Active Surveillance for Localized Prostate Cancer – Current Practices and Recommendations by Jennifer N. Wu, Marc A. Dall'Era

“…Prostate cancer is now the most commonly diagnosed solid tumor in American men, due in part to widespread screening and aggressive diagnostic practices. Prostate cancer autopsy studies show the uniquely high prevalence rates of small, indolent tumors in men dying of other causes. …”
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Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros by Konstantinos Makrilakis, Stavros Liatis

“…Coronary atherosclerosis is generally more aggressive and widespread in people with diabetes (PWD) and is frequently asymptomatic. …”
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Focal Treatment of Prostate Cancer with Vascular-Targeted Photodynamic Therapy by Scott E. Eggener, Jonathan A. Coleman

“…Focal therapy offers an attractive alternative for the patient faced with a choice between aggressive local intervention (radiation or surgery) and watchful waiting. …”
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Primary Leiomyosarcoma of the Kidney: A Case Report by Srijana Khati, Sagar Rana Magar, Ankita Simkhada, Ramesh Paudel, Surendra Khanal, Bishal Panthi, Sadmarg Thakur, Sujan Paudel, Prajjwol Luitel

“…ABSTRACT Primary renal leiomyosarcoma is a rare but highly aggressive tumor with a poor prognosis. Early detection and surgical excision provide the most effective initial treatment. …”
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Multiple Brain Abscesses due to Streptococcus anginosus: Prediction of Mortality by an Imaging Severity Index Score by K. O. Kragha

“…An elderly patient with altered mental status, brain abscesses, ventriculitis, and empyemas died of septic shock and brain abscesses secondary to Streptococcus anginosus despite aggressive treatment. An imaging severity index score with a better prognostic value than the Glasgow coma scale predicted mortality in this patient.…”
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Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literatu... by Erik W. Larson, Halloran E. Peterson, Robert K. Fairbanks, Wayne T. Lamoreaux, Alexander R. Mackay, Jason A. Call, John J. Demakas, Barton S. Cooke, Christopher M. Lee

“…This report provides evidence that aggressive local treatment with GKRS at the time of recurrence may be appropriate, depending on a patient’s individual clinical situation, and can lead to prolonged survival and improved quality of life.…”
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Anti-N-Methyl-D-Aspartate Encephalitis as Paraneoplastic Manifestation of Germ-Cells Tumours: A Cases Report and Literature Review by Claudia Geraldine Rita, Israel Nieto Gañan, Adriano Jimenez Escrig, Ángela Carrasco Sayalero

“…Management includes aggressive immunosuppression and surgical removal.…”
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Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases by W. F. Julius Scheurleer, Weibel W. Braunius, Bernard M. Tijink, Luuk M. Janssen, Frank A. Pameijer, Gerben E. Breimer, Ernst J. Smid, Remco de Bree, Lot A. Devriese, Johannes A. Rijken

“…Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. …”
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Cytokine Patterns in Brain Tumour Progression by Radu Albulescu, Elena Codrici, Ionela Daniela Popescu, Simona Mihai, Laura Georgiana Necula, Daniel Petrescu, Mihaela Teodoru, Cristiana Pistol Tanase

“…These molecules are involved in tumour progression and aggressiveness, and are also involved in a generation of disease associated pain.…”
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Persistent Mixed Donor Chimerism following Double Umbilical Cord Transplantation in a Patient with T-Cell Prolymphocytic Leukemia by Ronak H. Mistry, Elizabeth O. Hexner, James K. Mangan

“…T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive postthymic T-cell neoplasm with an associated survival time of 1 year when left untreated. …”
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Performance of Ground Clay Brick Mortars in Simulated Chloride and Sulphate Media by Festus Ngui Musyimi, Jackson Muthengia Wachira, Joseph Karanja Thiong’o, Joseph Mwiti Marangu

