Maillard reaction products in plant-based dairy alternatives and their release during simulated gastrointestinal digestion by Kira Bieck, Franziska Ebert, Tilman Grune, Jana Raupbach

“…During simulated gastrointestinal digestion, CML and MG-H1 were released either as modified amino acid or in peptide-bound form, respectively. CEL was released to a significantly lesser extent in peptide-bound form. …”
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Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans by Soo Heon Kwak, Yoon Ji Kim, Jeesoo Chae, Cue Hyunkyu Lee, Buhm Han, Jong-Il Kim, Hye Seung Jung, Young Min Cho, Kyong Soo Park

“…Although we had limited statistical power, we provide evidence that HLA haplotype and amino acid change can be a genetic risk factor of fulminant T1DM in Koreans. …”
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Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination by Darja Kanduc, Candida Fasano, Giovanni Capone, Antonella Pesce Delfino, Michele Calabrò, Lorenzo Polimeno

“…Proteins from poliovirus type 1, strain Mahoney, were analyzed for amino acid sequence identity to the human proteome at the pentapeptide level, searching for sequences that (1) have zero percent of identity to human proteins, (2) are potentially endowed with an immunologic potential, and (3) are highly conserved among poliovirus strains. …”
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Diversity of microbial communities in cigar filler leaves with different initial water contents analyzed based on high-throughput sequencing technology by Yumeng Gao, Yumeng Gao, Yihui Wang, Bingqing Hou, Guo Zhang, Chun Jiang, Song Fang, Qian Wang, Yang Ning

“…Functional predictions for the bacteria revealed their primary involvement in carbohydrate, lipid, and amino acid metabolism.ConclusionThe initial water content of cigar tobacco leaves influenced the structure and relative abundance of microbial communities during fermentation. …”
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Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1 by Pauline Malinge, Xavier Chauchet, Jérémie Bourguignon, Nicolas Bosson, Sébastien Calloud, Tereza Bautzova, Marie Borlet, Mette Laursen, Vinardas Kelpsas, Nadia Rose, Franck Gueneau, Ulla Ravn, Giovanni Magistrelli, Nicolas Fischer

“…Using homology modeling, the contributions of the amino acid modification to the affinity increase were analyzed. …”
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Guiding chili variety selection for Zao chili in Guizhou: Based on a systematic study of sensory, physicochemical, and volatile characteristics by Xueya Wang, Kuan Lu, Wenxin Li, Ju Chen, Yong Yin, Xiaojing Sun, Min Lu, Jianwen He

“…The ZC produced by FQB3 had the highest comprehensive sensory score (89.7), characterized by high total acid and amino acid nitrogen content and low crude fibre content. …”
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Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes by Miguel Vasconcelos Almeida, Moritz Blumer, Chengwei Ulrika Yuan, Pío Sierra, Jonathan L. Price, Fu Xiang Quah, Aleksandr Friman, Alexandra Dallaire, Grégoire Vernaz, Audrey L. K. Putman, Alan M. Smith, Domino A. Joyce, Falk Butter, Astrid D. Haase, Richard Durbin, M. Emília Santos, Eric A. Miska

“…The expanded piwil1 copies have signatures of positive selection and retain amino acid residues essential for catalytic activity. …”
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Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases by Karolin Wellner, Josefine Gnauck, Dorian Bernier, Stephan H. Bernhart, Heike Betat, Mario Mörl

“…This approach revealed unexpected requirements for amino acid composition in two motifs and gives new insights into the mechanism of CCA addition. …”
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Naturally Occurring Hepatitis B Virus B-Cell and T-Cell Epitope Mutants in Hepatitis B Vaccinated Children by Yu-Min Lin, Guey-Mei Jow, Shu-Chi Mu, Bing-Fang Chen

“…Fifteen, six, and eight amino acid substitutions within B-cell and T-cell epitopes of S, pre-S, and P regions were detected, respectively. …”
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Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus by Xu He, Xu He, Xu He, Wei Zhao, Wei Zhao, PeiHang Li, PeiHang Li, YinJiang Zhang, YinJiang Zhang, GuoHua Li, HongYu Su, BiNan Lu, BiNan Lu, ZongRan Pang, ZongRan Pang

“…Glucagon-like peptide-1 (GLP-1) is a 30-amino acid intestinal insulin-stimulating factor, which is mainly secreted by L cells in the distal ileum and colon. …”
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

“…Moreover, by identifying significantly smaller tripeptide pharmacophores of 14 amino acid PEPITEM, we may be able to deliver substantial financial advantages in synthesis and formulation. …”
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Catalase Biomimetic Sensor Based on Metal by Malikova Nurana Nahmad, Gurbanova Lala Maharram, Ali-Zadeh Nahmad Islam, Nagiev Tofik Murtuza, Shokhzod Ulashov, Kurbanova Shaxnoza

