PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

“…Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer. The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types. …”
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Functional activity of blood eosinophils in patients with <i>Opisthorchis felineus</i> invasion by V. V. Tsukanov, N. E. Veselova, A. A. Savchenko, O. A. Kolenchukova, I. I. Gvozdev, A. V. Vasyutin, J. L. Tonkikh, E. V. Kasparov, A. G. Borisov, E. G. Gorchilova, M. Yu. Olkhovskaia, N. O. Prokopieva

“…Patients with O. felineus invasion with an increase in the content of eosinophils in the blood due to the likelihood of an aggressive course of the pathology deserve the close attention of practitioners with the need for a thorough comprehensive examination of patients, including immunological methods.…”
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Functional and structural connectivity of the subregions of the amygdala in ADHD children with or without ODD by Zhao-Min Wu, Peng Wang, Xue-Chun Liu, Qing-Chao Zhou, Xiao-Lan Cao, Li Sun, Lu Liu, Qing-Jiu Cao, Li Yang, Yu-Feng Wang, Ying Qian, Bin-Rang Yang

“…Results The ADHD + ODD group had more anxious/depressed moods, more delinquent and aggressive behaviors, more emotional control problems, and more inhibition deficits than the ADHD-only group (all P Bonferroni−corrected < 0.05). …”
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Ethanolic Extract of <i>Averrhoa carambola</i> Leaf Has an Anticancer Activity on Triple-Negative Breast Cancer Cells: An In Vitro Study by Oscar F. Beas-Guzmán, Ariana Cabrera-Licona, Gustavo A. Hernández-Fuentes, Silvia G. Ceballos-Magaña, José Guzmán-Esquivel, Luis De-León-Zaragoza, Mario Ramírez-Flores, Janet Diaz-Martinez, Idalia Garza-Veloz, Margarita L. Martínez-Fierro, Iram P. Rodríguez-Sanchez, Gabriel Ceja-Espíritu, Carmen Meza-Robles, Víctor H. Cervantes-Kardasch, Iván Delgado-Enciso

“…This study aimed to assess the effects of ethanolic extract from <i>A. carambola</i> leaves on triple-negative breast cancer (TNBC), an aggressive subtype lacking specific therapy. <b>Methods</b>: Phytochemical analysis and HPLC profile and additional cell line evaluation employing MDA-MB-231 were carried out. …”
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A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report by Jingjing Chai, Jiaqi Lv, Jian Xiong, Xiuwen Chen, Senyuan Luo, Zhiguo Luo, Zhiguo Luo, Ming Luo

“…Anaplastic thyroid carcinoma (ATC) is a rare and highly aggressive malignancy characterized by a poor prognosis, with a median survival time of approximately 3 to 4 months. …”
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Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer by Seungyeul Yoo, Ayushi S. Patel, Sarah Karam, Yi Zhong, Li Wang, Feng Jiang, Ranran Kong, Sharon Bikvan, Wenhui Wang, Abhilasha Sinha, Charles A. Powell, Jun Zhu, Hideo Watanabe

“…Abstract Small cell lung cancer (SCLC) is an aggressive and heterogeneous subtype, representing 15% of lung cancer cases. …”
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Characteristics of US hospitals using extraordinary collections actions against patients for unpaid medical bills: a cross-sectional study by Dominique Vervoort, Farah Hashim, Sanuri Hennayake, Christi M Walsh, Chen Dun, Joseph Giuseppe Paturzo, Indrani G Das, Emily A Stewart, Jonathan A Teinor, Morissa A Schochet, Allyson Keslar, Ge Bai, Martin Makary

“…Objective This study aims to characterise and evaluate the largest 100 hospitals in the USA that have adopted aggressive collection tactics to pursue patients with unpaid medical bills, such as lawsuits, wage garnishments and liens.Design Cross-sectional study.Setting We examined state and county court record systems to measure the magnitude and prevalence of these practices at the largest 100 hospitals in the UA between 1 January 2018 and 31 July 2020.Main outcomes measures The main outcome of this study was the number of lawsuits, wage garnishments and liens. …”
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Effect of diabetes mellitus on levels of insulin-like growth factors and their carrier proteins in Guerin’s carcinoma and it’s perifocal tissue in rats by E. M. Frantsiyants, V. A. Bandovkina, I. V. Kaplieva, E. I. Surikova, I. V. Neskubina, Yu. A. Pogorelova, N. D. Cheryarina, P. S. Kachesova, L. A. Nemashkalova

“…DM in females upregulated levels of glucose both in the tumor and in perifocal tissues by 1.8 (p &lt; 0.05) and 8.1 times, respectively, but caused opposite changes in IGF-I - it's increase by 6.3 times in the tumor and decrease by 3.2 times in the perifocal area; as a result, such tumors with small primary nodes were more "aggressive" and actively metastasized. In males, induced DM downregulated levels of glucose, IGF-II and IGFBP2 in the carcinoma by 8.4, 3.1 and 1.7 (p &lt; 0.05) times, respectively, and increased levels of IGF-I and IGFBP2 by 1.4 and 1.3 times (p &lt; 0.05) in the perifocal area without changing glucose levels; as a result, tumor volumes exceeded the values in the standard growth, without metastasizing into visceral organs.Conclusion. …”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and often lethal malignancy, requiring the development of enhanced therapeutic approaches. …”
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GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells by Arianna Buglione, Giulia Alloisio, Chiara Ciaccio, David Becerril Rodriguez, Simone Dogali, Marco Luce, Stefano Marini, Antonio Cricenti, Magda Gioia

