Comprehensive profiling of gut bacterial communities in hybrid red tilapia with and without streptococcosis by Pathamawan Amthungphong, Natthaphong Sombuttra, Triwit Rattanarojpong, Kanthida Kusonmano, Saengchan Senapin, Satid Chatchaiphan, Watanalai Panbangred, Jirayut Euanorasetr

“…The 16S amplicon was sequenced in gut microbiome samples from healthy and diseased groups to analyze the bacterial composition profiles associated with red tilapia with and without streptococcosis. The alpha diversity of bacterial communities in the gut microbiome was significantly higher in the healthy group than in the diseased group. …”
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Protective Effects of Baicalein on Lipopolysaccharide-Induced AR42J PACs through Attenuation of Both Inflammation and Pyroptosis via Downregulation of miR-224-5p/PARP1 by Ming-Wei Liu, Chun-Hai Zhang, Shou-Hong Ma, De-Qiong Zhang, Li-Qiong Jiang, Yang Tan

“…The RNA and protein expression of miR-224-5p, poly ADP-ribose polymerase-1 (PARP1), nuclear transcription factor-κB65 (NF-κB65), phospho-kappa B alpha(p-IκB-α), interleukin(IL)-18R, NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), gasdermin D (GSDMD), apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1 was detected based on the WB and RT-PCR assays. …”
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Mapping knowledge landscapes and emerging trends in artificial intelligence for antimicrobial resistance: bibliometric and visualization analysis by Zhongli Wang, Zhongli Wang, Gaopei Zhu, Shixue Li, Shixue Li

“…Citation analysis highlighted two major breakthroughs: AlphaFold’s protein structure prediction (6,811 citations) and deep learning approaches to antibiotic discovery (4,784 citations). …”
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Combination of Mangosteen (Garcinia mangostana L.) Pericarp Extract and Physical Exercise Decreases Atherosclerotic Lesions in Atherogenic Diet-Fed Rats by Andreas Arie Setiawan, . Sugiri, Awal Prasetyo, Eirin Yovita Kurniawan, Dominikus Evano Putra

“…The mangosteen pericarp (MP) has xanthone compounds, particularly alpha-mangostin (α-MG), which have been shown to exhibit potent antioxidant and anti-inflammatory activities. …”
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Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration by Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao

“…Abstract Sterile alpha and Toll/interleukin-1 receptor motif containing 1 (SARM1), a nicotinamide adenine dinucleotide (NAD)-utilizing enzyme, mediates axon degeneration (AxD) in various neurodegenerative diseases. …”
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Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB by José Roberto Macías-Pérez, Bruno Jesús Vázquez-López, Martin Humberto Muñoz-Ortega, Liseth Rubí Aldaba-Muruato, Sandra Luz Martínez-Hernández, Esperanza Sánchez-Alemán, Javier Ventura-Juárez

“…Therefore, in the present work, the capacity of doxazosin (α1 antagonist), carvedilol (nonselective beta-adrenoceptor blocker with alpha 1-blocking properties), and curcumin (antioxidant and anti-inflammatory compound) to reverse liver cirrhosis and studying the possible modulation of Nrf-2 and NF-κB were evaluated. …”
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A Truncated Multi-Thiol Aptamer-Based SARS-CoV-2 Electrochemical Biosensor: Towards Variant-Specific Point-of-Care Detection with Optimized Fabrication by Sergio Roberto Molina Ramirez, Nafiseh Samiseresht, Mateo Alejandro Martínez-Roque, Ferdinando Catania, Kevin Graef, Martin Rabe, Andreas Offenhäusser, Dirk Mayer, Gabriela Figueroa-Miranda

“…Even more, it showed a three times higher sensitivity for the Omicron in comparison to the Wuhan strain (wild type), alpha, and beta variants of the SARS-CoV-2 virus. …”
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Entrepreneurship skills application among ICT Graduates of Muni University, Uganda by Ritah, Nafuna, Nicholas, Nkamwesiga, Phelix, Businge Mbabazi

“…The research instrument was reliable at Chronbach’s alpha 0.960. The results of the study identified that the key entrepreneurship skills acquired by Muni University ICT graduates are: innovativeness; business and economic management; human relations and interpersonal skills; and communication skills. …”
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Investigating the effect of learning and motivational strategies on the self-efficacy of physical education and sports science students with the mediating role of academic progress... by Ahmad Sabihabdollah Alharishavi, Hasan ghalavandi, Mohammad hassani

