Clinicopathological and Prognostic Characteristics of Malaysian Triple Negative Breast Cancer Patients Undergoing TAC Chemotherapy Regimen by Ahmad Aizat Abdul Aziz, Md Salzihan Md Salleh, Ravindran Ankathil

“…Triple negative breast cancer (TNBC) is associated with aggressive tumour phenotype and early tumour relapse following diagnosis. …”
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Disorders of esophageal clearance in gastroesophageal reflux disease and option of their treatment by O. A. Storonova, A. S. Trukhmanov, N. L. Dzhahaya, V. T. Ivashkin

“…Intake of smecta accelerates process of refluxate elimination from the esophagus for one order more and restores normal scores of рН, reducing duration of reflux and exposure to aggressive contents of the stomach to the esophagus in patients with NERD and GERD equally. …”
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Clinicopathological study and molecular subtyping of muscle-invasive bladder cancer (MIBC) using dual immunohistochemical (IHC) markers by R. Vaithegi, Kanthilatha Pai, Anuradha Calicut Kini Rao, Vidya Monappa, Swathi Prabhu, Nischitha Suvarna

“…Greater association of lymphovascular invasion and lymph nodal involvement in cystectomy specimens in basal type and distant metastasis in the double-negative subtype suggests a more aggressive clinical behaviour of these, necessitating more intensive treatment.…”
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Revolutionizing ESCC prognosis: the efficiency of tumor-infiltrating immune cells (TIIC) signature score by Haixia Wang, Shaowei Ma, Zixin Yang, Ren Niu, Haiyong Zhu, Shujun Li, Shaolin Gao, Zhirong Li, Yanhua Tian

“…Abstract Background Patients suffer from esophageal squamous cell carcinoma (ESCC), which is the ninth highly aggressive malignancy. Tumor-infiltrating immune cells (TIIC) exert as major component of the tumor microenvironment (TME), showing possible prognostic value in ESCC. …”
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Exploring RNA cargo in extracellular vesicles for pleural mesothelioma detection by Agnieszka Kraft, Michaela B. Kirschner, Vanessa Orlowski, Manuel Ronner, Caroline Bodmer, Valentina Boeva, Isabelle Opitz, Mayura Meerang

“…Abstract Background Pleural Mesothelioma (PM) is a highly aggressive cancer, for which effective early detection remains a challenge due to limited screening options and low sensitivity of biomarkers discovered so far. …”
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Is There a Mild Form of Pediatric Appendicitis? An Eight-Year Single-Center Retrospective Review by Eric Scheier, Khaled Khalilia, Pavel Peslin, Stav Amir, Luba Pasherstnik Bizer

“…Introduction: The literature has suggested two variants of appendicitis: a simple variant that may even resolve spontaneously and a more aggressive variant that may proceed to complication. …”
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Chinese Economic Diplomacy before and during the COVID-19 Pandemic by E. I. Safronova

“…The author notes that, under these circumstances the PRC’s ‘COVID-19 diplomacy’ becomes more aggressive, which negatively affects the already tarnished national image. …”
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Identification of Sr genes in new common wheat sources of resistance to stem rust race Ug99 using molecular markers by O. A. Baranova, I. F. Lapochkina, A. V. Anisimova, N. R. Gajnullin, I. V. Iordanskaya, I. Yu. Makarova

“…The need for new donors of resistance to aggressive race Ug99 of Puccinia graminis Pers. f. sp. tritici Eriks. et Henn has arisen because the pest approaches the territory of Russian Federation. …”
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Stentless Strategy by Drug-Coated Balloon Angioplasty following Directional Coronary Atherectomy for Left Main Bifurcation Lesion by Norihiro Kobayashi, Masahiro Yamawaki, Shinsuke Mori, Masakazu Tsutsumi, Yohsuke Honda, Kenji Makino, Shigemitsu Shirai, Masafumi Mizusawa, Yoshiaki Ito

“…On the other hand, its efficacy was limited for stent edge restenosis at the LAD ostium even after aggressive debulking by DCA.…”
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Comparative Analysis of COVID‐19 Severity and Mortality Among Vaccinated and Unvaccinated Individuals During the Delta Variant Surge in a Tertiary Care Center: A Cohort Study by Fatemeh Hasani, Zahra Norouzi, Kimia Jazi, Gholamreza Roshandel, Alireza Norouzi

