Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia by Xin-Yu Li, Wen-Kai Yu, Jing-Hao Wu, Wen-Jun He, Yu-Nan Cheng, Kai Gao, Yi-Han Wei, Yu-Sheng Li

“…Through Protein–Protein Interaction (PPI) network analysis, Support Vector Machine-Recursive Feature Elimination (SVM-RFE) , and Extreme Gradient Boosting (XGBoost) machine learning, we identified Cytochrome P4501B1 (CYP1B1) and Electron Transfer Flavoprotein Alpha (ETFA) as key hub genes. Subsequently, we employed CIBERSORT and single-sample gene set enrichment analysis (ssGSEA) to further investigate the association between hub genes and peripheral immune activation and inflammatory response. …”
Get full text

Instrumentos y escalas para medir la cultura organizacional: una revisión sistemática de la literatura en el período 2013-2023. by Javier Reyes Hernández, Juana Patlán Pérez

“…El 92,8 % de los instrumentos analizados supera el Alpha de Cronbach de 0,70, y para la validación, el 85,7 % empleó la validez de constructo. …”
Get full text

Clinical Efficacy of Subhypothermia in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy Combined with Myocardial Damage by XiaoPing Dang, XiaoJian Hu, Xun Jiang, WeiGuo Chen, YuanCui Meng, Qi Pan, Fen Yang

“…The serum levels of S-100β protein, Tau protein, neuron-specific enolase (NSE), creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (ɑ-HBDH), myoglobin (Myo), cardiac trophic factor-1 (CT-1), cardiac troponin I (cTnI), superoxide dismutase (SOD), reactive oxygen species (ROS), glutathione peroxidase (GSH-Px), interleukin-1β (IL-1β), interleukin-8 (IL-8), and tumor necrosis factor-ɑ (TNF-ɑ) were measured in both groups before and after treatment, respectively. …”
Get full text

Taxonomic and functional diversity of protists in saline and hypersaline lakes in southern Western Siberia, a region strongly affected by climate change by Elena A. Gerasimova, Alexander S. Balkin, Vladimir Y. Kataev, Ekaterina S. Filonchikova, Yulia V. Mindolina, Denis V. Tikhonenkov

“…Phototrophs dominated the delta-hypersaline waters, and free-living heterotrophs dominated the alpha- and beta-hypersaline lakes. The parasite amplicon sequence variants (ASVs) were affiliated mainly with mixohaline and beta-hypersaline lakes.…”
Get full text

Endoplasmic reticulum protein TXNDC5 modulates thyroid eye disease TGF-β1-induced myofibroblast transdifferentiation by Albert Y Wu, Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai

“…Moreover, TXNDC5 knockdown of attenuated TGFβ1 (5 ng/mL)-induced myofibroblast transdifferentiation and extracellular matrix protein upregulation whereas increasing TXNDC5 expression by a recombinant protein of TXNDC5 (rhTXNDC5) addition increased alpha smooth muscle actin, fibronectin and connective tissue growth factor protein expression.Conclusion In conclusion, targeting TXNDC5 may be a novel therapeutic approach against TGF-β1-induced myofibroblast transdifferentiation in TED orbital fibroblasts.…”
Get full text

Factors Affecting Student Academic Performance: A Combined Factor Analysis of Mixed Data and Multiple Linear Regression Analysis by Mohamed El Jihaoui, Oum El Kheir Abra, Khalifa Mansouri

“…FAMD analysis identified four underlying factors: prior academic performance, academic delay, socioeconomic status, and class environment; all these factors have good to excellent reliability, with Cronbach’s Alpha values ranging from 0.809 to 0.930. Feeding these factors into the MLR produces a robust model that explains 88.53% of the variance in the CGPA, indicating a strong fit. …”
Get full text

