Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

“…Si-PTEN reduced the expression of tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and inducible nitric oxide synthase (iNOS), which upregulated the expression of Arg-1, CD206, CD163, p-p38, JNK, and AP-1 (P-values < 0.05). …”
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Skin Temperature in Parkinson’s Disease Measured by Infrared Thermography by Mathias Møller Purup, Karoline Knudsen, Pall Karlsson, Astrid Juhl Terkelsen, Per Borghammer

“…Patients with Parkinson’s disease (PD) often show peripheral autonomic dysfunction and depositions of pathological alpha-synuclein aggregates in the skin. However, functional consequences of this skin involvement have received little attention. …”
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Effect of Centella asiatica Leaf Extract on the Dietary Supplementation in Transgenic Drosophila Model of Parkinson’s Disease by Yasir Hasan Siddique, Falaq Naz, Smita Jyoti, Ambreen Fatima, Saba Khanam, Rahul, Fahad Ali, Syed Faiz Mujtaba, Mohammad Faisal

“…The role of Centella asiatica L. leaf extract was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. The leaf extract was prepared in acetone and was subjected to GC-MS analysis. …”
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Development and validation of a tool for advising primiparous women during early labour: study protocol for the GebStart Study by Mechthild M Gross, Susanne Grylka-Baeschlin, Antonia N Mueller, Jessica Pehlke-Milde

“…Internal consistency of the tool will be assessed using Cronbach’s alpha and convergent validity computing correlations of items of the tool with the German versions of the Childbirth Self-Efficacy Inventory and the Cambridge-Worry Scale. …”
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Paradoxical Association of Postoperative Plasma Sphingosine-1-Phosphate with Breast Cancer Aggressiveness and Chemotherapy by Rajesh Ramanathan, Ali Raza, Jamie Sturgill, Debra Lyon, Jessica Young, Nitai C. Hait, Kazuaki Takabe

“…Baseline S1P levels had weak inverse correlation with levels of the inflammatory mediator interleukin- (IL-) 17 and CCL-2 and positive correlation with tumor necrosis factor alpha (TNF-α). Midpoint S1P levels during adjuvant therapy were lower than baseline, with near return to baseline after completion, indicating a relationship between chemotherapy and circulating S1P. …”
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The Development and Psychometric Properties of the Visuospatial Working Memory Assessment (VWMA) for Children by Thitiya Wangkawan, Cynthia Lai, Peeraya Munkhetvit, Trevor Yung, Supaporn Chinchai

“…The results revealed that the score of item-objective congruence index (IOC) was 1.0 in overall items of assessment. The Cronbach alpha test confirmed that the internal consistency of VWMA showed good reliability in both types of the assessment, with the total score of computerized tests being .88 and the tabletop tests being .81. …”
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Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100 by M. Yasmin Begum, Ali Alqahtani, Mohammed Ghazwani, Noura Abdullah Alhamood, Umme Hani, Avanthi Jajala, Mohamed Rahamathulla

“…Duloxetine HCl produces a toxic substance called alpha-naphthol when duloxetine HCl is in contact with gastric fluid. …”
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Pilot application of an inflammation and physiological dysregulation index based on noninvasive salivary biomarkers by Andrey I. Egorov, William Xue, Jason Kobylanski, Miyu Fuzawa, Shannon M. Griffin, Timothy J. Wade, Michael Nye

“…Samples were tested for the neuroendocrine biomarkers alpha-amylase, cortisol, and dehydroepiandrosterone (DHEA) as well as immune system/inflammation biomarkers C-reactive protein (CRP), interleukin (IL)-1β, IL-6 and total immunoglobulin A (IgA). …”
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Rasch Model Analysis of the Psychometric Properties of the Positive Mental Health Scale in Students by Noorellah Yousefi, Alireza Pirkhaefi

“…The person-item reliability coefficient was 0.88, Cronbach's alpha was 0.86, and McDonald's omega coefficient was 0.84.Discussion and conclusion: The results of the study indicated that the Positive Mental Health Scale is a unidimensional instrument with favorable psychometric properties for assessing positive mental health in students. …”
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Cluster analysis of digital competencies among professors in higher education by Karime Chahuán-Jiménez, Eduardo Lara-Yergues, Dominique Garrido-Araya, Elena Salum-Alvarado, Paulina Hurtado-Arenas, Rolando Rubilar-Torrealba

“…PurposeThis research focuses on the diagnosis and clustering of professor higher education in relation to digital competencies, based on different levels of digital competency development.MethodsThe methodology employed in this study involved an Ordinary Least Squares (OLS) regression analysis and cluster analysis using K-means clustering algorithm, considering the Silhouette score, based on the responses obtained through a questionnaire DigComEdu framework, and adjusted according to the experts who conducted a validity analysis.ResultsThe findings indicate that, for the sample professor who answers the questionnaire voluntarily and confidentially, considering margin of error of 5%, a confidence level of 95%, and a response distribution of 50%, corresponding to 314 professors, with a Crombach’s alpha of 0.56, there is no relation between the variables of investigation, age, gender, academic degree, academic hierarchy, and years in academy and the level of digital competencies among professors. …”
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Review and Clinical Perspectives for the Use of Infliximab in Ulcerative Colitis by Remo Panaccione, Richard N Fedorak, Guy Aumais, Edmond-Jean Bernard, Charles N Bernstein, Alain Bitton, Ken Croitoru, Levinus A Dieleman, Robert Enns, Brian G Feagan, Denis Franchimont, Gordon R Greenberg, Anne-Marie Griffiths, John K Marshall, Pierre Pare, Sunil Patel, Robert Penner, Craig Render, Ernest Seidman, A Hillary Steinhart

