Poststroke Cell Therapy of the Aged Brain by Aurel Popa-Wagner, Madalina Filfan, Adriana Uzoni, Pouya Pourgolafshan, Ana-Maria Buga

“…Our group proved that important differences appear in the aged brain compared with young one, that is, the accelerated progression of ischemic area, or the delayed initiation of neurological recovery. …”
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Neural Plastic Effects of Cognitive Training on Aging Brain by Natalie T. Y. Leung, Helena M. K. Tam, Leung W. Chu, Timothy C. Y. Kwok, Felix Chan, Linda C. W. Lam, Jean Woo, Tatia M. C. Lee

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Inflammatory biomarkers profiles and cognition among older adults by Aline Thomas, Jing Guo, Dolly Reyes-Dumeyer, Danurys Sanchez, Nikolaos Scarmeas, Jennifer J. Manly, Adam M. Brickman, Rafael A. Lantigua, Richard Mayeux, Yian Gu

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Dietary Fatty Acids and Predementia Syndromes by Vincenzo Solfrizzi, Vincenza Frisardi, Cristiano Capurso, Alessia D' Introno, Anna M. Colacicco, Gianluigi Vendemiale, Antonio Capurso, Francesco Panza

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Polyunsaturated Fatty Acid and S-Adenosylmethionine Supplementation in Predementia Syndromes and Alzheimer's Disease: A Review by Francesco Panza, Vincenza Frisardi, Cristiano Capurso, Alessia D'Introno, Anna M. Colacicco, Alessandra Di Palo, Bruno P. Imbimbo, Gianluigi Vendemiale, Antonio Capurso, Vincenzo Solfrizzi

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Pinpointing Synaptic Loss Caused by Alzheimer’s Disease with fMRI by Adam M. Brickman, Scott A. Small, Adam Fleisher

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Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system by Andrea Pedroni, Elanur Yilmaz, Lisa Del Vecchio, Prabesh Bhattarai, Inés Talaya Vidal, Yu-Wen E. Dai, Konstantinos Koutsogiannis, Caghan Kizil, Konstantinos Ampatzis

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The Processing of Global and Local Visual Information in Alzheimer’s Disease by Eriko Matsumoto, Yoshitaka Ohigashi, Misato Fujimori, Etsuro Mori

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Crossed Non-Dominant Hemisphere Syndrome in a Right-Hander by M. Fujimori, K. Wakisaka, A. Yamadori, T. Imamura, T. Uehara, K. Yamashita, M. Tabuchi

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Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain by Darine Villela, Claudia K. Suemoto, Renata Leite, Carlos Augusto Pasqualucci, Lea T. Grinberg, Peter Pearson, Carla Rosenberg

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Disentangling Tinnitus Distress and Tinnitus Presence by Means of EEG Power Analysis by Martin Meyer, Matthias S. Luethi, Patrick Neff, Nicolas Langer, Stefan Büchi

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Neuropsychiatric Symptoms in Patients with Idiopathic Normal Pressure Hydrocephalus by Yumiko Kito, Hiroaki Kazui, Yoshihiko Kubo, Tetsuhiko Yoshida, Masahiko Takaya, Tamiki Wada, Keiko Nomura, Mamoru Hashimoto, Shingo Ohkawa, Hiroji Miyake, Masatsune Ishikawa, Masatoshi Takeda

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Assessment of clinical prognosis in autoimmune encephalitis: Girona score by Gary Álvarez Bravo, Giuseppe Guglielmini, Ana Quiroga Varela, Almudena Boix Lago, Ariadna Gifreu Fraixinó, Daniele Urso, Daniele Urso, Daniele Urso, Daniele Urso, Giancarlo Logroscino, Giancarlo Logroscino, Giancarlo Logroscino, Giancarlo Logroscino, Lluís Ramió-Torrentà

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The WAVE complex in developmental and adulthood brain disorders by Hyung-Goo Kim, Clara Berdasco, Angus C. Nairn, Yong Kim

“…Abstract Actin polymerization and depolymerization are fundamental cellular processes required not only for the embryonic and postnatal development of the brain but also for the maintenance of neuronal plasticity and survival in the adult and aging brain. The orchestrated organization of actin filaments is controlled by various actin regulatory proteins. …”
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The Robustness of White Matter Brain Networks Decreases with Aging by Chenye Huang, Xie Wang, Daojun Xie

“…Conclusions: These findings suggest that WM pathologies are associated with aging and offer new insights into the imaging characteristics of the aging brain.…”
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Immune Challenge Alters Reactivity of Hippocampal Noradrenergic System in Prenatally Stressed Aged Mice by Gayane Grigoryan, Niklas Lonnemann, Martin Korte

“…Further exploration of the mechanisms of the observed phenomena will add to our understanding of the interaction between PS and proinflammatory immune activation and its contribution to the functional and structural integrity of the aging brain.…”
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Mapping and modeling age-related changes in intrinsic neural timescales by Kaichao Wu, Leonardo L. Gollo

“…However, the impact of these structural changes on temporal coding in the aging brain remains unclear. We mapped intrinsic timescales and gray matter volume (GMV) using magnetic resonance imaging (MRI) in young and elderly adults. …”
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Functional connectivity-based compensation in the brains of non-demented older adults and the influence of lifestyle: A longitudinal 7-year study by Pascal Frédéric Deschwanden, Isabel Hotz, Susan Mérillat, Lutz Jäncke

“…Introduction: The aging brain is characterized by structural decline and functional connectivity changes towards dedifferentiation, leading to cognitive decline. …”
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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

“…Despite these significant clinical observations, investigation into cerebrovascular dysfunction and neuropathology in MFS remains limited.MethodsUsing 6M-control (C57BL/6) and 6M-MFS (Fbn1C1041G/+) and healthy 12M-control male and female mice, we test the hypothesis that abnormal Fbn1 protein expression is associated with altered cerebral microvascular density, BBB permeability, and neuroinflammation in the PCA-perfused hippocampus, all indicative of a pre-mature aging brain phenotype. Glut1 immunostaining was used to quantify microvascular density, IgG staining to assess BBB permeability, and microglial counts to evaluate neuroinflammation.ResultsUsing Glut1 staining, 6M-MFS mice and 12M-CTRL similarly present decreased microvascular density in the dentate gyrus (DG), cornu ammonis 1 (CA1), and cornu ammonis 3 (CA3) regions of the hippocampus. 6M-MFS mice exhibit increased BBB permeability in the DG and CA3 as evident by Immunoglobulin G (IgG) staining. …”
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Surgery impairs glymphatic activity and cognitive function in aged mice by Kai Chen, Xingyu Du, Melissa A. Chao, Zhongcong Xie, Guang Yang

“…Impairments in glymphatic function have been observed in aging brains and various neurodegenerative conditions. …”
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