“…To address the challenges of osteosarcoma (OS), a highly aggressive cancer, we explored the mechanobiology of OS cells, in vitro. …”
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Molecular effects of clinically relevant chemotherapeutic agents on choline phospholipid metabolism in triple negative breast cancer cells by Caitlin M. Tressler, Kanchan Sonkar, Menglin Cheng, Vinay Ayyappan, Ruoqing Cai, Kristine Glunde

“…Triple-negative breast cancer (TNBC) is the most lethal breast cancer subtype, leading to poor patient outcomes despite aggressive treatment with surgery, radiation, and chemotherapy. …”
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SMARCA4 deficiency in small cell lung cancer: A case report and narrative review of the literature by Andreas M. Matthaiou, Ioannis Tomos, Nikoleta Bizymi, Ioannis Vamvakaris, Nektarios Anagnostopoulos, Aikaterini Papadopoulou, Kalliopi Angelou, Grigoris Stratakos, Adamantia Liapikou

“…This case indicates that SMARCA4-deficient small cell lung cancer may present with an aggressively deteriorating phenotype with poor outcomes for the patie …”
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Factors Affecting the Prognosis after Primary Tumor Resection for Patients with Metastatic Colorectal Cancer with Synchronous Peritoneal Metastasis: A Multi-center, Prospective, Ob... by Satoru Kagami, Kimihiko Funahashi, Hirotoshi Kobayashi, Kenjiro Kotake, Masayasu Kawasaki, Yusuke Kinugasa, Hideki Ueno, Kotaro Maeda, Takeshi Suto, Michio Itabashi, Heita Ozawa, Fumikazu Koyama, Shingo Noura, Hideyuki Ishida, Masayuki Ohue, Tomomichi Kiyomatsu, Soichiro Ishihara, Keiji Koda, Hideo Baba, Kenji Kawada, Yojiro Hashiguchi, Takanori Goi, Yuji Toiyama, Naohiro Tomita, Eiji Sunami, Fumihiko Fujita, Jun Watanabe, Kenichi Hakamada, Goro Nakayama, Kenichi Sugihara, Yoichi Ajioka

“…Conclusions: In patients with mCRC-SPM, postoperative complications are infrequent for P1 with localized peritoneal dissemination, and PTR may be considered as aggressive treatment. Factors including age 75 years, rectal cancer, presence of liver metastasis, increased PCI, non-curative resection, and non-treatment with systemic chemotherapy are associated with a reduced survival benefit from PTR.…”
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Case report: an unusual long-term evolution of a diffuse midline glioma, H3K27 altered by Michael Griessmair, Michael Griessmair, Claire Delbridge, Claus Zimmer, Eva Mayr, Arthur Wagner, Julian Canisius, Marie-Christin Metz, Benedikt Wiestler, Benedikt Wiestler

“…Interestingly, MR imaging conducted for migraine diagnosis 6 years ago in retrospect already showed a small, nodular T2w hyperintense lesion in the right thalamus.ConclusionDespite a more precise, molecularly driven classification of pediatric HGG (high-grade glioma) in the 5th edition of the WHO classification of CNS tumors, many genetic factors influencing the biological tumor development as well as the precise molecular evolution of tumors remain unclear. Given the highly aggressive clinical course of these tumors, with a median overall survival around 16 to 18 months, our report of a (presumable) precursor lesion years before clinical manifestation point towards a complex, multi-stage evolution of this tumor entity. …”
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Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma by Masahiro Nishikawa, Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Saya Ozaki, Hideaki Watanabe, Hajime Yano, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda

“…Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. …”
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Multimodality Treatment Including Triplet Regimen as First-Line Chemotherapy May Improve Prognosis of Serum AFP-Elevated Gastric Cancer with Liver Metastasis by Yakun Wang, Lin Shen, Ming Lu, Zhi Ji, Xiaotian Zhang

“…Multimodality treatment including aggressive first-line chemotherapy with triplet regimen may be needed when treating them.…”
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Aberrant Expression of MicroRNA-15a and MicroRNA-16 Synergistically Associates with Tumor Progression and Prognosis in Patients with Colorectal Cancer by Guangfa Xiao, Huihuan Tang, Wei Wei, Jian Li, Liandong Ji, Jie Ge

“…Collectively, the aberrant expression of miR-15a and miR-16 could be used to stratify patients with aggressive tumor progression of colorectal cancer. The combined pattern of miR-15a and miR-16 downregulation has a significant value for distinguishing patients with a worse prognosis of colorectal cancer after surgery.…”
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Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurpo... by Arnob Sarker, Burhan Uddin, Reaz Ahmmed, Sabkat Mahmud, Alvira Ajadee, Md. Al Amin Pappu, Md. Abdul Aziz, Md. Nurul Haque Mollah

“…Glioblastoma (GBM) is one of the most aggressive cancers due to its high mortality rate in spite of intensive treatment. …”
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Differences in expression profiles in malingant melanoma patients according to immunotherapy response by E. N. Lukyanova, M. S. Fedorova, E. A. Pudova, T. V. Nasedkina, E. V. Stepanova, K. M. Nyushko, A. Y. Popov, N. V. Koroban, A. A. Dmitriev, M. V. Kiseleva, A. V. Lipatova, A. S. Zasedatelev, A. V. Kudryavtseva

“…In the treatment of aggressive and rapidly became metastatic malignant tumors, such as melanoma, the presence of reliable markers that allow quick and accurate determination of treatment tactics is especially important. …”
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Prognostic factors and survival outcomes in patients with salivary duct carcinoma: a retrospective cohort study by Fei Chen, Liangbo Li, Jingqiao Tao, Nenghao Jin, Liwei Wang, Liang Zhu, Bo Qiao, Lejun Xing, Bo Wei, Jingqiu Bu, Haizhong Zhang

“…Abstract Background Salivary duct carcinoma (SDC) is a highly aggressive salivary gland malignancy with poor prognosis. …”
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