Phytochemical study and evaluation of the antidiabetic and antihyperglycemic activities of the fruit extracts of Physalis peruviana L. (Solanaceae) by Damien S.T. Tshibangu, Fortune S. Kavugho, Carlos N. Kabengele, Adrien T. Masunda, Gédéon N. Bongo, Giresse N. Kasiama, Domaine T. Mwanangombo, Clément L. Inkoto, Clément M. Mbadiko, Benjamin Z. Gbolo, Désiré M. Musuyu, Dorothée D. Tshilanda, Jean Paul K.N. Ngbolua, Pius T. Mpiana

“…This inhibition was confirmed by molecular docking analyzes by interacting the molecules of the studied plant with two receptors, alpha-glucosidase (PDB id: 3WY1) and the kinase domain of the 5HHW insulin receptor.These experimental results lend credibility to the use of this species in traditional Congolese medicine to treat type 2 diabetes.…”
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基于SMRT测序技术的塔里木马鹿冬季肠道菌群多样性分析 by 祁程, 姜李欢, 阿卜杜萨拉木·努尔麦麦提, 王开彦, 单文娟, 钟林强

“…为探究塔里木河流域塔里木马鹿（<italic>Cervus elaphus yarkandensis</italic>）冬季肠道菌群群落结构、多样性与功能，采用PacBio平台的单分子实时测序技术（single molecule real-time sequencing，SMRT）对塔里木河上游湿地自然保护区采集并筛选的25份塔里木马鹿粪便样本的16S rRNA基因全长进行测序，共获得298 578个clean reads，clean reads聚类获得28 026个OTU，包括25门684属。Alpha多样性分析结果显示，塔里木马鹿冬季肠道菌群Shannon指数为（7.764±0.044），Simpson指数为（0.015±0.001），Chao1指数为（12 242.668±695.106），ACE指数为（9 366.423±407.612）。…”
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The Gut Microbiota and Its Relevance to Peripheral Lymphocyte Subpopulations and Cytokines in Patients with Rheumatoid Arthritis by Yuan Li, Sheng-Xiao Zhang, Xu-Fang Yin, Ming-Xing Zhang, Jun Qiao, Xiao-Hong Xin, Min-Jing Chang, Chong Gao, Ya-Feng Li, Xiao-Feng Li

“…The serum levels of cytokines interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17, tumour necrosis factor-α (TNF-α), and interferon-γ (INF-γ) were tested by flow cytometric bead array (CBA). Alpha and beta diversity of gut microbiome were explored by bioinformatics analysis. …”
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The development and validation testing of a comprehensive frailty assessment in women with breast cancer by Sheng-Miauh Huang, Ling-Ming Tseng, Chi-Cheng Huang, Pei-Ju Lien, Su-Chen Fang, Yinhui Hong

“…The goodness of fit indices of the confirmatory factor analysis were as follows: chi-square = 234.498 (p < 0.01), normed chi-square = 2.322, SRMR = 0.055, RMSEA = 0.08, CFI = 0.930, and LI = 0.917. The Cronbach’s alpha calculated for the BCCFS (16 items) was 0.91 (95% confidence interval: 0.89 to 0.93), and the test-retest reliability coefficient was 0.60. …”
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Investigating the Role of Gut Microbiota in Pediatric Patients with Severe COVID-19 or MIS-C by Elena Franchitti, Paolo Bottino, Francesca Sidoti, Andrea Carpino, Giulia Pruccoli, Ugo Ramenghi, Cristina Costa, Ugo Ala, Emilia Parodi, Deborah Traversi

“…Significant differences in alpha and beta diversity were observed between COVID-19 and MIS-C patients, particularly concerning low-abundance species. …”
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Volatile Organic Compounds as Biomarkers of Gastrointestinal Diseases and Nutritional Status by Mariangela Rondanelli, Federica Perdoni, Vittoria Infantino, Milena Anna Faliva, Gabriella Peroni, Giancarlo Iannello, Mara Nichetti, Tariq A. Alalwan, Simone Perna, Clementina Cocuzza

