Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus by Maria Sultan, Maria Razzaq, Joohyun Lee, Shreyasi Das, Shrute Kannappan, Vinod Kumar Subramani, Wanki Yoo, Truc Kim, Hye-Ra Lee, Akhilesh K. Chaurasia, Kyeong Kyu Kim

“…Genome-wide bioinformatics analysis of G4 motifs and their mapping on S. aureus genome, identified the presence of G4-motif in the promoter of mraZ, a conserved master regulator of the dcw cluster regulating the coordinated cell division and cell wall synthesis. …”
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Correlation between Insulin Resistance and Thyroid Nodule in Type 2 Diabetes Mellitus by Yunzhao Tang, Tiantian Yan, Gang Wang, Yijun Chen, Yanjuan Zhu, Zhenhuan Jiang, Min Yang, Chenguang Li, Zhu Li, Ping Yu, Shanshan Wang, Nannan Zhu, Qiuyue Ren, Changlin Ni

“…Logistic regression analysis showed that age, sex, FT4, and HOMA-IR were positive factors for thyroid nodule. …”
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L’enterrement d’une triade divine féminine à Lugdunum : étude du dépôt de la place d’Albon à Lyon (Métropole de Lyon) by Lucas Guillaud, Emmanuel Bernot, Aline Colombier-Gougouzian, Amaury Gilles, Nicolas Garnier

“…Physical and chemical analysis of the residues –notably animal meat, wine, pitch and millet– found at the bottom of the vessel indicates that it was used for cooking.Inside the situla, a bronze cup (Bienert 69 type) and a glass flask (Isings 104b type) were discovered. …”
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Implementation of a genotyped African population cohort, with virtual follow-up: A feasibility study in the Western Cape Province, South Africa [version 2; peer review: 2 approved,... by Robert J Wilkinson, Francisco Lakay, Nicki Tiffin, Joel A Dave, Catherine Riou, Peter Raubenheimer, Anna K Coussens, Tsaone Tamuhla, Melissa J Blumenthal, Maleeka Abrahams

“…Principal component analysis showed extensive ancestry admixture in study participants. …”
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Risk of All-Cause Mortality in Mild Chronic Obstructive Pulmonary Disease: Evidence From the NHANES III and 2007–2012 by Zou W, Ou J, Wu F, Xiao S, Deng Z, Li H, Wang Z, Tang G, Liu S, Ye D, Zhu D, Hu J, Ran P

“…The subgroup analyses results for male sex, age ≥ 50 years, and current smokers were consistent with the main analysis.Conclusion: Patients with mild COPD had a higher all-cause mortality risk than those with normal spirometry, especially males, those aged ≥ 50 years, and current smokers. …”
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Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma by Hengchang Liu, Jialiang Liu, Xu Guan, Zhixun Zhao, Pu Cheng, Haipeng Chen, Zheng Jiang, Xishan Wang

“…Methods Data on gene expression and mutations in READ were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Bioinformatics analysis explored the correlation between TTN mutations and immune cell infiltration. …”
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Fracture-seepage characteristic zones of the overburden of extra-thick coal seams: Evolutionary patterns and their engineering applications by Xiangguo KONG, Tianshuo ZHAO, Haifei LIN, Pengxiang ZHAO, Xu WANG, Yuchu CAI, Pengfei JI, Di HE, Ke LI, Chuanyu XU

“…Based on the spatiotemporal evolution patterns of the fracture ratios, fracture entropy, connectivity coefficients, and permeability of these zones, this study developed an evolution model and identification flowchart for the fracture-seepage characteristic zones of the overburden of extra-thick coal seams. The analysis of the evolution model reveals that the medium-elevation transition zone and the high-elevation constant current zone were the dominant horizons for gas extraction, with the vertical distances of boreholes designed ranging from 6 m to 25 m. …”
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Effectiveness–implementation hybrid-2 randomised trial of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children (D... by Paula Lister, Kristen Gibbons, Zephanie Tyack, Luregn J Schlapbach, Samudragupta Bora, Maria Isabel Castillo, James Best, Debbie Long, Helen G Liley, Belinda Dow, Kerri-Lyn Webb, Christian Stocker, Debra Thoms, Carolyn Wharton, Lori Matuschka