“…The reliability of the tool was confirmed using Cronbach's alpha coefficient in a preliminary study for the learning strategies questionnaire 0.88, motivational strategies 0.91, academic achievement goals 0.87, academic enthusiasm 0.91, and academic self-efficacy 0.86. …”
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Developing and validation of religious education curriculum in preschool by Zeinab Ashrafi Soltan-Ahmadi, Sadegh Maleki Avarsin, Javad Keyhan, jahangir yari

“…To ensure the validity of the instrument, expert consensus was used using Delphi method and Cronbach's alpha method was used to determine reliability (α = 0.83). …”
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General existence principles for nonlocal boundary value problems with <mml:math alttext="$PHI$"> <mml:mi>&#x03C6;</mml:mi> </mml:math>-laplacian and their appl...

“…<p>The paper presents general existence principles which can be used for a large class of nonlocal boundary value problems of the form <mml:math alttext="$(phi(x'))'=f_1(t,x,x')+f_2(t,x,x')F_1x+f_3(t,x,x')F_2x$,$alpha(x)=0$"> <mml:mrow> <mml:msup> <mml:mrow> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>&#x03C6;</mml:mi> <mml:mrow> <mml:mo>(</mml:mo> <mml:msup> <mml:mi>x</mml:mi> <mml:mo>&#x2032;</mml:mo> </mml:msup> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> <mml:mo>&#x2032;</mml:mo> </mml:msup> <mml:mo>=</mml:mo> <mml:msub> <mml:mi>f</mml:mi> <mml:mn>1</mml:mn> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>t</mml:mi> <mml:mo>,</mml:mo> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:msup> <mml:mi>x</mml:mi> <mml:mo>&#x2032;</mml:mo> </mml:msup> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> <mml:mo>+</mml:mo> <mml:msub> <mml:mi>f</mml:mi> <mml:mn>2</mml:mn> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>t</mml:mi> <mml:mo>,</mml:mo> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:msup> <mml:mi>x</mml:mi> <mml:mo>&#x2032;</mml:mo> </mml:msup> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> <mml:msub> <mml:mi>F</mml:mi> <mml:mn>1</mml:mn> </mml:msub> <mml:mi>x</mml:mi> <mml:mo>+</mml:mo> <mml:msub> <mml:mi>f</mml:mi> <mml:mn>3</mml:mn> </mml:msub> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>t</mml:mi> <mml:mo>,</mml:mo> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:msup> <mml:mi>x</mml:mi> <mml:mo>&#x2032;</mml:mo> </mml:msup> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> <mml:msub> <mml:mi>F</mml:mi> <mml:mn>2</mml:mn> </mml:msub> <mml:mi>x</mml:mi> <mml:mo>,</mml:mo> <mml:mi>&#x03B1;</mml:mi> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>x</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mo>=</mml:mo> <mml:mn>0</mml:mn> </mml:mrow> </mml:math>, <mml:math alttext="$eta(x)=0$"> <mml:mi>&#x03B2;</mml:mi> <mml:mrow> <mml:mo>(</mml:mo> <mml:mi>x</mml:mi> <mml:mo>)</mml:mo> </mml:mrow> <mml:mo>=</mml:mo> <mml:mn>0</mml:mn> </mml:math>, where <mml:math alttext="$f_j$"> <mml:msub> <mml:mi>f</mml:mi> <mml:mi>j</mml:mi> </mml:msub> </mml:math> satisfy local Carathéodory conditions on some <mml:math alttext="$[0,T]imesmathcal{D}_jsubset R^2$"> <mml:mrow> <mml:mo>[</mml:mo> <mml:mrow> <mml:mn>0</mml:mn> <mml:mo>,</mml:mo> <mml:mi>T</mml:mi> </mml:mrow> <mml:mo>]</mml:mo> </mml:mrow> <mml:mo>&#x00D7;</mml:mo> <mml:msub> <mml:mi>&#x1D49F;</mml:mi> <mml:mi>j</mml:mi> </mml:msub> <mml:mo>&#x2282;</mml:mo> <mml:msup> <mml:mi>&#x211D;</mml:mi> <mml:mn>2</mml:mn> </mml:msup> </mml:math>, <mml:math alttext="$f_j$"> <mml:msub> <mml:mi>f</mml:mi> <mml:mi>j</mml:mi> </mml:msub> </mml:math> are either regular or have singularities in their phase variables <mml:math alttext="$(j=1,2,3)$"> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>j</mml:mi> <mml:mo>=</mml:mo> <mml:mn>1</mml:mn> <mml:mo>,</mml:mo> <mml:mn>2</mml:mn> <mml:mo>,</mml:mo> <mml:mn>3</mml:mn> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> </mml:math>, <mml:math alttext="$F_i: C^1[0,T] ightarrow C^0[0,T]$ $(i=1,2)$"> <mml:mrow> <mml:msub> <mml:mi>F</mml:mi> <mml:mi>i</mml:mi> </mml:msub> <mml:mo>:</mml:mo> <mml:msup> <mml:mi>C</mml:mi> <mml:mn>1</mml:mn> </mml:msup> <mml:mrow> <mml:mo>[</mml:mo> <mml:mrow> <mml:mn>0</mml:mn> <mml:mo>,</mml:mo> <mml:mi>T</mml:mi> </mml:mrow> <mml:mo>]</mml:mo> </mml:mrow> <mml:mo>&#x2192;</mml:mo> <mml:msup> <mml:mi>C</mml:mi> <mml:mn>0</mml:mn> </mml:msup> <mml:mrow> <mml:mo>[</mml:mo> <mml:mrow> <mml:mn>0</mml:mn> <mml:mo>,</mml:mo> <mml:mi>T</mml:mi> </mml:mrow> <mml:mo>]</mml:mo> </mml:mrow> <mml:mrow> <mml:mo>(</mml:mo> <mml:mrow> <mml:mi>i</mml:mi> <mml:mo>=</mml:mo> <mml:mn>1</mml:mn> <mml:mo>,</mml:mo> <mml:mn>2</mml:mn> </mml:mrow> <mml:mo>)</mml:mo> </mml:mrow> </mml:mrow> </mml:math>, and <mml:math alttext="$alpha,eta:C^1[0,T] ightarrowR$"> <mml:mrow> <mml:mi>&#x03B1;</mml:mi> <mml:mo>,</mml:mo> <mml:mi>&#x03B2;</mml:mi> <mml:mo>:</mml:mo> <mml:msup> <mml:mi>C</mml:mi> <mml:mn>1</mml:mn> </mml:msup> <mml:mrow> <mml:mo>[</mml:mo> <mml:mrow> <mml:mn>0</mml:mn> <mml:mo>,</mml:mo> <mml:mi>T</mml:mi> </mml:mrow> <mml:mo>]</mml:mo> </mml:mrow> <mml:mo>&#x2192;</mml:mo> <mml:mi>&#x211D;</mml:mi> </mml:mrow> </mml:math> are continuous. …”
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Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose by Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Zhaohui Ni

