Neurophysiological gradient in the Parkinsonian subthalamic nucleus as a marker for motor symptoms and apathy by Elena Bernasconi, Deborah Amstutz, Alberto Averna, Petra Fischer, Mario Sousa, Ines Debove, Katrin Petermann, Laura Alva, Andreia D. Magalhães, M. Lenard Lachenmayer, Thuy-Anh K. Nguyen, Michael Schuepbach, Andreas Nowacki, Claudio Pollo, Paul Krack, Gerd Tinkhauser

“…Importantly, apathetic symptoms can be related to reduced ventral alpha power. In conclusion, the STN spectral gradient may inform about the motor and neuropsychiatric domain, supporting integrative closed-loop strategies.…”
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Innovative CDR grafting and computational methods for PD-1 specific nanobody design by Jagadeeswara Reddy Devasani, Girijasankar Guntuku, Nalini Panatula, Murali Krishna Kumar Muthyala, Mary Sulakshana Palla, Teruna J. Siahaan

“…The three-dimensional structure of the nanobody was predicted using AlphaFold2, and molecular docking simulations via ClusPro were conducted to evaluate binding interactions with PD-1. …”
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Key Success Factors in Entrepreneurial Development among Women Micro-Entrepreneurs in Malaysia by Vikneswary Tirumalaisamy, Asokan Vasudevan, Rajani Balakrishnan, Suleiman Ibrahim Shelash Mohammad, A. Vasumathi, Ahmad Samed Al-Adwan, Barween Al Kurdi

“…Results indicated that most variables had reliable Cronbach Alpha values, though issues with discriminant validity were found. …”
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Ascorbic acid-immobilized zinc selenide for electrochemical monitoring of hydrogen peroxide in liver cancer samples by Shan E Zahra Jawad, Sibtain Ahmed, Dilshad Hussain, Javerya Najeeb, Ayub Alam, Muhammad Najam-ul-Haq, Batool Fatima

“…Elecys AFP assay results validate that increasing alpha-fetoprotein (AFP) concentration, a biomarker for liver cancer, can increase the H2O2 levels in serum samples. …”
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Residential Density and Illegal Waste Dumping In Cities by Mahamba C, and Ruhiiga TM

“…Finding: The results indicate a concentration of illegal waste dumps in low-income high density residential districts, an adjusted R2=0.186 and, a 2-tailed p-value at alpha 0.05 of 0.006 and 0.040 which are statistically significant. …”
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Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies by Jinlin Hou, Thomas Berg, Arndt Vogel, Teerha Piratvisuth, Jörg Trojan, Enrico N. De Toni, Masatoshi Kudo, Katarina Malinowsky, Peter Findeisen, Johannes Kolja Hegel, Wenzel Schöning, Kairat Madin, Konstantin Kroeniger, Henry Lik-Yuen Chan, Ashish Sharma

“…Background & Aims: We compared the clinical performance of the novel GAAD (gender [biological sex], age, alpha-fetoprotein [AFP], des-gamma carboxyprothrombin [DCP]) and GALAD (gender [biological sex], age, AFP, Lens culinaris agglutinin-reactive AFP [AFP-L3], DCP) algorithms to deduce the clinical utility of AFP-L3 for detecting early-stage hepatocellular carcinoma (HCC) from chronic liver disease (CLD). …”
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Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

“…Study design: The study targeted specific AD-related proteins, including acetylcholinesterase (AChE), alpha serine/threonine-protein kinase (AKT-1), β-secretase-1 (BACE-1), cyclooxygenase-2 (COX-2), caspase-3, glycogen synthase kinase-3 (GSK-3), interleukin-6 (IL-6), mitogen-activated protein kinase-2 (MAPK-2), matrix metalloproteins-8 (MMP-8), N-methyl-d-aspartate receptor (NMDAR), Peptidyl arginine deiminase-2 (PAD-2), Presenilin-1 (PSEN-1), mitogen-activated protein kinase-14 (MAPK-14/P38), and tumor necrosis factor-alpha (TNF-α). …”
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The application of blockchain with a comparative approach and its impact on risk, flexibility and internal control evaluation by mohammadsadegh aminipoor, HamidReza GholamniaRoshan, azadeh kiapour, Iman Dadashi

“…In this research, in order to measure the reliability, the Cronbach's alpha method was used. To check the reliability, the questionnaire was first distributed among 30 people, and the Cronbach's alpha was calculated by the SPSS software. …”
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Pirfenidone Inhibits Hypoxic Pulmonary Hypertension through the NADPH/ROS/p38 Pathway in Adventitial Fibroblasts in the Pulmonary Artery by Song Zhang, ZongXiu Yin, WeiDong Qin, XiaoLi Ma, Yao Zhang, EnXiu Liu, YanBiao Chu

“…The expression levels of smooth muscle alpha-actin (a-SMA) and procollagen I (COL1A1) were assessed by RT-PCR and western blot analysis. …”
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Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation by Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor

“…It was found that this structure seems to not express the neuronal acetylcholine (ACh) receptor subunit alpha-7, required for anti-inflammatory action of ACh. …”
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Psychometric Properties of the Apathy Scale in Advanced Parkinson’s Disease by John B. Wetmore, José Matías Arbelo, María José Catalán, Francesc Valldeoriola, Carmen Rodriguez-Blazquez, Pablo Martinez-Martin