“…We will also assess the difference between neurodevelopmental vulnerability and parental stress in two intervention groups and the impact of child, parent, sociodemographic and illness/treatment risk factors on child and parent outcomes.Methods and analysis Single-centre randomised effectiveness–implementation (hybrid-2 design) pilot trial for parents of children aged ≥2 months and <4 years discharged from PICU after critical illness or injury. …”
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Spatiotemporal range dynamics and conservation optimization for endangered medicinal plants in the Himalaya by Fu-Lv Liu, Winnie Wanjiku Mambo, Jie Liu, Guang-Fu Zhu, Raees Khan, Abdullah, Shujaul Mulk Khan, Lu Lu

“…Our conservation planning analysis revealed that northern parts of Pakistan such as Swat, Shangla, Hazara division, Jammu, and Kashmir are the core conservation areas for these ten species. …”
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Satisfactory Evaluation of Call Service Using AI After Ureteral Stent Insertion: Randomized Controlled Trial by Ukrae Cho, Yong Nam Gwon, Seung Ryong Chong, Ji Yeon Han, Do Kyung Kim, Seung Whan Doo, Won Jae Yang, Kyeongmin Kim, Sung Ryul Shim, Jaehun Jung, Jae Heon Kim

“…Multiple regression analysis was performed on all outcomes, and humans showed superior satisfaction than AI in the management of complications. …”
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Tasquinimod suppresses tumor cell growth and bone resorption by targeting immunosuppressive myeloid cells and inhibiting c-MYC expression in multiple myeloma by Marie Törngren, Rong Fan, Eline Menu, Helena Eriksson, Karin Vanderkerken, Andrew Chantry, Hatice Satilmis, Niels Vandewalle, Emma Verheye, Philip Vlummens, Anke Maes, Catharina Muylaert, Elke De Bruyne, Holly Evans, Nathan De Beule, Dirk Hose, Ken Maes, Karine Breckpot, Kim De Veirman

“…We aimed to gain more insights into its mechanisms of action both on the myeloma cells and the immune microenvironment.Methods We analyzed the effects of tasquinimod on MM cell viability, cell proliferation and downstream signaling pathways in vitro using RNA sequencing, real-time PCR, western blot analysis and multiparameter flow cytometry. Myeloid cells and T cells were cocultured at different ratios to assess tasquinimod-mediated immunomodulatory effects. …”
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Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Ionela Amalia Bradu, Titus Vlase, Dumitru-Daniel Herea, Marius Ciprian Văruţ, Roxana Maria Bălăşoiu, Andrei Biţă, Antonia Radu, George Dan Mogoşanu, Maria Viorica Ciocîlteu

“…These microparticles were thoroughly characterized using Fourier-transform infrared (FTIR) spectroscopy to confirm functional group interactions, scanning electron microscopy (SEM) for surface morphology, X-ray diffraction (XRD) for crystalline properties, and thermal analysis for stability assessment. The synthesized microparticles displayed uniform size distribution and efficient encapsulation, demonstrating compatibility with the gel matrix. …”
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Association between joint exposure to ambient air pollutants and carotid plaque: The mediating role of cardiometabolic risk factors by Yunfei Li, Ze Han, Xiaoyu Zhao, Yueruijing Liu, Zhiyuan Wu, Jinqi Wang, Xia Li, Xiuhua Guo, Lixin Tao

“…A modified Poisson regression model was conducted to investigate the relationship between exposure to air pollution and carotid plaque occurrence. Mediation analysis explored how cardiometabolic factors mediate the relationships between exposure to joint air pollution and carotid plaque risk. …”
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Injectable Hierarchical Bioactive Hydrogels with Fibroblast Growth Factor 21/Edaravone/Caffeic Acid Asynchronous Delivery for Treating Parkinson's Disease by Junpeng Xu, Peng Dai, Chen Zhang, Na Dong, Caiyan Li, Chonghui Tang, Zhihao Jin, Shih‐Ho Lin, Luyang Ye, Tianmiao Sun, Yukai Jin, Fenzan Wu, Lihua Luo, Ping Wu, Shengcun Li, Xiaokun Li, Shan‐hui Hsu, Dawei Jiang, Zhouguang Wang

