Loxoscelism: Cutaneous and Hematologic Manifestations by Ngan Nguyen, Manjari Pandey

“…Treatment of systemic loxoscelism involves aggressive supportive care including appropriate wound management, blood transfusions, intravenous fluid replacement, and appropriate antibiotic coverage. …”
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Self-Reported Violence Experienced by Swiss Prehospital Emergency Care Providers by Simon Savoy, Pierre-Nicolas Carron, Nathalie Romain-Glassey, Nicolas Beysard

“…In all cases of violence described, the patient and/or a relative initiated aggressive behavior in 96% of cases. Verbal assaults were the most common (99.2% of all acts), followed by intimidation (72.8%), physical assault (69.6%), and sexual harassment (16.3%). …”
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Identification and Functional Analysis of EPOR+ Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis by Yanxing Li, Ming Li, Rong Wei, Junlong Wu

“…We have characterized TAMs expressing EPOR and CD163+EPOR+ macrophages as TAMs in osteosarcoma lung metastasis patients, which are highly associated with tumor aggressiveness.…”
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Laminin-5 γ2 Chain Expression Correlates with Unfavorable Prognosis in Colon Carcinomas by C. Lenander, J. K. Habermann, Å. Öst, B. Nilsson, H. Schimmelpenning, K. Tryggvason, G. Auer

“…The results indicate that laminin-5 γ2 chain expression is up-regulated during the progression of human colon cancer and that it plays a role in the aggressiveness of these tumors. Demonstration of laminin-5 γ2 chain positivity also facilitates detection of individual cells or minor cell clusters invading the surrounding stroma.…”
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Porto Alegre Line predicts lenticulostriate arteries encasement and extent of resection in insular gliomas. A preliminary study by Gustavo Rassier Isolan, Gustavo Rassier Isolan, Gustavo Rassier Isolan, Samir Ale Bark, Samir Ale Bark, Jander Moreira Monteiro, Jander Moreira Monteiro, Tobias A. Mattei, Kaan Yağmurlu, Rafaela Fernandes Gonçalves, Rafaela Fernandes Gonçalves, Osvaldo Malafaia, Rafael Roesler, Rafael Roesler, Rafael Roesler, Jurandir Marcondes Ribas Filho

“…The resection limit of tumors placed medially to the Porto Alegre line was intraoperative direct LSTa visualization.ResultsThe LSTa involvement was the most critical medial limiting factor in more aggressive tumor resection and an excellent overall survival (P = 0.022). …”
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Integrative analysis of immunogenic PANoptosis and experimental validation of cinobufagin-induced activation to enhance glioma immunotherapy by Yonghua Cai, Heng Xiao, Shuaishuai Xue, Peng Li, Zhengming Zhan, Jie Lin, Zibin Song, Jun Liu, Wei Xu, Qixiong Zhou, Songtao Qi, Xi’an Zhang, Ziyi Luo

“…Abstract Background Glioma, particularly glioblastoma (GBM), is a highly aggressive tumor with limited responsiveness to immunotherapy. …”
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Testing the Purity of <i>Limnospira fusiformis</i> Cultures After Axenicity Treatments by Michael Schagerl, Alexander Kaptejna, Fabian Polz, Sameh S. Ali, Shuhao Huo, Joana Seneca, Petra Pjevac, Vera Hechtl

“…Contaminants are robust taxa, as they survived aggressive treatments. Sequencing data suggest that some of them are promising candidates for in-depth studies to commercially exploit them.…”
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Prognostic significance of mast cell and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1 by Roberto André Torres de Vasconcelos, Pedro Guimarães Coscarelli, Thyago Marsicano Vieira, Washington Silva Noguera, Davy Carlos Mendes Rapozo, Marcus André Acioly

“…Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive soft tissue sarcomas with a significant susceptibility to metastasize early in their course. …”
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Surgical Treatment Intensity at the End of Life in Patients With Cancer: A Systematic Review by Samuel Lawday, BMBS, MByRes, Benjamin E. Zucker, MA, MBBS, MRCS, Shona Gardner, MBChB, MRCS, James Robb, MBChB, MA, Lorna Leandro, MA, BM, BCh, William Hollingworth, PhD, Jane Blazeby, MBChB, MD, Angus G.K. McNair, PhD, FRCS, Charlotte Chamberlain, PhD, MRCP

“…Concern regarding overly ‘aggressive’ care or high health care utilization at the EoL, particularly in cancer, is growing. …”
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Pathological Features of Mitochondrial Ultrastructure Predict Susceptibility to Post-TIPS Hepatic Encephalopathy by Hong-bin Li, Zhen-dong Yue, Hong-wei Zhao, Lei Wang, Zhen-hua Fan, Fu-liang He, Xiao-qun Dong, Fu-quan Liu

