Peripheral Expression of IL-6, TNF-α and TGF-β1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

“…Therefore, we analyzed serum interleukin-6 (IL-6) and transforming growth factor-beta 1 (TGF-β1) levels and mRNA expressions of IL-6 and tumor necrosis factor-alpha (TNF-α) in peripheral blood mononuclear cells of AD patients and controls. …”
Get full text

CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…Cluster of differentiation 47 (CD47) is a transmembrane protein highly expressed in tumor cells that interacts with signal regulatory protein alpha (SIRPα) and triggers a “don’t eat me” signal to the macrophage, inhibiting phagocytosis and enabling tumor escape from immunosurveillance. …”
Get full text

The Prognostic Value of CRP/Alb Ratio in Predicting Overall Survival for Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Combined with Molecular-Targeted... by Huang X, Peng G, Kong Y, Cao X, Zhou X

“…The discriminatory capability of inflammation-based prognostic scores—including the CRP/Alb ratio, C-reactive protein and alpha-fetoprotein in immunotherapy (CRAFITY) score, modified Glasgow prognostic score (mGPS), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII)—was assessed using the area under the curve (AUC).Results: A total of 133 patients met the inclusion criteria. …”
Get full text

Performance Evaluation of Large Language Models in Cervical Cancer Management Based on a Standardized Questionnaire: Comparative Study by Warisijiang Kuerbanjiang, Shengzhe Peng, Yiershatijiang Jiamaliding, Yuexiong Yi

“…Seven models (ChatGPT-4.0 Turbo, Claude 2, Gemini Pro, Mistral-7B-v0.2, Starling-LM-7B alpha, HuatuoGPT, and BioMedLM 2.7B) provided stable responses. …”
Get full text

Retinal Protection of New Nutraceutical Formulation by Luca Rosario La Rosa, Veronica Pepe, Francesca Lazzara, Giovanni Luca Romano, Federica Conti, Erika Giuffrida, Claudio Bucolo, Santa Viola, Giuseppe De Pasquale, Maria Cristina Curatolo, Cristina Zappulla

“…Finally, Epicolin treatment on DBA/2J mice protected the RGCs from loss of function, as demonstrated by PERG analysis, and attenuated their death by enhancing brain-derived neurotrophic factor (<i>BDNF</i>) and reducing interleukin-1 beta (<i>IL-1β</i>) and tumor necrosis factor-alpha (<i>TNF-α</i>) expression. <b>Conclusions:</b> Epicolin, due to its neuroprotective, antioxidant, and anti-inflammatory properties, represents a promising potential treatment for glaucoma.…”
Get full text

Ursolic acid attenuates obesity-related metabolic dysfunction via modulation of peroxisome proliferator activated receptor-gamma in male Wistar rats fed with high-carbohydrate high... by Oluwatosin O. Omodara, Mohammed U. Kawu, Ibrahim G. Bako, Daniel H. Mhya, Theophilus T. Dawus

“…UA significantly decreased serum tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) and increased adiponectin level compared to the HCHFD + DW-fed animals. …”
Get full text

Evaluation of the merit of ethanolic extract of Annona reticulata as an anti-cancer agent in human colon cancer cell lines (HCT-116) [version 2; peer review: 2 approved, 1 not appr... by Sri Pragnya Cheruku, Krishnananda Prabhu, Akshatha G Nayak, Vijetha Shenoy Belle, Vanishree Rao, Pooja Prakash Rao, Nitesh Kumar

“…-sitosterol (10.45%), alpha.-tocopherol-beta.-D-mannoside (7.50%) and 3-amino-4-piperonyl-5-pyrazolone (5.84%). …”
Get full text