“…Western blot and real-time PCR analyses were used to detect PTX3, p-IKBa/IKBa (I-kappa-B-alpha), and p-eNOS/eNOS (endothelial nitric oxide synthase) expression in mice and HUVECs. …”
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Safety and immunogenicity of an mRNA-1273 vaccine booster in adolescents by Amparo L. Figueroa, Kashif Ali, Gary Berman, Wenqin Xu, Weiping Deng, Bethany Girard, Anne Yeakey, Karen Slobod, Jacqueline Miller, Rituparna Das, Frances Priddy

“…Further, the booster increased bAb levels relative to pre-booster baseline against SARS-CoV-2 variants (alpha [B.1.1.7], beta [B.1.351], gamma [P.1], and delta [B.1.617.2]), regardless of pre-booster SARS-CoV-2 status. …”
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Cresp®: transforming the landscape of chemotherapy-induced anemia - a comprehensive retrospective real-world analysis in 523 Indian patients by MV Chandrakanth, Vivek Agarwala, Pranav Sopory, Himadri Nayak, Purvish M. Parikh, Minakshi Roy, Rajib De, Pradeep Narayan, Anjuli Tuladhar Barai, Kaustav Mandal, Moinak Basu, Subhabrata Kumar, Rajdeep Singh Uppal, Syed Mujtaba Hussain Naqvi, Rohit Desai

