Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma by Zeynep Kacar, Eric Slud, Doron Levy, Julián Candia, Anuradha Budhu, Marshonna Forgues, Xiaolin Wu, Arati Raziuddin, Bao Tran, Jyoti Shetty, Yotsawat Pomyen, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Chirayu Auewarakul, Suleeporn Sangrajrang, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin Wei Wang

“…We find that linear evolving HCC is less aggressive than other types. GTF2IRD2B mutations are enriched in HCC with linear evolution, while TP53 mutations are the most frequent genetic alterations in HCC with non-linear models. …”
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Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature by Ryo Miyagi, Toshihiko Nishisho, Shinjiro Takata, Yoshimitsu Shimatani, Shunichi Toki, Koichi Sairyo

“…Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLS) is an intermediate or locally aggressive form of adipocytic soft tissue sarcoma. Muscular dystrophy (MD) is characterized by progressive muscle atrophy and its replacement by adipose and fibrous tissue. …”
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Histopathological assessment of AIDS-defining malignancies in the gastrointestinal tract presenting with acute abdomen: Improving diagnostic timeliness and patient care by M C Khaba, N E Mothata, M O Keetse, T Sumbana

“…While a large number of cases in an HIV setting may be attributed to infections, there has also been a rise in HIV- associated malignancies such as Kaposi sarcoma and aggressive B-cell lymphoma. Objective. To describe the clinicopathological features of cases with acute abdomen secondary to AIDS-defining malignancy in the gatrointestinal tract. …”
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NEIL3 and TOP2A as key drivers of esophageal cancer through WNT signaling by Hui Li, Panpan Wang, Huijuan Chen, Yanyan Shao, Hui Luo

“… Esophageal cancer (EC) is a highly aggressive malignancy with limited treatment options. …”
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Enterococcus faecium Mediastinitis Complicated by Disseminated Candida parapsilosis Infection after Congenital Heart Surgery in a 4-Week-Old Baby by Hanna Renk, Felix Neunhoeffer, Florian Hölzl, Michael Hofbeck, Matthias Kumpf

“…Although repeated antibiotic irrigation, debridement, and aggressive antibiotic treatment were started early, the pulmonary situation deteriorated. …”
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Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival by Lana Bijelic, Anjali S. Kumar, O. Anthony Stuart, Paul H. Sugarbaker

“…Preoperative systemic chemotherapy in appendix-originated PMCA is associated with a significant rate of histological response which may reduce the tumor burden, facilitate less aggressive and more complete CRS, and improve short-term survival in patients with a significant histological response.…”
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Laparoscopic Splenectomy to Salvage Renal Transplants from Severe Acute Antibody-Mediated Rejection by Michael Latzko, Sakshi Jasra, Sana Akbar, Harry Sun, Sadanand Palekar

“…In patients with preformed donor specific antibodies, rejection can be aggressive. We report here a case in which laparoscopic splenectomy was added to the standard rescue regimen. …”
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Gene Therapy with Endogenous Inhibitors of Angiogenesis for Neovascular Age-Related Macular Degeneration: Beyond Anti-VEGF Therapy by Selwyn M. Prea, Elsa C. Chan, Gregory J. Dusting, Algis J. Vingrys, Bang V. Bui, Guei-Sheung Liu

“…The advanced neovascular (or “wet”) form of the disease is responsible for severe and aggressive loss of central vision. Current treatments aim to seal off leaky blood vessels via laser therapy or to suppress vessel leakage and neovascular growth through intraocular injections of antibodies that target vascular endothelial growth factor (VEGF). …”
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Presence of Professional Burnout Syndrome in COVID-19 Care Areas by Elsy Labrada González, María Isabel Fong Betancourt, Lina Espinoza Pire, María del Carmen Yabor Labrada

“…<strong>Background:</strong> burnout or professional burnout syndrome manifests itself in workers, with a progressive loss of energy until reaching exhaustion, symptoms of anxiety, depression, job demotivation and aggressiveness. <br /><strong>Objective:</strong> to describe the characteristics of professional burnout syndrome in doctors in the COVID-19 care area. …”
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Detection of The TNFSF Members BAFF, APRIL, TWEAK and Their Receptors in Normal Kidney and Renal Cell Carcinomas by Vassiliki Pelekanou, George Notas, Katerina Theodoropoulou, Marilena Kampa, Dimitrios Takos, Vassilia-Ismini Alexaki, Jelena Radojicic, Frank Sofras, Andreas Tsapis, Efstathios N. Stathopoulos, Elias Castanas

