Enhancing the bioaccessibility and stability of curcumin through the formation of curcumin-piperine complexes in delivery systems based on nanoemulsions stabilized with phospholipi... by M.J. Hernández-Hernández, C.I. Beristain, M. Jiménez-Fernández, E. Bonilla-Zavaleta, L.A. Pascual-Pineda, M.P. Rascón-Díaz

“…Curcumin is a phenolic compound with multiple health benefits and limited use due to its low bioaccessibility and bioavailability, which can be improved by the addition of alkaloid piperine and the use of nanoencapsulation systems such as nanoemulsions (NEs). …”
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Identification of In Vivo Metabolites of Dictamnine in Mice Using HPLC-LTQ-Orbitrap Mass Spectrometry by Yudong Fu, Yujie Deng, Qing Yu, Xuxia Meng, Dabo Wang, Pei Wang, Ping Wang

“…Dictamnine (4-methoxyfuro[2,3-b]quinolone, DIC), a common furoquinoline alkaloid in the family of Rutaceae, showed diverse biological activities. …”
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Transcriptomics Analysis Reveals Differences in Purine and Phenylpropanoid Biosynthesis Pathways Between <i>Camellia sinensis</i> var. Shuchazao and <i>Camellia ptilophylla</i> by Waqar Khan, Peng Zheng, Binmei Sun, Shaoqun Liu

“…The RNA-seq analysis of two species (SCZ and CAF) revealed the differences in caffeine and catechins synthesis. In the purine alkaloid biosynthesis pathway, the S-adenosyl methionine (SAM) and adenosine monophosphate (AMP) pathway genes were significantly related to xanthosine synthesis in contrasting purine alkaloids among (<i>Camellia sinensis</i> var. …”
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Anti-Inflammatory therapeutic potential of Bungur (Lagerstroemia speciosa L.) leaves ethanolic extract against LPS-activated macrophage through TLR4/MD2 signaling: A computational... by Rosyadah Nuraini, Dwijayanti Dinia Rizqi, Annisa Yuslinda, Kamila Fairuz Sarah, Widyananda Muhammad Hermawan, Ulfa Siti Mariyah, Widodo Nashi

“…Bungur leaves (L. speciosa L.) were extracted using MAE extraction and subjected to phenol, flavonoid, terpenoid, alkaloid content and antioxidant DPPH assay. The compound profile was analyzed using LC-HRMS. …”
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Drugs and Constipation in Elderly in Nursing Homes: What Is the Relation? by Gunvor S. Fosnes, Stian Lydersen, Per G. Farup

“…Reduced activity of daily living (OR = 0.71, 95% CI : 0.60–0.84, P<0.001), other antidepressants (N06AX) (OR 3.08, 95% CI : 1.09–8.68, P=0.03), and benzodiazepine derivatives (N05BA) (OR = 2.80, 95% CI : 1.12–7.04, P=0.03) were significantly associated with constipation; drugs with markedly anticholinergic effect (OR = 3.7, 95% CI : 0.78–17.53, P=0.10), natural opium alkaloid (N02AA) (OR = 5.01, 95% CI : 0.95–25.94, P=0.06), and propionic acid derivatives (M01AE) (OR = 7.00, 95% CI : 0.75–65.08, P=0.09) showed a trend. …”
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Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways by Li Jia, Kuijin Xue, Junheng Liu, Ola A. Habotta, Lianhai Hu, Ahmed E. Abdel Moneim

“…Berberine (BER), a natural isoquinoline alkaloid, has been demonstrated to have appreciable anticolitis effects. …”
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Multiproxy analysis exploring patterns of diet and disease in dental calculus and skeletal remains from a 19th century Dutch population by Bartholdy, Bjørn Peare, Hasselstrøm, Jørgen B., Sørensen, Lambert K., Casna, Maia, Hoogland, Menno, Historisch Genootschap Beemster, Henry, Amanda G.

“…The detection of plant-derived residues such as alkaloids and their metabolites in dental calculus provides direct evidence of consumption by individuals within a population. …”
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Effects of Prosopis farcta Root Extract in the Vascular Reactivity of Isolated Goat Coronary Artery by Rezhna Adil Rasheed, Ismail Salih Ibrahim Kakey

“…On the other hand, the extract tended to relax the CA rings through its antagonizing of Ca+2, reducing and inhibiting Ca+2 influx and release from internal stores and interfering with the voltage-operated Ca+2 channels through its alkaloid and flavonoid active compounds which suggested to be the most predicted mechanisms for the maintenance of vasodilating tone and coronary circulation of the PFRE in coronary artery.  …”
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Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis by Wang Fang, Zhang Yang, Pang Rui, Shi Shaohong, Wang Ran

“…Scoulerine, a benzylisoquinoline alkaloid, has been reported effective against several carcinomas. …”
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Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…In this study, we synthesized a novel canthin-6-one alkaloid, namely methyl canthin-6-one-2-carboxylate (Cant), and assessed its effects on NLRP3 inflammasome activation in macrophages. …”
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Study of Antibacterial Activity of Root Bark, Leaves, and Pericarp Extracts of Diploknema butyracea and Evaluation of Prospective Antioxidant Activity by Alisha Karki Chhetry, Subhila Dhakal, Lalita Chaudhary, Khimdhoj Karki, Ram Bahadur Khadka, Gautam Prasad Chaudhary, Tonking Bastola, Amrit Poudel, Pramod Aryal, Jitendra Pandey

