Situational analysis of the quality of maternal, child, and adolescent health data in the health districts of Thiès, Mbour, Kédougou, and Saraya in Senegal by Fatoumata Binetou Diongue, Adama Faye, Cheikh Loucoubar, Ndèye Marème Sougou, Ibrahima Sy, Adama Tall, Youssoupha Ndiaye, Samba Cor Sarr

“…Data were collected using Performance of Routine Information Systems Management (PRISM) data collection tools and the ODK application and analyzed (univariate and bivariate) using R and Stata with an alpha risk of 5%. The following data quality indicators (accuracy, completeness, and promptness) were estimated. …”
Get full text

RfxCas13d-mediated inhibition of Circ1647 alleviates renal fibrosis via PI3K/AKT signaling pathway by Yufang Ni, Hongmin Zhang, Qianwen Xian, Wenjie Qin, Hongwei Su, Li Wang, Jianchun Li

“…In addition, overexpressing of Circ1647 in renal tubular epithelial cells (TCMK1) was performed to investigate the underlying mechanisms of Circ1647.Results Our results displayed that electroporation-mediated knockdown of Circ1647 by RfxCas13d knockdown plasmid significantly inhibited renal fibrosis in UUO mice as evidenced by reduced expression of fibronectin and α-SMA (alpha-smooth muscle actin). Conversely, overexpression of Circ1647 in TCMK1 cells promoted the fibrosis. …”
Get full text

Combined metabolomic and transcriptomic analysis to reveal the response of rice to Mn toxicity stress by Feng Li, Yushuang Yao, Jiapeng Ma, Zhengwei Wu, Dianfeng Zheng, Yingbin Xue, Ying Liu

“…Combined transcriptomic and metabolomic analyses revealed three key pathways: lysine degradation and phenylpropanoid biosynthesis in roots and alpha-linolenic acid metabolism in leaves. Metabolic substances and genes associated with metabolic enzymes were identified. …”
Get full text

The Life Functioning Scale: A Measurement Tool Developed to Assess the Physical Functioning Abilities of Community-Dwelling Adults Aged 50 Years or Older by Yunhwan Lee, Eunsaem Kim, Jihye Yun, Jaewon Choi, Jinhee Kim, Chang Won Won, Miji Kim, Soongnang Jang, Kyungwon Oh, Jihee Kim

“…The scale satisfied a one-dimensionality assumption with good item fit and demonstrated criterion validity, construct validity, high internal consistency (Cronbach’s alpha=0.93), and test-retest reliability (intra-class correlation coefficient=0.84; 95% confidence interval, 0.76–0.89). …”
Get full text

Composition of soil fungal communities and microbial activity along an elevational gradient in Mt. Jiri, Republic of Korea by Ana Mitcov, Daegeun Ko, Kwanyoung Ko, Jaeho Kim, Neung-Hwan Oh, Hyun Seok Kim, Hyeyeong Choe, Haegeun Chung

“…The decrease in β-1,4-N-acetylglucosaminidase suggests a reduction in fungal biomass with increasing altitude, while factors other than elevation may influence the increase in activity of the cellobiohydrolase, β-1,4-glucosidase and β-1,4-xylosidase. Fungal alpha diversity did not exhibit an elevational trend, whereas beta diversity formed two clusters (600–1,000 m and 1,200–1,400 m). …”
Get full text

Evaluating Tech Neck: A Pilot Study Using a Self-Developed Questionnaire on Symptoms, Posture, and Preventive Measures by Brigitte Osser, Csongor Toth, Carmen Delia Nistor-Cseppento, Gyongyi Osser, Caius Calin Miuța, Iosif Ilia, Diana Carina Iovanovici, Cristina Aur, Laura Ioana Bondar

“…Internal consistency was assessed using Cronbach’s Alpha. Statistical analyses, including descriptive statistics, Chi-squared tests, ANOVA, and Spearman’s correlation, were used to identify significant correlations and associations between variables. …”
Get full text

Listening habits and subjective effects of background music in young adults with and without ADHD by Kelly-Ann Lachance, Pénélope Pelland-Goulet, Pénélope Pelland-Goulet, Pénélope Pelland-Goulet, Nathalie Gosselin

