HbS-Sicilian (δβ)0-Thalassemia: A Rare Variant of Sickle Cell by Grace Onimoe, Genine Smarzo

“…Sickle cell disease (SCD) is caused by a mutation in the sixth codon of the β-globin gene on chromosome 11, which leads to a single amino acid substitution (glutamine to valine). Sickle-(δβ)0-thalassemia is a rare variant of sickle cell disease (delta-beta thalassemia occurring in association with sickle hemoglobin, HbS), sparsely reported in literature, and has been associated with symptomatology necessitating careful monitoring and follow-up. …”
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Emerging Trends in Bioavailability and Pharma-Nutraceutical Potential of Whey Bioactives by Adhithyan T. Pillai, Sonia Morya, Ladislaus Manaku Kasankala

“…Whey proteins exhibit great potential as biopolymers for creating bioactive delivery systems owing to their distinct health-enhancing characteristics and the presence of numerous amino acid groups within their structures. Whey has considerable factors such as antitumor, anti-inflammatory, antihypertensive, hypolipidemic, antiviral, and antibacterial properties in addition to chelating. …”
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HEALTH-PROMOTING PROPERTIES OF BROAD BEANS (VICIA FABA L.) by Alicja Baranowska

“…GABA (gamma-aminobutyric acid), present in broad beans, is an amino acid that lowers blood pressure. Bean seeds contain anti-nutritional substances, e.g. vicin and convicin, which exacerbate the symptoms of hemolytic anemia known as favaism. …”
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Fast and Sensitive Method for Determination of Domoic Acid in Mussel Tissue by Elena Barbaro, Roberta Zangrando, Carlo Barbante, Andrea Gambaro

“…Domoic acid (DA), a neurotoxic amino acid produced by diatoms, is the main cause of amnesic shellfish poisoning (ASP). …”
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Recent advances in L-Asparaginase enzyme production and formulation development for acrylamide reduction during food processing by Arindam Jana, Soumyajit Biswas, Ritu Ghosh, Rahul Modak

“…L-asparagine is an essential amino acid for cell growth and common constituent of all the proteins. …”
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Harmonious regulation flavor and lipid oxidation in dry-cured tenderloin through electrical stimulation: A study on lipase activity and sensory correlations by Lisha Lan, Li Chen, Xiaolin Zhong, Weiguo Cao, Ying Zhou, Jing Wan, Yuanyuan Liu, Qinjin Zhu

“…Compared to the control group, the electrically stimulated samples exhibited higher total amino acid and fatty acid contents. Furthermore, the electrically stimulated group demonstrated superior taste (as assessed by an electronic tongue) and aroma profiles (as assessed by an electronic nose). …”
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The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? by Sonja S. Mojsilovic, Slavko Mojsilovic, Victor H. Villar, Juan F. Santibanez

“…Here, we review the main functional TAM metabolic patterns influenced by TME, including glycolysis, amino acid, and fatty acid metabolism. Moreover, this review discusses antitumor immunotherapies that affect TAM functionality by inducing cell repolarizing and metabolic profiles towards an antitumoral phenotype. …”
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Wet pulverization combined with temperature cycling strategy for extraction of Stropharia rugosoannulata protein with attenuating hepatic steatosis on obese mice by Peng Liu, Chen Gao, Wen Li, Wanchao Chen, Zhong Zhang, Di Wu, Tingzhao Li, Shuai Sun, Yan Yang

“…Herein, S. rugosoannulata protein (SRA) with mainly molecular weight of 15, 40 and 50 kDa, complete amino acid composition and typical α-helix structure, was obtained by wet pulverization combined with temperature cycling strategy. …”
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Mini review of plant products as food supplement against MSG-induced liver injury: antioxidant, oxidative stress and histological prospects by Dwi Pratiwi Kasmara, Erlina Abdullah, Zaliha Harun, Fatmi Nirmala Sari, Norhashima Abd Rashid, Seong Lin Teoh

“…Monosodium glutamate (MSG) is an odorless white solid crystalline derived from the amino acid glutamic acid. It is widely used as a flavor enhancer, but its excessive consumption has been associated with toxicity to various organs. …”
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Effect of dual targeting procyanidins nanoparticles on metabolomics of lipopolysaccharide-stimulated inflammatory macrophages by Shanshan Tie, Lijuan Zhang, Bin Li, Shanghua Xing, Haitao Wang, Yannan Chen, Weina Cui, Shaobin Gu, Mingqian Tan