“…Methods COVID‐19 confirmed patients' data were extracted for this study from June 22, 2021, to September 22, 2021 including demographic characteristics, signs and symptoms, ICU admission, need for aggressive oxygen therapy, including intubation, mortality, and vaccination status. …”
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Bellini Duct Carcinoma Misdiagnosed with Urothelial Papillary Carcinoma by Joey El Khoury, Maher Abdessater, Rami Halabi, Fadi Nasr, Johnny Boustany, Anthony Kanbar, Charbel El Hachem, Raghid El Khoury

“…BDC remains one of the rare aggressive subtypes of RCC, having a multitude of initial clinical presentations and an unfavorable prognosis. …”
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The optimal treatment of invasive ductal and lobular carcinoma occurring at the same time needs to be established by Supriya Peshin, Rafi Iftekher, Rabia Iqbal, Shagun Singh, Moka Nagaishwarya

“…IDC, the most common breast cancer subtype, is known for its aggressive behaviour, nodal involvement and metastatic potential, while ILC, representing a smaller percentage of breast cancers, often exhibits an indolent course with diffuse growth patterns. …”
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The impact of educational intervention based on the theory of planned behavior on preventive behaviors for gastric cancer in obese and smoking individuals by Siamak Najafi, Fatemeh Mohammadkhah, Saina Alempour Salemi, Amirhossein Kamyab, Ali Khani Jeihooni

“…Abstract Background Gastric cancer remains a significant global health issue due to its aggressive nature and high heterogeneity, making early detection and prevention critical. …”
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Navigating the Collective: Nanoparticle-Assisted Identification of Leader Cancer Cells During Migration by Anastasia Alexandrova, Elizaveta Kontareva, Margarita Pustovalova, Sergey Leonov, Yulia Merkher

“…Thus, nanoparticle encapsulation offers a groundbreaking approach to identifying the most aggressive and invasive leader cells during the CCM process in breast cancer. …”
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Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…This study not only provides insights into the evolving TME of PDAC but also offers a new prognostic model and potential therapeutic strategies, contributing to improved management and treatment of this aggressive cancer.…”
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Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells. by Eiman Abdo, Mohammad A Ismail, Sabal Al Hadidi, Mairvat Al-Mrahleh, Tareq Saleh, Malik Zihlif, Nidaa A Ababneh

“…<h4>Background</h4>Hypoxia in tumor cells is linked to increased drug resistance and more aggressive behavior. In pancreatic cancer, the tumor microenvironment is notably hypoxic and exhibits strong immunosuppressive properties. …”
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Three-Year Outcomes of Patients with Neovascular Age-Related Macular Degeneration Treated with Aflibercept under the National Health Insurance Program in Taiwan by Kang-Jung Lo, Jin-Yu Chang, Hsin-Yi Chang, Shih-Hwa Chiou, De-Kuang Hwang, Shih-Jen Chen

“…After 3 years of treatment under the NHI program in Taiwan, 21.2% of the patients with nAMD still had a visual decline despite good anatomical outcomes. More aggressive treatment or other strategies should be used for patients who may have a poor prognosis.…”
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Biocementation Influence on Flexural Strength and Chloride Ingress by Lysinibacillus sphaericus and Bacillus megaterium in Mortar Structures by Daniel Karanja Mutitu, Jackson Muthengia Wachira, Romano Mwirichia, Joseph Karanja Thiong’o, Onesmus Mulwa Munyao, Muriithi Genson

“…Cement structures are subject to deterioration by the ingress of aggressive media. This study focused on the effects of Bacillus megaterium and Lysinibacillus sphaericus on flexural strength and chloride ingress in mortar prisms. …”
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Perianal Paget’s Disease: The 17-Year-Experience of a Single Institution in Taiwan by Yu-Chen Wang, Anna Fen-Yau Li, Shung-Haur Yang, Hsiu-Hsun Ma, Wen-Yih Liang

“…In this series of study, stage I CRC with PPD would have a higher metastatic rate, thus indicating aggressive treatment and follow-up. The CK7, CK20, CDX2, and GCDFP-15 immunostaining results for the PPD patients were not predictive of primary or secondary type.…”
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A Digital-based Talent Acquisition Framework for Start-ups: A Qualitative Multiple Case Study by Mohammad Hosein Kenarroodi, Hasan Boudlaie

“…The final stage of research coding identified ten key themes for talent acquisition in startups, including: taking an aggressive approach to talent acquisition, creating a strong employer brand, managing relationships with talents, identifying risks in talent selection, designing selection criteria and methods, determining selection quality, setting onboarding timelines, and developing learning methods and content for onboarding.     …”
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