Atypical conjunctival sporotrichosis secondary to Mooren’s ulcer: a case report by Qing Su, He Dong, Lin Cui, Lijun Zhang

“…Despite the progression of Mooren’s ulcers, which further dissolved and perforated during treatment, aggressive management helped the patient retain some vision. …”
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Force–Position Coordinated Compliance Control in the Adhesion/Detachment Process of Space Climbing Robot by Changtai Wen, Pengfei Zheng, Zhenhao Jing, Chongbin Guo, Chao Chen

“…When stepping on an obstacle, the compliant control method is shown to reduce unnecessarily aggressive control actions and result in a reduction in relevant normal and shear adhesion forces in the supporting legs by 44.8% and 35.1%, respectively, compared to a PID controller.…”
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Necrotising Myositis, the Deadly Impersonator by A. Rahman, A. K. Abou-Foul, A. Yusaf, J. Holton, L. Cogswell

“…Patient 1 had a high above knee amputation of the left leg with extensive debridement of the right. Despite aggressive surgical intervention and microbiological input with intensive care support, patient 2 died. …”
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Leiomyosarcoma of the Right Gonadal Vein: Review of the Approach and Prognostic in a Rare Case by Noa de la Fuente, Manuel Rodríguez Blanco, Gemma Cerdán, Antonio Moral, Vicenç Artigas

“…Venous leiomyosarcoma is an aggressive tumour, and prognosis is poor due to haematogenous spread. …”
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Insights into the Multidisciplinary Approach for Metastatic Acinic Cell Lung Carcinoma: The Pathologist’s Role in Romania Today by Dorela-Codruta Lazureanu, Amelia Burlea, Robert Barna, Daniela Cipu, Mihaela Pasca Fenesan, Ioan Icma, Marioara Cornianu

“…The pathologist involved in the discussion of oncological cases brings his expertise in solving cases, certifying the evolution of tumors considered less aggressive, such as in the case of lung ACCs.…”
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Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy by Ali Sakhdari, Guilin Tang, Lawrence E. Ginsberg, Cheryl F. Hirsch-Ginsberg, Carlos E. Bueso-Ramos, L. Jeffrey Medeiros, Roberto N. Miranda

“…In contrast, T-prolymphocytic leukemia (T-PLL) is a rare type of T-cell leukemia with most patients having an aggressive clinical course and a dismal prognosis. Therapies are limited for T-PLL patients and there is a high relapse rate. …”
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A Case of De Novo CD5+ Disseminated Intravascular Large B-Cell Lymphoma Presenting as Multiorgan Failure by Daulath Singh, Devika Kapuria, Suparna Nanua, Rakesh Gaur

“…The immunophenotypic studies performed revealed that our patient had de novo CD5+ intravascular large B-cell lymphoma which is known to be aggressive with very poor prognosis. Although it is an extremely rare lymphoma, it should be considered as a potential cause of multiorgan failure when no other cause has been identified. …”
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A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant forms of brain cancer. …”
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A Case Report Demonstrating How the Clinical Presentation of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma Can Mimic Benign Riedel’s Thyroiditis by Jennifer Walsh, Tomas P. Griffin, Carmel B. Ryan, James Fitzgibbon, Patrick Sheahan, Matthew S. Murphy

“…DSV-PTC is one of the more aggressive forms of thyroid cancer but with early diagnosis and appropriate treatment patients may have excellent outcomes.…”
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Severe Disabling Myalgia as an Initial Presentation of Polyarteritis Nodosa by H. M. Senarathna, C. L. Fonseka, H. A. S. Perera, P. U. T. De Silva, T. P. Weerarathna

“…With continuation of aggressive immunosuppression and rehabilitation for five months, the patient improved and was able to walk without support. …”
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Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma by Lin Zhong MM, Anqing Lu MB, Xiyue Lu MM, Xiaoyin Liu MD, Lujia Cao MM, Shihong Zhu MM, SiJun Diao MM, Xu Cheng MM, Hongwei Wu MB, Jing Chen MD