“…The durability of cement-based structures majorly depends on their resistivity to the aggressive media in the construction environment. The most aggressive ions commonly encountered in construction environment are chloride (Cl−) and sulphate (SO42−). …”
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Survival and prognostic factors for primary lung extranodal NK/T-cell lymphoma: a retrospective study of data from China and the SEER database by Qiuyu Li, Haoyu Zuo, Chengyang Liu, Jing Yang, Nini Dai

“…Background and aimExtranodal NK/T-cell lymphoma (ENKTL) is a rare and aggressive subtype of non-Hodgkin’s lymphoma that most commonly affects the nasal cavity and nasopharynx. …”
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EIF1AX mutation in thyroid tumors: a retrospective analysis of cytology, histopathology and co-mutation profiles by Noha Elsherbini, Dong Hyun Kim, Richard J. Payne, Thomas Hudson, Véronique-Isabelle Forest, Michael P. Hier, Alexandra E. Payne, Marc P. Pusztaszeri

“…Fisher’s Exact Test was used to determine the association of A113_splice mutation with aggressive malignancies compared to non-A113_splice mutations. …”
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Treatment of a Gastric Lactobezoar with N-Acetylcysteine by Brandon Sparks, Anil Kesavan

“…Lactobezoars are a rare finding with potentially serious sequelae in pediatric patients with feeding intolerance. Aggressive treatment may be preferred to traditional treatments to avoid complications in medically complex patients. …”
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Invasive Liver Abscess Syndrome in the Immunocompromised: A Case Report by Amey Joshi, Eki Wari, Harith Ghnaima, Georgette Nader, Surya Chennupati, Nagham Jafar

“…Early recognition in non‐endemic regions is crucial for prompt antibiotic therapy and source control, highlighting the need for increased suspicion and aggressive management of this rare disease to improve patient outcomes.…”
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Long-Term Exploitation of a Reinforced Concrete Beam on a Ground Base with Corrosion Damage by M. V. Berlinov, M. N. Berlinova

“…A method of dynamic calculation of reinforced concrete structures of structures of various types on a ground base operated in an aggressive environment is proposed, internal factors of rheological deformation are also taken into account, taking into account corrosion damage, reflecting their real work under the joint action of the load and the aggressive environment on the basis of the modern phenomenological theory of deformation of the elastic creeping body. …”
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Impact of Driver Age and Behavior on the Effectiveness of ADAS in Cyclist Safety on Rural Roads: A Simulator Study by Nouman Usama, Ahmed M. Al-Wathinani, Krzysztof Goniewicz, Sami Babar

“…Utilizing a driving simulator, the study analyzed the overtaking maneuvers of 300 male participants, categorized by aggressive and passive driving styles, across three age groups: young (20–34), middle-aged (35–49), and older (50–64) drivers. …”
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A Case of Chemotherapy-Refractory “THRLBCL like Transformation of NLPHL” Successfully Treated with Lenalidomide by Mamatha Siricilla, Lydia Irwin, Andres Ferber

“…Of note, NLPHL has a small risk of transformation to an aggressive lymphoma such as THRLBCL.…”
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Current Trends in Targeted Therapies for Glioblastoma Multiforme by Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

“…Glioblastoma multiforme (GBM) is one of the most frequently occurring tumors in the central nervous system and the most malignant tumor among gliomas. Despite aggressive treatment including surgery, adjuvant TMZ-based chemotherapy, and radiotherapy, GBM still has a dismal prognosis: the median survival is 14.6 months from diagnosis. …”
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Case report: Exploring efficacy of tofacitinib in modulating interferon response in five case of anti-MDA5+ dermatomyositis with interstitial lung disease by Jie Zhao, Yan Bao, Ying Gao, Keliang Xie

“…Other four similar cases underscore the critical importance of early and aggressive intervention in MDA5-DM patients, as well as the potential therapeutic avenues involving IFN blockers by JAK inhibitors. …”
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