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70561
Effects of Climatic Conditions and Agronomic Practices on Health, Tuber Yield, and Mineral Composition of Two Contrasting Potato Varieties Developed for High and Low Input Producti...
Published 2024-12-01“…Results from both ANOVA and redundancy analysis (RDA) indicate that the effects of climatic (precipitation, radiation, and temperature) and agronomic (fertilization and crop protection) explanatory variables on crop health and yield differed considerably between the two varieties. …”
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70562
Repairbads: An automatic and adaptive method to repair bad channels and segments for OPM-MEG
Published 2025-02-01“…However, the position instability or jitter of OPM sensors can result in bad channels and segments, which significantly impede subsequent preprocessing and analysis. Most common methods directly reject or interpolate to repair these bad channels and segments. …”
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70563
Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital
Published 2025-01-01“…A total of 990 patients were included in the analysis (median age: 62, Stage IV: 82.5%). Using the Association for Molecular Pathology genetic variant classification system, we found that 257 (26.0%) patients harbored tier I variants, and 859 (86.8%) patients carried tier II variants. …”
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70564
Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13])
Published 2025-01-01“…Abstract Background The PALLAS trial investigated the addition of palbociclib to standard adjuvant endocrine therapy to reduce breast cancer recurrence. This pre-specified analysis was conducted to determine whether adjuvant palbociclib benefited patients diagnosed with lower risk stage IIA disease compared to those with higher stage disease. …”
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70565
AKRASIJA IR SUBJEKTAS EGONOMIKOJE
Published 2000-01-01“…Under certain conditions homuncular functionalist mode of analysis can have explanatory power and play heuristically indispensable role as way-station to the scientific explanation of behaviour, accomplished in the vocabularies of the construction stance and of the physical stance. …”
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70566
Occurrence of micropollutants in surface water and removal by catalytic wet peroxide oxidation enhanced filtration using polymeric membranes loaded with carbon nanotubes
Published 2025-03-01“…Our campaign enabled the identification and quantification of 28 contaminants and showed that 27 increased in amount after WWTP discharge entered the river. The statistical analysis revealed the correlation between the pollutants, showed the oscillation in their amounts, and enabled the identification of specific pollutant groups that deserve attention for treatment, such as antibiotics and antidepressants. …”
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70567
Acute respiratory tract infections during the first 6 years of life – results from the German birth cohort study LoewenKIDS
Published 2025-04-01“…Parents recorded daily ARI symptoms, which were classified into episodes for incidence and characteristics analysis. Regression analyses explored the influence of exposure factors on ARI incidence. …”
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70568
Clostridioides difficile infection and recurrence in cancer patients (CIRCA): A multicentre, international study
Published 2025-04-01“…Methods: Retrospective analysis on all CDI episodes from 2020 to 2022 in three Australian hospitals and one Spanish hospital. …”
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70569
Study protocol for Video Images about Decisions to Improve Ethical Outcomes with Palliative Care Educators (VIDEO-PCE): a pragmatic stepped wedge cluster randomised trial of older...