“…In particular, C15H30 1-pentadecene, 3-methyl-1-butanal, octane, acetic acid, alpha-pinene, and m-cymene are elevated in active ulcerative colitis. …”
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Burden of caregivers of older people in Sri Lanka: an overlooked concern in the health care system by Nirmala Rathnayake, Wedura Kannangara, Thilina Abeygunasekara, Warsha De Zoysa, Dhammika Palangasinghe, Sarath Lekamwasam

“…Results The study revealed that the internal consistency of the Sinhala version of the BSFC-s, measured by Cronbach’s alpha, was 0.90, with item-total correlations ranging from 0.38 to 0.82. …”
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Gut Microbiota as Mediator and Moderator Between Hepatitis B Virus and Hepatocellular Carcinoma: A Prospective Study by Bingren Hu, Yi Yang, Jiangqiao Yao, Ganglian Lin, Qikuan He, Zhiyuan Bo, Zhewei Zhang, Anlvna Li, Yi Wang, Gang Chen, Yunfeng Shan

“…Bacteroidia and Bacteroidales were demonstrated to exert mediating effects between HBV and HCC, and the moderating effects varied across Bacilli, Lactobacillales, Erysipelotrichaceae, Actinomyces, and Roseburia. HBV, alpha‐fetoprotein, alanine transaminase, triglyceride, and Child‐Pugh were identified as independent risk factors for HCC occurrence. …”
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The validation and cross-cultural adaptation of the PainDETECT questionnaire in osteoarthritis-related pain by Xiaofeng Chang, Shuxin Yao, Jie Wei, Lei Shang, Chao Xu, Jianbing Ma

“…We assessed internal consistency using Cronbach’s alpha and test-retest reliability via intraclass correlation coefficient (ICC). …”
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Lactococcus lactis D4 Decreases NF-κB and α-SMA in Rat Models of Obstructive Jaundice by Avit Suchitra, Alvarino Alvarino, Eryati Darwin, Harnavi Harun, Muhammad Iqbal Rivai, Ade Sukma

“…Some inflammatory mediators like nuclear factor kappa B (NF-κB), alpha-smooth muscle actin (α-SMA), and interleukin-6 (IL-6) are important in this process. …”
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Autoimmune Hepatitis in Children: The Current State of the Problem by G. V. Volynets, A. I. Khavkin, T. A. Skvortsova, V. V. Matkash

“…For a small number of patients, who do not respond to standard treatment and those who suffer from frequent disease relapses, it is advisable to offer an alternative immunosuppressive treatment, the effectiveness of which is still ambiguous and poorly understood (including, in order of priority, mycophenolate mofetil, calcineurin inhibitors, rituximab, Inhibitor of tumor necrosis factor-alpha). In cases of refractoriness to therapy and the disease progression to liver cirrhosis and its decompensation, liver transplantation is justified. …”
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Tumor Microenvironment Responsive Key Nanomicelles for Effective Against Invasion and Metastasis in Ovarian Cancer Using Mice Model by Liu Y, Kong L, Yu Y, Zang J, Zhang L, Guo RB, Li ST, Cheng L, Li XT, Chen YQ

“…In addition, by regulating the expression levels of E-Cadherin, N-Cadherin, matrix metalloproteinases (MMPs), hypoxia-inducible factor 1-alpha (HIF-1α), and vascular endothelial growth factor (VEGF), it exhibited an inhibitory effect on epithelial-mesenchymal transformation (EMT) and tumor cell angiogenesis, and effectively inhibited the invasion and metastasis of ovarian cancer cells.Conclusion: PVGLIG-MTX-D/T-NMs achieved passive targeting of tumor sites by enhancing permeability and retention (EPR) effects. …”
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In Vitro Effect of Estradiol and Progesterone on Ovine Amniotic Epithelial Cells by Annunziata Mauro, Hashimita Sanyal, Angelo Canciello, Paolo Berardinelli, Valentina Russo, Nicola Bernabò, Luca Valbonetti, Barbara Barboni

“…The results indicated that EMT can be prevented exclusively in the presence of high doses of P4, while it occurred rapidly in cells exposed to E2 as denoted by protein (cytokeratin-8 and alpha-SMA) and gene expression (vimentin and snail) profiles. …”
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From classroom to screen: a cross-sectional study on medical students’ first experiences with e-learning during the COVID-19 pandemic by Laleh Khojasteh, Zahra Karimian, Elham Nasiri, Sedigheh Sharifzadeh, Majid Reza Farrokhi

