Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy by Chunhuan Jin, Xinyu Zhou, Minhui Xu, Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai

“…Both compounds showed comparable dissociation rates, suggesting that N-acetylation does not affect the interaction responsible for slow dissociation. …”
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Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry by Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich, Feng Yang

“…Glycosylation affects the safety and efficacy of therapeutic proteins and is often considered a critical quality attribute (CQA). …”
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Cystic Kidney Diseases in Sudanese Children: Pattern, Clinical Presentation, and Outcome by Maali Alwathig Alameen, Ebtihal Eltyeb, Rashid Ellidir

“…Males and <1 year olds were more affected among children. Early detection and renal replacement therapy can improve the outcome in such cases. …”
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The short-term and long-term results of three-stage surgical treatment of ulcerative colitis with formation of ileal J-pouch by P. V. Tsarkov, A. Yu. Kravchenko, I. A. Tulina, Yury Ye. Kitsenko

“…To estimate results of three- stage treatment approach in severe ulcerative colitis aimed for resection of affected colon and restoration of intestinal continuity. …”
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Attribution of a record-breaking cold event in the historically warmest year of 2023 and assessing future risks by Yangbo Ye, Cheng Qian, Aiguo Dai, Yuting Zhang, Jiacheng Jiang, Xiaoye Zhang

“…The manner in which such an extraordinary cold event was formed under global warming is unclear, as is the way in which anthropogenic climate change may affect the present and future frequency and intensity of similar cold events. …”
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A Two-Step Damage Diagnostic Approach Based on Static Strain Energy and Model-Updating via the Equilibrium Optimizer by Behrouz Safa, Asghar Rasouli, Yahya Nasira

“…Interestingly, the method is capable of detecting damaged elements with great speed and accuracy, and the quality of the results has not been seriously affected in the presence of perturbing factors. Moreover, information from even a limited number of first modes has been enough to solve the problem, which means that the approach does not require all vibration modes. …”
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Using the Knowledge Acquired During Studies in Shaping Attitudes Towards Sustainable Development by Małgorzata Jagodzińska, Anna Strumińska-Doktór

“…Although a clear difference in the use of knowledge in this area between students of teaching and non-teaching fields of study can be observed, it is still necessary to include the sustainable development related knowledge in the curricula of various study subjects, which will certainly affect the development of social capital, and thus education of people socially and environmentally responsible for their actions…”
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Ethiopia's Potato Seed System: Regulatory Challenges, Quality Assurance Issues, and Pathways for Improvement ─ A mini review [version 1; peer review: 2 approved] by Ebrahim Seid, Lemma Tessema

“…The regulatory environment is characterized by inconsistent seed certification practices and a dependence on informal seed sources, negatively affecting the quality of potato seeds available to farmers. …”
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Effect of annealing on the structural, morphological, optical, magnetic, and dielectric properties of nickel-doped cobalt nanoferrites for electronic applications by Md Shihabun Sakib, Md Naimur Rahman, Md Alamgir Hossain, Md Rashedur Rahman

“…Dielectric constant and losses decreased with higher annealing temperature and frequency. Annealing affected interionic bond lengths, distances, and angles, resulting in an increase in coercivity from 77.15 to 117.70 Oe, while saturation magnetization decreased from 9.15 to 5.32 emu/g, indicating the soft magnetic properties of CNSF nanoparticles. …”
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Strain Monitoring of Combustible Gas Implosion Test Based on Fiber Bragg Grating by Lei Gao, Qinghua Zhang, Erbing Li, Yangyang Sun, Zhenglin Zhang, Shikun Pu, Xiejun Cheng, Fengjuan Rong

“…The reliability and repeatability of the strain change of the FBG affected by detonation overpressure and combustion were tested at this point. …”
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Livestock Depredation and Pastoralist Attitudes towards Carnivore in the Landscape of Lions Associated with Gambella National Park, Abobo District, Western Ethiopia by Getahun Gedif Abie, Krishnagouda Shankargouda Goudar, Hussein Ibrahim, Gezahegn Getachew

“…The livelihoods of individuals in Ethiopia are severely affected by the livestock depredation from wild animals. …”
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Main Rotor Wake Interference Effects on Tail Rotor Thrust in Crosswind by Chang Wang, Min Qi Huang, Shuai Ma, Hao Wen Wang, Min Tang

