Molecular Basis of Triple Negative Breast Cancer and Implications for Therapy by Parvin F. Peddi, Matthew J. Ellis, Cynthia Ma

“…Triple negative breast cancer is an aggressive form of breast cancer with limited treatment options and is without proven targeted therapy. …”
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Aortoenteric Fistula Assocaited with Acute Myocardial Infarcation by Robert J Fingerote, Alan BR Thomson

“…A 64-year-old male with a prior abdominal aortic graft for lower limb ischemia presented with melena and myocardial infarction. Despite aggressive investigation, an aortoenteric fistula was not diagnosed until after massive gastrointestinal hemorrhage. …”
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Necrotizing Soft Tissue Infection Occurring after Exposure to Mycobacterium marinum by Shivani S. Patel, M. Lance Tavana, M. Sean Boger, Soe Soe Win, Bassam H. Rimawi

“…While previous cases of necrotizing soft tissue infections related to M. marinum have been documented, the importance of our presenting case is to illustrate the aggressive nature of M. marinum resulting in a persistent necrotizing soft tissue infection of a finger that required multiple aggressive wound debridements, followed by an amputation of the affected extremity, in order to hasten recovery.…”
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Merkel Cell Carcinoma: Interdisciplinary Management of a Rare Disease by Sven Schneider, Dietmar Thurnher, Boban M. Erovic

“…Management of this rare but highly aggressive skin cancer is a complex undertaking that necessitates an understanding of its etiology, epidemiology, clinical presentation, and the coordinated work of several clinical specializations. …”
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Necrotizing Craniocervical Soft Tissue Infections: Clinical Experience and Personal Considerations by Stefania Gallo, Apostolos Karligkiotis, Riccardo Lenzi, Paolo Castelnuovo, Iacopo Dallan

“…Early diagnosis and aggressive, multimodality treatment can reduce mortality and morbidity rates. …”
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The Conundrum of Septic Shock Imitators in Patients with Hematologic Cancers: Case Presentation and Possible Differential Diagnoses by Giorgio Berlot, Giulia Moratelli, Martina Tarchini, Katiuscia Battaglia, Paolo Grassi, Nadia Zarrillo, Vincenzo Colella, Rossana Bussani

“…One daafter the last cycle, he was admitted to our Intensive Care Unit with a septic shock-like clinical picture which didn’t respond to the aggressive treatment and the patient died a few hours later. …”
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Evaluating Rainy Weather Effects on Driving Behaviour Dimensions of Driving Behaviour Questionnaire by Vahid Bakhshi, Kayvan Aghabayk, Nasser Parishad, Nirajan Shiwakoti

“…Exploratory and confirmatory factor analysis concluded a four-factor solution (high velocity with a law violation, slips, positive and cautious behaviours, and aggressive driving behaviours) with a 52% explanation of variance. …”
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Immunotherapy for Metastatic Melanoma with Right Atrial Involvement in a Patient with Rheumatoid Arthritis by Zachary Benson, Sarah Gordon, Patricia Nicolato, Andrew Poklepovic

“…Given improvements in survival, aggressive surgical treatment may be considered in patients with life-threatening complications from their disease that would not otherwise be considered in advanced disease. …”
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Gap Minimization for Peer-Evaluation in DEA Cross-Efficiency by Anrong Yang, Zigang Zhang, Yishi Zhang, Dunliang Chen

“…Gap minimization criterion is introduced in aggressive and benevolent cross-efficiency methods to avoid possible extreme efficiency from peer-evaluation and to get equitable results. …”
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Clinical Resolution of Osmotic Demyelination Syndrome following Overcorrection of Severe Hyponatremia by Ruhin Yuridullah, Vinod Kumar, Sushant Nanavati, Monisha Singhal, Chandra Chandran

“…Our aim here is to show that, with aggressive therapy and long-term care, recovery is possible in these patients.…”
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Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis by Giorgio Berlot, Ariella Tomasini, Lorenzo Zandonà, Eugenio Leonardo, Rossana Bussani, Nadia Zarrillo

“…At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered.…”
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The Baker’s Dozen: Key Nations Can and Should Act Together to Prevent Further Dangerous Climate Change by Kirsten Oleson, Lauren Hartzell, Michael Mastrandrea

“…With aggressive measures, their action would be sufficient to greatly reduce the likelihood of additional dangerous climate change, defined as widespread and irreversible change. …”
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Expression of Leptin Receptor and Effects of Leptin on Papillary Thyroid Carcinoma Cells by Marilena Celano, Valentina Maggisano, Saverio Massimo Lepore, Marialuisa Sponziello, Valeria Pecce, Antonella Verrienti, Cosimo Durante, Marianna Maranghi, Piernatale Lucia, Stefania Bulotta, Giuseppe Damante, Diego Russo

“…Obesity has been hypothesized to contribute to the aggressiveness of thyroid cancer through the production of abnormal levels of serum adipokines. …”
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Concomitant Central Giant Cell Granuloma and Aneurysmal Bone Cyst in a Young Child by Deepika Pai, Abhay Taranath Kamath, Adarsh Kudva, Monica Monica Charlotte Solomon, Saurabh Kumar, Prem Sasikumar

“…Although Central Giant Cell Granuloma (CGCG) is a benign tumor of the jaw and aneurysmal bone cyst seen in children, its aggressive behavior causes extensive loss of hard tissue requiring wide excision and extensive rehabilitation. …”
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Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases by Syeed Mehbub Ul Kadir, Mukti Rani Mitra, Riffat Rashid, Murtuza Nuruddin, Md. Kamrul Hassan Khan, Golam Haider, Mst. Sayedatun Nessa

“…Hence, it is essential to build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. …”
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Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells by Song Shengyou, Tai Lunwei, Zhou Lei, Jiang Junling, Zhao Junfeng

“…To investigate how lathyrol affects aggressive behaviors and related proteins of the androgen receptor (AR) 786-O cells.…”
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A Case Report of Complete Resolution of Auricular Mucormycosis in an 18-Month-Old Diabetic Child by Mariam Aljehani, Hatem Alahmadi, Mansour Alshamani

“…Mucormycosis is considered a very fatal and aggressive infection that has a very high mortality rate in immunocompromised patients. …”
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Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer by Riley J. Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

“…Inflammatory breast cancer is a rare, yet highly aggressive form of breast cancer, which accounts for less than 5% of all locally advanced presentations. …”
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Denosumab Chemotherapy for Recurrent Giant-Cell Tumor of Bone: A Case Report of Neoadjuvant Use Enabling Complete Surgical Resection by Amit Agarwal, Brandon T. Larsen, Lawrence D. Buadu, Jack Dunn, Russell Crawford, Jonathan Daniel, Maria C. Bishop

“…The tumor is generally benign but sometimes can be locally aggressive. There are no standardized approaches to the treatment of GCTB. …”
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Primary Small Cell Neuroendocrine Carcinoma of Paranasal Sinuses by Maliha Khan, Sobia Nizami, Aibek E. Mirrakhimov, Benjamin Maughan, Justin A. Bishop, William H. Sharfman

“…Small cell neuroendocrine carcinoma of the paranasal sinuses is an extremely rare and aggressive neoplasm. Despite aggressive management, the tumor carries a poor prognosis, with a high risk of local recurrence or distant metastases. …”
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