Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment by Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang

Get full text

Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

Get full text

Editorial: Insights in clinical and translational physiology: 2023 by Gaetano Santulli, Gaetano Santulli, Gaetano Santulli, Markus W. Hollmann, Christina M. Pabelick, Johannes J. Van Lieshout, Johannes J. Van Lieshout

Get full text

Aging, cancer, and autophagy: connections and therapeutic perspectives by Begoña Zapatería, Esperanza Arias, Esperanza Arias

Get full text

Dysfunction of G Protein-Coupled Receptor Kinases in Alzheimer's Disease by William Z. Suo, Longxuan Li

Get full text

Inflammatory Signalings Involved in Airway and Pulmonary Diseases by I-Ta Lee, Chuen-Mao Yang

Get full text

Cancer care in German centers of excellence during the first 2 years of the COVID-19 pandemic by Volker Arndt, Daniela Doege, Stefan Fröhling, Peter Albers, Hana Algül, Ralf Bargou, Carsten Bokemeyer, Martin Bornhäuser, Christian H. Brandts, Peter Brossart, Sara Yvonne Brucker, Tim H. Brümmendorf, Hartmut Döhner, Norbert Gattermann, Michael Hallek, Volker Heinemann, Ulrich Keilholz, Thomas Kindler, Cornelia von Levetzow, Florian Lordick, Ulf Peter Neumann, Christoph Peters, Dirk Schadendorf, Stephan Stilgenbauer, Thomas Zander, Daniel Zips, Delia Braun, Thomas Seufferlein, Gerd Nettekoven, Michael Baumann

Get full text

Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes by Luca Pangrazzi, Andreas Meryk

Get full text

Decreases in mRNA by an siRNA Complex Do not Alter Blood Pressure in Mice by Su-Min Ji, Young-Bin Shin, So-Yon Park, Hyeon-Ju Lee, Bermseok Oh

“…The Global Blood Pressure Genetics (Global BPgen) and Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) consortiums identified 14 loci that govern blood pressure on a genomewide significance level, one of which is CASZ1 confirmed in both Europeans and Asians. …”
Get full text

Anti-aging versus positive-aging language in scientific literature: Raising questions for future research by Akbar Azizi-Zeinalhajloo, Haidar Nadrian, Nafiseh Ghassab-Abdollahi, Elham Lotfalinejad, Hassan Rezaeipandari, Devender Bhalla

Get full text

A descriptive epidemiological study of the prevalence of self-reported sensory difficulties by age group, sex, education, disability, and migration status in Sweden in 2020 by Andreea-Corina Badache, Elina Mäki-Torkko, Stephen Widen, Stefan Fors

Get full text

The burden of prostate cancer in the North Africa and Middle East Region from 1990 to 2021 by Saeid Safiri, Ali Shamekh, Kamaleddin Hassanzadeh, Asra Fazlollahi, Mark J. M. Sullman, Mortaza Raeisi, Ali-Asghar Kolahi

Get full text

The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization by Annekatrin Richter, Hanna Mörl, Maria Thielemann, Markus Kleemann, Raphael Geißen, Robert Schwarz, Carolin Albertz, Philipp Koch, Andreas Petzold, Torsten Kroll, Marco Groth, Nils Hartmann, Amaury Herpin, Christoph Englert

“…Here, we demonstrate that the Y-chromosomal copy of the TGF-β family member gdf6 (gdf6Y) in Nothobranchius furzeri, an emerging model organism in aging research, gained the function of the male sex determinant through allelic diversification while retaining the skeletal developmental function shared with the X-chromosomal gdf6 allele (gdf6X). …”
Get full text

Portrait of WWP1: the current state in human cancer by Jiaming Lei, Jun Chen, Wenwen Yu, Qing Wu, Shuang Jing, Yuanguang Tang, Li Lin, Meichun Hu

Get full text

Epidemiology of urinary tract infections in the Middle East and North Africa, 1990–2021 by Fatemeh Amiri, Saeid Safiri, Reza Aletaha, Mark J. M. Sullman, Kamaleddin Hassanzadeh, Ali-Asghar Kolahi, Shahnam Arshi

Get full text

Burden and trends of dietary iron deficiency in the Middle East and North Africa region, 1990–2021 by Saeid Safiri, Saeid Safiri, Fatemeh Amiri, Nahid Karamzad, Nahid Karamzad, Mark J. M. Sullman, Mark J. M. Sullman, Ali-Asghar Kolahi, Morteza Abdollahi

Get full text

Psychological experience of inpatients with acute pancreatitis: a qualitative study by Yuanyuan Chen, Guotao Lu, Can Zhang, Yiwen Gao, Jingwen Qin, Weiwei Chen, Yan Ren, Shuli Ma, Weijuan Gong, Xiaoxi Yang, Hongmei He

Get full text

Precise and interpretable neural networks reveal epigenetic signatures of aging across youth in health and disease by David Martínez-Enguita, Thomas Hillerton, Julia Åkesson, Daniel Kling, Maria Lerm, Mika Gustafsson

“…Our models offer broad applications in personalized medicine and aging research, providing a valuable resource for interpreting aging trajectories in health and disease.…”
Get full text

Translational Science in Vascular Aging: From Bench to Bedside—Insights from a VascAgeNet Roundtable by Elisabetta Bianchini, Lynn Roth, Pierre Boutouyrie, Smriti Badhwar, Achim Schwarz, Vincenzo Gemignani, Rosa Maria Bruno, Bernhard Hametner, Chloe Park, Giacomo Pucci, Ioana Mozos, Dimitrios Terentes-Printzios, Rachel E. Climie, Andrea Guala, Jordi Alastruey, Christopher C. Mayer

“…Abstract Translating vascular aging research from bench to bedside presents both significant opportunities and challenges. …”
Get full text

Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia by Shutaro Shibata, Moeko Noguchi-Shinohara, Ayano Shima, Taro Ozaki, Yuta Usui, Yasuyuki Taki, Kazuhiro Uchida, Takanori Honda, Jun Hata, Tomoyuki Ohara, Tatsuya Mikami, Tetsuya Maeda, Masaru Mimura, Kenji Nakashima, Jun-ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Kenjiro Ono, On behalf of the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group

Get full text