The Influence of Migration Timing and Local Conditions on Reproductive Timing in Arctic‐Breeding Birds by W. B. English, B. Lagassé, S. Brown, M. Boldenow, J. Burger, B. Casler, A. D. Dey, S. Feigin, S. Freeman, H. R. Gates, K. E. Iaquinto, S. Koch, J. F. Lamarre, R. B. Lanctot, C. Latty, V. Loverti, L. McKinnon, D. Newstead, L. Niles, E. Nol, D. Payer, R. Porter, J. Rausch, S. T. Saalfeld, F. Sanders, N. R. Senner, S. Schulte, K. Sowl, B. Winn, L. Wright, M. B. Wunder, P. A. Smith

“…We used tracking and breeding data from 248 individuals of 8 species and subspecies of Arctic‐breeding shorebirds to estimate how the timing of nest initiation is related to local conditions like snowmelt phenology versus prior conditions, measured by the timing and speed of migration. Using path analysis, our global model showed that local and prior conditions have similar effect sizes (Standardised Path Coefficients ± SE of 0.44 ± 0.07 and 0.43 ± 0.07 for snowmelt and arrival timing, respectively), suggesting that both influence the timing of breeding and therefore potentially reproductive output. …”
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Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis by Leandro Junqueira Moragas, Laíza Vianna Arruda, Laíza Vianna Arruda, Lucca de Lima Siqueira Oliveira, Felipe de Andrade Vieira Alves, Felipe de Andrade Vieira Alves, Natália Gedeão Salomão, Natália Gedeão Salomão, Jemima Fuentes Ribeiro da Silva, Carlos Alberto Basílio-de-Oliveira, Rodrigo Panno Basílio-de-Oliveira, Ronaldo Mohana-Borges, Caio Gonçalves Azevedo, Gabriela Xavier de Oliveira, Jorge José de Carvalho, Fernando Colonna Rosman, Fernando Colonna Rosman, Marciano Viana Paes, Kíssila Rabelo, Kíssila Rabelo

“…The aim of this article was to evaluate the inflammatory and histopathological profile of the lung tissue of three fatal cases of children infected with DENV, which represents a group more susceptible to fatality due to its incomplete development.MethodsHistopathological analysis was carried out using Hematoxylin and Eosin staining and special stains. …”
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Impact of Immune Checkpoint Inhibitors and Local Radical Treatment on Survival Outcomes in Synchronous Oligometastatic NSCLC by Mandy Jongbloed, MD, Valentina Bartolomeo, MD, Martina Bortolot, MD, Shahan Darwesh, MD, Jarno W.J. Huijs, MD, Safiye Dursun, MD, Juliette Degens, MD, PhD, Ben E.E.M. van den Borne, MD, PhD, Maggy Youssef-El Soud, MD, PhD, Marcel Westenend, MD, PhD, Cordula Pitz, MD, PhD, Dirk K.M. De Ruysscher, MD, PhD, Lizza E.L. Hendriks, MD, PhD

“…The median OS was significantly longer in the chemotherapy-ICI compared with the chemotherapy-only group (33.6 versus 15.9 mo, hazard ratio [HR] = 0.5, 95% confidence interval [CI]: 0.4–0.7, p < 0.001), in the subgroups who were candidate for LRT (36.1 versus 17.2 mo, HR = 0.5, 95% CI: 0.4–0.7, p < 0.001) and those proceeding to LRT (not reached versus 23.1 mo, HR = 0.4, 95% CI: 0.2–0.7, p < 0.001). In multivariate analysis, an ICI-based strategy was associated with improved survival in the total group (HR = 0.6, 95% CI: 0.4–0.9, p < 0.001), in those with intention of LRT (HR = 0.6, 95% CI: 0.4–0.9, p = 0.02) and those who proceeded to LRT (HR = 0.3, 95% CI: 0.1–0.6, p = 0.002). …”
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LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…The cohort was genotyped for five LRRK2 mutations (p.Gly2019Ser, p.Arg1441His, p.Tyr1699Cys, p.Ile2020Thr, and p.Asn1437His) and three East Asian disease-associated variants (p.Gly2385Arg, p.Ala419Val, and p.Arg1628Pro) via Kompetitive allele-specific polymerase chain reaction assay analysis. Results. None of the study subjects carried LRRK2 mutations, whereas the following Asian variants were found with insignificant odds ratios (OR): p.Gly2385Arg (1.2%, minor allele frequency (MAF) 0.007, OR 1.25, p=0.8), p.Ala419Val (3.7%, MAF 0.02, OR 1.5, p=0.4), and p.Arg1628Pro was found only in 1% of controls. p.Gly2385Arg was positive in a big family with PD and tremor, although with incomplete segregation. …”
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Statewide Forest Canopy Cover Mapping of Florida Using Synergistic Integration of Spaceborne LiDAR, SAR, and Optical Imagery by Monique Bohora Schlickmann, Inacio Thomaz Bueno, Denis Valle, William M. Hammond, Susan J. Prichard, Andrew T. Hudak, Carine Klauberg, Mauro Alessandro Karasinski, Kody Melissa Brock, Kleydson Diego Rocha, Jinyi Xia, Rodrigo Vieira Leite, Pedro Higuchi, Ana Carolina da Silva, Gabriel Maximo da Silva, Gina R. Cova, Carlos Alberto Silva