“…Infliximab is a chimeric, monoclonal anti-tumour necrosis factor-alpha antibody. It has been previously demonstrated to be an effective treatment for patients with Crohn’s disease who do not achieve the desired response with conventional treatments. …”
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Spor video oyunları oyuncu deneyimi ölçeğinin Türkçe uyarlaması by Barıs Mergan, Cemal Ozman, Mehmet Kargun, Neslisah Aktas-Ustun

“…Ölçeğin Türkçe formunda yer alan alt boyutların Cronbach’s Alpha ve CR değerleri 0,82 ile 0,96 arasında dağılım göstermektedir. …”
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The Frequency and the Significance of TNF-&#945;+CD19+ B-cell Population in Lymph Nodes of Patients with Squamous Cell Carcinoma of Head and Neck by Marzieh Norouzian, Fereshteh Mehdipour, Mohammad Javad Ashraf, Bijan Khademi, Abbas Ghaderi

“…Materials and Methods: Thirty-six draining lymph nodes from untreated patients with tongue and larynx SCC were stimulated with CpG, recombinant CD40L and phorbol-12-myristate-13-acetate/ionomycin and analyzed by flow cytometry for the frequency of B-cell subsets based on interleukin (IL)-10 and tumor necrosis factor-alpha (TNF-&#945;) cytokine production. Results: It was indicated that patients with uninvolved lymph nodes and low stage of the disease had an increased percentage of TNF-&#945;+CD19+ B-cells (p=0.006 and p=0.041, respectively), whereas the frequency of IL-10+CD19+ B-cells showed an increasing trend in tumor-draining lymph nodes (TDLNs) of patients with grade 2+3 compared to grade 1 (p=0.054). …”
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Translation, cross-cultural adaptation and validation of the Chinese version of supportive and palliative care indicators tool (SPICT-CH) to identify cancer patients with palliativ... by Zhishan Xie, Siyuan Tang, Claire E. Johnson, Lin Xiao, Jinfeng Ding, Chongmei Huang

“…The SPICT-CH exhibited good coherence (Cronbach’s alpha = 0.76) and reliability (Kappa = 0.71, 95% CI 0.71-0.72, P < 0.05). …”
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Is the Family Health Center Professionals’ Knowledge Level About Child Abuse and Neglect Sufficent? A Comprehensive Field Study by Serdar Deniz, Muhammet Bayraktar, Tufan Nayir, Elçin Balcı, Feyza İnceoğlu

“…Materials and methods: In this study, a 67-item scale with a Cronbach’s alpha value of 0.92 was used. A score of more than 3 on the scale meant that the score was at a sufficient level. …”
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A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients by Christoph Hölscher, Lisa Heitmann, Ellis Owusu-Dabo, Rolf D. Horstmann, Christian G. Meyer, Stefan Ehlers, Thorsten Thye

“…The contribution of interleukin- (IL-) 4 receptor-alpha- (Rα-) dependent events in the pathogenesis of tuberculosis (TB) is controversial. …”
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Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats by Md. Iqbal Alam, Naba Sami, Aftab Alam, Sheema Wazib, Neha Dhyani, Sher Afghan, Mairaj Ahmed Ansari

“…Plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) were measured, along with those of the inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and high mobility group box-1 (HMGB-1). …”
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hUC-MSCs Attenuate Acute Graft-Versus-Host Disease through Chi3l1 Repression of Th17 Differentiation by Weijiang Liu, Fulin Yuan, Haitao Bai, Yuanlin Liu, Xue Li, Yang Wang, Yi Zhang

“…We found that hUC-MSCs treated with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) exhibited increased expression of Chi3l1 and concurrently repressed T-helper 17 cell (Th17) differentiation through inhibition of signal transducer and activator of transcription 3 (STAT3) activation. …”
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Linguistic-cultural validation of a French version of the oral health assessment tool by Rapp Lucie, Vergnes Jean-Noel, Monsarrat Paul, Kémoun Philippe, Balardy Laurent, Lacoste-Ferré Marie-Hélène

“…Internal consistency was considered good in the retrospective sample (Cronbach’s alpha value of 0.73) and excellent in the prospective sample (Cronbach’s alphas were 0.90 for each examiner). …”
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Work-Domain Goal Orientation: A Theoretical Framework for the Construct and Turkish Adaptation of a Work-Domain Goal Orientation Instrument by Aysun Gurol, Dilek Ilhan Findikoglu, Mehmet Gurol, Fuat Findikoglu, Mehmet Yesilkaya

“…The internal consistency was reliable, with Cronbach’s alpha values ranging from 0.84 to 0.86 across subscales. …”
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