“…Phytochemical screening of different samples of D. butyracea in different solvents revealed the presence of varied extent of alkaloid, saponin, terpenoid, anthraquinones, tannin, cardiac glycoside, flavonoid, carbohydrate, polyphenol, protein and amino acid, resin, and phytosterol. …”
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Comparison of the Efficiency of Lepidium sativum, Ficus carica, and Punica granatum Methanolic Extracts in Relieving Hyperglycemia and Hyperlipidemia of Streptozotocin-Induced Diab... by Shimaa Ramadan, Amany Mohamed Hegab, Yahya S. Al-Awthan, Mohammed Ali Al-Duais, Ahmed A. Tayel, Mahmoud A. Al-Saman

“…Phytochemical analysis revealed that the highest amounts of polyphenolic compounds were present in L. sativum seeds and P. granatum leaves, while leaves of F. carica showed the highest amounts of alkaloid and flavonoid content compared to other extracts. …”
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Nanonaringenin and Vitamin E Ameliorate Some Behavioral, Biochemical, and Brain Tissue Alterations Induced by Nicotine in Rats by Mohamed A. Kandeil, Eman T. Mohammed, Rania A. Radi, Fatma Khalil, Abdel-Razik H. Abdel-Razik, Mohamed M. Abdel-Daim, Ghada M. Safwat

“…Nicotine is the major alkaloid present in cigarettes that induces various biochemical and behavioral changes. …”
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Daya Hambat Ekstrak Daun Pegagan (Centella asiatica) yang Diambil di Batusangkar terhadap Pertumbuhan Kuman Vibrio cholerae secara In Vitro by Nelvita Sari Ramadhan, Roslaili Rasyid, Elmatris Sy

“…Antibacterial effect obtained as Centella asiatica contains anti-bacterial substances, such as saponins, tannins, alkaloids, and flavonoids. This study was conducted to determine the inhibition of extracts of Centella asiatica on the growth of Vibrio cholerae in vitro. …”
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The Influence of Monoamine Oxidase Variants on the Risk of Betel Quid-Associated Oral and Pharyngeal Cancer by Ping-Ho Chen, Bin Huang, Tien-Yu Shieh, Yan-Hsiung Wang, Yuk-Kwan Chen, Ju-Hui Wu, Jhen-Hao Huang, Chun-Chia Chen, Ka-Wo Lee

“…Betel quid (BQ) and areca nut (AN) (major BQ ingredient) are group I human carcinogens illustrated by International Agency for Research on Cancer and are closely associated with an elevated risk of oral potentially malignant disorders (OPMDs) and cancers of the oral cavity and pharynx. The primary alkaloid of AN, arecoline, can be metabolized via the monoamine oxidase (MAO) gene by inducing reactive oxygen species (ROS). …”
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Synthesis and Spatial Structure of 3-Phenylacrylic Acid Octahydroquinolizin-1-Ylmethyl Ester and 2-(Octahydroquinolizin-1-Ylmethyl)Isoindole-1,3-Dione by Zh.S. Nurmaganbetov, O.A. Nurkenov, S.D. Fazylov, D.M. Turdybekov, Ye.V. Minayeva, G. Khabdolda, A.M. Ibraybekova, Zh.S. Tilla, K.M. Turdybekov

“… The reactions of lupinine alkaloid and its chlorine derivative with cinnamoyl chloride and 2-K-isoindole-1,3-dione were investigated to obtain 3-phenylacrylic acid octahydroquinolizin-1-ylmethyl ester and 2-(octahydroquinolizin-1-ylmethyl)isoindole-1,3-dione, respectively. …”
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Expression of a Splice Variant of CYP26B1 in Betel Quid-Related Oral Cancer by Ping-Ho Chen, Ka-Wo Lee, Cheng-Chieh Hsu, Jeff Yi-Fu Chen, Yan-Hsiung Wang, Ker-Kong Chen, Hui-Min David Wang, Hurng-Wern Huang, Bin Huang

“…Arecoline is the primary alkaloid in the AN and can be metabolized through the cytochrome P450 (CYP) superfamily by inducing reactive oxygen species (ROS) production. …”
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Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. …”
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Screening of Solvent Systems for Countercurrent Chromatography Separation of Polar Constituents from <i>Ginkgo biloba</i> L. Seeds by Ruxi Hu, Zhuo Liu, Yi Zhou, Peng Tian, Luqi Li, Zhi Yang, Yatuan Ma

“…At last, five constituents were purified and identified, including 4′-O-methylpyridoxine (<b>1</b>); two indole alkaloid N-glucosides, ginkgoside B (<b>2</b>) and ginkgoside A (<b>3</b>); 2-(4-hydroxybenzyl) malic acid (<b>4</b>); and coniferyl alcohol (<b>5</b>). …”
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Repurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4 by Asma Khatoon Zaidi, Anurag Kumar, Rohit Kumar, Jyoti Singh, Sneha Yadav, Archana Bharti Sonkar, Dharmendra Kumar, Neeraj Kumar Shrivastava, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas

“…BRU is a monoterpenoid indole alkaloid and is used in the regulation of high blood pressure and other comparatively benign cardiac ailments. …”
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