“…However, correcting anemia can lead to notable improvements in these parameters. Notably, darbepoetin alpha (DA) has shown efficacy in addressing anemia in this context. …”
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Intimate partner violence help-seeking norms: scale reliability and cross-sectional multilevel associations with intimate partner violence among youth in Nairobi, Kenya by Peter Gichangi, Mary Thiongo, Anaise Williams, Bianca Devoto, Shannon N. Wood, G Wamue-Ngare, Kristin G. Bevilacqua, Michele R. Decker

“…Multilevel mixed-effects models assessed associations with IPV experience for young women.Setting and participants A youth cohort of 586 men and 591 women aged 15–24 years in Nairobi, Kenya.Primary outcome measure Past 6-month physical and/or sexual IPV among young women.Results The IPV Help-Seeking Attitudes Scale had acceptable internal reliability (Cronbach’s alpha &gt;0.60). IPV prevalence was 17.5%, among whom 21.7% had sought any help for the past 6-month IPV. …”
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Knowledge, attitude and practices associated with COVID-19 among undergraduate students from Malaysian public universities during the endemic phase: a cross-sectional study by Nur Umairah Mohd Hawary, Nor Malia Abd Warif, Ismarulyusda Ishak, Arimi Fitri Mat Ludin, Barathan Muttiah, Navindra Kumari P, Kumutha Malar Vellasamy, Vanitha Mariappan

“…Validity and reliability tests were conducted to assess the level of consistency of KAP content with Cronbach alpha values of 0.617, 0.616 and 0.722 for each section, respectively. …”
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Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies by Ekaterina S. Porfireva, Anton D. Zadorozhny, Anastasia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Alexey A. Lagunin

“…SSPR models were created for each protein using the MultiPASS software based on the Bayesian algorithm and different levels of MNA (Multilevel Neighborhoods of Atoms) descriptors for the representation of structural formulas of protein fragments including AAS.ResultsThe accuracy of prediction was assessed through a 5-fold cross-validation and compared to other bioinformatics tools, such as SIFT4G, Polyphen2 HDIV, FATHMM, MetaSVM, PROVEAN, ClinPred, and Alpha Missense. The best SSPR models demonstrated high accuracy, with an average ROC AUC of 0.831 ± 0.037, a Balanced accuracy of (0.763 ± 0.034), MCC (0.457 ± 0.06), and F-measure (0.623 ± 0.07) across all genes, outperforming the most popular bioinformatics tools.ConclusionsThe best created SSPR models for the prediction of pathogenicity of amino acid substitutions related with PIDs have been implemented in a freely available web application SAV-Pred (Single Amino acid Variants Predictor, http://www.way2drug.com/SAV-Pred/), which may be a useful tool for medical geneticists and clinicians. …”
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Propiedades psicométricas de la Escala de Comunicación Familiar en estudiantes universitarios / Psychometric Properties of the Family Communication Scale in College Students by Anthony John Erik Copez-Lonzoy, David Villarreal-Zegarra, Ángel Paz-Jesús

“…Model errors and gender invariance were analyzed and finally a reliability alpha was established with different estimators, obtaining a high level of internal consistency. …”
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Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells by K. S. Young, G. R. Hancock, E. C. Fink, A. Zigrossi, B. Flowers, D. A. Cooper, V. T. Nguyen, M. C. Martinez, K. S. Mon, M. Bosland, D. R. Zak, A. P. Runde, M. N. Sharifi, I. Kastrati, D. D. L. Minh, S. Kregel, Sean W. Fanning

“…Mutations to estrogen receptor alpha (ERα) arise after continued therapeutic pressure. …”
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Comparative Analysis of Meat Quality and Hindgut Microbiota of Cultured and Wild Bighead Carp (<i>Hypophthalmichthys nobilis</i>, Richardson 1845) from the Yangtze River Area by Abdullateef Mukhtar Muhammad, Chang Yang, Bo Liu, Cunxin Sun, Linghong Miao, Xiaochuan Zheng, Liangkun Pan, Dong Xia, Qun-Lan Zhou

“…Moreover, the hindgut microbiota was analyzed using 16S rRNA high-throughput sequencing. The alpha and beta diversity differences between the cultured and wild groups were significant. …”
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