The Development and Initial Validation of the REST Questionnaire: A Multidimensional Tool for Assessing Fatigue in Individuals with and Without a History of Cancer by Giuseppe Di Lorenzo, Carlo Buonerba, Raffaele Baio, Eleonora Monteleone, Francesco Passaro, Antonio Tufano, Vittorino Montanaro, Vittorio Riccio, Ilaria Gallo, Francesca Cappuccio, Federica Fortino, Anna Buonocore, Federica Monaco, Antonio Verde, Anna Rita Amato, Oriana Strianese, Ferdinando Costabile, Luca Scafuri

“…Results: The REST Questionnaire demonstrated excellent internal consistency (Cronbach’s alpha = 0.918) and construct validity. Higher fatigue scores were associated with lower well-being, female gender, and the presence of certain chronic conditions (cancer, kidney stones, gastric ulcers). …”
Get full text

Internal Facilitation by Health Assistants for the &ldquo;WHO Lay Health Worker Dementia Care&rdquo; in Rural Uganda: A Formative Evaluation by Wakida EK, Obua C, Rukundo GZ, Samantha M, Maling S, Karungi CK, Talib ZM, Haberer J, Bartels SJ

“…Edith K Wakida,1,2 Celestino Obua,2 Godfrey Zari Rukundo,3 Mary Samantha,2 Samuel Maling,4 Christine K Karungi,2 Zohray M Talib,1 Jessica Haberer,5,6 Stephen J Bartels5,6 1Department of Medical Education, California University of Science and Medicine, Colton, California, USA; 2Department of Research and Development, Alpha Center for Research Administration, Mbarara, Uganda; 3Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada; 4Department of Psychiatry, Mbarara University of Science and Technology, Mbarara, Uganda; 5Department of Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; 6Harvard Medical School, Harvard University, Boston, Massachusetts, USACorrespondence: Edith K Wakida, Email Edith.Wakida@cusm.eduBackground: Dementia is characterized by cognitive symptoms like memory loss, difficulty with language, and impaired judgment, alongside behavioral and psychological symptoms such as depression, anxiety, and aggression. …”
Get full text

AI-optimized electrochemical aptasensors for stable, reproducible detection of neurodegenerative diseases, cancer, and coronavirus by Amira Elsir Tayfour Ahmed, Th.S. Dhahi, Tahani A. Attia, Fawzia Awad Elhassan Ali, Mohamed Elshaikh Elobaid, Tijjani Adam, Subash C.B. Gopinath

“…Similarly, Square Wave Voltammetry (SWV) and potentiometric sensors have detected alpha-fetoprotein (AFP) at 5 fM and epithelial cell adhesion molecule (EpCAM) at 100 fM, respectively. …”
Get full text

Serum Vitamin A and Inflammatory Markers in Individuals with and without Chronic Obstructive Pulmonary Disease by L. M. O. Caram, R. A. F. Amaral, R. Ferrari, S. E. Tanni, C. R. Correa, S. A. R. Paiva, I. Godoy

“…We evaluated dietary intake, serum and sputum vitamin A, tumor necrosis factor alpha, interleukin- (IL-) 6, IL-8, and C-reactive protein in 50 COPD patients (age = 64.0 ± 8.8 y; FEV1 (forced expiratory volume in the first second) (%) = 49.8 ± 16.8) and 50 controls (age = 48.5 ± 7.4 y; FEV1 (%) = 110.0 ± 15.7). …”
Get full text

Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC by Kai-Xia Zhou, Shan Huang, Li-Peng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Lin-Li Yao, Yanqiu Yu, Yao-Qi Zhou, Lei Zhu, Jianguang Ji, Zhi-Gang Zhang

“…Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. …”
Get full text

The Innovation Intermediaries Role in the Adoption of Emerging Technologies in Iran's Automotive Industry by Ali Maleki, Hadi Nilforoushan

“…The reliability and validity of the research instrument were measured using composite reliability tests, factor loadings, Cronbach's alpha, convergent, and divergent validity. The data were analyzed using SmartPLS 3 and SPSS 24. …”
Get full text

