Dyslipidaemia in patients with chronic kidney disease – a neglected cardiovascular risk factor by M R Essop, F Seedat, F J Raal

“…Despite the role of CKD in ASCVD and recommendations to control lipid levels aggressively, landmark lipid studies have often excluded patients with advanced CKD. …”
Get full text

Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…Abstract Background Multiple myeloma (MM) is the most aggressive and prevalent primary malignant tumor within the blood system, and can be classified into grades RISS-I, II, and III. …”
Get full text

Immunohistochemical expression of parathyroid hormone-related protein and ezrin in invasive breast carcinoma of no special type: a retrospective analysis by Menna Allah Gamil Ali Shalaby, Marwa Mohammed Dawoud, Marwa Salah Gadallah, Asmaa Gaber Abdou

“…Elevated levels of these proteins are associated with more aggressive disease, suggesting their capability as prognostic indicators and treatment targets in breast cancer. …”
Get full text

X-Linked Autism Type 9 Caused by a Hemizygote Pathogenic Variant in the TMLHE Gene: Etiological Diagnosis in an Adult Male with Moderate Intellectual Disability by Verhoeven WM, Pfundt R, Engelke UF, Kluijtmans LA, Egger JI

“…Also, Whole Exome Sequencing (WES) and Next-Generation Metabolic Screening (NGMS) were performed.Results: Moderate intellectual disability along with obsessive and aggressive behaviour in the context of autism spectrum disorders was established as well as symptoms from the catatonic spectrum. …”
Get full text

Gasoline Direct Injection Engine Emissions of OC and EC: Laboratory Comparisons with Port Fuel Injection Engine by Jie Zhang, John Liggio, Tak W. Chan, Lin Huang, Jeffrey R. Brook

“…However, the OC emission from the PFI vehicle was higher than GDI during an aggressive driving cycle by 146%. By considering OC collected on a quartz filter behind a Teflon filter, the emissions from PFI vehicle were found to be more volatile than the GDI vehicle. …”
Get full text

Uncarboxylated osteocalcin induced miR-143-3p targets SP7 and activates PI3K/Akt signaling in TNBC cells to promote invasion and migration by Qian Du, Jiaojiao Xu, Miao Zhang, Jianhong Yang

“…Triple-negative breast cancer (TNBC) is an exceptionally aggressive malignancy with poor prognosis. Patients often have elevated mortality and recurrence rates, along with a pronounced risk of distant metastasis. …”
Get full text

USP8‐Dependent Family Tyrosine Kinase Promotes the Malignant Progression of Esophageal Squamous Cell Carcinoma by Upregulating Protein Tyrosine Kinase 2 Expression by Yuechang Wu, Dubiao Xian, Yunzhong Liu, Ding Huang, Qingfeng Liu, Shubo Yang

“…ABSTRACT Background Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy, and the molecular underpinnings of its aggressive behavior are not fully understood. FYN proto‐oncogene, Src family tyrosine kinase (FYN) has been linked to cancer progression, yet its role in ESCC remains elusive. …”
Get full text

Case Report: The Versatile Art of Reconstruction: A Decade‐Long Journey With Recurrent Facial Basal Cell Carcinoma by T. H. Pathirana, V. Bandaranayake, A. P. Nellihela, S. Nikeshala, T. Saranga, A. Abegunasekara, S. Gunathilake, N. J. Asanthi

“…While most BCC is relatively indolent, aggressive subtypes, including infiltrative BCC, pose the treatment challenges of ensuring functional and aesthetic preservation with a high risk of recurrence. …”
Get full text

A dynamic co-expression approach reveals Gins2 as a potential upstream modulator of HNSCC metastasis by Nasibeh Khayer, Samira Shabani, Maryam Jalessi, Mohammad Taghi Joghataei, Frouzandeh Mahjoubi

“…Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer that is notably associated with a high risk of lymph node metastasis, a major cause of cancer mortality. …”
Get full text