“…The reliability of the questionnaire, based on the internal consistency of the questions, was confirmed by a Cronbach’s alpha of 97.5%. Data were analyzed using a one-sample t-test, independent t-test, ANOVA, and MANOVA.ResultsStudents had satisfactory e-learning experiences, and the average of e-learning components was: technological facilities (4.29 ± 1.13), technical support (4.00 ± 1.08), e-content quality (3.84 ± 1.05), synchronous education (3.59 ± 1.31), asynchronous education (3.73 ± 1.20), and teacher-student interaction (3.63 ± 1.32). …”
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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Consequently, the suppression of FASN expression led to reduced expression and secretion of tumor necrosis factor-alpha following LPS stimulation in MG6 cells. Conclusions These findings suggest that testosterone modulates inflammation in male microglia by regulating fatty acid synthesis, potentially contributing to the observed sex differences in AD pathogenesis.…”
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Tüketicilerin E-Ticaret Algılarının İncelenmesi (Gaziantep ve Adıyaman Örneği) - A Research On the E-Commerce Perception of Consumer (The Sample of Gaziantep and Adıyaman) by Sabiha Annaç Göv, Yavuz Akçi

“…Pilot uygulamanın g&uuml;venirliği i&ccedil;in yapılan hesaplamada cronbach&rsquo;s alpha değeri, 775 olarak hesaplanmıştır. Ana uygulama y&uuml;z y&uuml;ze ve on-line anket şeklinde yapılmıştır. …”
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Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

“…The PPI network manifested 7 key targets including albumin (ALB), epidermal growth factor receptor (EGFR), solute carrier family 2 member 1 (SLC2A1), insulin-like growth factor 1 (IGF1), mitogen-activated protein kinase 1 (MAPK1), peroxisome proliferator activated receptor alpha (PPARA) and peroxisome proliferator activated receptor gamma (PPAR-γ, PPARG). …”
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Neuropsychological features of patients of reproductive age diagnosed with breast cancer at the stage of surgical treatment using xenon-oxygen therapy by D. A. Rozenko, A. I. Shikhlyarova, L. N. Vaschenko, N. N. Popova, Yu. Yu. Arapova, A. Yu. Ardzha, A. A. Korobov

“…Against the background of an improvement in the psychophysiological state, the EEG showed a significant increase in the power of slow delta and theta rhythms, an increase in the power of the alpha rhythm and a decrease in the power of the beta rhythm, while in the patients of the control group only a decrease in the power of the beta rhythm was noted.Conclusion. …”
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Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling by Xi Xiao Huang, Ley Moy Ng, Po-Hsien Lee, Peiyong Guan, Mun Juinn Chow, Aisyah Binte Mohamed Bashir, Meina Lau, Kenric Yi Shu Tan, Zhimei Li, Jason Yongsheng Chan, Jing Han Hong, Sheng Rong Ng, Tun Kiat Ko, Hong Lee Heng, Hsiang Ling Teo, Daniela Rhodes, Patrick Tan, Puay Hoon Tan, Donald P. McDonnell, Bin Tean Teh

“…Abstract Point mutations in the ligand binding domain of retinoic acid receptor alpha (RARα) are linked to breast fibroepithelial tumor development, but their role in solid tumorigenesis is unclear. …”
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Wnt/ β-catenin and CTNNB1 gene mutation in hepatocellular carcinoma, a case study in Egyptian patients by Ramy A. Abdelsalam, Ibrahim M. El-Shawaf, Azza Abdel-Aziz, Tarek A. Bismar, Shaimaa M. Yussif

“…However, no significant association was detected with tumor site, presence of lymph node spread, distant metastasis, tumor necrosis, local recurrence and alpha-fetoprotein level. No significant association was seen between Wnt2 IHC staining with either tumor site, tumor size, number of tumor nodules, presence of LVE, tumor necrosis, tumor grade, TNM stage or presence of local recurrence. …”
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