Outcomes of COVID-19 in the Omicron-predominant wave: large-scale real-world data analysis with a comparison to influenza by Koichi Miyashita, Hironao Hozumi, Kazuki Furuhashi, Eiji Nakatani, Yusuke Inoue, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Toshiyuki Ojima, Takafumi Suda

“…Results The mortality rates (average number of deaths/cases per week) of COVID-19 decreased over time, being 2.7% (169/6312), 2.1% (397/18,754), 0.7% (195/28,273), and 0.4% (1613/378,848) in the wild-type–, Alpha-, Delta-, and Omicron-predominant waves, respectively. …”
Get full text

The endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 3 attenuates the unfolded protein response and has pro-survival and pro-viral roles in hepatoma cells and... by Alina-Veronica Ghionescu, Mihaela Uta, Andrei Sorop, Catalin Lazar, Petruta R. Flintoaca-Alexandru, Gabriela Chiritoiu, Livia Sima, Stefana-Maria Petrescu, Simona Olimpia Dima, Norica Branza-Nichita

“…Emerging evidence indicates consistent upregulation of ERAD factors, including members of the ER degradation-enhancing alpha-mannosidase-like protein (EDEM) family in infection and various tumor types. …”
Get full text

Designing a Policy-Making Model for Biomass Energy Development Training in the Agricultural Supply Chain Sector by Tahereh Pourelmi, Seyed Mohammad Shobeiri, Enayatollah Yazdanpanah, Gholam Reza Bakhshi Khaniki, Mahdieh Rezaei

“…The validity and reliability of the components were examined, and Cronbach’s alpha of all components was higher than 0.7. The essential components of the effective factors were measured in the education policy of biomass energy development in the agricultural sector. …”
Get full text

Importin subunit beta‐1 mediates ERK5 nuclear translocation, and its inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation by Zoe Lombardi, Lucia Gardini, Anatolii V. Kashchuk, Alessio Menconi, Matteo Lulli, Ignazia Tusa, Alessandro Tubita, Luisa Maresca, Barbara Stecca, Marco Capitanio, Elisabetta Rovida

“…Here, we investigated the role of importin subunit alpha (α importin) and importin subunit beta‐1 (importin β1) in ERK5 nuclear shuttling to identify additional targets for cancer treatment. …”
Get full text

Application of Computer Simulation in Exploring the Effects of <italic>Achyranthis Bidentatae Radix</italic> on Simultaneously Treating Wei Syndrome and Bi Syndrome of Osteoarthrit... by Chunsong ZHENG, Hongzhi YE, Jinxia YE, Changlong FU

“…Based on the platforms of quantitative structure-activity relationship and principal component analysis, the distributions of the above datasets were analyzed in the chemical space.②Matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-3 (MMP-3), and transforming growth factor beta-1 (TGF-β1) were chosen as the targets of treating Wei Syndrome of OA, while interleukine-1 beta (IL-1β), interleukine-6 (IL-6), tumor necrosis factor-alpha (TNF-α) were chosen as the targets of treating Bi syndrome of OA. …”
Get full text

Capsaicin Modulates Ruminal Fermentation and Bacterial Communities in Beef Cattle with High-Grain Diet-Induced Subacute Ruminal Acidosis by Wei You, Haijian Cheng, Xin Hu, Enliang Song, Fugui Jiang

“…The addition of capsaicin increased the alpha diversity of ruminal bacteria relative to the SARA group, as evidenced by a lower Simpson index (<i>p</i> < 0.05), together with increases in the Ace, Chao, and Shannon indices (<i>p</i> < 0.05). …”
Get full text

Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis by Mengmeng Zhang, Hong Lv, Xiaoyin Bai, Gechong Ruan, Qing Li, Kai Lin, Hong Yang, Jiaming Qian

“…In tumor necrosis factor-alpha-stimulated HCT116 cells, mitochondrial ROS, NLRP3 and IL-1β expression increased less and mitochondrial respiration had an upregulated trend after knocking down ALDH1L1. …”
Get full text