Context aware machine learning techniques for brain tumor classification and detection – A review by Usman Amjad, Asif Raza, Muhammad Fahad, Doaa Farid, Adnan Akhunzada, Muhammad Abubakar, Hira Beenish

“…Malignant gliomas, due to their aggressive growth and dismal prognosis, stand out among various brain tumor types. …”
Get full text

Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes by Cheng C, Wang Y, Zhao J, Wu D, Li H, Zhao H

“…TNBC represents about 15% to 20% of all breast cancers and is aggressive and highly malignant. Currently, TNBC diagnosis primarily depends on pathological examination, while treatment efficacy is assessed through imaging, biomarker detection, pathological evaluation, and clinical symptom improvement. …”
Get full text

A durability- based design approach for structural applications with advanced cement-based materials by Francesco Soave, Liberato Ferrara

“…This structure can benefit from a performance-based durability-design tailored to the use of high-performance construction materials since the retaining tank walls are exposed to a highly aggressive environment: both XA and XD exposure classes, as per EN206 can be considered since the water is characterized by high concentration of chlorides and sulphates. …”
Get full text

A nomogram for predicting prognosis for young cervical neuroendocrine carcinoma: A SEER-based study and external validation by Ning Xie, Haijuan Yu, Jie Lin, Sufang Deng, Linying Liu, Yang Sun

“…BackgroundNeuroendocrine carcinoma of the cervix (NECC) is a rare and highly aggressive subtype of cervical carcinomas with poor prognosis. …”
Get full text

The Identification and Validation of a Robust Immune-Associated Gene Signature in Cutaneous Melanoma by Le-Bin Song, Jiao-Chen Luan, Qi-Jie Zhang, Lin Chen, Hao-Yang Wang, Xue-Chen Cao, Ning-Hong Song, Yan Lu

“…Cutaneous melanoma is defined as one of the most aggressive skin tumors in the world. An increasing body of evidence suggested an indispensable association between immune-associated gene (IAG) signature and melanoma. …”
Get full text

Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer by Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon

“…The histopathological analysis confirmed the aggressive nature of resistant tumors and showed the presence of necrotic core which could be implicated to EMT. …”
Get full text

Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms by Zhengjie Shen, Yongjuan Gu, Ruiyang Jiang, Heya Qian, Siyuan Li, Lixian Xu, Wenzhe Gu, Yun Zuo

“…Triple-negative breast cancer (TNBC), one type of breast cancer, is more aggressive and has a worse prognosis. Demethylzeylasteral (T-96) is isolated from Tripterygium wilfordii Hook F. …”
Get full text

Pulmonary Mucormycosis – An Experience from a Tertiary Care Center in Southern India: A PULM MUCOR Study by Ashwin Oliver Arul, K. Rajiv Karthik, Devasahayam Jesudas Christopher

“…Treatment requires a multipronged approach with control of risk factors, appropriate antifungal therapy, and aggressive early surgery where feasible.…”
Get full text

Socio-economic inequality in the nutritional deficiencies among the world countries: evidence from global burden of disease study 2019 by Mohsen Bayati, Elham Arkia, Mehrnoosh Emadi

“…More attention should be paid to the development of prevention and primary treatment measures in low HDI countries, such as improving nutrition-related health education, nutritional support and early aggressive treatment, and also eliminating hunger.…”
Get full text

Individual profiles of psychological suitability for police service (according to the results of the individual typological questionnaire) by V. I. Barko, V. V. Barko, O. O. Yevdokimova

“…The high level is inherent in employees with balanced tendencies, mainly stoic, leadership, sociable profile types, which are characterised by extraversion, general activity, optimism, moderate aggressiveness, positive self-esteem, determination, tendency to self-realisation, defending one’s interests, dominance and self-assertion. …”
Get full text

PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials by Samuel Pratama, Lowilius Wiyono, Martien Silviandy Setiawan, Brigitta Cindy Lauren

“…Background: Small Cell Lung Cancer (SCLC) is a neuroendocrine carcinoma characterized by aggressive behavior and poor prognosis with limited treatment options. …”
Get full text