A novel molecular classification system based on the molecular feature score identifies patients sensitive to immune therapy and target therapy by Yang Li, Yang Li, Yinan Ding, Yinan Ding, Jinghao Wang, Xiaoxia Wu, Xiaoxia Wu, Dinghu Zhang, Dinghu Zhang, Han Zhou, Han Zhou, Pengfei Zhang, Pengfei Zhang, Guoliang Shao, Guoliang Shao

“…Subsequently, machine learning algorithms were used to predict the classifications and prognoses. …”
Get full text

Soil Moisture Retrieval in Winter Wheat Fields at Different Growth Stages: Integrating a Two-Component Polarimetric SAR Decomposition With CIEM by Wenxin Xue, Qinghua Xie, Xing Peng, J. David Ballester-Berman, Jinfei Wang, Jiali Shang, Haiqiang Fu, Jianjun Zhu

“…Nevertheless, there is no consensus within the synthetic aperture radar community when it comes to the identification of those existing physically based models and algorithms providing the best performances in terms of accuracy, reproducibility, complexity, and generalizability (i.e., their application to different crops and growth stages). …”
Get full text

Identification and mechanism analysis of biomarkers related to butyrate metabolism in COVID-19 patients by Wenchao Zhou, Hui Li, Juan Zhang, Changsheng Liu, Dan Liu, Xupeng Chen, Jing Ouyang, Tian Zeng, Shuang Peng, Fan Ouyang, Yunzhu Long, Yukun Li

“…Six machine learning algorithms were employed to determine the best model for identifying biomarkers, and receiver operating characteristic (ROC) curves were plotted to evaluate the diagnostic value of the biomarkers in COVID-19. …”
Get full text

Deep learning radiomics nomogram predicts lymph node metastasis in laryngeal squamous cell carcinoma by Yun Liang, Yun Liang, Min He, Wenqing Chen, Wenqing Chen, Lizhen Li, Lizhen Li, Yumeng Dong, Yumeng Dong, Gang Liang, Hui Huangfu, Zengyu Jiang, Zengyu Jiang, Sheng He, Sheng He, Sheng He

“…Radiomics features were extracted from CT images, and 7 machine learning algorithms were used to develop 7 radiomics models, which were combined with deep learning features extracted from the ResNet50 deep learning network to form deep learning radiomics (DLR) models. …”
Get full text

Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effectsResearch in context by Deeksha Malhan, Janina Hesse, Nina Nelson, Kay Stankov, Jessica Nguyen, Ouda Aboumanify, Josefin Garmshausen, Gunther Rogmans, Bastian Czogalla, Jens Gerber, Martin Koch, Tomáš Kupec, Oliver Tomé, Ralf Witteler, Mustafa Deryal, Michael Eichbaum, Jalid Sehouli, Elena Ioana Braicu, Angela Relógio

“…In a subset of these patients, we performed differential gene expression and rhythmicity analysis on up to 800 genes, including clock and clock-controlled genes. Machine learning algorithms and mathematical modelling were employed to simulate patient-specific toxicity profiles and to explore correlations between gene expression patterns and treatment-related side effects. …”
Get full text

Peningkatan Keamanan Basis Data menggunakan Kombinasi Algoritma RC4 dan SHA3-512 by Asep Rizal Nurjaman, Sofia Umaroh

“…Keywords: SHA3-512, Encryption, Decryption, Hashing, RC4, Algorithm…”
Get full text

Age and Saving Lives in Crisis Standards of Care: A Multicenter Cohort Study of Triage Score Prognostic Accuracy by Michael Hermsen, MD, MS, Patrick G. Lyons, MD, MS, Govind Persad, JD, PhD, Alice F. Bewley, MS, Chengsheng Mao, PhD, Kaveri Chhikara, MS, Anoop Mayampurath, PhD, Matthew Churpek, MD, PhD, Monica E. Peek, MD, MPH, MSc, Yuan Luo, PhD, William F. Parker, MD, PhD

“…Incorporating age into prioritization algorithms could save more lives in a crisis scenario.…”
Get full text

Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs by Jinjun Li, Kai Zhao, Guotai Yang, Haohao Lv, Renxin Zhang, Shuhan Li, Zhiyuan Chen, Min Xu, Naixue Yang, Shaoxing Dai

“…By applying MoLFormer-based oversampling and testing different algorithms, it was found that the Support Vector Machine (SVM) and Multilayer Perceptron (MLP) models with MoLFormer embeddings exhibited the best performance, achieving Area Under the Curve (AUC) scores of 0.998 and 0.997, and F1 scores of 0.948 and 0.941, respectively. …”
Get full text

