Integrating machine learning with mendelian randomization for unveiling causal gene networks in glioblastoma multiforme by Lixin Du, Pan Wang, Xiaoting Qiu, Zhigang Li, Jianlan Ma, Pengfei Chen

“…Abstract Background Glioblastoma multiforme (GBM) is a highly aggressive brain cancer with poor prognosis and limited treatment options. …”
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Screening of necroptosis-related genes and evaluating the prognostic capacity, clinical value, and the effect of their copy number variations in acute myeloid leukemia by Dake Wen, Ru Yan, Lin Zhang, Haoyang Zhang, Xuyang Chen, Jian Zhou

“…Abstract Background Acute myeloid leukemia (AML) is an aggressive hematological neoplasm. Little improvement in survival rates has been achieved over the past few decades. …”
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Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study by Mohamed A Baba, Ahmed Kharbach, Mohamed Lmejjati, Nawal Adali

“…Background: Glioblastomas are aggressive brain tumours that significantly impact patients’ functional and psychological well-being, making the evaluation of health-related quality of life (HRQoL) essential. …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Yajuan Yan,1,* Ting Duan,1,* Xiaonan Xue,1,* Xiaojuan Yang,2 Miao Liu,2 Bin Ma,3,4 Xiangguo Duan,2 Chunxia Su1 1Department of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Inspection, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 3Department of Surgery, The First People’s Hospital of Yinchuan, Yinchuan, Ningxia, People’s Republic of China; 4The Second School of Clinical Medicine, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunxia Su; Xiangguo Duan, Email chunxiasu@qq.com; duanxiangguo@nxmu.edu.cnBackground: Colorectal cancer (CRC) is a highly malignant and aggressive gastrointestinal tumor. Due to its weak immunogenicity and limited immune, cell infiltration lead to ineffective clinical outcomes. …”
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Impact of invasive infections on clinical outcomes in acute pancreatitis: early predictive factors and implications for prophylactic anti-infective therapy by Fabienne Bender, Theresa König, Matthias Hecker, Moritz Fritzenwanker, Jacqueline Braun, Joern Pons-Kühnemann, Matthias Wolff, Andreas Hecker, Martin Reichert

“…The presence of ascites and elevated white blood cell count at onset of acute pancreatitis are significant predictive factors indicating the risk of invasive infection with relevant bacterial load. Thus, an aggressive, early anti-infective strategy against pathogens of intestinal origin should be considered in these cases and may improve patient outcomes.…”
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Ethical attitudes of the future Russian officials and businessmen: Comparative analysis by A. A. Maksimenko, O. S. Deyneka, D. V. Krylova, E. V. Zabelina, E. A. Bulgakova

“…Future officials turned out to have higher indicators on the scales of cynicism, aggressiveness and hostility than students in the field of business education. …”
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Long-term outcome of photodynamic therapy with hexyl aminolevulinate, 5-aminolevulinic acid nanoemulsion and methyl aminolevulinate for low-risk Basal Cell Carcinomas by M. Salmivuori, M. Grönroos, T. Tani, J. Räsänen, E. Snellman, N. Neittaanmäki

“…The recurrent lesions were excised as second line treatment. No aggressive subtypes were reported, with only superficial or nodular growth in the final histopathological report. …”
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E-HEART score: A novel scoring system for undifferentiated chest pain in the emergency department by V. Yuvaraj, Sachin Sujir Nayak, S. Vimal Krishnan

“…The elevated risk of MACE in patients with high E-HEART scores (7–11) may facilitate more aggressive workup measures and avoid disposition errors. …”
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Clinicopathological Characteristics and Prognosis of Upper Gastric Cancer Patients in China: A 32-Year Single-Center Retrospective Clinical Study by Yingbo Gong, Pengliang Wang, Zhi Zhu, Junyan Zhang, Jinyu Huang, Huimian Xu

