The impact of a hazardous external environment on the quality of life, physical activity, and health of students in Ukraine, Poland, and Romania by Vladimir Potop, Igor Vypasniak, Iryna Ivanyshyn, Vasyl Lutskyi, Iryna Kryventsova, Lyudmila Shesterova, Krzysztof Prusik

“…The results were processed using PyCharm CE and specialized Python codes with relevant libraries. Cronbach's alpha coefficient (α Cronbach's = 0.765) was used to assess the internal consistency of the questionnaire responses. …”
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Fiber-optic system for monitoring stability of quarry slopes by P. Sh. Madi, А. D. Аlkina, A. V. Yurchenko, A. D. Mekhtiyev, R. Zh. Aimagambetova

“…The experimental data obtained are processed using the Wolfram Alpha computer program. A hardware-software control complex has also been developed with a wide range of elements that allows you to adjust sensitivity and has machine learning elements.…”
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Cross-cultural validation and reference norms for the DCDDaily-Q questionnaire Chinese version (DCDDaily-Q-CN): evaluating children’s motor performance in activities of daily livin... by Meihuan Huang, Yujun Zhan, Haishan Zhou, Ping Song, Yanping Fan, Yang Lu, Yijing Chen, Zhen Lv, Qing Liu, Guojun Yun, Jianguo Cao

“…The instrument demonstrated excellent internal consistency across the total and the three subscales (Cronbach’s alpha = 0.83–0.91). The confirmatory factor analysis showed a good fit for the original three-factor model (CFI = 0.936, RMSEA = 0.049). …”
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Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…Methods Tumor necrosis factor-alpha (TNF-α) induced inflammation in RA-derived fibroblast-like synoviocytes (RA-FLS), and the expression of proinflammatory mediators was assessed using q-RT PCR and ELISA after treatment with various SBR concentrations. …”
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Validação do questionário de saúde e performance para policiais e bombeiros militares (QSPM) by Anderson Caetano Paulo, Cintia de Lourdes Nahhas Rodacki, Hallyne Bergamini Silva Caetano, Alexandre dos Santos Cabral, Rodrigo Hoinatski, Cristiano Israel Caetano, Ciro Romelio Rodriguez-Añez, Rogério César Fermino

“…A reprodutibilidade apresentou valores de %C entre 97,2 - 100,0%, Kappa entre 0,94 - 1,00 (p < 0,05) e alpha de Cronbach entre 0,80 - 1,00 (p < 0,05). Conclui-se que o QSPM apresentou validade de conteúdo, constructo e fidedignidade para avaliar a frequência da demanda física e operacional, as condições de saúde e de trabalho de policiais e bombeiros militares. …”
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Co-occurrence of entomopathogenic nematodes and earthworms enhances enduring biocontrol activity and microbial diversity in a naturalized plant-soil system by Maryam Chelkha, Rubén Blanco-Pérez, David Labarga, María de Toro, Jorge Dueñas-Hernani, Kyle Wickings, Raquel Campos-Herrera

“…Bacterial community changes were observed 30 days post-inoculation, with increased alpha diversity in co-applications of EPNs and EWs. …”
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Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil by Eliana Lucchinetti, Phing-How Lou, Alessandro Quaranta, Craig E. Wheelock, Akash Chakravarty, Martin Hersberger, Stefanie D. Krämer, Michael Zaugg

“…Tumor necrosis factor alpha and interleukin-6 (IL6) tissue concentrations were increased in livers of mice in the SMOF group and interleukin-6 (IL6) to interleukin-10 (IL10) ratios were lower in livers and epididymal white adipose tissue of mice in the VEGA group. …”
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Therapeutic Potential of Clove Oil in Mitigating Cadmium-Induced Hepatorenal Toxicity Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Mechanisms by Inas M. Elgharib, Fatma M. Abdelhamid, Gehad E. Elshopakey, Hatem Sembawa, Talat A. Albukhari, Waheed A. Filimban, Rehab M. Bagadood, Mohamed E. El-Boshy, Engy F. Risha