“…Importantly, group B had worse incidence of PSE than group A [P=0.014, hazard ratio (95%CI): 2.172 (1.190-4.678)]. Conclusion. Aggressive damage to mitochondrial ultrastructure in liver shunt predicts susceptibility to PSE. …”
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Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection by Simone Giuliano, Jacopo Angelini, Floriana Campanile, Paola Conti, Sarah Flammini, Alberto Pagotto, Francesco Sbrana, Luca Martini, Denise D’Elia, Mohd H. Abdul-Aziz, Menino O. Cotta, Jason A. Roberts, Robert A. Bonomo, Carlo Tascini

“…Most patients achieved an aggressive PK/PD target (T > 4–8 minimum inhibitory concentration, MIC) when this alternative drug combination regimen was used. …”
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Outcomes of Surgical Treatment for Localized Tenosynovial Giant-Cell Tumor of the Foot and Ankle: A Case Series by Edoardo Ipponi, Alfio Damiano Ruinato, Leonardo Lombardi, Martina Cordoni, Silvia De Franco, Antonio D'Arienzo, Lorenzo Andreani

“… Background: Giant cell tumor of the tendon sheath (GCTTS), also termed Tenosynovial giant cell tumor (TGCT), is a locally aggressive tumor which originates from tendon sheaths or bursas. …”
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Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma by Dimitrios K. Manatakis, Sofia Tseleni-Balafouta, Dimitrios Balalis, Vasiliki N. Soulou, Dimitrios P. Korkolis, George H. Sakorafas, Georgios Plataniotis, Emmanouil Gontikakis

“…We found increased NLR values in papillary carcinomas with poorer histopathological profile and more aggressive clinical behaviour. Whether this systemic inflammatory response, as expressed by the NLR, represents the inflammatory microenvironment leading to tumourigenesis, or is a tumour-associated phenomenon, remains to be elucidated and warrants further study.…”
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Non-Destructive Testing of Concrete Materials from Piers: Evaluating Durability Through a Case Study by Abraham Lopez-Miguel, Jose A. Cabello-Mendez, Alejandro Moreno-Valdes, Jose T. Perez-Quiroz, Jose M. Machorro-Lopez

“…These techniques make it possible to characterize the concrete and obtain information such as the total volume of pores, susceptibility to corrosion of the reinforcing steel, decrease in mechanical resistance, cracks, presence of humidity, and aggressive ions inside the concrete. In this work, two durability studies are presented with non-destructive tests carried out on active piers that are 20 and 40 years old. …”
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<i>Vibrio vulnificus</i>—A Review with a Special Focus on Sepsis by Marcello Candelli, Marta Sacco Fernandez, Cristina Triunfo, Andrea Piccioni, Veronica Ojetti, Francesco Franceschi, Giulia Pignataro

“…For necrotizing infections, prompt and aggressive surgical intervention remains essential to improving patient outcomes. …”
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A Clinicopathological Study of 24 Cases of DFSP by Miyako Kachi, Atsumori Hamahata, Kohei Oashi, Hisato Konoeda, Miho Kirita, Masashi Ishikawa, Hirotaka Koyanagi, Hiroyuki Sakurai

“…Dermatofibrosarcoma protuberans is locally aggressive regardless of the depth of the principal lesion, and appropriate initial surgical excision with an adequate surgical margin is crucial for definitive treatment.…”
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Approbation of the mechanism of economic reliability on the example of an industrial enterprise by A. R. Terentyeva

“…The author of the article came to the following conclusions: the implemented mechanism of economic reliability in the activity of an industrial enterprise allows identifying bottlenecks, as well as developing measures to eliminate them, thereby increasing the level of economic reliability; the action of this mechanism should be continuous, since the intensification of technological dynamics is an aggressive factor influencing the efficiency, stability and sustainability of the functioning of an industrial enterprise. …”
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Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia by Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Tatsushi Yoshida

“…Background: Acute myeloid leukemia (AML) is a common and aggressive form of leukemia, yet current treatment strategies remain insufficient. …”
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Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction by Stéphanie Verbeke, Aurélien Bourdon, Mathilde Lafon, Vanessa Chaire, Bertolo Frederic, Amina Naït Eldjoudi, Marie-Alix Derieppe, Francis Giles, Antoine Italiano

“…Undifferentiated pleomorphic sarcoma (UPS) is the most frequent and the most aggressive sarcoma subtype for which therapeutic options are limited. …”
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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…Moreover, attenuation of TMEM45A expression reduces cancer aggressiveness by decreasing the expression of EMT and glycolysis-related proteins. …”
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