Baicalin Mitigates Cardiac Hypertrophy and Fibrosis by Inhibiting the p85a Subunit of PI3K by Lu He, Min Zhu, Rui Yin, Liangli Dai, Juan Chen, Jie Zhou

“…Baicalin displayed a significant cardioprotective effect via the inhibition of the PI3K signaling pathway by binding with five amino acid residues of the p85a regulatory subunit of PI3K. …”
Get full text

Elite Alleles of EPE1 Identified via Genome-wide Association Studies Increase Panicle Elongation Length in Rice by Hao Sun, Qiqi Yao, Mei Hai, Tianhu Li, Jinghan Sun, Zhengbo Liu, Yang Ang, Yingying Zhao, Yanan Zhang, Xianping Cheng, Tao Huang, Yinping Chang, Mingyu Du, Erbao Liu

“…Haplotype analysis showed that the two polymorphisms of HapD cause amino acid residue changes from phenylalanine to leucine (F/L43) and isoleucine to phenylalanine (I/F52), which lead to the enhancement of panicle exsertion; therefore, we renamed this gene ENHANCED PANICLE EXSERTION (EPE1). …”
Get full text

Lignin Metabolism Is Crucial in the Plant Responses to <i>Tambocerus elongatus</i> (Shen) in <i>Camellia sinensis</i> L. by Wenli Wang, Xiaogui Zhou, Qiang Hu, Qiuhong Wang, Yanjun Zhou, Jingbo Yu, Shibei Ge, Lan Zhang, Huawei Guo, Meijun Tang, Xin Li

“…We first focused on the primary metabolism and found that the amino acid levels decreased significantly with increasing <i>T. elongatus</i> infestation, while sugar accumulation showed an opposite trend. …”
Get full text

Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

“…Sphingomonas and Sediminibacterium were liable to remodulate lipid and essential amino acid degradations to embrace progression after immunotherapies. …”
Get full text

The Effect of Cysteine on the Removal of Cadmium in Paddy Soil by Combination with Bioremediation and the Response of the Soil Microbial Community by Emmanuel Konadu Sarkodie, Kewei Li, Ziwen Guo, Jiejie Yang, Yan Deng, Jiaxin Shi, Yulong Peng, Yuli Jiang, Huidan Jiang, Hongwei Liu, Yili Liang, Huaqun Yin, Xueduan Liu, Luhua Jiang

“…The microbial metabolic functions, such as replication and repair and amino acid metabolism, were also increased after treatment, which benefitted the microbial survival and adaptation to the environment. …”
Get full text

KMO-driven metabolic reconfiguration and its impact on immune cell infiltration in nasopharyngeal carcinoma: a new avenue for immunotherapy by Nijun Chen, Yuan Zong, Chen Yang, Lei Li, Yang Yi, Jiawen Zhao, Xiaoyu Zhao, Xianfei Xie, Xingmei Sun, Ning Li, Liting Jiang

“…Results Malignant epithelial cells in NPC exhibited altered mitochondrial metabolism, including dysregulation of amino acid and glucose metabolism, when compared to non-malignant cells. …”
Get full text

Application of Biochar-Immobilized <i>Bacillus megaterium</i> for Enhancing Phosphorus Uptake and Growth in Rice by Keru Yu, Zhenyu Wang, Wenyan Yang, Shuai Li, Dongtao Wu, Hongtao Zheng, Zhengqian Ye, Shaona Yang, Dan Liu

“…Additionally, carbon utilization analysis was applied using the commercial Biolog system, revealing that the MOF treatment significantly increased the utilization of carbohydrates, polymers, and amino acid carbon sources. Moreover, compared to the control, MOF treatment significantly increased the shoot (0.469%) and root P (0.516%) content while promoting root development and thereby supporting rice growth. …”
Get full text

First genome-scale insights into the virulence of the snow mold causal fungus Microdochium nivale by Ivan Tsers, Ekaterina Marenina, Azat Meshcherov, Olga Petrova, Olga Gogoleva, Alexander Tkachenko, Natalia Gogoleva, Yuri Gogolev, Evgenii Potapenko, Olga Muraeva, Mira Ponomareva, Viktor Korzun, Vladimir Gorshkov

“…In addition to disclosing plant-metabolite-upregulated M. nivale functional gene groups (including those related to host plant protein destruction and amino acid metabolism, xenobiotic detoxication (including phytoalexins benzoxazinoids), cellulose destruction (cellulose monooxygenases), iron transport, etc.), the performed analysis pointed to a crucial role of host plant lipid destruction and fungal lipid metabolism modulation in plant-M. nivale interactions.…”
Get full text

ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism by Christoffer Löf, Nasrin Sultana, Neha Goel, Samuel Heron, Gudrun Wahlström, Andrew House, Minna Holopainen, Reijo Käkelä, Johanna Schleutker

“…Targeted metabolomics showed reduced levels of the amino acid aspartate, indicating disrupted mitochondrial function in the ANO7-expressing cells. …”
Get full text

The potential of supplementing compound organic trace elements at lower levels in Chinese yellow- feathered broiler diets, part II: Impacts on growth performance, gut health, intes... by Xiaoyan Nie, Fei Zhao, Yucheng Yin, Qi Lu, Yang Dai, Rui Wang, Yiwen Ji, Huihua Zhang, Cui Zhu

