Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets by Ding Nan, Weiping Yao, Luanluan Huang, Ruiqi Liu, Xiaoyan Chen, Wenjie Xia, Hailong Sheng, Haibo Zhang, Xiaodong Liang, Yanwei Lu

“…Abstract Glutamine is the most abundant amino acid in human serum, and it can provide carbon and nitrogen for biosynthesis, which is crucial for proliferating cells. …”
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Intermediate MCAD Deficiency Associated with a Novel Mutation of the ACADM Gene: c.1052C>T by Holli M. Drendel, Jason E. Pike, Katherine Schumacher, Karen Ouyang, Jing Wang, Mary Stuy, Stephen Dlouhy, Shaochun Bai

“…The replacement is a nonconservative amino acid change that occurs in the C-terminal all-alpha domain of the MCAD protein. …”
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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism by Jie An, Inna Astapova, Guofang Zhang, Andrew L. Cangelosi, Olga Ilkayeva, Hannah Marchuk, Michael J. Muehlbauer, Tabitha George, Joseph Brozinick, Mark A. Herman, Christopher B. Newgard

“…Despite suppression of pyruvate kinase, pyruvate levels are maintained, possibly via increased expression of pyruvate and amino acid transporters. In addition, expression of multiple anaplerotic enzymes is decreased by GalNac-siChREBP treatment, affecting TCA cycle intermediates. …”
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Oxidation state of bioavailable dissolved organic matter influences bacterioplankton respiration and growth efficiency by Brandon M. Stephens, Paolo Stincone, Daniel Petras, Chance J. English, Keri Opalk, Stephen Giovannoni, Craig A. Carlson

“…., more oxidized DOM), as detected by liquid chromatography-tandem mass spectrometry, coincided with increased hydrolyzable amino acid removal, increased ARQs and bacterioplankton respiration (BR), and a decreased bacterioplankton growth efficiency (BGE). …”
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Structural characterization of oligosaccharide from Spirulina platensis and its effect on the faecal microbiota in vitro by Bingna Cai, Xiangxi Yi, Qian Han, Jianyu Pan, Hua Chen, Huili Sun, Peng Wan

“…In addition, the change in intestinal microbiota function predicted by phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) after treatment with SPO-1 is mainly related to the terms “carbohydrate metabolism” and “amino acid metabolism”. These results suggest that SPO-1 is a potential oligosaccharide in regulation of intestinal microbiota.…”
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Citrulline – The Powerhouse Nutrient for Cardiometabolic and Brain Health by Daria Pedrycz, Mateusz Drabczyk, Emilia Pedrycz, Karolina Karoń, Grzegorz Drapała, Wojciech Grabowski, Łukasz Karoń, Anna Zygmunt, Sławomir Karoń

“…Citrulline, a non-essential amino acid and precursor to L-arginine, plays a pivotal role in nitric oxide (NO) synthesis, with profound implications for vascular health and neuroprotection. …”
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Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats by Haley A. Vecchiarelli, Chaitanya P. Gandhi, Matthew N. Hill

“…Tryptophan is an essential dietary amino acid that is necessary for protein synthesis, but also serves as the precursor for serotonin. …”
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Lead toxicity in Nicotiana tabacum L.: Damage antioxidant system and disturb plant metabolism by Tengfei Liu, Kai Zhang, Chunlan Ming, Jiashu Tian, Huanyu Teng, Zicheng Xu, Jiewang He, Fengfeng Liu, Yinghui Zhou, Jiayang Xu, Mohamed G. Moussa, Shenghua Zhang, Wei Jia

“…These results indicate that increasing the content of photosynthetic pigments and hormones, clearing reactive oxygen species by enhancing antioxidant enzyme activity, and improving amino acid metabolism may play an important role in reducing the toxicity of Pb to tobacco.…”
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Proteins from insects: A sustainable alternative for oral health within the one health concept and the planetary health diet by Marta Mazur, Maciej Jedliński, Irena Duś-Ilnicka, Artnora Ndokaj, Florence Carrouel, Livia Ottolenghi, Denis Bourgeois

“…By offering complete amino acid profiles, omega-3 fatty acids, and antimicrobial peptides, insect proteins may help address nutritional gaps and positively influence oral tissue regeneration and microbiome balance. …”
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Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms by Pengcheng Zhang, Zixian Zhou, Jiaqi Yao, Yuhong Jiang, Hang Lei, Zhijun Xie, Juan Li, Xianlin Zhao, Lv Zhu, Meihua Wan, Ling Liu, Wenfu Tang