“…Cadmium toxicity caused elevated expression of liver apoptosis markers, such as tumor necrosis factor-alpha (TNF-α) and caspase-3, and inflammation. CLO ameliorated the oxidative effects of Cd through decreasing urea (27.4%), creatinine (41.6%), liver enzymes, and hepatic apoptotic markers while increasing levels of total protein, albumin, and hepatic values of SOD (60.37%), CAT (64.49%), GSH (50.41%), and GST (9.16%). …”
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Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…Furthermore, tumor necrosis factor-alpha- (TNF-α-) induced expression of phosphorylated c-Jun N-terminal kinases (JNK) and P38 MAPK were inhibited by iguratimod. …”
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Effects of Stocking Density on Fatty Acid and Amino Acid Composition in Muscle, Serum Cortisol, Stress and Immune Response in Large Yellow Croaker (<i>Larimichthys crocea</i>) by Youbin Yu, Liang Wang, Wenyun Huang, Duo Yu, Qiaoxuan Sun, Mingcao Cui

“…Results of immune response analyses showed that there was a clear decrease in immunoglobulin M (IgM), complement component 4 (C4), and lysozyme (LZM) in serum, lysozyme (LZM) genes, tumor necrosis factor-alpha (TNF-α) genes and interleukin-1β (IL-1β) genes in the head kidney of large yellow croakers reared in the HD group. …”
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Role of Gut and Urinary Microbiome in Children with Urinary Tract Infections: A Systematic Review by Anjali Srivastava, Omprakash Shete, Annu Gulia, Sumit Aggarwal, Tarini Shankar Ghosh, Vineet Ahuja, Sachit Anand

“…The consistent loss of microbiome alpha-diversity with an enrichment of specific putative pathobiont microbes was observed among the included studies. …”
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Validity and reliability of the brief form of the normative male alexithymia scale among Chinese patients after radical prostatectomy by F. Wang, X. Zhang, L. Huang, X. Zhang, W. Jie, X. Chang, Y. Chu, L. Wang, W. Jia, B. Zhang

“…Additionally, Pearson’s correlation, t-tests, and analysis of variance (ANOVA) were used to identify factors influencing the NMAS-BF. The Cronbach’s alpha coefficient for the Chinese version of the NMAS-BF was 0.856. …”
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Cassava–soybean intercropping alleviates continuous cassava cropping obstacles by improving its rhizosphere microecology by Huixian Chen, Lixia Ruan, Sheng Cao, Wen He, Haixia Yang, Zhenhua Liang, Hengrui Li, Wanling Wei, Zhenling Huang, Xiu Lan

“…However, there was significant positive correlation with phenol glucuronide, alpha-CEHC deoxyguanosine and other carbohydrates, nucleotide substances, organic matter, and pH. …”
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Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial) by Stepan Havranek, Jiri Jarkovsky, Otakar Jiravský, Pavel Osmancik, Veronika Bulková, Jan Chovančík, Tomáš Roubíček, Dalibor Heřman, Zuzana Čarná, Vladimír Tuka, Martin Matoulek, Martin Fiala, Sylvie Stregl-Hruskova, Adam Latiňák, Jiřina Kotryová

“…An AF freedom of 65% in the RFM+AAD and of 60% in the CA is expected; therefore, 202 patients will be enrolled to achieve the non-inferiority with 80% power, 5% one-sided alpha and a non-inferiority margin of 12%.Ethics and dissemination The PRAGUE-25 trial will determine if modern non-invasive AF treatment strategies are non-inferior to CA. …”
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Fluoride exposure, personal susceptibility and osteoarticular degeneration: Evidence from farmers in the Yellow River Basin of Henan Province by Zichen Feng, Long Sun, Shu Niu, Bin Liu, Ruijie Ba, Guoqing Wang, Qing Sun, Chunxiang Li, Yan Wang, Fangfang Yu, Guoyu Zhou, Yue Ba