“…PICRUST prediction of microbial function revealed that OTM treatment enriched the pathways related to amino acid metabolism and DNA replication. In conclusion, dietary supplementation at lower levels of compound OTM to replace ITM could improve growth performance and intestinal health, and reduce the fecal excretion of trace elements by modulation of cecal microbiota community and diversity in Chinese yellow-feathered broilers.…”
Get full text

Effects of Dietary Tea Polyphenols on the Growth, Antioxidant Status, Immune Function, and Intestinal Microbiota of Largemouth Bass (<i>Micropterus salmoides</i>) by Zixin Yang, Qiuwen Su, Jiafa Yang, Zhijun Li, Shanren Lan, Xu Jia, Paihuai Ouyang, Huijuan Tang

“…With the increase in dietary TPs, distinct differences were observed in the intestinal microbial composition and the relative abundance of potential pathogens, especially <i>Clostridiaceae</i>, which decreased, along with the enrichment of pathways related to metabolism, including amino acid metabolism, carbohydrate metabolism, and lipid metabolism. …”
Get full text

Comparative In vitro antibacterial activity of nemonoxacin and other fluoroquinolones in correlation with resistant mechanisms in contemporary methicillin-resistant Staphylococcus... by Pao -Yu Chen, Mao-Wang Ho, Po-Liang Lu, Hung-Jen Tang, Cheng Len Sy, Jann-Tay Wang, Taiwan Staphylococcus aureus Consortium (TSAC)

“…Among 89 isolates sequenced, 44.1% of ST8 and all ST239 isolates had ≥ 3 amino acid substitutions (AAS) in gyrA/parC (group A) or 2 AAS in gyrA/parC with additional AAS in gyrB/parE (group B). …”
Get full text

Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women by Kayla R. Getz, Myung Sik Jeon, Lili Liu, Lei Liu, Haixiang Zhang, Chongliang Luo, Jingqin Luo, Adetunji T. Toriola

“…Conclusions Metabolites in amino acid, lipid, cofactor/vitamin, and xenobiotic super-pathways as well as lipid species across the phospholipid, neutral complex lipid and sphingolipid super-pathways mediated the associations of BMI in early-life and MBD in premenopausal women. …”
Get full text

Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…Corticotropin-releasing factor (CRF) is a 41-amino-acid neuropeptide involved in stress responses initiated from several brain areas, including the amygdala formation. …”
Get full text

Effects of Fermented Soybean Meal Substituting Plant Protein and Fish Meal on Growth, Flesh Quality, and Intestinal Microbiota of Largemouth Bass (Micropterus salmoides) by Beibei Guo, Lingling Huang, Xiaoqin Li, Yunfeng Chen, Tianyu Huang, Lizhou Ma, Xiangjun Leng

“…Compared with the FSM-0 group, the flesh hardness, shear force, total collagen, hot soluble collagen, and total free amino acid contents of FSM-20 group were significantly increased, and FSM-10-SM group also presented higher flesh hardness and shear force. …”
Get full text

Screening of West Siberian patients with primary congenital glaucoma for CYP1B1 gene mutations by D. E. Ivanoshchuk, S. V. Mikhailova, O. G. Fenkova, E. V. Shakhtshneider, A. Z. Fursova, I. V. Bychkov, M. I. Voevoda

“…The latter can cause a frame shift, changed amino acid composition, and a formation of truncated in the protein. …”
Get full text

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…RNA sequencing illuminated a potential relationship between HVEM and GPT2, an enzyme tied to amino acid metabolism and cellular energetics. Subsequent experiments confirmed that HVEM’s influence on T cell activation and metabolism is potentially mediated through its regulation of GPT2. …”
Get full text

No rumen fermentation profiles and associated microbial diversities difference were found between Hu sheep and Karakul sheep fed a cottonseed hull diet by Jishu Wang, Guangxu E, Meng Zhang, Yanlong Zhang, Tiantian Bai, XuanXuan Pu, Junfeng Liu, Xuefeng Guo, Subir Sarker, Long Cheng

“…Metabolomic results revealed that the metabolic pathways in stage I were mainly concentrated in purine metabolism and lipid metabolism, while stage II was dominated by amino acid metabolism. Stage III involved mainly in pyrimidine and purine metabolism. …”
Get full text

Comparison of Predictive In Silico Tools on Missense Variants in GJB2, GJB6, and GJB3 Genes Associated with Autosomal Recessive Deafness 1A (DFNB1A) by Vera G. Pshennikova, Nikolay A. Barashkov, Georgii P. Romanov, Fedor M. Teryutin, Aisen V. Solov’ev, Nyurgun N. Gotovtsev, Alena A. Nikanorova, Sergey S. Nakhodkin, Nikolay N. Sazonov, Igor V. Morozov, Alexander A. Bondar, Lilya U. Dzhemileva, Elza K. Khusnutdinova, Olga L. Posukh, Sardana A. Fedorova

“…In silico predictive software allows assessing the effect of amino acid substitutions on the structure or function of a protein without conducting functional studies. …”
Get full text

Integrated metabolome and transcriptome analysis reveals key genes and pathways associated with egg yolk percentage in chicken by Wen Li, Yuxing Luo, Shoujia Zhu, Mengyuan Wang, Xuli Zhao, Zhonghua Ning

“…In the magnum, UGT1A1, MAOB, and ALDH3B2 participated in drug metabolism-cytochrome P450 and amino acid metabolism, ensuring a proper environment for egg white formation and potentially influencing nutrient allocation to the yolk. …”
Get full text