“…Overall, the parameters of feasibility/acceptability were satisfactory, except for a moderate-to-high floor effect in AS items but not in its total score (both 3.3%). Cronbach’s alpha was 0.78, while item homogeneity coefficient was 0.21. …”
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Pengaruh Keragaman Pangan, Junk Food, dan Produk Tinggi Gula Terhadap Kejadian Gizi Lebih Remaja SMAN 6 Depok by Salma Aulia Kencanaputri, Ibnu Malkan Bakhrul Ilmi, Sintha Fransiske Simanungkalit

“…Hasil: Analisis uji validitas menunjukkan valid dan uji realibilitas menunjukkan nilai Cronbach Alpha > r tabel (0,314). Analisis bivariat menunjukkan bahwa remaja mayoritas tidak mengalami gizi lebih (80,4%), remaja mengonsumsi pangan yang beragam (86,6%), dan remaja jarang mengonsumsi makanan (80,4%) dan minuman (69,6%) manis, serta junk food (70,5%). …”
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Distinctive Gut Microbiota Alteration Is Associated with Poststroke Functional Recovery: Results from a Prospective Cohort Study by Yini Dang, Xintong Zhang, Yu Zheng, Binbin Yu, Dijia Pan, Xiaomin Jiang, Chengjie Yan, Qiuyu Yu, Xiao Lu

“…Relationships between discriminant bacteria and poststroke functional outcomes were estimated. Results. Higher alpha diversity of gut microbiota was observed in poststroke patients as compared to the healthy controls (p<0.05). …”
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Acute metabolic decompensation after liver transplant in a patient with maple syrup urine disease by Shao Ching Tu, Marium Khan, Katie Wolfe, Sakil S. Kulkarni, Elizabeth Toolan, Dorothy K. Grange

“…Abstract Maple syrup urine disease (MSUD) is an inborn error of metabolism characterized by the accumulation of branched‐chain amino acids (leucine, isoleucine, and valine) caused by a defect in the branched‐chain alpha‐keto acid dehydrogenase complex. Liver transplant is an effective therapy for MSUD, and patients can usually tolerate a regular diet after transplant without symptomatic metabolic decompensation. …”
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利用Illumina MiSeq测序平台分析健康与腹泻食蟹猴粪样菌群 by 张飞燕 1 金洁 1 刘超 1 胡正飞 1 张玉林 1 谢丽分 1 邬继文 1 吕龙宝 1

“…采集成年腹泻与健康食蟹猴粪样各6份，用细菌16Sr DNA通用引物扩增V3—V4 区，采用Illumina MiSeq测序平台对食蟹猴粪便微生物进行研究。结果表明，Alpha多样性指数分析，健康组与腹泻组的微生物多样性指数（Shannon、Simpson）差异不显著，群落丰富度指数（Chao、Ace）差异显著。…”
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SNAP II and SNAPPE II as Predictors of Neonatal Mortality in a Pediatric Intensive Care Unit: Does Postnatal Age Play a Role? by Mirta Noemi Mesquita Ramirez, Laura Evangelina Godoy, Elizabeth Alvarez Barrientos

“…The Hosmer-Lemeshow test and the receiver operating characteristics (ROC) curve were used with SPSS 17.0 for statistical analysis. An Alpha error <5% was considered significant. Results. …”
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Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilo... by Elie Nemr, Elie El Helou, Georges Mjaess, Albert Semaan, Josselin Abi Chebel

“…Male patients aged ≥40 years, who had had mild to moderate LUTS for >6 months at screening, with no previous therapy or who are still symptomatic despite current use of alpha-blockers, were recruited. Exclusion criteria were an IPSS >19 and an age >80 years. …”
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Effect of Zolpidem in the Aftermath of Traumatic Brain Injury: An MEG Study by Praveen Sripad, Jessica Rosenberg, Frank Boers, Christian P. Filss, Norbert Galldiks, Karl-Josef Langen, Ralf Clauss, N. Jon Shah, Jürgen Dammers

“…MEG recordings taken before and after zolpidem showed a reduction in power in the theta-alpha (4–12 Hz) and lower beta (15–20 Hz) frequency bands. …”
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Anti-Inflammatory Effects of Artemisia Leaf Extract in Mice with Contact Dermatitis In Vitro and In Vivo by Chanyong Yun, Youngchul Jung, Wonjoo Chun, Beodeul Yang, Junghyun Ryu, Chiyeon Lim, Jung-Hoon Kim, Hyungwoo Kim, Su-In Cho

“…ALE prevented epidermal hyperplasia and infiltration of immune cells and lowered the production of interferon- (IFN-) gamma (γ), tumour necrosis factor- (TNF-) alpha (α), and interleukin- (IL-) 6 in inflamed tissues. …”
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Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C by Y. Kishida, N. Imaizumi, H. Tanimura, Y. Haruna, S. Kashiwamura, T. Kashiwagi

“…This study investigated the hypothesis that an induction approach with nIFN-beta for 24 weeks followed by PEG-IFN-alpha+ribavirin (standard of care: SOC) for 48 weeks (novel combination treatment: NCT) would increase the initial virologic response rate and restore innate and adaptive immune responses in CHC. …”
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