In Vitro and in Vivo Hypolipidemic Effects of Protein-Polysaccharide Complexes from Three Species of Edible Fungi by GAO Chen, LI Wen, CHEN Wanchao, WU Di, ZHANG Zhong, LIU Peng, XIA Yongjun, YANG Yan

“…Protein-polysaccharide complexes of Agaricus bisporus, Stropharia rugosa and Morchella esculenta were prepared and their protein and polysaccharide contents as well as amino acid and monosaccharide composition were evaluated. …”
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Pipeline for development of acylated peptide based CGRP receptor antagonist with extended half-life for migraine treatment by Jens Bjelke Kristensen, Lisbeth Elster, Morten Lundh, Borja Ballarín-González, Flora Alexopoulou, Martin Kræmer, Ditte Marie Jensen, Ulrike Leurs, Jens Christian Nielsen, Henrik H. Hansen, Kristian A. Haanes, Matilda Degn

“…An hαCGRP8-37 analogue conjugated with a C20 diacid at position 25 was subjected to an amino acid substitution scan to identify mutations that could further enhance hCGRP receptor antagonism. …”
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Evaluating the reflux suppression properties of Gaviscon Infant powder with different milk formulations using an in vitro model of the infant stomach by Fiona McLaughlin, Jeanine Fisher, Mark Atherton, Cathal Coyle

“…Various milk formulations are commercially available to help manage GER and CMPA symptoms (extensively hydrolyzed [eHF], partially hydrolyzed [pHF], and amino-acid formulas [AAF]). We aimed to understand if an alginate product (Gaviscon Infant powder) worked as intended in the presence of different milk formulations. …”
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Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy by Christopher R. Starr, Assylbek Zhylkibayev, Oleg Gorbatyuk, Alli M. Nuotio-Antar, James Mobley, Maria B. Grant, Marina Gorbatyuk

“…The retinal proteomic landscape revealed a decline in the KEGG pathways associated with phototransduction, amino acid metabolism, and cell adhesion. Furthermore, rod-specific caChREBP induced TXNIP expression. …”
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REVIEW ON PROTEIN FOOTPRINTING AS A TOOL IN STRUCTURAL BIOLOGY by Oluwatosin Ogundairo, Oluwatoyin Ayo-Farai, Chinedu Paschal Maduka, Chiamaka Chinaemelum Okongwu, Abdulraheem Olaide Babarinde, Olamide Sodamade

“…The study elucidates the underlying principles of these methods, discussing the mechanisms by which protein-footprinting agents interact with amino acid residues and elucidate structural details. …”
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Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis by Ding X, Bai Z, Wang W, Gu Y, Li Z, Fan Y

“…The core genes EIF2B4 and NRBP1, along with biological processes such as glycosylation and amino acid metabolism, may serve as crucial links.Keywords: androgenetic alopecia, fasting insulin, Mendelian randomization, GWAS, bioinformatics…”
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Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients by Esmat Khaleqsefat, Khder Hussein Rasul, Ramiar Kamal Kheder, Sonia Baban, Jamil Baban

“…This mutation altered the amino acid sequence in the flap domain, replacing isoleucine with a stop codon. …”
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Cost-effectiveness Analysis of Hypoallergenic Milk Formulas for the Management of Cow’s Milk Protein Allergy in the United Kingdom by Rui Martins, Mark P. Connolly, Eleanor Minshall

“…**Methods:** A trial-based decision analytic cohort model was developed to simulate the occurrence of urticaria, eczema, asthma, rhinoconjunctivitis, or being symptom-free in infants with CMPA in the United Kingdom. Amino acid-based formula (AAF), extensively hydrolysed casein formula containing Lactobacillus rhamnosus Gorbach Goldin (EHCF+LGG), extensively hydrolysed whey formula (EHWF), and soy formula (SF) were compared using the National Health Service (NHS) perspective, 3-year time horizon and 3.5% discount rate for cost and health consequences. …”
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The Effects of Garlic and Red Chilli Pepper Powder on Physicochemical, Microbiological, and Sensory Properties of Cincalok by Risa Nofiani, Novi Maulidi Syahmurdiandi, Puji Ardiningsih

“…Overall, the water, ash, and fat content; titratable acid (TA); total volatile base nitrogen (TVBN); and amino acid nitrogen (AAN) showed insignificant differences (p>0.05) among the recipes during 28 days of the same observation. …”
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Development of Fermentation-induced Soymilk Gel: Effects of Different Lactic Acid Bacteria on the Physicochemical Characteristics by Fatemeh Rahmani, Ali Moayedi, Marteza Khomeiri, Mahboobeh Kashiri

“…To understand the effects of acidifying and proteolytic activity of starter culture, syneresis, cell counts, free amino acid content (O-phthalaldehyde method), evaluation of proteolysis using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and textural parameters of soymilk gels during fermentation were investigated. …”
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Comparative analysis of acids and temperatures in gelatin extraction from the skin of yellowfin tuna (Thunnus albacares) by Vicky Prajaputra, Sri Agustina, Nadia Isnaini, Agillia Nabila, Hikma Kasih Margolang, Sahra Apriani, Siti Maqfirah