“…External validation with airborne laser scanning (ALS) data across three sites yielded an R² of 0.70, RMSD of 0.29, and MD of −0.22, confirming the model’s accuracy and robustness in unseen areas. Statewide analysis showed lower canopy cover in southern versus northern Florida, with wetland forests exhibiting higher cover than upland sites. …”
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Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

“…Results: Twenty-five adult patients aged 20 years and older with severe asthma were included in the analysis. Serum mepolizumab concentrations significantly increased at 6 and 12 months compared with those at 3 months, particularly in those with disease that responded to therapy. …”
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Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…Additionally, the liver tissue was examined for pathological analysis, fibrosis, bacterial content, and the distribution of immune cells. …”
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Estimación de la cubierta de nieve en el norte de la provincia del Neuquén. by Marisa Gloria Cogliati, Damián Groch, Florencia Gisella Finessi

“…The snow and ice cover analysis in mountainous terrain is an important information for hydrology, and can be obtained from remote sensors. …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…Results In multivariate regression analysis, the sole independent risk factor of LP was the level of SOD1 (OR 0.922, 95% CI: 0.878 ~ 0.967, P < 0.001), while smoking status (β= -0.177, 95% CI -18.645~-2.836, P = 0.008), diabetes mellitus (β= -0.191, 95% CI: -20.442~-3.592, P = 0.005), and total sialic acid (TSA) (β= -0.426, 95% CI: -0.915~ -0.433, P < 0.001) independently influenced the level of SOD1. …”
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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…In particular, our RNA-Seq analysis showed a significant up-regulation of several genes involved in different immunological processes, such as PARP9/PARP14 axes, in macrophages exposed to D614G, Alpha, and Gamma variants. …”
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The diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia by Liping Fan, Jiahao Chen, Chong Chen, Yongwei Zhang, Yeqing Yang, Zhe Chen

“…In the sex stratification analysis, in males, the AUCs of TC, FFAs, IL-6, and the ApoA1/ApoB ratio for the prediction of osteoporosis or osteopenia were 0.596, 0.688, 0.739, and 0.539, respectively. …”
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Enhancing reproductive capacity in hybrid Red Tilapia (Oreochromis niloticus ×‎ O. mossambicus) via dietary administration of date palm pollen (Phoenix dactylifera L.)‎ by Nashi K. Alqahtani, Hesham S. Ghazzawy, Roshmon Thomas Mathew, Yousef‎ Ahmed Alkhamis, Rashid Saleh Alngada, Moaheda E.H. Eissa, Sameh A. Abdelnour, Sara F. Ghanem, Layla A. Almutairi, El-Sayed Hemdan Eissa

“…Red Tilapia broodstock (150 ± 5.77 g), with a female: male ratio of 3:1, were fed an isonitrogenous and isocaloric basal diet (DPP0) or diets supplemented with 10 g (DPP10), 20 g (DPP20), and 40 g (DPP40) of DPP per kilogram of diet for a period of two months. GC-MS analysis of DPP revealed the presence of several bioactive compounds, including butan-1-one, tetradecanoic acid, cholestan-3-one, octasiloxane, and heptasiloxane, which have been reported to exhibit promising antimicrobial, antioxidant, and immunomodulatory properties. …”
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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

“…We performed gene set enrichment analysis to identify RECQL4‐dependent signalling pathways and explored the association between RECQL4 levels and immunoscores. …”
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Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia by Muazzam Sheriff Maqbul, Reem Saleh Alzaki, Reema Sami Meeralam, Norah Abdulmajeed Alqutami, Bayan Mohammed Alturki, Lina Sultan Alhazmi, Reem Mamdouh Alaseeri, Lama Saad Alghamdi, Reem Khalid bin Brik, Shaima Tariq Mansoor Beig, Muath Saeed Alamri, Wjood Abdullah A. Alshehri, Turki Ayed Almutairi, Maha Abdullah Alqurashi, Ahmed Jamal Nasef