“…The triple‐loaded hydrogel is injected into the brains of PD rats, showing behavioral improvement. Histological analysis revealed that the triple‐loaded OACDP hydrogels are effective in achieving immediate neuroprotection, i.e., reduction the loss of tyrosine hydroxylase in substantia nigra compacta and striatum (retained ≈10‐fold versus control), decreasing oxidative stress, reducing astrocyte and microglia activation, and stimulating the AMPK/PGC‐1α axis to regulate the mitochondrial function, providing a multi‐dimensional PD therapy. …”
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Solid‐Solution Limits and Thorough Characterization of Bulk β‐(AlxGa1‐x)2O Single Crystals Grown by the Czochralski Method by Zbigniew Galazka, Andreas Fiedler, Andreas Popp, Palvan Seyidov, Saud Bin Anooz, Roberts Blukis, Jana Rehm, Kornelius Tetzner, Mike Pietsch, Andrea Dittmar, Steffen Ganschow, Arub Akhtar, Thilo Remmele, Martin Albrecht, Tobias Schulz, Ta‐Shun Chou, Albert Kwasniewski, Manuela Suendermann, Thomas Schroeder, Matthias Bickermann

“…Transmission Electron Microscopy (TEM) analysis reveals random distribution of Al across both octahedral and tetrahedral sites. …”
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Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“…However, our recent studies with metagenomic analysis of rumen methanogens showed that Methanobrevibacter was the predominant genus for cattle and buffalo. …”
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Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes by Hailing Zhao, Haojun Zhang, Yan Wang, Tingting Zhao, Meihua Yan, Xi Dong, Qian Wang, Jialin Li, Liang Ma, Ping Li

“…PNPLA2 rs1138693 (T>C), a missense SNP, showed no association with DKD (genotype, P=0.966; allele, P=0.845). Genetic model analysis revealed that minor allele G of PNPLA2 rs28633403 was a protective factor of DKD in a dominant model adjusted by confounders (AG+GG vs. …”
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Evaluasi TKTI Puri Saron Hotel Seminyak dengan Framework Cobit 5 by Norsa Yudhi Arso, Made Wisnu Antara Kesiman, Dewa Gede Hendra Divayana

“…The findings of the analysis are centered on the COBIT Process, specifically the domains (EDM04) IT Resources, (APO01) Consistency Management, (APO03) IT Architecture, (APO04) IT Innovation, (APO07) Resource Management, (BAI04) Balancing Flows and Future Needs , (BAI09) Company Assets, (BAI10) Configuration Management, (DSS01) Operations Management, (DSS03) Managing Company Life Cycle Problems, and ( The process of planning, assessing and adjusting Puri Saron Hotel Seminyak for a better direction, and most of the domain activities have been executed, policies and norms have been written, and communication has improved. …”
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Penerapan Model Technology Readiness Index untuk Mengukur Tingkat Kesiapan Mahasiswa dalam Penerimaan Sistem E-Polvot by M Khairul Anam, Fransiskus Zoromi, Soni, Torkis Nasution, Khusaeri Andesa

“…The research objective is to assess the readiness of students in using the e-polvot system. The analysis of students' readiness utilizes the Technology Readiness Index (TRI) model, which consists of four variables: Optimism, Innovativeness, Discomfort, and Insecurity. …”
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Pengaruh Pesan Keagamaan Dalam Nadham Maulid Al-Dhiyâ’ Al-Lâmi’ Terhadap Jamaah Majelis Taklim Al-Hidayat Gampong Peulanggahan Banda Aceh; Kajian Ritual Effect by Syarifuddin, Cut Masthura Rahmatillah, Abd Razak, Rahma Salbiah

“…This research employs a qualitative method with a public opinion survey approach, gathering data through observation, interviews, and documentation studies. Data analysis is conducted through data reduction, presentation, and conclusion drawing, while data validity is ensured through continuous observation, increased rigor, and triangulation. …”
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