“…The increase in TR thrust at moderate wind speeds is due to the increase in leading edge dynamic pressure caused by the opposite swirl direction of the disc vortex contrasted to the TR. The MR disc loading affects the TR thrust due to the change of disc vortex strength and position.…”
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Determining Dust Sources of Middle East and Assessing Their Impact on Agricultural Lands in Euphrates-Tigris River Basin (Syria-Iraq) by Ayhan Ateşoğlu, Metin Tunay, Talha Berk Arıkan, Saffet Yıldız

“…By interpreting the results of the classification with regard to the Middle East, especially respect to sand/dune areas, agricultural lands and water resources, the evaluations are made especially on the scale of Iraq and Syria affected by Euphrates and Tigris River.…”
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Physical Inactivity and Food Insecurity Are Associated with Social Capital: A Large-Scale Population-Based Study in Tehran by Amin Nakhostin-Ansari, Paria Akbari, Maryam Selk-Ghaffari, Amir Hossein Memari, Mohamad-Reza Vaez-Mahdavi, Mohsen Asadi-Lari

“…The prevalence of food insecurity and physical inactivity is relatively high among Tehran residents. As a factor affecting the physical activity and food security, social capital can be targeted in interventions to improve physical activity and food security among Iranians.…”
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Explaining the interactions of city and border with the sustainable development approach Based on the logic of fuzzy multi-criteria decision making Case study: Zahedan ,Mijaveh, D... by reza mohammadi, zyinab karkaabadi, ghlam reza miri

“…Findings and results showed.the most important effective factor on city-boundary relations is social factors with a mean of 3.55 and among weaknesses, Most affected were social weaknesses with a mean of 3.63 and among the opportunities examined, economic and managerial factors with a mean of 3.53 and Finally, they have the most impact on all types of threats, injuries and social threats with an average of 3.75. …”
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Efficacy of Exenatide Administered Twice Daily in Body Mass Index Reduction in Patients with Type 2 Diabetes Mellitus by Jie Zhang, Tong-Zhang Xian, Yu Teng, Xiuzhi Wang, Ming-Xiao Wu, Chen Li, Weihao Wang, Fuli Man, Xianbo Zhang, Xiaoxia Wang, Li-Xin Guo

“…BMI scores improved after exenatide treatment for 52 weeks in T2DM patients. Weight loss was affected by baseline body weight and blood glucose level. …”
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Increased Visual Attentional Demands Alter Lower Extremity Sidestep Cutting Kinematics in Male Basketball Players by Koen T.H. Rikken, Tom Panneman, Fabian Vercauteren, Alli Gokeler, Anne Benjaminse

“…It is unknown how visual attention affects sidestep cutting kinematics during the entire energy absorption phase of the cut in an ecologically valid environment…”
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Carboxylated Multiwalled Carbon Nanotubes as Dispersive Solid-Phase Extraction Sorbent to Determine Eighteen Polychlorinated Biphenyls in Vegetable Samples by Gas Chromatography-Ma... by Tengfei Liu, Daifeng Yang, Jian Mao, Xueming Zhang, Minghui Dong

“…A simple, rapid, and reliable method based on dispersive solid-phase extraction (d-SPE) and gas chromatography-mass spectrometry (GC-MS) was developed for quantitating polychlorinated biphenyls (PCBs) in vegetable samples. Parameters affecting both the extraction yields and cleanup efficiency, including the type and volume of extraction solvent, extraction time, type and volume of cleanup sorbent, and cleanup time, were optimized. …”
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Investigating Metabolic Phenotypes for Sarcoidosis Diagnosis and Exploring Immunometabolic Profiles to Unravel Disease Mechanisms by Mohammad Mehdi Banoei, Abdulrazagh Hashemi Shahraki, Kayo Santos, Gregory Holt, Mehdi Mirsaeidi

“…<b>Background:</b> Sarcoidosis is a granulomatous disease affecting multiple organ systems and poses a diagnostic challenge due to its diverse clinical manifestations and absence of specific diagnostic tests. …”
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The Effectiveness of Mindfulness-Based Schema Therapy on Anxiety , Quality of life and Frustration Tolerance of Patients with Multiple Sclerosis by Niloofar Jafarian, Ali Rezaie, Fatemeh Izadi

“…Introduction: Multiple sclerosis is a progressive neurological disease that leads to various disabilities in affected individuals. The combination of symptoms and the chronic nature of this condition can significantly impact a person's mental well-being, contributing to broader psychological issues related to the progression of the disease. …”
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