“…Further studies should assess the gel strength and amino acid composition of the extracted gelatin. Keywords: environmental chemistry below water biopolymer gelatin marine chemistry waste valorization yellowfin tuna…”
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First detection of the S989P+V1016G+D1763Y haplotype and expansion of voltage-gated sodium channel mutations in Aedes aegypti in Taiwan in 2016-2023. by Han-Hsuan Chung, Hwa-Jen Teng, Chin-Gi Huang, I-Jung Tsai, Hung-Jui Chen, Osamu Komagata, Shinji Kasai, Kun-Hsien Tsai, Shiu-Ling Chen

“…The frequencies of S989P, V1016G, T1520I, F1534C, and D1763Y amino acid variants increased over the surveillance period. …”
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Microbial diversity, functional attributes, and nutritional proficiency of yogurts produced in Bangladesh by Md. Tanvir Islam, M. Shaminur Rahman, Susmita Roy Chowdhury, Tanay Chakrovarty, S. M. Kador, Md. Mazharul Islam, Khondoker Tanjim Islam, Mohammad Imtiaj Uddin Bhuiyan, Ovinu Kibria Islam

“…Carbohydrate metabolism was dominant in both types, with increased amino acid metabolism (11.72%) and xenobiotics biodegradation (3.94%) in sour yogurt. …”
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Epigene functional diversity: isoform usage, disordered domain content, and variable binding partners by Leroy Bondhus, Aileen A. Nava, Isabelle S. Liu, Valerie A. Arboleda

“…Epigenes’ unique functions that require the assembly of pools within the nucleus suggest that their structure and amino acid composition would have been enriched for features that enable efficient assembly of chromatin and DNA for transcription, splicing, and post-translational modifications. …”
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Study of Antibacterial Activity of Root Bark, Leaves, and Pericarp Extracts of Diploknema butyracea and Evaluation of Prospective Antioxidant Activity by Alisha Karki Chhetry, Subhila Dhakal, Lalita Chaudhary, Khimdhoj Karki, Ram Bahadur Khadka, Gautam Prasad Chaudhary, Tonking Bastola, Amrit Poudel, Pramod Aryal, Jitendra Pandey

“…Phytochemical screening of different samples of D. butyracea in different solvents revealed the presence of varied extent of alkaloid, saponin, terpenoid, anthraquinones, tannin, cardiac glycoside, flavonoid, carbohydrate, polyphenol, protein and amino acid, resin, and phytosterol. Our study showed that methanolic root bark extract exhibited the potent antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Klebsiella pneumonia with an average zone of inhibition of 17.33 mm, 14.33 mm, and 13.0 mm, respectively. …”
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CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. by John T Loffredo, Thomas C Friedrich, Enrique J León, Jason J Stephany, Denise S Rodrigues, Sean P Spencer, Alex T Bean, Dominic R Beal, Benjamin J Burwitz, Richard A Rudersdorf, Lyle T Wallace, Shari M Piaskowski, Gemma E May, John Sidney, Emma Gostick, Nancy A Wilson, David A Price, Esper G Kallas, Helen Piontkivska, Austin L Hughes, Alessandro Sette, David I Watkins

“…All seven regions encoding Mamu-B*08-restricted CD8+ T cell epitopes also exhibit amino acid replacements typically seen only in the presence of Mamu-B*08, suggesting that the variation we observe is indeed selected by CD8+ T cell responses. …”
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In silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies by Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin, Anne S. De Groot

“…Computational tools that identify T cell epitopes from primary amino acid sequences have been used to assess the immunogenic potential of therapeutic candidates for several decades. …”
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Genetic analysis of nucleotide sequences of neuraminidase gene of highly pathogenic avian influenza A/H5N8 virus isolates recovered in the Russian Federation in 2020 by P. B. Akshalova, N. G. Zinyakov, A. V. Andriyasov, P. D. Zhestkov, Z. B. Nikonova, S. N. Kolosov, I. A. Chvala

“…During the analysis of the amino acid sequence of the studied isolates, no substitutions were found in the positions that affect resistance to neuraminidase inhibitors. …”
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Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach by Partha Biswas, Ommay Hany Rumi, Dhrubo Ahmed Khan, Md Nasir Ahmed, Nusratun Nahar, Rownak Jahan, Md Nazmul Hasan Zilani, Tridib K Paul, Anamul Hasan, Tohmina Afroze Bondhon, Khoshnur Jannat, Md Nazmul Hasan, Mohammed Rahmatullah

“…Melongosides B, F, and N showed interactions with His51, while melongoside G interacted with Asp75 of NS3, to be noted, these are important amino acid residues in the catalytic site of the NS3 protease. …”
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Tetracycline and chloramphenicol exposure induce decreased susceptibility to tigecycline and genetic alterations in AcrAB-TolC efflux pump regulators in Escherichia coli and Klebsi... by Nian Anwar Nasralddin, Mehri Haeili, Sasan Karimzadeh, Fatemeh Alsahlani

“…About 58% of variants (n = 7) carried genetic alterations in AcrAB regulators including ramR (frameshift mutations/locus deletion), MarR (L33R, A70T, G15S amino acid substitutions) and Lon (L630F change, frameshift mutation) which were associated with acrB upregulation. …”
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