γ‐Glutamyl Transferase and Long‐Term Survival in the SYNTAXES Trial: Is It Just the Liver? by Kai Ninomiya, Patrick W. Serruys, Scot Garg, Shigetaka Kageyama, Nozomi Kotoku, Shinichiro Masuda, Pruthvi C. Revaiah, Neil O'leary, Arie Pieter Kappetein, Michael J. Mack, David R. Holmes, Piroze M. Davierwala, Friedrich W. Mohr, Daniel J. F. M. Thuijs, Yoshinobu Onuma

“…Background Recently, machine learning algorithms have identified preprocedural γ‐glutamyl transferase (GGT) as a significant predictor of long‐term mortality after coronary revascularization in the SYNTAX (Synergy Between PCI [Percutaneous Coronary Intervention] With Taxus and Cardiac Surgery) trial. …”
Get full text

Postauthorization safety study of the DPP-4 inhibitor saxagliptin: a large-scale multinational family of cohort studies of five outcomes by Qing Liu, Sean Hennessy, Qufei Wu, K Rajender Reddy, Arlene M Gallagher, Kevin Haynes, David J Margolis, Brian L Strom, Vincent Lo Re, M Elle Saine, Craig W Newcomb, Jason A Roy, Serena Cardillo, Stephen E Kimmel, Peter P Reese, Andrea J Apter, Harshvinder Bhullar, Daina B Esposito, Dean M Carbonari

“…Outcomes were hospitalized major adverse cardiovascular events (MACE), acute kidney injury (AKI), acute liver failure (ALF), infections, and severe hypersensitivity events, evaluated using diagnostic coding algorithms and medical records. Cox regression was used to determine HRs with 95% CIs for each outcome. …”
Get full text

Recent Developments to the ANSWERS® Monte Carlo Codes MONK® and MCBEND® by Fildes Jessica, Richards Simon, Bird Adam, Cox Andrew, Fry Timothy, Hanlon David, Jones Brian, Long David, Tantillo Francesco, Wright George, Hiles Richard

“…The geometry capabilities have been enhanced by the addition of novel stochastic geometry algorithms for modelling highly disordered heterogeneous mixtures and random distributions of shapes. …”
Get full text

Fibrosis-4plus score: a novel machine learning-based tool for screening high-risk varices in compensated cirrhosis (CHESS2004): an international multicenter study by Bingtian Dong, Ruiling He, Shenghong Ju, Yuping Chen, Ivica Grgurevic, Jianzhong Ma, Ying Guo, Huizhen Fan, Qiang Yan, Chuan Liu, Huixiong Xu, Anita Madir, Kristian Podrug, Jia Wang, Linxue Qian, Zhengzi Geng, Shanghao Liu, Tao Ren, Guo Zhang, Kun Wang, Meiqin Su, Fei Chen, Sumei Ma, Liting Zhang, Zhaowei Tong, Yonghe Zhou, Xin Li, Fanbin He, Hui Huan, Wenjuan Wang, Yunxiao Liang, Juan Tang, Fang Ai, Tingyu Wang, Liyun Zheng, Zhongwei Zhao, Jiansong Ji, Wei Liu, Jiaojiao Xu, Bo Liu, Xuemei Wang, Yao Zhang, Qiong Yan, Hui Liu, Xiaomei Chen, Shuhua Zhang, Yihua Wang, Yang Liu, Li Yin, Yanni Liu, Yanqing Huang, Li Bian, Ping An, Xin Zhang, Shaoting Zhang, Jinhua Shao, Xiangman Zhang, Wei Rao, Chaoxue Zhang, Christoph Frank Dietrich, Won Kim, Xiaolong Qi

“…., age, aspartate aminotransferase, alanine aminotransferase, and platelet count [PLT]) were combined using machine learning algorithms (logistic regression [LR] and extreme gradient boosting [XGBoost]) to develop the LR-FIB-4plus and XGBoost-FIB-4plus models, respectively. …”
Get full text

CYLD as a key regulator of myocardial infarction-to-heart failure transition revealed by multi-omics integration by Jingya Xu, Jingya Xu, Zhonghua Dong, Zhaodong Li, Xuan Wang, Xuan Wang

“…Our multistep analytical pipeline included weighted gene coexpression network analysis (WGCNA) to map interacting genes, machine learning algorithms for robust classification, functional annotation via Kyoto Encyclopedia of Genes and Genomes (KEGG) to explore biological pathways, CIBERSORT correlation analysis linking hub genes with immune cell states, transcriptional regulation profiling of key hubs, and single-cell sequencing to assess the functional relevance of these hubs.ResultsOur findings revealed that 413 DEGs were significantly different between MI and HF. …”
Get full text

Unraveling the complex genetic landscape of OTOF-related hearing loss: a deep dive into cryptic variants and haplotype phasing by Pei-Hsuan Lin, Cheng-Yu Tsai, Yu-Ting Chiang, Chang-Han Ho, Yue-Sheng Lu, Jacob Shu-Jui Hsu, Yen-Fu Cheng, Shih-Feng Tsai, Chuan-Jen Hsu, Pei-Lung Chen, Chen-Chi Wu