A Review on Bioactive Phytochemical Constituents and Pharmacological Activities of Aegiceras corniculatum: A Pharmaceutically Important Mangrove Plant by Pritam Sarkar, Tasfiya Rufaidah Ahnaf, Razina Rouf, Jamil Ahmad Shilpi, Shaikh Jamal Uddin

“…The data revealed that anti-inflammatory compounds from this plant suppress iNOS, myeloperoxidase, COX, LOX, and cytokines (like TNF-alpha, IL-1ß, LTB4, IL-12, and IL-6) to reduce inflammation. 5-O-Butyl-embelin, 2-hydroxy-5-ethoxy-3-nonyl1, 4-benzoquinone, 5-O-methylembelin, 5-O-methyl-rapanone, s-saponin, and 5-O-ethylembelin are some phytochemicals of A. corniculatum with anticancer properties, although their mechanism is unclear. …”
Get full text

The cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and related signaling pathw... by Ning Chai, Tanja Stachon, Sabrina Häcker, Tim Berger, Zhen Li, Maryam Amini, Shweta Suiwal, Berthold Seitz, Achim Langenbucher, Nóra Szentmáry

“…The expression levels of interleukin-1β (IL-1β), IL-6, IL-8, interferon alpha 2 (IFNA2), IFNB1, intercellular adhesion molecule 1 (ICAM-1), chemokine (C-C motif) ligand 4 (CCL-4), collagen I, collagen V, lysyl oxidase (LOX), transforming growth factor β 1(TGF-β1) were measured using qPCR, ELISA, or western blot. …”
Get full text

Development and Validation of the Pediatric Well-Being Picture Scale© Using a Mixed-Methods Research Design by Judith Quaranta, Rosa Darling, Mei-Hsiu Chen, Julia DeMartino, Madison Kozlowski

“…The test/retest reliability demonstrated strong correlations, with an ICC of 0.823 (95% CI [0.690, 0.905]). The Cronbach’s alpha for all the administrations was 0.74, 0.74, 0.84, and 0.89. …”
Get full text

Alterations in whole muscle quality and physiological cross-sectional area measured with quantitative MRI following ACL injury by Meredith K. Owen, Lauren Richardson, Darren L. Johnson, Moriel H. Vandsburger, Thorsten Feiweier, Katherine L. Thompson, Christopher S. Fry, Peter A. Hardy, Brian Noehren

“…Outcomes were compared between limbs for each muscle of interest with paired t-tests or Wilcoxon signed-rank tests with the alpha level set to 0.05. Results T1ρ relaxation times were significantly longer for the vastus lateralis (7.0%), rectus femoris (15.4%), and vastus intermedius (9.4%) of ACL-deficient limb; whereas, relaxation times were similar between limbs for all hamstring muscles. …”
Get full text

Mobilization of Fluids in the Intensive Treatment of Primary and Secondary Lymphedemas by Jose Maria Pereira de Godoy, Henrique Jose Pereira de Godoy, Thatiany Gracino de Marqui, Luis Cesar Spessoto, Maria de Fatima Guerreiro Godoy

“…The unpaired t-test and Fisher’s exact test were used for statistical analysis with an alpha error of 5% (p value < 0.05) being considering acceptable. …”
Get full text

Association between time consumption of electronic screens with eating behaviors and academic performance for pupils in elementary schools by Mohammed A. S. Al-Wily, Luay A. M. Al-Waly

“…A pilot study was conducted to measure reliability from December 28 to 30, 2023. By Cronbach’s Alpha measurement, the results were 0. 815 at SPSS version 26. …”
Get full text

Mechanism of engineered macrophage membrane bionic gene-carrying nanospheres for targeted drug delivery to promote wound repair in deep second-degree burns by Zhihan Zhu, Xinghua Zhu, Shichen Miao, Bolin Wang, Zihan Li, Dinghao Zhang, Shentian Zou, Yi Zhang, Qingrong Zhang, Kesu Hu