“…The double-targeting PC nanoparticles had better inhibitory effect than single-targeting PC nanoparticles on the leakage of lactate dehydrogenase and reactive oxygen species overexpression induced by LPS. Amino acid metabolism, energy metabolism and purine metabolism were disordered in LPS-treated group, and metabolic pathway analysis indicated that the double-targeting PC nanoparticles reversed some of LPS impacts. …”
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Pompe Disease Could Mimic Exam Findings of Amyloidosis: Two Rare Diagnoses Bona Fide by Jithma P. Abeykoon, Narjust Duma, Jennifer A. Tracy, Margherita Milone, Ronald Go

“…Given the classic physical finding of macroglossia, the patient underwent extensive evaluation for amyloidosis which proved to be negative apart from a bone marrow biopsy which stained positive for transthyretin without amino acid sequence abnormality, thus giving wild-type transthyretin amyloidosis. …”
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Comparative Glycopeptide Analysis for Protein Glycosylation by Liquid Chromatography and Tandem Mass Spectrometry: Variation in Glycosylation Patterns of Site-Directed Mutagenized... by Young Hye Hahm, Sung Ho Hahm, Hyoun Young Jo, Yeong Hee Ahn

“…Furthermore, the comparative analysis of a mutagenized rAb glycoprotein proved that a single amino acid mutation in the Fc portion of the antibody molecule caused increased variations in glycosylation patterns. …”
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Effect of Phosphate Starvation on Gene Expression in <i>Komagataella phaffii</i> Cells by Valeria V. Ishtuganova, Anton V. Sidorin, Anastasiya S. Makeeva, Marina V. Padkina, Andrey M. Rumyantsev

“…<i>K. phaffii</i> cells demonstrated a response to this macronutrient deficiency through an altered gene expression of carbon and amino acid metabolism. We observed the activation of phosphate and polyphosphate metabolism gene expression. …”
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Purification and immunoglobulin E epitopes identification of low molecular weight glutenin: an allergen in Chinese wheat by Yanbo Wang, Yihang Tong, Jinru Zhou, Dong Yang, Linglin Fu

“…Two specific epitopes were found to be in the non-conserved region of the amino acid sequence of LMW-GS, which was speculated to be the specific epitope of Chinese wheat. …”
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A Lipocalin-Derived Peptide Modulating Fibroblasts and Extracellular Matrix Proteins by Linda Christian Carrijo-Carvalho, Durvanei A. Maria, Janaina S. Ventura, Kátia L. P. Morais, Robson L. Melo, Consuelo Junqueira Rodrigues, Ana Marisa Chudzinski-Tavassi

“…Lipocalins are β-barrel proteins, which have three conserved motifs in their amino acid sequence. One of these motifs was shown to be a sequence signature involved in cell modulation. …”
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Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain by Alexandra Dumitriu, Carlee Moser, Tiffany C. Hadzi, Sally L. Williamson, Christopher D. Pacheco, Audrey E. Hendricks, Jeanne C. Latourelle, Jemma B. Wilk, Anita L. DeStefano, Richard H. Myers

“…We examined expression of the full-length SNCA transcript (140 amino acid protein isoform), as well as total SNCA mRNA levels in 165 frontal cortex samples (101 PD, 64 control) using quantitative real-time polymerase chain reaction. …”
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Hemoglobins Likely Function as Peroxidase in Blood Clam Tegillarca granosa Hemocytes by Sufang Wang, Xiaopei Yu, Zhihua Lin, Shunqin Zhang, Liangyi Xue, Qinggang Xue, Yongbo Bao

“…Tg-Hbs shared few similarities in amino acid sequence and overall structural characteristics with known peroxidases. …”
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Biochemical, dielectric and surface characteristics of freeze-dried donkey milk powder by Renu Garhwal, Anuradha Bhardwaj, Harish Kumar, Karnam Sangwan, Ankur Kumari, Bhavya, Manjjri Singal, Varij Nayan, Yash Pal, Tarun Kumar Bhattacharya, B. N. Tripathi

“…DMP contains notably, high lactose content (62.09%), protein content was determined to be 21.49% with having relatively low-fat content (2.19%). Minerals, amino acid, and fatty acid profiles highlighted nutritional value of DMP. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Moreover, energy metabolism and amino acid metabolism were the main signaling pathways in response to cold stress for <i>P. sinensis</i>.…”
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Discovery of Novel Inhibitors for Nek6 Protein through Homology Model Assisted Structure Based Virtual Screening and Molecular Docking Approaches by P. Srinivasan, P. Chella Perumal, A. Sudha

“…The overall quality of computed model showed 87.4% amino acid residues under the favored region. A 3 ns molecular dynamics simulation confirmed that the structure was reliable and stable. …”
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