“…The integration of advanced sequencing technologies, predictive algorithms, and functional validation assays will improve the accuracy of molecular diagnosis and inform personalized treatment strategies for individuals with DFNB9. …”
Get full text

DMP-PUNet: A novel network for two-dimensional InSAR phase unwrapping under severe noise and complex fringes conditions by Yu Chen, Shuai Wang, Yandong Gao, Yanjian Sun, Jinqi Zhao, Kun Tan, Peijun Du

“…This simulation, combined with quasi-real interferometric phase data obtained from DEM inversion algorithms, forms the comprehensive training dataset. …”
Get full text

Advancing sustainability: The impact of emerging technologies in agriculture by Ashoka Gamage, Ruchira Gangahagedara, Shyamantha Subasinghe, Jeewan Gamage, Chamini Guruge, Sera Senaratne, Thevin Randika, Chamila Rathnayake, Zammil Hameed, Terrence Madhujith, Othmane Merah

“…The integration of data analytics and machine learning algorithms is transforming supply chain management and enhancing the capabilities of predictive analytics in the context of crop diseases. …”
Get full text

Prognostic value of multi-PLD ASL radiomics in acute ischemic stroke by Zhenyu Wang, Yuan Shen, Xianxian Zhang, Qingqing Li, Congsong Dong, Shu Wang, Haihua Sun, Mingzhu Chen, Xiaolu Xu, Pinglei Pan, Pinglei Pan, Zhenyu Dai, Fei Chen, Fei Chen

“…Features were selected using least absolute shrinkage and selection operator regression, and three models were developed: a clinical model, a CBF radiomics model, and a combined model, employing eight ML algorithms. Model performance was assessed using receiver operating characteristic curves and decision curve analysis (DCA). …”
Get full text

Integrated multiomics analysis identifies PHLDA1+ fibroblasts as prognostic biomarkers and mediators of biological functions in pancreatic cancer by Rui Wang, Rui Wang, Guan-Hua Qin, Guan-Hua Qin, Yifei Jiang, Fu-Xiang Chen, Fu-Xiang Chen, Zi-Han Wang, Zi-Han Wang, Lin-Ling Ju, Lin Chen, Da Fu, En-Yu Liu, Su-Qing Zhang, Wei-Hua Cai

“…A 7-gene mCAF-associated risk model was constructed using advanced machine learning algorithms, and the biological significance of PHLDA1 was validated through co-culture experiments and pan-cancer analyses.ResultsOur multiomics analysis revealed that the novel 7-gene model (comprising USP36, KLF5, MT2A, KDM6B, PHLDA1, REL, and DDIT4) accurately predicts patient survival, immunotherapy response, and TME status. …”
Get full text

Multilevel determinants of racial/ethnic disparities in severe maternal morbidity and mortality in the context of the COVID-19 pandemic in the USA: protocol for a concurrent triang... by Bankole Olatosi, Jiajia Zhang, Xiaoming Li, Chen Liang, Jihong Liu, Peiyin Hung, Shan Qiao, Berry A Campbell, Myriam E Torres, Neset Hikmet

“…Non-Hispanic black and Hispanic pregnant women appear to have disproportionate SARS-CoV-2 infection and death rates.Methods and analysis We will use the socioecological framework and employ a concurrent triangulation, mixed-methods study design to achieve three specific aims: (1) examine the impacts of the COVID-19 pandemic on racial/ethnic disparities in severe maternal morbidity and mortality (SMMM); (2) explore how social contexts (eg, racial/ethnic residential segregation) have contributed to the widening of racial/ethnic disparities in SMMM during the pandemic and identify distinct mediating pathways through maternity care and mental health; and (3) determine the role of social contextual factors on racial/ethnic disparities in pregnancy-related morbidities using machine learning algorithms. We will leverage an existing South Carolina COVID-19 Cohort by creating a pregnancy cohort that links COVID-19 testing data, electronic health records (EHRs), vital records data, healthcare utilisation data and billing data for all births in South Carolina (SC) between 2018 and 2021 (>200 000 births). …”
Get full text

Optimizing wind energy conversion system efficiency using advanced modified super-twisting direct power control: Real-time implementation on dSPACE 1104 board by Mourad Yessef, Habib Benbouhenni, Ahmed Lagrioui, Youness El Mourabit, Nicu Bizon, Ilhami Colak, Badre Bossoufi, Ayman Alhejji

“…This enhanced technique is characterized by its algorithmic simplicity, a reduced number of control gains, straightforward implementation on embedded platforms, and low computational and hardware cost, making it particularly suitable for real-time control applications. …”
Get full text