“…Enzymes are proteins with prosthetic groups, and proteins are polymers formed from amino acid links. The number of different enzymes in a cell is the same as the number of different chemical reactions that occur in it. …”
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Deficiency in Galectin-3 Promotes Hepatic Injury in CDAA Diet-Induced Nonalcoholic Fatty Liver Disease by Kazuhiro Nomoto, Takeshi Nishida, Yuko Nakanishi, Makoto Fujimoto, Ichiro Takasaki, Yoshiaki Tabuchi, Koichi Tsuneyama

“…We investigated whether galectin-3 is involved in the development of NASH by comparing galectin-3 knockout (gal3−/−) mice and wild-type (gal3+/+) mice with choline-deficient L-amino-acid-defined (CDAA) diet-induced NAFLD/NASH. Hepatic injury was significantly more severe in the gal3−/− male mice, as compared to the gal3+/+ mice. …”
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Production of antihypertensive and antidiabetic peptide fractions from quinoa (Chenopodium quinoa Willd.) by electrodialysis with ultrafiltration membranes by Adrián González-Muñoz, Marion Valle, Rotimi E. Aluko, Laurent Bazinet, Javier Enrione

“…Quinoa is a pseudo-cereal highlighted by its high protein content, amino acid profile and adapting growing conditions. …”
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Comparative transcriptomics and metabolomics provide insight into degeneration‐related physiological mechanisms of Morchella importuna after long‐term preservation by Ying Chen, Xuelian Cao, Liyuan Xie, Jie Tang, Lixu Liu, Di Wang, Xiang Wu, Tianhai Liu, Yang Yu, Yong Wang, Francis Martin, Weihong Peng, Hao Tan

“…Altogether, metabolic alterations related to sulfur‐containing amino‐acid biosynthesis, DNA repair, and cellular structural maintenance contributed to improved preservation outcomes in terms of morel fruiting capability. …”
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Thiacloprid exposure disrupts the gut-liver axis and induces liver dysfunction in the Reeves' turtles (Mauremys reevesii) by Shuqin Lin, Yunjuan Xiao, Siyu Li, Liyan Tang, Haitao Shi, Meiling Hong, Li Ding

“…Metabolomic and transcriptomic analyses indicated that metabolic dysregulation and differences in gene expression were concentrated in amino acid metabolism and lipid metabolism, ultimately resulting in severe liver damage and steatosis. …”
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A Novel Mutation of the Calcium-Sensing Receptor Gene Causing Familial Hypocalciuric Hypercalcemia Complicates Medical Followup after Roux-en-Y Gastric Bypass: A Case Report and a... by Elin Rebecka Carlsson, Mai-Britt Toft Nielsen, Anne Mette Høgh, Rikke Veggerby Grønlund, Mogens Fenger, Louise Ambye

“…Sequencing of the CaSR-gene revealed a mutation in nucleotide 437, changing the amino acid in position 146 from Glycine to Aspartate. …”
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The Chloroplastic Small Heat Shock Protein Gene KvHSP26 Is Induced by Various Abiotic Stresses in Kosteletzkya virginica by Xiaohua Liu, Lizi Zhao, Jianzhao Li, Lijun Duan, Kai Zhang, Xuqiang Qiao, Weihuan Li, Chengchao Zheng, Xiaoli Tang, Hongxia Zhang

“…Bioinformatics analyses revealed that KvHSP26 encoded a chloroplastic protein with the typical features of sHSPs. Amino acid sequence alignment and phylogenetic analysis demonstrated that KvHSP26 shared 30%-77% homology with other sHSPs from Arabidopsis, cotton, durian, salvia, and soybean. …”
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Citric Acid Improves Egg White Protein Foaming Characteristics and Meringue 3D Printing Performance by Huajiang Zhang, Shihui Hua, Mengzhuo Liu, Rui Chuang, Xin Gao, Hanyu Li, Ning Xia, Chaogeng Xiao

“…The secondary structure of CA-treated EWP remained intact, and the exposure of amino acid residues in the tertiary structure increased with the expansion of the hydrophobic region. …”
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Effect of Defatting Method on Japanese Quince (<i>Chaenomeles japonica</i>) Fruit Seed Protein Isolate Technological Properties by Danija Lazdiņa, Dalija Segliņa, Zaiga Anna Zvaigzne, Aldis Butlers, Inga Ciproviča

“…Defatting did not significantly affect amino acid composition but had a significant effect on every tested functional property (solubility, water, and oil binding capacity, apparent viscosity, foaming capacity, and emulsifying activity index). …”
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