Get full text

Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma by Charles Lalnunfela, Pawi Bawitlung Lalthanpuii, Hmar Tlawmte Lalremsanga, Zothansiama, Chhaihlo Lalmuansangi, Mary Zosangzuali, Nachimuthu Senthil Kumar, Tochhawng Lalhriatpuii, Kholhring Lalchhandama

“…Molecular docking revealed high ligand binding ability of 2,6-di-tert-butylphenol to chemokine receptor CXCR4, DNA topoisomerase 2-alpha, DNA topoisomerase 2-beta, histone deacetylases (HDAC1, HDAC2, HDAC3), Janus kinase 1 and programmed cell death protein 1. …”
Get full text

The impact of successive Montessori programmes on cognitive achievement by Maria Angelica Paez-Barrameda

“…Statistical analysis revealed highly significant differences in GPA scores among the groups (alpha ≤ 0.01, P = 0.000 to 0.001). Additionally, the number of Montessori Programmes Attended (MPA) and Erdkinder Academic Rating (EAR) were positively correlated with CAT suc­cess. …”
Get full text

Epigenome-wide association study of Chinese monozygotic twins identifies DNA methylation loci associated with estimated glomerular filtration rate by Xueting Qi, Jingjing Wang, Tong Wang, Weijing Wang, Dongfeng Zhang

“…Enrichment analysis revealed several important biological functions and pathways related to eGFR, including alpha-2A adrenergic receptor binding pathway and corticotropin-releasing hormone receptor activity pathway. …”
Get full text

Serum levels of Wnt5a in Egyptian women with obesity and their association with toll like receptor 2 Arg753Gln gene polymorphism in a pilot case control study of obesity as a state... by Shaimaa H. Fouad, Mai Eldeeb, Shereen A. Baioumy, Sara I. Taha, Rehab Ali Ibrahim, Aya Elgendy, Azza Omran, Marwa Hamdy, Raed A. Alharbi, Abdulmajeed A. A. Sindi, Sylvia W. Roman

“…We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females. …”
Get full text

Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines by Gezina Tanya Mei Ling Oei, Hamid Aslami, Raphaela Priscilla Kerindongo, Renske Johanna Steenstra, Charlotte Jacqueline Peter Beurskens, Anita Maria Tuip-de Boer, Nicole Petra Juffermans, Markus Werner Hollmann, Benedikt Preckel, Nina Claudia Weber

“…Increased protein levels of cytokine-induced neutrophil chemoattractant (CINC-3) and interleukin-1 beta (IL-1β) were found after 30 or 60 min of helium inhalation, in comparison to control. 30 min of helium increased mRNA levels of CINC-3, IL-1β, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) in myocardial tissue not directly subjected to ischemia/reperfusion. …”
Get full text

FTO attenuates TNF-α-induced damage of proximal tubular epithelial cells in acute pancreatitis-induced acute kidney injury via targeting AQP3 in an N6-methyladenosine-dependent man... by Xinghui Li, Qi Liang, Lu Liu, Shujun Chen, Yong Li, Yu Pu

“…Previous investigations have revealed the involvement of FTO alpha-ketoglutarate-dependent dioxygenase (FTO) and aquaporin 3 (AQP3) in AKI. …”
Get full text

CD36 inhibition enhances the anti-proliferative effects of PI3K inhibitors in PTEN-loss anti-HER2 resistant breast cancer cells by You-Yu Liu, Wei-Lun Huang, Sin-Tian Wang, Hui-Ping Hsu, Tzu-Ching Kao, Wei-Pang Chung, Kung-Chia Young

“…However, subsequent reprogramed tumor progression due to PI3K signaling pathway activation by PIK3CA mutations and/or PTEN-loss cause anti-HER2 resistance. Previously, alpha isoform-specific PI3K inhibitors were shown to potentiate HER2-targeted therapy in breast cancer cells carrying PI3K pathway alterations with less potent effects on PTEN-loss than PIK3CA-mutant cells. …”
Get full text

Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity by Na Pang, Qianqian Wang, Jiamin Pei, Hailin Zhang, Yi Yuan, Jiaqing Yan