“…Result: The survey in Jeddah, Saudi Arabia, examined peptic ulcer disease (PUD) prevalence and associated factors. Demographic analysis showed 561 participants, almost evenly split by gender (269 males, 292 females), with varying ages and educational backgrounds. …”
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Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study by Xiaoying Ding, Ying Xu, Yufan Wang, Xiaohua Li, Chunhua Lu, Jing Su, Yuting Chen, Yuhang Ma, Yanhua Yin, Yong Wu, Yaqiong Jin, Lihua Yu, Junyi Jiang, Naisi Zhao, Qingwu Yan, Andrew S. Greenberg, Haiyan Sun, Mingyu Gu, Li Zhao, Yunhong Huang, Yijie Wu, Chunxian Qian, Yongde Peng

“…Insulin resistance [OR = 1.31 (1.15, 1.49)], MetS [OR = 1.18 (1.03, 1.35)], and diabetes [OR = 1.25 (1.06, 1.48)] were all independent risk factors for TN in total subjects, whereas, after stratified analysis of gender, MetS [OR = 1.29, (1.09, 1.53)] and diabetes [OR = 1.47, (1.17, 1.84)] are still strongly and independently associated with the higher risks of TN in female subjects, but not in males. …”
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A Comprehensive Study of Type I (Thermonuclear) Bursts in the New Transient SRGA J144459.2–604207 by Tao Fu, Zhaosheng Li, Yuanyue Pan, Long Ji, Yupeng Chen, Lucien Kuiper, Duncan K. Galloway, Maurizio Falanga, Renxin Xu, Xiaobo Li, Mingyu Ge, L. M. Song, Shu Zhang, Shuang-Nan Zhang

“…We report an analysis of Insight-HXMT observations of the newly discovered accreting millisecond pulsar SRGA J144459.2–604207. …”
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Bone marrow mesenchymal stem cells derived cytokines associated with AKT/IAPs signaling ameliorate Alzheimer’s disease development by Yalan Lu, Yanfeng Xu, Li Zhou, Siyuan Wang, Yunlin Han, Kewei Wang, Chuan Qin

“…Then the tissue RNA sequencing and mBMMSC cytokine analysis were performed. A cytokine antibody array for BMMSCs and the brain slice models were performed with AD model tissues were used to elucidate the molecular mechanisms. …”
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Brucella suis ΔmapB outer membrane vesicles as an acellular vaccine against systemic and mucosal B. suis infection by Florencia Muñoz González, Florencia Muñoz González, Magali G. Bialer, Maria L. Cerutti, Silvia M. Estein, Lila Y. Ramis, Pablo C. Baldi, Pablo C. Baldi, Ángeles Zorreguieta, Ángeles Zorreguieta, Mariana C. Ferrero, Mariana C. Ferrero

“…To determine the level of protection conferred by immunization, mice were challenged with virulent B. suis via intraperitoneal or intratracheal routes, and the bacterial load was quantified post-challenge.ResultsDynamic Light Scattering of the OMVs from both strains revealed the presence of spherical structures of 90-130 nm. Proteomic analysis identified 94 and 95 proteins in the wt and ΔmapB OMVs, respectively, including several known Brucella immunogens. …”
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Cluster randomised controlled trial of screening for atrial fibrillation in people aged 70 years and over to reduce stroke: protocol for the pilot study for the SAFER trial by Martin R Cowie, Stephen Morris, Gregory Lip, Richard J McManus, Stephen Sutton, Jonathan Mant, Simon J Griffin, Sarah Hoare, Jenni Burt, Rachel Johnson, Mark Lown, Alison Powell, Natalie Armstrong, FD Richard Hobbs, Trudie Lobban, Rakesh Narendra Modi, Ben Freedman, David A Fitzmaurice, Stephen Kaptoge, Jenny Lund, Duncan Edwards, Kate Williams, H Thom, Francesco Fusco, Michael J Sweeting, Andrew Dymond, The SAFER Authorship Group

“…The aim of the pilot study is to assess feasibility of the main trial and inform implementation of screening and trial procedures.Methods and analysis SAFER is planned to be a pragmatic randomised controlled trial (RCT) of over 100 000 participants aged 70 years and over, not on long-term anticoagulation therapy at baseline, with an average follow-up of 5 years. …”
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Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study by Marieke Bierhoff, Chaisiri Angkurawaranon, Aung Myat Min, Mary Ellen Gilder, Nay Win Tun, Arunrot Keereevijitt, Aye Kyi Win, Elsi Win, Verena Ilona Carrara, Tobias Brummaier, Cindy S. Chu, Laurence Thielemans, Kanlaya Sriprawat, Borimas Hanboonkunupakarn, Marcus Rijken, François Nosten, Michele van Vugt, Rose McGready

“…Logistic regression analysis was used to evaluate associations between HBV group (controls HBsAg negative, HBsAg+/HBeAg-, or HBsAg+/HBeAg+) and pregnancy outcome and comorbidity. …”
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