Published 2022-07-01“…This paper presents the rationale, design and methods for a trial aimed at addressing barriers to goals-of-care conversations for hospitalised adults aged 65 and older and those with Alzheimer’s disease and related Dementias, regardless of age.Methods and analysis The Video Image about Decisions to Improve Ethical Outcomes with Palliative Care Educators is a pragmatic stepped wedge, cluster randomised controlled trial, which aims to improve and extend goals-of-care conversations in the hospital setting with palliative care educators trained in serious illness communication and video decision aids. …”
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70570
Age-related calcium signaling disturbance restricted cAMP metabolism and induced ovarian oxidation stress in laying ducks
Published 2025-01-01“…Then, according to RNA-Seq analysis, we detected those aged ducks displayed lower Ca concentration in the ovary, while Ca channel related gene expression was increased in GCs to maintain homeostasis. …”
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70571
Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts
Published 2025-01-01“…This study highlights the critical role of cytosolic Phospholipase A2 (cPLA2)/ Yin Yang 1 (YY1)/ carnitine palmitoyltransferase 1b (CPT1B) signaling in coordinating VSMC mechanical activation by inhibiting fatty acid β‐oxidation. Metabolomic analysis showed that a 15%–1 Hz arterial cyclic stretch, compared to a 5%–1 Hz venous stretch, increased long‐chain fatty acids in VSMCs. cPLA2, identified as a mechanoresponsive molecule, produces excessive arachidonic acid (ArAc) under the 15%–1 Hz stretch, inhibiting CPT1B expression, a key enzyme in fatty acid β‐oxidation. …”
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70572
A pharmacoinformatic approach for studying Atractylodes Lancea DC’s anticancer potential and control ROS-mediated apoptosis against prostate cancer cells
Published 2025-02-01“…Colony formation assays revealed a significant reduction in prolif-eration, while TUNEL and annexin V-FITC/PI staining indicated enhanced apoptosis. Western blot analysis showed that ALD modulates critical survival pathways, leading to apoptotic cell death.DiscussionThese findings demonstrate that ALD exerts potent anticancer effects against metastatic prostate cancer cells through ROS-mediated apoptosis and mitochondrial dysfunction, while exhibiting minimal cytotoxicity toward normal prostate cells. …”
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70573
Improving quality and outcomes of extracorporeal cardiopulmonary resuscitation in refractory cardiac arrest: the Phoenix ECPR project
Published 2025-02-01“…Harefield Hospital has been performing ECPR for over a decade; however outcomes have been historically poor.Methods A retrospective analysis was performed of all ECPR cases at Harefield Hospital between April 2018 and April 2023. …”
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70574
Uptake and hesitancy of the second booster dose of COVID-19 vaccine among the general population in China after the surge period of the COVID-19 pandemic: a large-scale national st...
Published 2025-02-01“…Univariate and multivariate logistic regression analysis were performed to identify factors associated with the hesitancy of the second booster dose of COVID-19 vaccine among the general population. …”
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70575
Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study
Published 2019-09-01“…The goal of this study is to inform primary care planning by: (1) identifying values and preferences shaping the practice intentions and choices of family medicine residents and early career PCPs, (2) comparing practice patterns of early-career and established PCPs to determine if changes over time reflect cohort effects (attributes unique to the most recent cohort of PCPs) or period effects (changes over time across all PCPs) and (3) integrating findings to understand the dynamics among practice intentions, practice choices and practice patterns and to identify policy implications.Methods and analysis We plan a mixed-methods study in the Canadian provinces of British Columbia, Ontario and Nova Scotia. …”
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70576
Effects of intra-class peer mentorship intervention programme on the academic performances of academically underperforming medical students in Nigeria
Published 2025-01-01“…The dimensions of students’ subjective vitality and the school engagement were considered in the analysis. Results A total of 49 students were included in the study, with 7 (14.3%) in the mentee group, 12 (24.3%) in the mentor group and 30 (61.2%) in the control group. …”
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70577
Макроморфологічні та мікроморфологічні дослідження ґрунтів Консулівського городища (І ст. до н. е. – ІІ ст. н. е.)...
Published 2024-12-01“…Five palaeopedological sections were created in and outside the excavation, from which 158 samples were taken for further laboratory analysis. The first results were published by the authors earlier. …”
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70578
Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes
Published 2025-01-01“…Methods We performed a retrospective analysis of prospectively collected data from consecutive adult AIS‐LVO patients with successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b/2c/3). …”
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70579
Perfusate Liver Arginase 1 Levels After End-Ischemic Machine Perfusion Are Associated with Early Allograft Dysfunction
Published 2025-01-01“…Receiver operating characteristic analysis indicated that ARG-1 at the end of MP had a good predictive accuracy for EAD (AUC = 0.713; <i>p</i> = 0.02). …”
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70580
Rare and common single nucleotide variants in childhood-onset systemic lupus erythematosus
Published 2025-02-01“…In cSLE, RD SNVs were observed in the C1S, DDX58, IFIH1, IKZF1, RNASEH2A and C8A genes. A PRS analysis showed that patients with cSLE with any of these gene variants had a similar average PRS as control individuals.Conclusion RD SNVs were observed in a small proportion of cSLE and carriers of these RD SNVs had a PRS similar to healthy individuals, suggesting the importance of rare coding heterozygous variants in driving disease risk in a subset of children with SLE.…”
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