“…BAFF was found in all RCC; APRIL expression is associated with an aggressive phenotype, correlating negatively with patients' disease-free survival, while TWEAK and its receptor Fn14 are heterogeneously expressed, correlating negatively with the grade and survival of RCC patients. …”
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Gliosarcoma with Primary Skull Base Invasion by Quoc-Bao D. Nguyen, Avital Perry, Christopher S. Graffeo, Cody L. Nesvick, Aditya Raghunathan, Mark E. Jentoft, Brian P. O’Neill, Padraig P. Morris, Jonathan M. Morris, Jamie J. Van Gompel

“…This case report highlights the rapid aggressiveness of gliosarcomas and further a prior undescribed radiographic and anatomic finding of skull base invasion with this entity.…”
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The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma by Shahid Banday, Alok K. Mishra, Romana Rashid, Tianyi Ye, Amjad Ali, Junhui Li, Jason T. Yustein, Michelle A. Kelliher, Lihua Julie Zhu, Sara K. Deibler, Sunil K. Malonia, Michael R. Green

“…Abstract Ewing sarcoma (ES) is an aggressive bone cancer driven by the oncogenic fusion-protein EWSR1::FLI1, which is not present in normal cells and is therefore an attractive therapeutic target. …”
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Androgen Metabolism Gene Polymorphisms, Associations with Prostate Cancer Risk and Pathological Characteristics: A Comparative Analysis between South African and Senegalese Men by Pedro Fernandez, Charnita M. Zeigler-Johnson, Elaine Spangler, André van der Merwe, Mohamed Jalloh, Serigne M. Gueye, Timothy R. Rebbeck

“…The CYP3A4 rs2740574 polymorphism was associated with prostate cancer risk and tumor aggressiveness in South African men, after correction for population stratification, and the SRD5A2 rs523349 CG genotype was inversely associated with high-stage disease in Senegalese men. …”
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Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment by Emma Assi, Davide Cervia, Laura Bizzozero, Annalisa Capobianco, Sarah Pambianco, Federica Morisi, Clara De Palma, Claudia Moscheni, Paolo Pellegrino, Emilio Clementi, Cristiana Perrotta

“…The inflammatory microenvironment induces tumours to acquire an aggressive and immunosuppressive behaviour. Since acid sphingomyelinase (A-SMase) downregulation in melanoma was shown to determine a malignant phenotype, we aimed here to elucidate the role of A-SMase in the regulation of tumour immunogenic microenvironment using in vivo melanoma models in which A-SMase was either downregulated or maintained at constitutively high levels. …”
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Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis by Andrea Cassoni, Valentina Terenzi, Davina Bartoli, Oriana Rajabtork Zadeh, Andrea Battisti, Mario Pagnoni, Davide Conte, Alessandro Lembo, Sandro Bosco, Francesco Alesini, Valentino Valentini

“…This sarcoma demonstrates an aggressive growth pattern with an high rate of recurrence with hematologic dissemination; the most common sites are lung, liver, and peritoneal cavity, head and neck district being rarely interested. …”
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Elevated Blood Ammonia Level Is a Potential Biological Risk Factor of Behavioral Disorders in Prisoners by Yunfeng Duan, Xiaoli Wu, Shan Liang, Feng Jin

“…Forty-nine male prisoners and 52 control volunteers took part in the study. An aggressive behavior assessment, the Self-Rating Depression Scale (SDS), and the State-Trait Anxiety Inventory (STAI) were used to characterize the participants’ mental health status. …”
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Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry by Aline Menezes, Yara Martins, Fábio Nogueira, Denise De Abreu Pereira, Katia Carneiro

“…Glioblastoma (GBM) is the most aggressive brain tumor, and different efforts have been employed in the search for new drugs and therapeutic protocols for GBM. …”
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The Structure-Performance Nexus and Efficiency in the Malaysian Banking Sector by Rafik Harkati, Syed Musa Alhabshi, Salina Kassim

“…It also investigates whether bank managers have been demotivated and settled for a quiet life due to market power or have been aggressive due to the search for efficiency and market share. …”
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Effects of environmental enrichment and lack of beak trimming on aspects of health, behaviour and production of commercial turkeys by Josiane G. Busatta, Luciana Foppa, Jhonatan Sperandio, Daniele S. Martins, Cristiane G. Titto

“…Research highlights: We can conclude that debeaking decreases the number of aggressive injuries in animals, and further research needs to be conducted to search for a possible alternative to EE to avoid BT, reduce injuries, and enhance performance. …”
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Protein Kinase Cα Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells by Alicia M. Thorne, Twila A. Jackson, Van C. Willis, Andrew P. Bradford

“…PKCα-dependent pathways may provide much needed prognostic markers of aggressive disease and novel therapeutic targets in ER positive tumors.…”
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