Significant room for improvement in the prehospital assessment and treatment of acute abdominal pain: a retrospective observational study by Rasmus Bjerén, Carl Magnusson, Johan Herlitz, Denise Bäckström

“…This is particularly relevant given the long-standing controversy surrounding the use of analgesia in AAP patients before a final diagnosis is made, which may still influence the prehospital pain management. …”
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Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achie... by Susan J. Skledar, Brian A. Williams, Manuel C. Vallejo, Patricia L. Dalby, Jonathan H. Waters, Ronald Glick, Michael L. Kentor

“…We now propose a “zero-tolerance” antiemetic algorithm for outpatients that involves routine prophylaxis by first avoiding volatile agents and opioids to the extent possible, using locoregional anesthesia, multimodal analgesia, and low doses of three nonsedating off-patent antiemetics. …”
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Understanding Cognition, Oxytocin, and Pain in Elders (UCOPE): protocol for a double-blinded cross-over trial in chronic knee osteoarthritis pain by Yenisel Cruz-Almeida, Soamy Montesino-Goicolea, Pedro Valdes-Hernandez, Zhiguang Huo, Roland Staud, Natalie C. Ebner

“…A promising treatment is the neuropeptide oxytocin (OT), which has been shown to play a role in endogenous analgesia with human and animal studies demonstrating anti-nociceptive effects. …”
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Comparison of the Postoperative Analgesic Effects between Ultrasound-Guided Transmuscular Quadratus Lumborum Block and Thoracic Paravertebral Block in Laparoscopic Partial Nephrect... by Jin Wang, Xulei Cui, Liying Ren, Xu Li, Yuelun Zhang, Yi Xie, Zhigang Ji, Yuguang Huang

“…This prospective, randomized, double-blinded, noninferiority study aimed to compare the effects of analgesia and recovery between transmuscular quadratus lumborum block (TMQLB) and paravertebral block (PVB). …”
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Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies by Jacinta Cheng, Tia Solomon, Mahnuma Estee, Flavia M. Cicuttini, Yuan Z. Lim

“…In pre-clinical studies, GLP-1A was assessed for its effect on structural (n ​= ​6); immunomodulation (n ​= ​7); analgesia (n ​= ​1) and molecular pathways in osteoarthritis (n ​= ​5). …”
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Gabapentin Does Not Appear to Improve Postoperative Pain and Sleep Patterns in Patients Who Concomitantly Receive Regional Anesthesia for Lower Extremity Orthopedic Surgery: A Rand... by Jean Daniel Eloy, Christy Anthony, Shawn Amin, Moorice Caparó, Mark C. Reilly, Steven Shulman

“…This was done in the setting of ensuring adequate postoperative analgesia with regional blocks and opioid PCA, as is protocol at our institution. …”
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Diabetic Myonecrosis: An Atypical Presentation by José Hernán Martínez, Oberto Torres, Michelle M. Mangual García, Coromoto Palermo, María de Lourdes Miranda, Eva González, Ignacio Chinea Espinoza, Ivan Laboy, Mirelis Miranda, Kyrmarie Dávila, Rafael Tirado, Mildred Padilla

“…Management consists of conservative measures including analgesia and rest. Short-term prognosis is good, but long-term prognosis is poor with most patients dying within 5 years. …”
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Mechanism and Pharmacodynamic Substance Basis of Raw and Wine-Processed Evodia rutaecarpa on Smooth Muscle Cells of Dysmenorrhea Mice by Yeqian Liu, Hong Li, Lei Chen, Hongxia Zhao, Jian Liu, Shan Gong, Danfeng Ma, Chunming Chen, Shuiqing Zeng, Hongping Long, Weiqiong Ren

“…Evodia rutaecarpa (ER) is a well-known herbal Chinese medicine traditionally used for analgesia in dysmenorrhea, headaches, abdominal pain, etc. …”
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Is There a Mild Form of Pediatric Appendicitis? An Eight-Year Single-Center Retrospective Review by Eric Scheier, Khaled Khalilia, Pavel Peslin, Stav Amir, Luba Pasherstnik Bizer

“…Children receiving medical treatment received intravenous analgesia more frequently (88% versus 50%, <i>p</i> = 0.009). …”
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Clinical Utility of a Structured Program to Reduce the Risk of Health-Related Quality of Life Impairment after Discharge from Intensive Care Unit: A Real-World Experience by Angelica Venni, Francesca Ioia, Silvia Laviola, Francesca Frigieri, Alessandra Pieri, Simona Marilli, Daniela Balzi, Piercarlo Ballo, Stefano Gori, Diletta Guarducci

“…A total of 159 patients hospitalized in our ICU with a length of stay >72 hours were enrolled in an institutional management protocol including specific recommendations: adequate sedation and analgesia protocols, to ensure a valid delirium prevention strategy, and to provide a planned midterm after discharge. …”
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Assessment of Patient’s Satisfaction and Associated Factors regarding Postoperative Pain Management at the University of Gondar Compressive Specialized Hospital, Northwest Ethiopia... by Yosef Belay Bizuneh, Girmay Fitiwi Lema, Demeke Yilkal Fentie, Yophtahe Woldegerima Berhe, Henos Enyew Ashagrie