“…Upper gastric cancers were more aggressive, had a worse prognosis, and were more prone to recurrence and metastasis compared with lower gastric cancers. …”
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Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…A subset of CRPC evolves into treatment-emergent neuroendocrine prostate cancer (t-NEPC), an aggressive form characterized by poor prognosis. Currently, there is no reliable biomarker for early detection of t-NEPC. …”
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Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis by Qi Xu, Xiaoyu Feng, Siyuan Qin, Yu Hong, Rui Cui, Jia Liang, Zhuya Xiao, Yuan Li

“…BackgroundBreast cancer, particularly triple-negative (TNBC), is a leading malignancy with aggressive traits and high metastasis rates. Clinical trial is an important tool for optimizing therapeutic strategies in the evaluation of the safety and efficacy for TNBC. …”
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Clinicopathological characteristics and survival outcomes of women aged ≤45 and >45 years with endometrial adenocarcinoma in tertiary referral hospital: a 21-year cohort study by Tarinee Manchana, Pinyada Panyavaranant, Juthamas Rattanachaipipat

“…Independent prognostic factors consist of non-endometrioid histology, involvement of the lower uterine segment and cervix, omental metastasis, lymphovascular invasion and advanced stage.Conclusions Young patients with endometrial cancer exhibit distinct favourable clinicopathological characteristics associated with better oncological outcomes compared with older patients. However, certain aggressive disease features should be taken into consideration as they have a negative influence on prognosis significantly. …”
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Efficacy of biocontrol agents against damping-off and Sclerotinia stem rot diseases and their role in eliciting defense in chickpea plants by Yaser H. El-Gammal, Salama A. S. El-Blasy, Neamat A. M. Khalifa, Shereen Abu El-Maaty, Sara B. H. Awaly

“…(PQ558663) was the most aggressive isolate. Trichoderma atroviride was the most effective fungal bioagent in vitro since recorded the highest S. sclerotiorum growth decrease, followed by T. hamatum and T. harzianum; meanwhile, Serratia sp. was the least effective isolate. …”
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A Nomogram Built on Clinical Factors and CT Attenuation Scores for Predicting Treatment Response of Acute Myeloid Leukemia Patients by Linna Liu, Wenzheng Lu, Li Xiong, Han Qi, Robert Peter Gale, Bin Yin

“…<b>Background:</b> Acute myeloid leukemia (AML) is an aggressive cancer with variable treatment responses. …”
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Utilization of cardiopulmonary bypass at radical nephrectomy for renal cell carcinoma with tumour thrombus by Chalairat Suk‐Ouichai, Mitchell M. Huang, Clayton Neill, Christopher K. Mehta, Ashley E. Ross, Shilajit D. Kundu, Kent T. Perry Jr, Duc T. Pham, Hiten D. Patel

“…Morbidity and mortality rates tend to correlate with aggressiveness of tumour and TT level. Methods Patients undergoing radical nephrectomy with thrombectomy (2006–2023) were retrospectively identified. …”
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THE RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH ADRENAL TUMORS by A. A. Kostin, N. V. Vorobyev, A. O. Tolkachev, A. G. Muradyan, S. V. Popov

“…Malignant adrenal tumors such as adrenocortical cancer (ACC) and malignant pheochromocytoma (MPCC) have a particularly aggressive course, leading to higher mortality in these patients, especially in the later stages of the disease. …”
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Investigation of <i>ITGB3</i> Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer by Asiye Busra Boz Er

“…HER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…Abstract Background Renal cell carcinoma (RCC) is a frequent and aggressive type of kidney cancer with limited therapeutic options. …”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, characterized by its high recurrence rate, aggressive metastasis, and resistance to chemotherapy. …”
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Genetic trends and common BRCA1/2 pathogenic sequence variants in black African and Indian breast cancer patients presenting at Inkosi Albert Luthuli Central Hospital, KwaZulu-Nata... by M Makhetha, C Aldous, N Chabilal

“…Hereditary breast cancer is characterised by the presence of a pathogenic sequence variant passed from one generation to the next. These cancers are aggressive, develop early, and account for 5 - 10% of all breast cancer cases. …”
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