“…Genetic susceptibility analysis showed that the CG genotype of calcitonin related polypeptide alpha (CALCA) rs1553005 loci was related to higher OAD risk (OR=1.959; 95 %CI: 1.003, 3.825), whereas higher methylation status of GNAS complex locus (GNAS) (OR=0.617; 95 %CI: 0.410, 0.929) and TC genotype of rs7121 loci (OR=0.569; 95 %CI: 0.371, 0.871) showed protective effect on OAD. …”
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Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation by Roos-Marijn Berbers, Fernanda L. Paganelli, Joris M. van Montfrans, Pauline M. Ellerbroek, Marco C. Viveen, Malbert R. C. Rogers, Moniek Salomons, Jaap Schuurmans, Martine van Stigt Thans, Remi M. M. Vanmaris, Lodewijk A. A. Brosens, Maria Marlot van der Wal, Virgil A. S. H. Dalm, P. Martin van Hagen, Annick A. J. M. van de Ven, Hae-Won Uh, Femke van Wijk, Rob J. L. Willems, Helen L. Leavis

“…Increased bacterial load, decreased alpha diversity and distinct beta diversity were observed in CVIDid (n = 42) compared to HC (n = 48), and similar results were seen in CVID with IgA deficiency (n = 40) compared to HC. …”
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Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC by Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye

“…Abstract Background Integrin alpha 5 (ITGA5) was previously confirmed to be related to prognosis in several cancer types; however, its function in clear cell renal cell carcinoma (ccRCC) and how this molecule regulates tumor progression and the tumor microenvironment (TME) remain to be elucidated. …”
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From α-to β-diversity: Understanding the historical, present, and future diversity patterns of Fagaceae in Southwestern China by Bikram Pandey, Fengying Zhang, Basu Dev Poudel, Rong Li, Mohammed A. Dakhil, Bishal Gurung, Zhaxi Luobu, Yawen Gan, Ziyan Liao, Lin Zhang

“…This study investigates the alpha (α) and beta (β) diversity facets of Fagaceae across past (historical), present, and future timelines in Southwestern China. …”
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Normal butanol fraction of Polygonum hydropiper L. flavonoids reduces inflammation caused by PCV2 infections in cell and mouse models by Yu-heng Wei, Shu-mian Zhou, Shu-mian Zhou, Shu-mian Zhou, Wen Zhao, Qi Chen, Qiu-hua Wang, Qiu-hua Wang, Mei-ling Yu, Ying-yi Wei, Ting-jun Hu, Ting-jun Hu, Ting-jun Hu

“…Inflammatory factors such as Monocyte Chemoattractant Protein-1 (MCP-1), interleukin-6 (IL-6), IL-8, IL-10, Tumor Necrosis Factor-alpha (TNF-α), Reactive Oxygen Species (ROS), and Nitric Oxide (NO) were quantified using ELISA, RT-qPCR and immunohistochemistry.ResultsResults showed that a PCV2 titer of 104.5 TCID50/0.1 mL when applied to RAW264.7 cells effectively established an in vitro inflammatory model at 12 and 24 h post-infection. …”
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Energy management education for persons living with long COVID-related fatigue (EMERGE): protocol of a two-parallel arms target trial emulation study in a multicentre outpatient in... by Emilia Riggi, Marco Barbero, Gian Luca Di Tanna, Ruth Hersche, Andrea Weise

“…The estimated sample size to detect a post-intervention difference of 1.5 points in self-efficacy to implement energy conservation strategies with 90% power (0.05 alpha) is 122 people (1:1 ratio).Persons with long COVID-related fatigue who follow EME as part of their standard care will be recruited and included in the experimental group (EG), while potential participants for the control group (CG) will be recruited from a register and prospectively matched to a participant in the EG by applying the propensity score technique. …”
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