius, Christopher Sjöwall, Solbritt Rantapää-Dahlqvist, Sule Yavuz, Øyvind Molberg, Dag Leonard, Andrei Alexsson, Maija-Leena Eloranta, Ann-Christine Syvänen, Johanna K Sandling, Gunnel Nordmark, Roland Jonsson, Roald Omdal, Christine Bengtsson, Anders A Bengtsson, Pascal Pucholt, Kerstin Lindblad-Toh, Sergey V Kozyrev, Peter Söderkvist, Johanna Dahlqvist, Jonas Carlsson Almlöf, Daniel Eriksson, Ahmed Sayadi, Åsa Karlsson, Gerli Rosengren Pielberg, Anna Lobell, Eva Murén, Kerstin M Ahlgren, Nils Landegren, Olle Kämpe, Fabiana HG Farias, Argyri Mathioudaki, Jennifer Meadows, Jessika Nordin

    Published 2025-02-01
    “…In cSLE, RD SNVs were observed in the C1S, DDX58, IFIH1, IKZF1, RNASEH2A and C8A genes. A PRS analysis showed that patients with cSLE with any of these gene variants had a similar average PRS as control individuals.Conclusion RD SNVs were observed in a small proportion of cSLE and carriers of these RD SNVs had a PRS similar to healthy individuals, suggesting the importance of rare coding heterozygous variants in driving disease risk in a subset of children with SLE.…”
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