“…The results showed that TUS: 1) reduced the amplitude and the strength of the <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\theta } $ </tex-math></inline-formula> frequency band in LFPs in the hippocampus and M1; 2) decreased the coupling strength of the <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\delta }$ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma } $ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\theta } $ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma }$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\alpha } $ </tex-math></inline-formula> - <inline-formula> <tex-math notation="LaTeX">$\boldsymbol {\gamma } $ </tex-math></inline-formula> frequency bands in the hippocampus and M1; and 3) weakened the correlation of neural activity between the hippocampus and M1. …”
Get full text

Comparative Performance of Ante-Mortem Diagnostic Assays for the Identification of <i>Mycobacterium bovis</i>-Infected Domestic Dogs (<i>Canis lupus familiaris</i>) by Conor O’Halloran, Paul Burr, Danielle A. Gunn-Moore, Jayne C. Hope

“…The production of antigen-specific tumour necrosis factor-alpha (TNF-α) by PBMC in response to a cocktail of ESAT-6 and CFP-10 peptides correlated very strongly with the overall IGRA results, suggesting future diagnostic potential. …”
Get full text

Impact of non-invasive oxygen reserve index versus standard SpO2 monitoring on peripheral oxygen saturation during endotracheal intubation in the intensive care unit: Protocol for... by Hugo Hille, Aurélie Le Thuaut, Pierre Asfar, Quentin Quelven, Emmanuelle Mercier, Anthony Le Meur, Jean-Pierre Quenot, Virginie Lemiale, Grégoire Muller, Martin Cour, Alexis Ferré, Asael Berge, Anaïs Curtiaud, Maxime Touron, Gaetan Plantefeve, Jean-Charles Chakarian, Jean-Damien Ricard, Gwenhael Colin, Arthur Orieux, Patrick Girardie, Mathieu Jozwiak, Manon Rouaud, Camille Juhel, Jean Reignier, Jean-Baptiste Lascarrou, CRICS-TRIGGERSEP Network

“…Assuming a 10% standard deviation for the lowest SpO2 value in the control group, no missing data, and crossover of 5% of patients, with the bilateral alpha risk set at 0.05, including 950 patients will provide 85% power for detecting a 2% between-group absolute difference in the lowest SpO2 value. …”
Get full text

Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats by Riddhi Vichare, Yalcin Kulahci, Rebecca McCallin, Fatih Zor, Fatma Nurefsan Selek, Lu Liu, Caitlin Crelli, Anneliese Troidle, Michele Herneisey, James M. Nichols, Andrew J. Shepherd, Vijay S. Gorantla, Jelena M. Janjic

“…In vitro, we showed that curcumin-loaded nanoemulsion suppressed polarization of macrophages towards M1-like phenotype, consequently decreasing the release of pro-inflammatory cytokines and mediators like IL-6, IL- $$\:\beta\:,$$ TNF- $$\:\alpha\:$$ , and nitric oxide (NO). Furthermore, curcumin-loaded nanoemulsion increased the level of IL-10, an anti-inflammatory cytokine, and protected macrophages against ferroptosis compared to drug-free nanoemulsion. …”
Get full text

Investigation of the Influence of Deletional and Non-Deletional Hemoglobin H Disease on Pregnancy Outcomes by Zhao KS, Pan QA, Yang HY, Su JY, Deng L

“…Additionally, the non-deletional group had a significantly higher incidence of postpartum blood transfusion, fetal growth restriction (FGR), and low birth weight (LBW) compared to the deletional group, with a statistically significant difference (p< 0.05).Conclusion: Pregnant patients with alpha-thalassemia HbH disease and non-deletional HbH disease commonly experience moderate anemia, increasing the risk of adverse pregnancy outcomes, particularly in non-deletional HbH disease cases where negative outcomes are more prevalent. …”
Get full text

Characterization and comparison of gut microbiota in patients with acute pancreatitis by metagenomics and culturomics by Liang Gong, Xue Li, Li Ji, Guorong Chen, Ziying Han, Lei Su, Dong Wu

“…Compared to healthy controls, patients with AP exhibited a significant decrease in alpha diversity; a higher abundance of unclassified Enterococcus species (sp), Enterococcus faecium, and Enterococcus faecalis; and a lower abundance of Eubacterium rectale. …”
Get full text