“…Expression of B-cell lymphoma 2-associated X-protein was significantly lower, and B-cell lymphoma 2, cluster of differentiation 31, HGF, alpha smooth muscle actin, and PCNA expression was significantly higher in the HGF@ETMM@NPS group compared with the other two groups. …”
Get full text

Eccentric exercise‐induced muscle damage and inflammation in conjunction with high‐altitude decompression in adults by Frode Gottschalk, Mikael Gennser, Mattias Günther, Ola Eiken, Antonis Elia

“…Creatine kinase (CK) and myoglobin were used to assess muscle damage, while interleukin‐6 (IL‐6), tumor necrosis factor alpha (TNF‐α), C‐reactive protein (CRP), and fibrinogen were used to evaluate inflammation. …”
Get full text

Six Novel ATM Gene Variants in Sri Lankan Patients with Ataxia Telangiectasia by D. Hettiarachchi, Hetalkumar Panchal, B. A. P. S. Pathirana, P. D. Rathnayaka, A. Padeniya, P. S. Lai, V. H. W. Dissanayake

“…They may also have ocular telangiectasias and high levels of blood alpha-fetoprotein (AFP). The ataxia telangiectasia mutated gene (ATM) is associated with this condition and codes for the ATM protein which is a phosphatidylinositol 3-kinase. …”
Get full text

A Transcriptomic Analysis Reveals Diverse Regulatory Networks That Respond to Cold Stress in Strawberry (Fragaria×ananassa) by Yong Zhang, Yunting Zhang, Yuanxiu Lin, Ya Luo, Xiaorong Wang, Qing Chen, Bo Sun, Yan Wang, Mengyao Li, Haoru Tang

“…Functional enrichment analysis showed that DEGs were significantly (adjusted P value < 0.05) overrepresented in six pathways including plant hormone signal transduction, flavonoid biosynthesis, mitogen-activated protein kinase (MAPK) signaling, starch and sucrose metabolism, circadian rhythm, and alpha-linolenic acid metabolism. The cold signaling initiated expression of downstream cold-responsive (COR) genes with cis-acting element ABRE or CRT/DRE in the ABA-independent or ABA-dependent pathway to impel plant defense against the stress. …”
Get full text

Profile of intestinal fungal microbiota in acute pancreatitis patients and healthy individuals by Meng-Qi Zhao, Miao-Yan Fan, Meng-Yan Cui, Su-Min Chen, Jing-Jing Wang, Ying-Ying Lu, Qiao-Li Jiang

“…Results Results showed a decline in alpha diversity in AP patients. The overall fungal microbiota in the test group was significantly different from that of the control group (P < 0.05). …”
Get full text

The Impact of Role Conflict Originating from Mid-Level Manager Actions on Intention to Leaving the Job and Performance by Şükran Gökce, Ahmet Diken, Ümran Münire Kahraman

“…The explanatory factor analysis was applied to investigate the construct validity and the factor structure of the items was revealed. Alpha model was used to determine the reliability of the scale. …”
Get full text

The effect of mortality salience and early-life maternal care on neuroendocrine, autonomic, and psychological stress responses by Ulrike U. Bentele, Paula Strobel, Maria Meier, Annika B. E. Benz, Raphaela J. Gaertner, Elea S. C. Klink, Bernadette F. Denk, Stephanie J. Dimitroff, Eva Unternaehrer, Jens C. Pruessner

“…Salivary cortisol and alpha amylase, heart rate variability and subjective stress levels were assessed repeatedly. …”
Get full text

Tailored exercise and manual therapy versus standardised exercise for patients with shoulder subacromial pain: a feasibility randomised controlled trial (the Otago MASTER trial) by J Haxby Abbott, Daniel C Ribeiro, Zohreh Jafarian Tangrood, Gisela Sole, Ross Wilson

“…Since this is a feasibility study, we did not adjust alpha for multiple comparisons, and considered 75% CI as the probability threshold at 3-month follow-up. …”
Get full text