“…RNA sequencing and metabolomic analyses revealed that the pathways affected by DDVP exposure in hepatocytes include ABC transporters and amino acid biosynthesis processes. Furthermore, targeting IRGM overexpression through hepatic portal vein injection of adeno-associated virus mitigated DDVP-induced liver injury. …”
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Unveiling inverted D genes and D-D fusions in human antibody repertoires unlocks novel antibody diversity by Ponraj Prabakaran, Abhinav Gupta, Sambasiva P. Rao, Deepak Rajpal, Maria Wendt, Yu Qiu, Partha S. Chowdhury

“…These InvDs utilize all three reading frames during translation, producing distinct amino acid profiles enriched in histidine, proline, and lysine in CDR-H3s of antibodies with potential functional diversity. …”
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Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics by Xiao Ma, Tengda Huang, Xiangzheng Chen, Qian Li, Mingheng Liao, Li Fu, Jiwei Huang, Kefei Yuan, Zhen Wang, Yong Zeng

“…Viewed through the lens of metabolic reprogramming, these pathways highlight how shifts in glucose, lipid, and amino acid metabolism support the cellular functions essential for liver repair and regeneration. …”
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Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1H NMR-Based Metabolomics Analysis by Yu Hao, Hong Zheng, Ruo-Han Wang, Hui Li, Li-Li Yang, Suwas Bhandari, Yong-Jian Liu, Jun Han, Fang Gao Smith, Hong-Chang Gao, Sheng-Wei Jin

“…However, these metabolic disorders, mainly involving energy and amino acid metabolism, can be recovered by MaR1 treatment. …”
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Co-Existing Nanoplastics Further Exacerbates the Effects of Triclosan on the Physiological Functions of Human Serum Albumin by Yan Bao, Yaoyao Wang, Hongbin Liu, Jing Lan, Zhicai Li, Wansong Zong, Zongshan Zhao

“…The experimental results show that TCS significantly inhibits HSA esterase activity, with exacerbating inhibition in the presence of PSNPs, which is attributed to the alteration of HSA conformation and microenvironment of the amino acid residues induced by PSNPs. Molecular docking and site marker competitive studies indicate that TCS predominantly binds to site I of subdomain Sudlow II and the presence of PSNPs does not affect the binding sites. …”
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Antiemetic activity of Sesamol possibly through serotonergic and dopaminergic receptor interaction pathways: In vivo and in silico studies by Touhidul Islam Tanim, Ayman M. Al-Qaaneh, Raihan Chowdhury, Md. Shimul Bhuia, Tabassum Islam, Md Showkoth Akbor, Md. Tahajul Islam, Md. Mohasin Miah, Ali Raza Ishaq, Mostafa A. Abdel-Maksoud, Mohamed A. El-Tayeb, Mohamed El-Shazly, Muhammad Torequl Islam, Heba A.S. El-Nashar

“…An in-silico study showed SEL has moderate binding activity (−5.9 and − 5.7 kcal/mol) for serotonin (5HT3) and dopaminergic (D2) receptors, respectively, via hydrogen and hydrophobic bonds with specific amino acid residues.…”
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Microalgal proteins as ingredients for creating dairy mimetic products: Prospects for substituting bovine milk proteins by Jayani Samarathunga, Thi Phuong Linh Le, Max Gabard, Katrina Strazdins, Jeroen Rens, Benu Adhikari

“…Due to their balanced amino acid profile, high digestibility, and superior techno-functional properties, microalgal proteins are emerging as promising ingredients, often outperforming terrestrial plant proteins in several respects. …”
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A Novel Spontaneous Mutation of the SOX10 Gene Associated with Waardenburg Syndrome Type II by Sen Chen, Yuan Jin, Le Xie, Wen Xie, Kai Xu, Yue Qiu, Xue Bai, Hui-Min Zhang, Xiao-Zhou Liu, Xiao-Hui Wang, Wei-Jia Kong, Yu Sun

“…According to analysis based on nucleic acid and amino acid sequences, this mutation may produce a truncated protein, with loss of the HMG structure domain. …”
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Effects of in situ experimental warming on metabolic expression in a soft sediment bivalve by Orlando Lam-Gordillo, Emily J. Douglas, Sarah F. Hailes, Vonda Cummings, Andrew M. Lohrer

“…The metabolic response was related to pathways such as metabolic energetics, amino acid and lipid metabolism, and accumulation of stress-related metabolites. …”
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Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate by Hui-Min Yap, Kwan-Liang Lye, Loh Teng-Hern Tan

“…The increased concentration of extracellular glutamate has been reported to play a key role in most of the neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, even though its importance as an amino acid neurotransmitter in mammalian. Glutamate toxicity, which can be caused by excessive intake of monosodium glutamate (MSG), is the major contributor to pathological neuronal cell death. …”
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The effects of citrulline supplementation on athlete´s performance: systematic review by Silvia Burgos, Aysu Dursun, Valentin Emilio Fernández Elias

“… Background: Citrulline is a non-essential amino acid that may enhance exercise performance and reduce soreness after exercise. …”
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