“…This disease is highly aggressive. For decades, high-dose methotrexate-based induction regimens have been the standard treatment for PCNSL and have significantly improved patient overall survival (OS). …”
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B cells enhance IL-1 beta driven invasiveness in triple negative breast cancer by Nicole J. Toney, Lynn M. Opdenaker, Lisa Frerichs, Shirin R. Modarai, Aihui Ma, Holly Archinal, Grace O. Ajayi, Jennifer Sims-Mourtada

“…Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype often characterized by high lymphocyte infiltration, including tumor-infiltrating B cells (TIBs). …”
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Successful Treatment with Mycophenolate Mofetil and Tacrolimus in Juvenile Severe Lupus Nephritis by Tomoo Kise, Hiroshi Yoshimura, Shigeru Fukuyama, Masatsugu Uehara

“…Lupus nephritis (LN) of juvenile onset often has severe disease presentation. Despite aggressive induction therapy, up to 20% of patients with LN are resistant to initial therapy and up to 44% suffer a renal relapse. …”
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Neovascular Glaucoma as the First Symptom of Bilateral Occlusive Retinal Vasculitis in a 4-Year-Old Girl: A Case Report by Klaudia Rakusiewicz-Krasnodębska, Joanna Jędrzejczak-Młodziejewska, Krystyna Kanigowska, Wojciech Hautz

“…The management of this case was challenging due to the progressive and aggressive nature of the disease in a 4-year-old patient. …”
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Inverted Papilloma Originating Primarily from the Nasolacrimal Duct: A Case Report and Review of the Pertinent Literature by Hussein Z. Walijee, Sandeep Berry, Stuart Quine, Carol Lane, Daniel S. Morris, Benedict Bowman

“…Inverted papilloma (IP) is an uncommon, benign yet aggressive neoplasm characterised by high recurrence rates and tendency towards malignant transformation. …”
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Global, regional, and national burden of esophageal cancer using the 2019 global burden of disease study by Liangchao Sun, Kaikai Zhao, Xiaoli Liu, Xue Meng

“…Abstract Esophageal cancer, with its aggressive nature and high mortality, poses diverse epidemiological challenges worldwide. …”
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Dialysate White Blood Cell Change after Initial Antibiotic Treatment Represented the Patterns of Response in Peritoneal Dialysis-Related Peritonitis by Pichaya Tantiyavarong, Opas Traitanon, Piyatida Chuengsaman, Jayanton Patumanond, Adis Tasanarong

“…Clinicians should focus on the delayed response and failure patterns in order to make a decision whether to continue medical therapies or to aggressively remove the peritoneal catheter.…”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…Abstract Medulloblastoma (MB) is the most common aggressive paediatric brain tumour and, despite the recent progress in the treatments of MB patients, there is still an urgent need of complementary or alternative therapeutic options for MB infants. …”
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Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel by Seungkyu Choi, Jai Hyang Go, Eun Kyung Kim, Hojung Lee, Won Mi Lee, Chun-Sung Cho, Kyudong Han

“…Extranodal natural killer (NK)/T-cell lymphoma, nasal type (NKTCL), is a malignant disorder of cytotoxic lymphocytes of NK or T cells. It is an aggressive neoplasm with a very poor prognosis. Although extranodal NKTCL reportedly has a strong association with Epstein-Barr virus, the molecular pathogenesis of NKTCL has been unexplored. …”
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Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma with Intramuscular Lipoma-Like Component of the Thigh by Chairat Burusapat, Nuttadon Wongprakob, Nutthapong Wanichjaroen, Chatchai Pruksapong, Kantang Satayasoontorn

“…Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is a locally aggressive mesenchymal neoplasm composed either entirely or partly of an adipocytic proliferation showing at least focal nuclear atypia in both adipocytes and stromal cells. …”
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