“…Moreover, we suggested that all patients who underwent major surgery should receive peripheral nerve block as part of multimodal analgesia to decrease the incidence and severity of post op pain.…”
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Analgesic Efficacy of Intravenous Ibuprofen in the Treatment of Postoperative Acute Pain: A Phase III Multicenter Randomized Placebo-ControlledDouble-Blind Clinical Trial by Hong-Su Zhou, Ting-Ting Li, Yu Pi, Ting-Hua Wang, Fei Liu, Liu-Lin Xiong

“…Patients with an intravenous (IV) patient-controlled analgesia device after abdominal or orthopedic surgery were randomly divided into placebo, IVIB 400 mg, and IVIB 800 mg groups. …”
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The Impact of Pelvic Floor Muscle Strengthening on the Functional State of Women Who Have Experienced OASIS After Childbirth by Atėnė Simanauskaitė, Justina Kačerauskienė, Dalia Regina Railaitė, Eglė Bartusevičienė

“…Risk factors for OASIS were found to be fetal macrosomia (<i>p</i> = 0.012), fetal occiput posterior position (<i>p</i> = 0.001), and epidural analgesia (<i>p</i> = 0.003). After one year of performing PFM strengthening exercises, some women in the study group exhibited stronger PFM contractions (<i>p</i> = 0.076), while others held the contracted PFM for a longer time (<i>p</i> = 0.133). …”
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Multimodal low-opioid anesthesia as a factor in reducing the activation of the proinflammatory response in cardiac surgery by S.R. Maruniak, O.A. Loskutov, O.M. Druzhyna, I.R. Malysh, V.G. Kolesnikov, N.O. Korotchuk

“…The use of a combination of ketamine, lidocaine and dexmedetomidine for multimodal low opioid anesthesia is characterized by relative safety, a sufficient level of analgesia and a low level of inflammatory response.…”
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Efficacy of Intravenous Ibuprofen and Paracetamol on Postoperative Pain and Tramadol Consumption After Arthroscopic Shoulder Surgery: A Prospective, Randomized, Double-blind Clinic... by Muhittin CALIM, Serdar YESILTAS, Mustafa GUNAY, Ismail SUMER, Sedat AKBAS

“…All participants were managed using IV patient-controlled analgesia. These patients were then randomly assigned in a double-blind manner to two groups: one receiving paracetamol (n=32), and the other receiving ibuprofen (n=32). …”
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Retrospective Comparison of Postoperative Fascia Iliaca Block and Multimodal Drug Injection on Early Function of the Knee in Femoral Fractures Using Retrograde Intramedullary Naili... by Songtao Li, Ping Luo, Yuhu Huang, Huarong Xia, Wushu Wei, Wendun Wei, Tianyu Xia, Kai Xu

“…A retrospective analysis of 41 patients receiving femoral fracture treatment with retrograde intramedullary nailing, was performed during 2018–2020. 19 patients were treated with MDI as postoperative analgesia, and 22 patients were treated with FIB. Rehabilitation started on the first postoperative day and lasted for 3 months. …”
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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…Recently, functional magnetic resonance imaging (fMRI) has been extensively applied in studying the brain mechanisms of acupuncture analgesia. Currently, network analysis based on brain connectomics is a focal point in acupuncture imaging research. …”
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Effects of photobiomodulation combined with rehabilitation exercise on pain, physical function, and radiographic changes in mild to moderate knee osteoarthritis: A randomized contr... by Yan Ling Tay, Mohd Azzuan Ahmad, Nor Hamdan Mohamad Yahaya, Devinder Kaur Ajit Singh

“…The treatment protocol includes both pulse mode (25 Hz, 5 W, 190 J) for analgesia and continuous mode (5 W, 3000 J) for biostimulation. …”
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Use of virtual reality in port implantation to reduce perioperative anxiety and pain: protocol for a randomised controlled pilot trial at a single German university hospital (VIP-t... by Christoph W Michalski, Felix J Hüttner, Colette Dörr-Harim, Sandra Graf, Hannah Feldmann, Lisa S Hunold, Kira C Steinkraus, Nadir Nasir

“…Further outcomes include patient satisfaction and tolerability, perioperative analgesia and sedation, occurrence of postoperative nausea, vomiting and VR sickness symptoms, surgeon’s satisfaction, procedure duration, postoperative complications until postoperative day 30 and patient willingness to hypothetically undergo port implantation again under the same conditions.Ethics and dissemination The VIP trial has been approved by the Ethics Committee of the Medical Faculty of Ulm University (reference number 03/22). …”
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The Use of Electronic Consent (eConsent) Within the Ketamine for Long-Lasting Pain Relief After Surgery (KALPAS) Multicenter Trial by Doan LV, Burr J, Perez R, Martinez H, Cuevas R, Watt K, Wang J

“…It has streamlined the process of consenting patients and has been shown to benefit the research study team and participants.eConsent in the Ketamine Analgesia for Long-Lasting Pain Relief After Surgery (Kalpas) Study: The KALPAS study is a multicenter, double-blind, randomized controlled study investigating the effectiveness of ketamine in reducing chronic post-mastectomy pain in women undergoing mastectomy for oncologic indication. …”
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